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PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 192-457 OBJECTIVE denotes Recently, two different cyclooxygenase (COX) genes, COX-1 and -2, were identified. In this study, topographic and chronological profiles of COX-2 messenger (m)RNA and c-fos mRNA expression were investigated using in situ hybridization after focal cerebral ischemia.
T2 467-1652 METHODS denotes Rats undergoing permanent ischemia were decapitated at 30 and 90 minutes and at 2, 4, 8, and 24 hours after middle cerebral artery (MCA) occlusion, and rats undergoing transient ischemia were decapitated at 4, 8, and 24 hours after MCA occlusion that lasted for either 30 or 90 minutes. After brief transient MCA occlusion, c-fos mRNA was induced in the whole MCA territory, adjacent cortex (cingulate cortex), and distant brain regions such as the hippocampus and substantia nigra. In contrast, COX-2 mRNA was not induced in the ischemic core (lateral striatum) but only in the penumbral area (MCA cortex). Long transient and permanent MCA occlusion did not induce c-fos and COX-2 mRNAs in the ischemic core but strongly induced both mRNAs in the penumbral area (medial striatum and periphery of MCA cortex) and adjacent cortex (cingulate cortex). In brain regions distant from the ischemic territory, although c-fos mRNA was induced in the thalamus, substantia nigra, and hippocampus after extended transient and permanent occlusion, COX-2 mRNA was only induced in the bilateral hippocampi. The induction of COX-2 mRNA persisted in all locations even at 24 hours after MCA occlusion.
T3 1666-2074 CONCLUSIONS denotes The distribution of COX-2 mRNA induction was apparently different from that of c-fos mRNA after MCA occlusion. These results pertaining to COX-2 mRNA agree well with the previous observations of changes in prostaglandin metabolism induced by focal cerebral ischemia. However, whether this induction of the COX-2 gene contributes to the histopathological outcome of cerebral ischemia remains to be elucidated.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 439-456 HP_0002637 denotes cerebral ischemia

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
10584847-0#13#29#gene5743 13-29 gene5743 denotes cyclooxygenase-2
10584847-0#74#106#diseaseC0740391 74-106 diseaseC0740391 denotes middle cerebral artery occlusion
10584847-11#39#44#gene4513 1972-1977 gene4513 denotes COX-2
10584847-11#39#44#gene5743 1972-1977 gene5743 denotes COX-2
10584847-11#98#115#diseaseC0007785 2031-2048 diseaseC0007785 denotes cerebral ischemia
10584847-11#98#115#diseaseC0917798 2031-2048 diseaseC0917798 denotes cerebral ischemia
10584847-11#98#115#diseaseC0007785 2031-2048 diseaseC0007785 denotes cerebral ischemia
10584847-11#98#115#diseaseC0917798 2031-2048 diseaseC0917798 denotes cerebral ischemia
13#29#gene574374#106#diseaseC0740391 10584847-0#13#29#gene5743 10584847-0#74#106#diseaseC0740391 associated_with cyclooxygenase-2,middle cerebral artery occlusion
39#44#gene451398#115#diseaseC0007785 10584847-11#39#44#gene4513 10584847-11#98#115#diseaseC0007785 associated_with COX-2,cerebral ischemia
39#44#gene451398#115#diseaseC0917798 10584847-11#39#44#gene4513 10584847-11#98#115#diseaseC0917798 associated_with COX-2,cerebral ischemia
39#44#gene451398#115#diseaseC0007785 10584847-11#39#44#gene4513 10584847-11#98#115#diseaseC0007785 associated_with COX-2,cerebral ischemia
39#44#gene451398#115#diseaseC0917798 10584847-11#39#44#gene4513 10584847-11#98#115#diseaseC0917798 associated_with COX-2,cerebral ischemia
39#44#gene574398#115#diseaseC0007785 10584847-11#39#44#gene5743 10584847-11#98#115#diseaseC0007785 associated_with COX-2,cerebral ischemia
39#44#gene574398#115#diseaseC0917798 10584847-11#39#44#gene5743 10584847-11#98#115#diseaseC0917798 associated_with COX-2,cerebral ischemia
39#44#gene574398#115#diseaseC0007785 10584847-11#39#44#gene5743 10584847-11#98#115#diseaseC0007785 associated_with COX-2,cerebral ischemia
39#44#gene574398#115#diseaseC0917798 10584847-11#39#44#gene5743 10584847-11#98#115#diseaseC0917798 associated_with COX-2,cerebral ischemia

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1805-1810 gene:4513 denotes COX-2
T1 1914-1931 disease:C0007785 denotes cerebral ischemia
T2 1805-1810 gene:4513 denotes COX-2
T3 1914-1931 disease:C0917798 denotes cerebral ischemia
T4 1805-1810 gene:5743 denotes COX-2
T5 1914-1931 disease:C0007785 denotes cerebral ischemia
T6 1805-1810 gene:5743 denotes COX-2
T7 1914-1931 disease:C0917798 denotes cerebral ischemia
R1 T0 T1 associated_with COX-2,cerebral ischemia
R2 T2 T3 associated_with COX-2,cerebral ischemia
R3 T4 T5 associated_with COX-2,cerebral ischemia
R4 T6 T7 associated_with COX-2,cerebral ischemia