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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-139 Sentence denotes CFTR antisense phosphorothioate oligodeoxynucleotides (S-ODns) induce tracheo-bronchial mucin (TBM) mRNA expression in human airway mucosa.
TextSentencer_T2 140-222 Sentence denotes Mucus hypersecretion is a critical component of cystic fibrosis (CF) pathogenesis.
TextSentencer_T3 223-399 Sentence denotes The effects of dysfunction of the cystic fibrosis transmembrane regulator (CFTR) on mucin expression were examined using the tracheo-bronchial mucin (TBM) gene as an indicator.
TextSentencer_T4 400-524 Sentence denotes TBM mRNA expression was assessed in a human bronchial epithelial cell line (HBE1) and human nasal mucosal explants in vitro.
TextSentencer_T5 525-733 Sentence denotes Antisense phosphorothioate oligodeoxynucleotides (S-ODN) to TBM suppressed baseline expression of TBM mRNA in both systems, but had no effect on glyceraldehyde phosphate dehydrogenase mRNA (GAPDH) expression.
TextSentencer_T6 734-820 Sentence denotes Sense and missense (multiple scrambled control oligonucleotides) S-ODNs had no effect.
TextSentencer_T7 821-882 Sentence denotes 8Br-cAMP and PGE1 significantly elevated TBM mRNA expression.
TextSentencer_T8 883-956 Sentence denotes These increases were also specifically inhibited by the antisense S-ODNs.
TextSentencer_T9 957-1030 Sentence denotes In order to induce a CF-like state, S-ODN to CFTR were added to explants.
TextSentencer_T10 1031-1152 Sentence denotes Antisense CFTR S-ODNs were anticipated to reduce the expression of cellular CFTR protein, and the level of CFTR function.
TextSentencer_T11 1153-1246 Sentence denotes Antisense, but not sense or missense, CFTR S-ODN significantly increased TBM mRNA expression.
TextSentencer_T12 1247-1421 Sentence denotes These data suggest that mucin hypersecretion in CF may be a direct consequence of CFTR dysfunction; the specific mechanism through which this effect is mediated is not known.
T1 0-139 Sentence denotes CFTR antisense phosphorothioate oligodeoxynucleotides (S-ODns) induce tracheo-bronchial mucin (TBM) mRNA expression in human airway mucosa.
T2 140-222 Sentence denotes Mucus hypersecretion is a critical component of cystic fibrosis (CF) pathogenesis.
T3 223-399 Sentence denotes The effects of dysfunction of the cystic fibrosis transmembrane regulator (CFTR) on mucin expression were examined using the tracheo-bronchial mucin (TBM) gene as an indicator.
T4 400-524 Sentence denotes TBM mRNA expression was assessed in a human bronchial epithelial cell line (HBE1) and human nasal mucosal explants in vitro.
T5 525-733 Sentence denotes Antisense phosphorothioate oligodeoxynucleotides (S-ODN) to TBM suppressed baseline expression of TBM mRNA in both systems, but had no effect on glyceraldehyde phosphate dehydrogenase mRNA (GAPDH) expression.
T6 734-820 Sentence denotes Sense and missense (multiple scrambled control oligonucleotides) S-ODNs had no effect.
T7 821-882 Sentence denotes 8Br-cAMP and PGE1 significantly elevated TBM mRNA expression.
T8 883-956 Sentence denotes These increases were also specifically inhibited by the antisense S-ODNs.
T9 957-1030 Sentence denotes In order to induce a CF-like state, S-ODN to CFTR were added to explants.
T10 1031-1152 Sentence denotes Antisense CFTR S-ODNs were anticipated to reduce the expression of cellular CFTR protein, and the level of CFTR function.
T11 1153-1246 Sentence denotes Antisense, but not sense or missense, CFTR S-ODN significantly increased TBM mRNA expression.
T12 1247-1421 Sentence denotes These data suggest that mucin hypersecretion in CF may be a direct consequence of CFTR dysfunction; the specific mechanism through which this effect is mediated is not known.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 373-376 gene:4586 denotes TBM
T1 257-272 disease:C0010674 denotes cystic fibrosis
R1 T0 T1 associated_with TBM,cystic fibrosis

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 95-98 Disease denotes TBM http://purl.obolibrary.org/obo/MONDO_0044684
T2 188-203 Disease denotes cystic fibrosis http://purl.obolibrary.org/obo/MONDO_0009061
T3 205-207 Disease denotes CF http://purl.obolibrary.org/obo/MONDO_0009061
T4 257-272 Disease denotes cystic fibrosis http://purl.obolibrary.org/obo/MONDO_0009061
T5 373-376 Disease denotes TBM http://purl.obolibrary.org/obo/MONDO_0044684
T6 400-403 Disease denotes TBM http://purl.obolibrary.org/obo/MONDO_0044684
T7 585-588 Disease denotes TBM http://purl.obolibrary.org/obo/MONDO_0044684
T8 623-626 Disease denotes TBM http://purl.obolibrary.org/obo/MONDO_0044684
T9 862-865 Disease denotes TBM http://purl.obolibrary.org/obo/MONDO_0044684
T10 978-980 Disease denotes CF http://purl.obolibrary.org/obo/MONDO_0009061
T11 1226-1229 Disease denotes TBM http://purl.obolibrary.org/obo/MONDO_0044684
T12 1295-1297 Disease denotes CF http://purl.obolibrary.org/obo/MONDO_0009061

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 119-124 OrganismTaxon denotes human 9606
T2 438-443 OrganismTaxon denotes human 9606
T3 486-491 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 125-131 Body_part denotes airway http://purl.obolibrary.org/obo/UBERON_0000117|http://purl.obolibrary.org/obo/UBERON_0001005
T3 132-138 Body_part denotes mucosa http://purl.obolibrary.org/obo/UBERON_0000344
T4 140-145 Body_part denotes Mucus http://purl.obolibrary.org/obo/UBERON_0000912
T5 273-286 Body_part denotes transmembrane http://purl.obolibrary.org/obo/GO_0016020
T6 444-469 Body_part denotes bronchial epithelial cell http://purl.obolibrary.org/obo/CL_0002328

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 444-469 Cell denotes bronchial epithelial cell http://purl.obolibrary.org/obo/CL:0002328
T2 454-469 Cell denotes epithelial cell http://purl.obolibrary.org/obo/CL:0000066