PubMed:10585453
Annnotations
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 27-38 | Cell | denotes | somatotrope | http://purl.obolibrary.org/obo/CL:0002312 |
| T2 | 330-342 | Cell | denotes | somatotropes | http://purl.obolibrary.org/obo/CL:0002312 |
| T3 | 1320-1331 | Cell | denotes | somatotrope | http://purl.obolibrary.org/obo/CL:0002312 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-180 | Sentence | denotes | Pit-1 binding sites at the somatotrope-specific DNase I hypersensitive sites I, II of the human growth hormone locus control region are essential for in vivo hGH-N gene activation. |
| T2 | 181-261 | Sentence | denotes | The human growth hormone gene cluster is composed of five closely related genes. |
| T3 | 262-391 | Sentence | denotes | The 5'-most gene in the cluster, hGH-N, is expressed exclusively in somatotropes and lactosomatotropes of the anterior pituitary. |
| T4 | 392-765 | Sentence | denotes | Although the hGH-N promoter contains functional binding sites for multiple transcription factors, including Sp1, Zn-15, and Pit-1, predictable and developmentally appropriate expression of hGH-N transgenes in the mouse pituitary requires the presence of a previously characterized locus control region (LCR) composed of multiple chromatin DNase I hypersensitive sites (HS). |
| T5 | 766-938 | Sentence | denotes | LCR determinant(s) necessary for hGH-N transgene activation are largely conferred by two closely spaced HS (HS I,II) located 14.5 kilobase pairs upstream of the hGH-N gene. |
| T6 | 939-1069 | Sentence | denotes | The region sufficient to mediate this activity has recently been sublocalized to a 404-base pair segment of HS I,II (F14 segment). |
| T7 | 1070-1205 | Sentence | denotes | In the present study, we identified multiple binding sites for the pituitary POU domain transcription factor Pit-1 within this segment. |
| T8 | 1206-1380 | Sentence | denotes | Using a transgenic founder assay, these sites were shown to be required for high level, position-independent, and somatotrope-specific expression of a linked hGH-N transgene. |
| T9 | 1381-1576 | Sentence | denotes | Because the Pit-1 sites in the hGH-N gene promoter are insufficient for such gene activation in vivo, these data suggested a unique chromatin-mediated developmental role for Pit-1 in the hGH LCR. |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1056-1059 | http://www.glycoepitope.jp/epitopes/AN0590 | denotes | F14 |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 381-390 | http://purl.obolibrary.org/obo/MAT_0000077 | denotes | pituitary |
| T2 | 611-620 | http://purl.obolibrary.org/obo/MAT_0000077 | denotes | pituitary |
| T3 | 1137-1146 | http://purl.obolibrary.org/obo/MAT_0000077 | denotes | pituitary |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 10585453-3#13#18#gene2688 | 405-410 | gene2688 | denotes | hGH-N |
| 10585453-3#113#118#gene23036 | 505-510 | gene23036 | denotes | Zn-15 |
| 10585453-3#189#194#gene2688 | 581-586 | gene2688 | denotes | hGH-N |
| 10585453-3#339#346#gene1773 | 731-738 | gene1773 | denotes | DNase I |
| 10585453-3#219#228#diseaseC0032002 | 611-620 | diseaseC0032002 | denotes | pituitary |
| 10585453-6#109#114#gene5449 | 1179-1184 | gene5449 | denotes | Pit-1 |
| 10585453-6#109#114#gene6574 | 1179-1184 | gene6574 | denotes | Pit-1 |
| 10585453-6#67#76#diseaseC0032002 | 1137-1146 | diseaseC0032002 | denotes | pituitary |
| 13#18#gene2688219#228#diseaseC0032002 | 10585453-3#13#18#gene2688 | 10585453-3#219#228#diseaseC0032002 | associated_with | hGH-N,pituitary |
| 113#118#gene23036219#228#diseaseC0032002 | 10585453-3#113#118#gene23036 | 10585453-3#219#228#diseaseC0032002 | associated_with | Zn-15,pituitary |
| 189#194#gene2688219#228#diseaseC0032002 | 10585453-3#189#194#gene2688 | 10585453-3#219#228#diseaseC0032002 | associated_with | hGH-N,pituitary |
| 339#346#gene1773219#228#diseaseC0032002 | 10585453-3#339#346#gene1773 | 10585453-3#219#228#diseaseC0032002 | associated_with | DNase I,pituitary |
| 109#114#gene544967#76#diseaseC0032002 | 10585453-6#109#114#gene5449 | 10585453-6#67#76#diseaseC0032002 | associated_with | Pit-1,pituitary |
| 109#114#gene657467#76#diseaseC0032002 | 10585453-6#109#114#gene6574 | 10585453-6#67#76#diseaseC0032002 | associated_with | Pit-1,pituitary |
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 295-300 | gene:2688 | denotes | hGH-N |
| T1 | 381-390 | disease:C0032002 | denotes | pituitary |
| T2 | 581-586 | gene:2688 | denotes | hGH-N |
| T3 | 611-620 | disease:C0032002 | denotes | pituitary |
| T4 | 731-738 | gene:1773 | denotes | DNase I |
| T5 | 611-620 | disease:C0032002 | denotes | pituitary |
| T6 | 405-410 | gene:2688 | denotes | hGH-N |
| T7 | 611-620 | disease:C0032002 | denotes | pituitary |
| T8 | 1179-1184 | gene:6574 | denotes | Pit-1 |
| T9 | 1137-1146 | disease:C0032002 | denotes | pituitary |
| T10 | 1179-1184 | gene:5449 | denotes | Pit-1 |
| T11 | 1137-1146 | disease:C0032002 | denotes | pituitary |
| R1 | T0 | T1 | associated_with | hGH-N,pituitary |
| R2 | T2 | T3 | associated_with | hGH-N,pituitary |
| R3 | T4 | T5 | associated_with | DNase I,pituitary |
| R4 | T6 | T7 | associated_with | hGH-N,pituitary |
| R5 | T8 | T9 | associated_with | Pit-1,pituitary |
| R6 | T10 | T11 | associated_with | Pit-1,pituitary |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 56-70 | Disease | denotes | hypersensitive | http://purl.obolibrary.org/obo/MONDO_0000605 |
| T2 | 381-390 | Disease | denotes | pituitary | http://purl.obolibrary.org/obo/MONDO_0021156 |
| T3 | 611-620 | Disease | denotes | pituitary | http://purl.obolibrary.org/obo/MONDO_0021156 |
| T4 | 739-753 | Disease | denotes | hypersensitive | http://purl.obolibrary.org/obo/MONDO_0000605 |
| T5 | 1137-1146 | Disease | denotes | pituitary | http://purl.obolibrary.org/obo/MONDO_0021156 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 381-390 | Body_part | denotes | pituitary | http://purl.obolibrary.org/obo/MAT_0000077 |
| T2 | 611-620 | Body_part | denotes | pituitary | http://purl.obolibrary.org/obo/MAT_0000077 |
| T3 | 1137-1146 | Body_part | denotes | pituitary | http://purl.obolibrary.org/obo/MAT_0000077 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 56-70 | Phenotype | denotes | hypersensitive | HP:0041092 |
| T2 | 739-753 | Phenotype | denotes | hypersensitive | HP:0041092 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 56-70 | Phenotype | denotes | hypersensitive | HP:0041092 |
| T2 | 739-753 | Phenotype | denotes | hypersensitive | HP:0041092 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-180 | Sentence | denotes | Pit-1 binding sites at the somatotrope-specific DNase I hypersensitive sites I, II of the human growth hormone locus control region are essential for in vivo hGH-N gene activation. |
| T2 | 181-261 | Sentence | denotes | The human growth hormone gene cluster is composed of five closely related genes. |
| T3 | 262-391 | Sentence | denotes | The 5'-most gene in the cluster, hGH-N, is expressed exclusively in somatotropes and lactosomatotropes of the anterior pituitary. |
| T4 | 392-765 | Sentence | denotes | Although the hGH-N promoter contains functional binding sites for multiple transcription factors, including Sp1, Zn-15, and Pit-1, predictable and developmentally appropriate expression of hGH-N transgenes in the mouse pituitary requires the presence of a previously characterized locus control region (LCR) composed of multiple chromatin DNase I hypersensitive sites (HS). |
| T5 | 766-938 | Sentence | denotes | LCR determinant(s) necessary for hGH-N transgene activation are largely conferred by two closely spaced HS (HS I,II) located 14.5 kilobase pairs upstream of the hGH-N gene. |
| T6 | 939-1069 | Sentence | denotes | The region sufficient to mediate this activity has recently been sublocalized to a 404-base pair segment of HS I,II (F14 segment). |
| T7 | 1070-1205 | Sentence | denotes | In the present study, we identified multiple binding sites for the pituitary POU domain transcription factor Pit-1 within this segment. |
| T8 | 1206-1380 | Sentence | denotes | Using a transgenic founder assay, these sites were shown to be required for high level, position-independent, and somatotrope-specific expression of a linked hGH-N transgene. |
| T9 | 1381-1576 | Sentence | denotes | Because the Pit-1 sites in the hGH-N gene promoter are insufficient for such gene activation in vivo, these data suggested a unique chromatin-mediated developmental role for Pit-1 in the hGH LCR. |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 56-70 | Disease | denotes | hypersensitive | MONDO:0000605 |
| T2 | 739-753 | Disease | denotes | hypersensitive | MONDO:0000605 |
GlyCosmos15-Taxon
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 90-95 | Organism | denotes | human | 9606 |
| T2 | 185-190 | Organism | denotes | human | 9606 |
| T3 | 605-610 | Organism | denotes | mouse | 10088|10090 |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 1056-1059 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | F14 | http://www.glycoepitope.jp/epitopes/AN0590 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 27-38 | Body_part | denotes | somatotrope | http://purl.obolibrary.org/obo/CL_0002312 |
| T2 | 330-342 | Body_part | denotes | somatotropes | http://purl.obolibrary.org/obo/CL_0002312 |
| T3 | 372-390 | Body_part | denotes | anterior pituitary | http://purl.obolibrary.org/obo/UBERON_0002196 |
| T4 | 611-620 | Body_part | denotes | pituitary | http://purl.obolibrary.org/obo/UBERON_0000007 |
| T5 | 1036-1043 | Body_part | denotes | segment | http://purl.obolibrary.org/obo/UBERON_0000914 |
| T6 | 1060-1067 | Body_part | denotes | segment | http://purl.obolibrary.org/obo/UBERON_0000914 |
| T7 | 1137-1146 | Body_part | denotes | pituitary | http://purl.obolibrary.org/obo/UBERON_0000007 |
| T8 | 1197-1204 | Body_part | denotes | segment | http://purl.obolibrary.org/obo/UBERON_0000914 |
| T9 | 1320-1331 | Body_part | denotes | somatotrope | http://purl.obolibrary.org/obo/CL_0002312 |
GlyCosmos15-FMA
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 381-390 | Body_part | denotes | pituitary | FMA:13889 |
| T2 | 611-620 | Body_part | denotes | pituitary | FMA:13889 |
| T3 | 721-730 | Body_part | denotes | chromatin | FMA:67526 |
| T4 | 1137-1146 | Body_part | denotes | pituitary | FMA:13889 |
| T5 | 1513-1522 | Body_part | denotes | chromatin | FMA:67526 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 381-390 | Body_part | denotes | pituitary | http://purl.obolibrary.org/obo/MAT_0000077 |
| T2 | 611-620 | Body_part | denotes | pituitary | http://purl.obolibrary.org/obo/MAT_0000077 |
| T3 | 1137-1146 | Body_part | denotes | pituitary | http://purl.obolibrary.org/obo/MAT_0000077 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 90-95 | OrganismTaxon | denotes | human | 9606 |
| T2 | 185-190 | OrganismTaxon | denotes | human | 9606 |
| T3 | 605-610 | OrganismTaxon | denotes | mouse | 10088|10090 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 27-38 | Body_part | denotes | somatotrope | http://purl.obolibrary.org/obo/CL_0002312 |
| T2 | 330-342 | Body_part | denotes | somatotropes | http://purl.obolibrary.org/obo/CL_0002312 |
| T3 | 372-390 | Body_part | denotes | anterior pituitary | http://purl.obolibrary.org/obo/UBERON_0002196 |
| T4 | 611-620 | Body_part | denotes | pituitary | http://purl.obolibrary.org/obo/UBERON_0000007 |
| T5 | 1036-1043 | Body_part | denotes | segment | http://purl.obolibrary.org/obo/UBERON_0000914 |
| T6 | 1060-1067 | Body_part | denotes | segment | http://purl.obolibrary.org/obo/UBERON_0000914 |
| T7 | 1137-1146 | Body_part | denotes | pituitary | http://purl.obolibrary.org/obo/UBERON_0000007 |
| T8 | 1197-1204 | Body_part | denotes | segment | http://purl.obolibrary.org/obo/UBERON_0000914 |
| T9 | 1320-1331 | Body_part | denotes | somatotrope | http://purl.obolibrary.org/obo/CL_0002312 |