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PubMed:10579481 JSONTXT

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DisGeNET

Id Subject Object Predicate Lexical cue
T0 562-573 gene:495 denotes proton pump
T1 474-483 disease:C0017152 denotes gastritis
T2 562-573 gene:479 denotes proton pump
T3 474-483 disease:C0017152 denotes gastritis
T4 562-573 gene:495 denotes proton pump
T5 487-499 disease:C0030920 denotes peptic ulcer
T6 562-573 gene:479 denotes proton pump
T7 487-499 disease:C0030920 denotes peptic ulcer
R1 T0 T1 associated_with proton pump,gastritis
R2 T2 T3 associated_with proton pump,gastritis
R3 T4 T5 associated_with proton pump,peptic ulcer
R4 T6 T7 associated_with proton pump,peptic ulcer

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
10579481-0#0#7#gene1557 0-7 gene1557 denotes CYP2C19
10579481-0#89#108#diseaseC0374997 89-108 diseaseC0374997 denotes Helicobacter pylori
10579481-3#147#158#gene495 562-573 gene495 denotes proton pump
10579481-3#147#158#gene479 562-573 gene479 denotes proton pump
10579481-3#147#158#gene495 562-573 gene495 denotes proton pump
10579481-3#147#158#gene479 562-573 gene479 denotes proton pump
10579481-3#228#231#gene2691 643-646 gene2691 denotes INN
10579481-3#59#68#diseaseC0017152 474-483 diseaseC0017152 denotes gastritis
10579481-3#72#84#diseaseC0030920 487-499 diseaseC0030920 denotes peptic ulcer
10579481-3#59#68#diseaseC0017152 474-483 diseaseC0017152 denotes gastritis
0#7#gene155789#108#diseaseC0374997 10579481-0#0#7#gene1557 10579481-0#89#108#diseaseC0374997 associated_with CYP2C19,Helicobacter pylori
147#158#gene49559#68#diseaseC0017152 10579481-3#147#158#gene495 10579481-3#59#68#diseaseC0017152 associated_with proton pump,gastritis
147#158#gene49572#84#diseaseC0030920 10579481-3#147#158#gene495 10579481-3#72#84#diseaseC0030920 associated_with proton pump,peptic ulcer
147#158#gene49559#68#diseaseC0017152 10579481-3#147#158#gene495 10579481-3#59#68#diseaseC0017152 associated_with proton pump,gastritis
147#158#gene47959#68#diseaseC0017152 10579481-3#147#158#gene479 10579481-3#59#68#diseaseC0017152 associated_with proton pump,gastritis
147#158#gene47972#84#diseaseC0030920 10579481-3#147#158#gene479 10579481-3#72#84#diseaseC0030920 associated_with proton pump,peptic ulcer
147#158#gene47959#68#diseaseC0017152 10579481-3#147#158#gene479 10579481-3#59#68#diseaseC0017152 associated_with proton pump,gastritis
147#158#gene49559#68#diseaseC0017152 10579481-3#147#158#gene495 10579481-3#59#68#diseaseC0017152 associated_with proton pump,gastritis
147#158#gene49572#84#diseaseC0030920 10579481-3#147#158#gene495 10579481-3#72#84#diseaseC0030920 associated_with proton pump,peptic ulcer
147#158#gene49559#68#diseaseC0017152 10579481-3#147#158#gene495 10579481-3#59#68#diseaseC0017152 associated_with proton pump,gastritis
147#158#gene47959#68#diseaseC0017152 10579481-3#147#158#gene479 10579481-3#59#68#diseaseC0017152 associated_with proton pump,gastritis
147#158#gene47972#84#diseaseC0030920 10579481-3#147#158#gene479 10579481-3#72#84#diseaseC0030920 associated_with proton pump,peptic ulcer
147#158#gene47959#68#diseaseC0017152 10579481-3#147#158#gene479 10579481-3#59#68#diseaseC0017152 associated_with proton pump,gastritis
228#231#gene269159#68#diseaseC0017152 10579481-3#228#231#gene2691 10579481-3#59#68#diseaseC0017152 associated_with INN,gastritis
228#231#gene269172#84#diseaseC0030920 10579481-3#228#231#gene2691 10579481-3#72#84#diseaseC0030920 associated_with INN,peptic ulcer
228#231#gene269159#68#diseaseC0017152 10579481-3#228#231#gene2691 10579481-3#59#68#diseaseC0017152 associated_with INN,gastritis

PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 122-405 OBJECTIVE denotes Omeprazole is used for the treatment of infection caused by Helicobacter pylori, and it is metabolized by the polymorphic cytochrome P4502C19 (CYP2C19). We have found that the anti-H pylori efficacy by the combination of omeprazole and antibiotics is related to the CYP2C19 genotype.
T2 415-1025 METHODS denotes One hundred eight patients with cultured H pylori-positive gastritis or peptic ulcer were treated with three regimens: quadruple treatment without proton pump inhibitors (n = 25), dual treatment with omeprazole and amoxicillin (INN, amoxicilline) (n = 26), and triple treatment with omeprazole, amoxicillin, and clarithromycin (n = 57). The CYP2C19 genotype was determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method and the assessment of the eradication of H pylori was based on all negative examinations, including culture, histology, and 13C-urea breath test.
T3 1035-1280 RESULTS denotes The eradication rates for the extensive metabolizers were 50% and 86% for the dual and triple treatments, respectively. In contrast, all of the poor metabolizers treated with omeprazole and antibiotics (n = 15) showed an eradication of H pylori.
T4 1293-1586 CONCLUSIONS denotes The anti-H pylori effect of dual treatment is highly efficient for CYP2C19 poor metabolizers, which suggests that clarithromycin is not necessary as a first line of therapy for this type of patients. Genotyping can provide a choice for the optimal regimen based on individual CYP2C19 genotype.