PubMed:10611486
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/10611486","sourcedb":"PubMed","sourceid":"10611486","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/10611486","text":"Substitution of amino acid residue in influenza A virus hemagglutinin affects recognition of sialyl-oligosaccharides containing N-glycolylneuraminic acid.\nSialic acids are essential components of cell surface receptors used by influenza viruses. To determine the molecular mechanisms of viral recognition of two major species of sialic acids, N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc), we tested the binding reactivity of nine human H3 influenza A viruses to sialylglycolipids containing type II sugar chain and different molecular species of terminal sialic acids. All human H3 viruses tested except A/Memphis/1/71 bound both Neu5Ac and Neu5Gc. Nucleotide sequence analysis suggests that amino acids at 143, 155, and 158 are linked to the viral recognition of Neu5Gc.","tracks":[{"project":"IAV-Glycan_IAV_H3_human","denotations":[{"id":"T1","span":{"begin":155,"end":167},"obj":"sialic acid"},{"id":"T2","span":{"begin":329,"end":341},"obj":"sialic acid"},{"id":"T3","span":{"begin":582,"end":594},"obj":"sialic acid"}],"attributes":[{"subj":"T1","pred":"source","obj":"IAV-Glycan_IAV_H3_human"},{"subj":"T2","pred":"source","obj":"IAV-Glycan_IAV_H3_human"},{"subj":"T3","pred":"source","obj":"IAV-Glycan_IAV_H3_human"}]},{"project":"IAV-Glycan_IAV_human","denotations":[{"id":"T1","span":{"begin":155,"end":167},"obj":"sialic acid"},{"id":"T2","span":{"begin":329,"end":341},"obj":"sialic acid"},{"id":"T3","span":{"begin":582,"end":594},"obj":"sialic acid"}],"attributes":[{"subj":"T1","pred":"source","obj":"IAV-Glycan_IAV_human"},{"subj":"T2","pred":"source","obj":"IAV-Glycan_IAV_human"},{"subj":"T3","pred":"source","obj":"IAV-Glycan_IAV_human"}]},{"project":"IAV-Glycan_IAV_H3","denotations":[{"id":"T1","span":{"begin":155,"end":167},"obj":"sialic acid"},{"id":"T2","span":{"begin":329,"end":341},"obj":"sialic acid"},{"id":"T3","span":{"begin":582,"end":594},"obj":"sialic acid"}],"attributes":[{"subj":"T1","pred":"source","obj":"IAV-Glycan_IAV_H3"},{"subj":"T2","pred":"source","obj":"IAV-Glycan_IAV_H3"},{"subj":"T3","pred":"source","obj":"IAV-Glycan_IAV_H3"}]},{"project":"IAV-Glycan_IAV_human_2","denotations":[{"id":"T1","span":{"begin":0,"end":12},"obj":"substitution"},{"id":"T2","span":{"begin":155,"end":167},"obj":"sialic acid"},{"id":"T3","span":{"begin":209,"end":218},"obj":"receptor"},{"id":"T4","span":{"begin":329,"end":341},"obj":"sialic acid"},{"id":"T5","span":{"begin":463,"end":465},"obj":"H3"},{"id":"T6","span":{"begin":582,"end":594},"obj":"sialic acid"},{"id":"T7","span":{"begin":606,"end":608},"obj":"H3"}],"attributes":[{"subj":"T1","pred":"source","obj":"IAV-Glycan_IAV_human_2"},{"subj":"T2","pred":"source","obj":"IAV-Glycan_IAV_human_2"},{"subj":"T3","pred":"source","obj":"IAV-Glycan_IAV_human_2"},{"subj":"T4","pred":"source","obj":"IAV-Glycan_IAV_human_2"},{"subj":"T5","pred":"source","obj":"IAV-Glycan_IAV_human_2"},{"subj":"T6","pred":"source","obj":"IAV-Glycan_IAV_human_2"},{"subj":"T7","pred":"source","obj":"IAV-Glycan_IAV_human_2"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"IAV-Glycan_IAV_H3_human","color":"#ec93a4","default":true},{"id":"IAV-Glycan_IAV_human","color":"#93beec"},{"id":"IAV-Glycan_IAV_H3","color":"#d8ec93"},{"id":"IAV-Glycan_IAV_human_2","color":"#e593ec"}]}]}}