Id |
Subject |
Object |
Predicate |
Lexical cue |
T1 |
0-91 |
Sentence |
denotes |
Mechanisms underlying spontaneous rhythmical contractions in irideal arterioles of the rat. |
T2 |
92-94 |
Sentence |
denotes |
1. |
T3 |
95-249 |
Sentence |
denotes |
Mechanisms underlying spontaneous rhythmical contractions have been studied in irideal arterioles of the rat using video microscopy and electrophysiology. |
T4 |
250-252 |
Sentence |
denotes |
2. |
T5 |
253-414 |
Sentence |
denotes |
Rhythmical contractions (4 min-1) were more common during the second and third postnatal weeks and were always preceded by large, slow depolarizations (5-40 mV). |
T6 |
415-417 |
Sentence |
denotes |
3. |
T7 |
418-627 |
Sentence |
denotes |
Spontaneous contractions were unaffected by tetrodotoxin (1 microM), neurotransmitter receptor antagonists, the sympathetic neurone blocker, guanethidine (5 microM) or sensory neurotoxin, capsaicin (1 microM). |
T8 |
628-630 |
Sentence |
denotes |
4. |
T9 |
631-741 |
Sentence |
denotes |
Stimulation of sensory nerves inhibited spontaneous activity and this was not prevented by L-NAME (10 microm). |
T10 |
742-744 |
Sentence |
denotes |
5. |
T11 |
745-937 |
Sentence |
denotes |
L-NAME (10 microm) caused an increase in frequency of spontaneous contractions, while forskolin (30 nM), in the presence of L-NAME, abolished spontaneous, but not nerve-mediated, contractions. |
T12 |
938-940 |
Sentence |
denotes |
6. |
T13 |
941-1117 |
Sentence |
denotes |
Spontaneous activity was not affected by felodipine (1 nM) or nifedipine (1 microM), but was abolished by cadmium chloride (1 microM) or superfusion with calcium-free solution. |
T14 |
1118-1120 |
Sentence |
denotes |
7. |
T15 |
1121-1281 |
Sentence |
denotes |
Caffeine (1 mM), thapsigargin (2 microM) and cyclopiazonic acid (3 microM), but not ryanodine (3 microM), abolished spontaneous and nerve-mediated contractions. |
T16 |
1282-1384 |
Sentence |
denotes |
After preincubation in L-NAME (10 microM), cyclopiazonic acid abolished spontaneous contractions only. |
T17 |
1385-1387 |
Sentence |
denotes |
8. |
T18 |
1388-1491 |
Sentence |
denotes |
Spontaneous depolarizations and contractions were abolished by 18alpha-glycyrrhetinic acid (20 microM). |
T19 |
1492-1494 |
Sentence |
denotes |
9. |
T20 |
1495-1703 |
Sentence |
denotes |
Results suggest that spontaneous rhythmical contractions are myogenic and result from the cyclical release of calcium from intracellular stores, without a contribution from voltage-dependent calcium channels. |
T21 |
1704-1870 |
Sentence |
denotes |
Intercellular coupling through gap junctions appears to be essential for co-ordination of these events which could be modulated by nitric oxide and increases in cAMP. |
T22 |
1871-1988 |
Sentence |
denotes |
The possibility that different intracellular stores underly spontaneous and nerve-mediated contractions is discussed. |