PubMed:10608819
Annnotations
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 75-87 | Cell | denotes | Schwann cell | http://purl.obolibrary.org/obo/CL:0000218|http://purl.obolibrary.org/obo/CL:0000692|http://purl.obolibrary.org/obo/CL:0002376|http://purl.obolibrary.org/obo/CL:0002377|http://purl.obolibrary.org/obo/CL:0002573 |
| T6 | 345-357 | Cell | denotes | Schwann cell | http://purl.obolibrary.org/obo/CL:0000218|http://purl.obolibrary.org/obo/CL:0000692|http://purl.obolibrary.org/obo/CL:0002376|http://purl.obolibrary.org/obo/CL:0002377|http://purl.obolibrary.org/obo/CL:0002573 |
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 232-243 | Glycan_Motif | denotes | sialic acid | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY |
| T2 | 698-709 | Glycan_Motif | denotes | sialic acid | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY |
| T3 | 773-782 | Glycan_Motif | denotes | GT1aalpha | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G02149VR |
| T4 | 837-846 | Glycan_Motif | denotes | GQ1balpha | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54733XO |
| T5 | 1001-1010 | Glycan_Motif | denotes | GQ1balpha | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54733XO |
| T6 | 1013-1022 | Glycan_Motif | denotes | GT1aalpha | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G02149VR |
| T7 | 1035-1039 | Glycan_Motif | denotes | GT1b | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G40183QN|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G05952XV |
| T9 | 1041-1045 | Glycan_Motif | denotes | GD1a | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G69277LC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46677TE |
| T11 | 1048-1051 | Glycan_Motif | denotes | GM1 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI |
| T13 | 1209-1221 | Glycan_Motif | denotes | sialic acids | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY |
| T14 | 1266-1277 | Glycan_Motif | denotes | sialic acid | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY |
| T15 | 1372-1381 | Glycan_Motif | denotes | GT1aalpha | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G02149VR |
| T16 | 1614-1623 | Glycan_Motif | denotes | GT1aalpha | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G02149VR |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-176 | Sentence | denotes | Enhanced binding of the neural siglecs, myelin-associated glycoprotein and Schwann cell myelin protein, to Chol-1 (alpha-series) gangliosides and novel sulfated Chol-1 analogs. |
| T2 | 177-483 | Sentence | denotes | Extended glycoconjugate binding specificities of three sialic acid-dependent immunoglobulin-like family member lectins (siglecs), myelin-associated glycoprotein (MAG), Schwann cell myelin protein (SMP), and sialoadhesin, were compared by measuring siglec-mediated cell adhesion to immobilized gangliosides. |
| T3 | 484-902 | Sentence | denotes | Synthetic gangliosides bearing the alpha-series determinant (NeuAc alpha2,6-linked to GalNAc on a gangliotetraose core) were tested, including GD1alpha (IV(3)NeuAc, III(6)NeuAc-Gg(4)OseCer), GD1alpha with modified sialic acid residues at the III(6)-position, and the "Chol-1" gangliosides GT1aalpha (IV(3)NeuAc, III(6)NeuAc, II(3)NeuAc-Gg(4)OseCer) and GQ1balpha (IV(3)NeuAc, III(6)NeuAc, II(3)(NeuAc)(2)-Gg(4)OseCer). |
| T4 | 903-1173 | Sentence | denotes | The alpha-series gangliosides displayed enhanced potency for MAG- and SMP-mediated cell adhesion (GQ1balpha > GT1aalpha, GD1alpha > GT1b, GD1a > GM1 (nonbinding)), whereas sialoadhesin-mediated adhesion was comparable with alpha-series and non-alpha-series gangliosides. |
| T5 | 1174-1354 | Sentence | denotes | GD1alpha derivatives with modified sialic acids (7-, 8-, or 9-deoxy) or sulfate (instead of sialic acid) at the III(6)-position supported adhesion comparable with that of GD1alpha. |
| T6 | 1355-1659 | Sentence | denotes | Notably, a novel GT1aalpha analog with sulfates at two internal sites of sialylation (NeuAcalpha2,3Galbeta1,4GalNAc-6-sulfatebeta1, 4Gal3-sulfatebeta1,4Glcbeta1,1'ceramide) was the most potent siglec-binding structure tested to date (10-fold more potent than GT1aalpha in supporting MAG and SMP binding). |
| T7 | 1660-1891 | Sentence | denotes | Together with prior studies, these data indicate that MAG and SMP display an extended structural specificity with a requirement for a terminal alpha2, 3-linked NeuAc and great enhancement by nearby precisely spaced anionic charges. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 232-243 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | sialic acid |
| T2 | 698-709 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | sialic acid |
| T3 | 773-782 | https://glytoucan.org/Structures/Glycans/G02149VR | denotes | GT1aalpha |
| T4 | 837-846 | https://glytoucan.org/Structures/Glycans/G54733XO | denotes | GQ1balpha |
| T5 | 1001-1010 | https://glytoucan.org/Structures/Glycans/G54733XO | denotes | GQ1balpha |
| T6 | 1013-1022 | https://glytoucan.org/Structures/Glycans/G02149VR | denotes | GT1aalpha |
| T7 | 1035-1039 | https://glytoucan.org/Structures/Glycans/G05952XV | denotes | GT1b |
| T8 | 1035-1039 | https://glytoucan.org/Structures/Glycans/G40183QN | denotes | GT1b |
| T9 | 1041-1045 | https://glytoucan.org/Structures/Glycans/G46677TE | denotes | GD1a |
| T10 | 1041-1045 | https://glytoucan.org/Structures/Glycans/G69277LC | denotes | GD1a |
| T11 | 1048-1051 | https://glytoucan.org/Structures/Glycans/G46613JI | denotes | GM1 |
| T12 | 1048-1051 | https://glytoucan.org/Structures/Glycans/G48558GR | denotes | GM1 |
| T13 | 1209-1221 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | sialic acids |
| T14 | 1266-1277 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | sialic acid |
| T15 | 1372-1381 | https://glytoucan.org/Structures/Glycans/G02149VR | denotes | GT1aalpha |
| T16 | 1614-1623 | https://glytoucan.org/Structures/Glycans/G02149VR | denotes | GT1aalpha |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 773-782 | http://www.glycoepitope.jp/epitopes/EP0111 | denotes | GT1aalpha |
| T2 | 837-846 | http://www.glycoepitope.jp/epitopes/EP0112 | denotes | GQ1balpha |
| T3 | 1001-1010 | http://www.glycoepitope.jp/epitopes/EP0112 | denotes | GQ1balpha |
| T4 | 1013-1022 | http://www.glycoepitope.jp/epitopes/EP0111 | denotes | GT1aalpha |
| T5 | 1035-1039 | http://www.glycoepitope.jp/epitopes/EP0067 | denotes | GT1b |
| T6 | 1041-1045 | http://www.glycoepitope.jp/epitopes/EP0056 | denotes | GD1a |
| T7 | 1048-1051 | http://www.glycoepitope.jp/epitopes/EP0050 | denotes | GM1 |
| T8 | 1372-1381 | http://www.glycoepitope.jp/epitopes/EP0111 | denotes | GT1aalpha |
| T9 | 1614-1623 | http://www.glycoepitope.jp/epitopes/EP0111 | denotes | GT1aalpha |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 545-550 | Glycan | denotes | NeuAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
| T2 | 570-576 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T3 | 627-635 | Glycan | denotes | GD1alpha | https://api.glycosmos.org/wurcs2image/latest/png/binary/G07394RV |
| T4 | 642-647 | Glycan | denotes | NeuAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
| T5 | 655-660 | Glycan | denotes | NeuAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
| T6 | 675-683 | Glycan | denotes | GD1alpha | https://api.glycosmos.org/wurcs2image/latest/png/binary/G07394RV |
| T7 | 773-782 | Glycan | denotes | GT1aalpha | https://api.glycosmos.org/wurcs2image/latest/png/binary/G02149VR |
| T8 | 789-794 | Glycan | denotes | NeuAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
| T9 | 802-807 | Glycan | denotes | NeuAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
| T10 | 814-819 | Glycan | denotes | NeuAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
| T11 | 837-846 | Glycan | denotes | GQ1balpha | https://api.glycosmos.org/wurcs2image/latest/png/binary/G54733XO |
| T12 | 853-858 | Glycan | denotes | NeuAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
| T13 | 866-871 | Glycan | denotes | NeuAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
| T14 | 879-884 | Glycan | denotes | NeuAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
| T15 | 1001-1010 | Glycan | denotes | GQ1balpha | https://api.glycosmos.org/wurcs2image/latest/png/binary/G54733XO |
| T16 | 1013-1022 | Glycan | denotes | GT1aalpha | https://api.glycosmos.org/wurcs2image/latest/png/binary/G02149VR |
| T17 | 1024-1032 | Glycan | denotes | GD1alpha | https://api.glycosmos.org/wurcs2image/latest/png/binary/G07394RV |
| T18 | 1035-1039 | Glycan | denotes | GT1b | https://api.glycosmos.org/wurcs2image/latest/png/binary/G40183QN |
| T19 | 1041-1045 | Glycan | denotes | GD1a | https://api.glycosmos.org/wurcs2image/latest/png/binary/G46677TE |
| T20 | 1048-1051 | Glycan | denotes | GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
| T21 | 1174-1182 | Glycan | denotes | GD1alpha | https://api.glycosmos.org/wurcs2image/latest/png/binary/G07394RV |
| T22 | 1345-1353 | Glycan | denotes | GD1alpha | https://api.glycosmos.org/wurcs2image/latest/png/binary/G07394RV |
| T23 | 1372-1381 | Glycan | denotes | GT1aalpha | https://api.glycosmos.org/wurcs2image/latest/png/binary/G02149VR |
| T24 | 1614-1623 | Glycan | denotes | GT1aalpha | https://api.glycosmos.org/wurcs2image/latest/png/binary/G02149VR |
| T25 | 1820-1825 | Glycan | denotes | NeuAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 773-782 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GT1aalpha | http://www.glycoepitope.jp/epitopes/EP0111 |
| T2 | 837-846 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GQ1balpha | http://www.glycoepitope.jp/epitopes/EP0112 |
| T3 | 1001-1010 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GQ1balpha | http://www.glycoepitope.jp/epitopes/EP0112 |
| T4 | 1013-1022 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GT1aalpha | http://www.glycoepitope.jp/epitopes/EP0111 |
| T5 | 1035-1039 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GT1b | http://www.glycoepitope.jp/epitopes/EP0067 |
| T6 | 1041-1045 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GD1a | http://www.glycoepitope.jp/epitopes/EP0056 |
| T7 | 1048-1051 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T8 | 1372-1381 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GT1aalpha | http://www.glycoepitope.jp/epitopes/EP0111 |
| T9 | 1614-1623 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GT1aalpha | http://www.glycoepitope.jp/epitopes/EP0111 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 75-87 | Cell | denotes | Schwann cell | http://purl.obolibrary.org/obo/CL:0000218|http://purl.obolibrary.org/obo/CL:0000692|http://purl.obolibrary.org/obo/CL:0002376|http://purl.obolibrary.org/obo/CL:0002377|http://purl.obolibrary.org/obo/CL:0002573 |
| T6 | 345-357 | Cell | denotes | Schwann cell | http://purl.obolibrary.org/obo/CL:0000218|http://purl.obolibrary.org/obo/CL:0000692|http://purl.obolibrary.org/obo/CL:0002376|http://purl.obolibrary.org/obo/CL:0002377|http://purl.obolibrary.org/obo/CL:0002573 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 40-46 | Body_part | denotes | myelin | http://purl.obolibrary.org/obo/UBERON_0000345 |
| T2 | 75-87 | Body_part | denotes | Schwann cell | http://purl.obolibrary.org/obo/CL_0000218|http://purl.obolibrary.org/obo/CL_0002377|http://purl.obolibrary.org/obo/CL_0002573 |
| T5 | 88-94 | Body_part | denotes | myelin | http://purl.obolibrary.org/obo/UBERON_0000345 |
| T6 | 307-313 | Body_part | denotes | myelin | http://purl.obolibrary.org/obo/UBERON_0000345 |
| T7 | 345-357 | Body_part | denotes | Schwann cell | http://purl.obolibrary.org/obo/CL_0000218|http://purl.obolibrary.org/obo/CL_0002377|http://purl.obolibrary.org/obo/CL_0002573 |
| T10 | 358-364 | Body_part | denotes | myelin | http://purl.obolibrary.org/obo/UBERON_0000345 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-176 | Sentence | denotes | Enhanced binding of the neural siglecs, myelin-associated glycoprotein and Schwann cell myelin protein, to Chol-1 (alpha-series) gangliosides and novel sulfated Chol-1 analogs. |
| T2 | 177-483 | Sentence | denotes | Extended glycoconjugate binding specificities of three sialic acid-dependent immunoglobulin-like family member lectins (siglecs), myelin-associated glycoprotein (MAG), Schwann cell myelin protein (SMP), and sialoadhesin, were compared by measuring siglec-mediated cell adhesion to immobilized gangliosides. |
| T3 | 484-902 | Sentence | denotes | Synthetic gangliosides bearing the alpha-series determinant (NeuAc alpha2,6-linked to GalNAc on a gangliotetraose core) were tested, including GD1alpha (IV(3)NeuAc, III(6)NeuAc-Gg(4)OseCer), GD1alpha with modified sialic acid residues at the III(6)-position, and the "Chol-1" gangliosides GT1aalpha (IV(3)NeuAc, III(6)NeuAc, II(3)NeuAc-Gg(4)OseCer) and GQ1balpha (IV(3)NeuAc, III(6)NeuAc, II(3)(NeuAc)(2)-Gg(4)OseCer). |
| T4 | 903-1173 | Sentence | denotes | The alpha-series gangliosides displayed enhanced potency for MAG- and SMP-mediated cell adhesion (GQ1balpha > GT1aalpha, GD1alpha > GT1b, GD1a > GM1 (nonbinding)), whereas sialoadhesin-mediated adhesion was comparable with alpha-series and non-alpha-series gangliosides. |
| T5 | 1174-1354 | Sentence | denotes | GD1alpha derivatives with modified sialic acids (7-, 8-, or 9-deoxy) or sulfate (instead of sialic acid) at the III(6)-position supported adhesion comparable with that of GD1alpha. |
| T6 | 1355-1659 | Sentence | denotes | Notably, a novel GT1aalpha analog with sulfates at two internal sites of sialylation (NeuAcalpha2,3Galbeta1,4GalNAc-6-sulfatebeta1, 4Gal3-sulfatebeta1,4Glcbeta1,1'ceramide) was the most potent siglec-binding structure tested to date (10-fold more potent than GT1aalpha in supporting MAG and SMP binding). |
| T7 | 1660-1891 | Sentence | denotes | Together with prior studies, these data indicate that MAG and SMP display an extended structural specificity with a requirement for a terminal alpha2, 3-linked NeuAc and great enhancement by nearby precisely spaced anionic charges. |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-176 | Sentence | denotes | Enhanced binding of the neural siglecs, myelin-associated glycoprotein and Schwann cell myelin protein, to Chol-1 (alpha-series) gangliosides and novel sulfated Chol-1 analogs. |
| T2 | 177-483 | Sentence | denotes | Extended glycoconjugate binding specificities of three sialic acid-dependent immunoglobulin-like family member lectins (siglecs), myelin-associated glycoprotein (MAG), Schwann cell myelin protein (SMP), and sialoadhesin, were compared by measuring siglec-mediated cell adhesion to immobilized gangliosides. |
| T3 | 484-902 | Sentence | denotes | Synthetic gangliosides bearing the alpha-series determinant (NeuAc alpha2,6-linked to GalNAc on a gangliotetraose core) were tested, including GD1alpha (IV(3)NeuAc, III(6)NeuAc-Gg(4)OseCer), GD1alpha with modified sialic acid residues at the III(6)-position, and the "Chol-1" gangliosides GT1aalpha (IV(3)NeuAc, III(6)NeuAc, II(3)NeuAc-Gg(4)OseCer) and GQ1balpha (IV(3)NeuAc, III(6)NeuAc, II(3)(NeuAc)(2)-Gg(4)OseCer). |
| T4 | 903-1173 | Sentence | denotes | The alpha-series gangliosides displayed enhanced potency for MAG- and SMP-mediated cell adhesion (GQ1balpha > GT1aalpha, GD1alpha > GT1b, GD1a > GM1 (nonbinding)), whereas sialoadhesin-mediated adhesion was comparable with alpha-series and non-alpha-series gangliosides. |
| T5 | 1174-1354 | Sentence | denotes | GD1alpha derivatives with modified sialic acids (7-, 8-, or 9-deoxy) or sulfate (instead of sialic acid) at the III(6)-position supported adhesion comparable with that of GD1alpha. |
| T6 | 1355-1659 | Sentence | denotes | Notably, a novel GT1aalpha analog with sulfates at two internal sites of sialylation (NeuAcalpha2,3Galbeta1,4GalNAc-6-sulfatebeta1, 4Gal3-sulfatebeta1,4Glcbeta1,1'ceramide) was the most potent siglec-binding structure tested to date (10-fold more potent than GT1aalpha in supporting MAG and SMP binding). |
| T7 | 1660-1891 | Sentence | denotes | Together with prior studies, these data indicate that MAG and SMP display an extended structural specificity with a requirement for a terminal alpha2, 3-linked NeuAc and great enhancement by nearby precisely spaced anionic charges. |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 773-782 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GT1aalpha | http://www.glycoepitope.jp/epitopes/EP0111 |
| T2 | 837-846 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GQ1balpha | http://www.glycoepitope.jp/epitopes/EP0112 |
| T3 | 1001-1010 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GQ1balpha | http://www.glycoepitope.jp/epitopes/EP0112 |
| T4 | 1013-1022 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GT1aalpha | http://www.glycoepitope.jp/epitopes/EP0111 |
| T5 | 1035-1039 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GT1b | http://www.glycoepitope.jp/epitopes/EP0067 |
| T6 | 1041-1045 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GD1a | http://www.glycoepitope.jp/epitopes/EP0056 |
| T7 | 1048-1051 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T8 | 1372-1381 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GT1aalpha | http://www.glycoepitope.jp/epitopes/EP0111 |
| T9 | 1614-1623 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | GT1aalpha | http://www.glycoepitope.jp/epitopes/EP0111 |
Lectin-Jamboree-Sentence
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-176 | Sentence | denotes | Enhanced binding of the neural siglecs, myelin-associated glycoprotein and Schwann cell myelin protein, to Chol-1 (alpha-series) gangliosides and novel sulfated Chol-1 analogs. |
| T2 | 177-483 | Sentence | denotes | Extended glycoconjugate binding specificities of three sialic acid-dependent immunoglobulin-like family member lectins (siglecs), myelin-associated glycoprotein (MAG), Schwann cell myelin protein (SMP), and sialoadhesin, were compared by measuring siglec-mediated cell adhesion to immobilized gangliosides. |
| T3 | 484-902 | Sentence | denotes | Synthetic gangliosides bearing the alpha-series determinant (NeuAc alpha2,6-linked to GalNAc on a gangliotetraose core) were tested, including GD1alpha (IV(3)NeuAc, III(6)NeuAc-Gg(4)OseCer), GD1alpha with modified sialic acid residues at the III(6)-position, and the "Chol-1" gangliosides GT1aalpha (IV(3)NeuAc, III(6)NeuAc, II(3)NeuAc-Gg(4)OseCer) and GQ1balpha (IV(3)NeuAc, III(6)NeuAc, II(3)(NeuAc)(2)-Gg(4)OseCer). |
| T4 | 903-1173 | Sentence | denotes | The alpha-series gangliosides displayed enhanced potency for MAG- and SMP-mediated cell adhesion (GQ1balpha > GT1aalpha, GD1alpha > GT1b, GD1a > GM1 (nonbinding)), whereas sialoadhesin-mediated adhesion was comparable with alpha-series and non-alpha-series gangliosides. |
| T5 | 1174-1354 | Sentence | denotes | GD1alpha derivatives with modified sialic acids (7-, 8-, or 9-deoxy) or sulfate (instead of sialic acid) at the III(6)-position supported adhesion comparable with that of GD1alpha. |
| T6 | 1355-1659 | Sentence | denotes | Notably, a novel GT1aalpha analog with sulfates at two internal sites of sialylation (NeuAcalpha2,3Galbeta1,4GalNAc-6-sulfatebeta1, 4Gal3-sulfatebeta1,4Glcbeta1,1'ceramide) was the most potent siglec-binding structure tested to date (10-fold more potent than GT1aalpha in supporting MAG and SMP binding). |
| T7 | 1660-1891 | Sentence | denotes | Together with prior studies, these data indicate that MAG and SMP display an extended structural specificity with a requirement for a terminal alpha2, 3-linked NeuAc and great enhancement by nearby precisely spaced anionic charges. |
GlyCosmos15-FMA
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 75-87 | Body_part | denotes | Schwann cell | FMA:62121 |
| T2 | 345-357 | Body_part | denotes | Schwann cell | FMA:62121 |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 545-550 | Glycan | denotes | NeuAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
| T2 | 570-576 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T3 | 627-635 | Glycan | denotes | GD1alpha | https://api.glycosmos.org/wurcs2image/latest/png/binary/G07394RV |
| T4 | 642-647 | Glycan | denotes | NeuAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
| T5 | 655-660 | Glycan | denotes | NeuAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
| T6 | 675-683 | Glycan | denotes | GD1alpha | https://api.glycosmos.org/wurcs2image/latest/png/binary/G07394RV |
| T7 | 773-782 | Glycan | denotes | GT1aalpha | https://api.glycosmos.org/wurcs2image/latest/png/binary/G02149VR |
| T8 | 789-794 | Glycan | denotes | NeuAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
| T9 | 802-807 | Glycan | denotes | NeuAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
| T10 | 814-819 | Glycan | denotes | NeuAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
| T11 | 837-846 | Glycan | denotes | GQ1balpha | https://api.glycosmos.org/wurcs2image/latest/png/binary/G54733XO |
| T12 | 853-858 | Glycan | denotes | NeuAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
| T13 | 866-871 | Glycan | denotes | NeuAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
| T14 | 879-884 | Glycan | denotes | NeuAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
| T15 | 1001-1010 | Glycan | denotes | GQ1balpha | https://api.glycosmos.org/wurcs2image/latest/png/binary/G54733XO |
| T16 | 1013-1022 | Glycan | denotes | GT1aalpha | https://api.glycosmos.org/wurcs2image/latest/png/binary/G02149VR |
| T17 | 1024-1032 | Glycan | denotes | GD1alpha | https://api.glycosmos.org/wurcs2image/latest/png/binary/G07394RV |
| T18 | 1035-1039 | Glycan | denotes | GT1b | https://api.glycosmos.org/wurcs2image/latest/png/binary/G40183QN |
| T19 | 1041-1045 | Glycan | denotes | GD1a | https://api.glycosmos.org/wurcs2image/latest/png/binary/G46677TE |
| T20 | 1048-1051 | Glycan | denotes | GM1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR |
| T21 | 1174-1182 | Glycan | denotes | GD1alpha | https://api.glycosmos.org/wurcs2image/latest/png/binary/G07394RV |
| T22 | 1345-1353 | Glycan | denotes | GD1alpha | https://api.glycosmos.org/wurcs2image/latest/png/binary/G07394RV |
| T23 | 1372-1381 | Glycan | denotes | GT1aalpha | https://api.glycosmos.org/wurcs2image/latest/png/binary/G02149VR |
| T24 | 1614-1623 | Glycan | denotes | GT1aalpha | https://api.glycosmos.org/wurcs2image/latest/png/binary/G02149VR |
| T25 | 1820-1825 | Glycan | denotes | NeuAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 40-46 | Body_part | denotes | myelin | http://purl.obolibrary.org/obo/UBERON_0000345 |
| T2 | 75-87 | Body_part | denotes | Schwann cell | http://purl.obolibrary.org/obo/CL_0000218|http://purl.obolibrary.org/obo/CL_0002377|http://purl.obolibrary.org/obo/CL_0002573 |
| T5 | 88-94 | Body_part | denotes | myelin | http://purl.obolibrary.org/obo/UBERON_0000345 |
| T6 | 307-313 | Body_part | denotes | myelin | http://purl.obolibrary.org/obo/UBERON_0000345 |
| T7 | 345-357 | Body_part | denotes | Schwann cell | http://purl.obolibrary.org/obo/CL_0000218|http://purl.obolibrary.org/obo/CL_0002377|http://purl.obolibrary.org/obo/CL_0002573 |
| T10 | 358-364 | Body_part | denotes | myelin | http://purl.obolibrary.org/obo/UBERON_0000345 |