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PubMed:10575009 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-126 Sentence denotes The influence of endoproteolytic processing of familial Alzheimer's disease presenilin 2 on abeta42 amyloid peptide formation.
T2 127-295 Sentence denotes Mutant presenilins (PS) contribute to the pathogenesis of familial Alzheimer's disease (FAD) by enhancing the production of Abeta42 from beta-amyloid precursor protein.
T3 296-423 Sentence denotes Presenilins are endoproteolytically processed to N-terminal and C-terminal fragments, which together form a stable 1:1 complex.
T4 424-550 Sentence denotes We have mapped the cleavage site in the PS2 protein by direct sequencing of its C-terminal fragment isolated from mouse liver.
T5 551-747 Sentence denotes Three different N-terminal residues were identified starting at Val-299, Thr-301, and Leu-307 that correspond closely to the previously described N termini of the C-terminal fragment of human PS1.
T6 748-966 Sentence denotes Mutational analysis of the PS2 cleavage site indicates that the principal endoproteolytic cleavage occurs at residues Met-298/Val-299 and that the N terminus is subsequently modified by secondary proteolytic cleavages.
T7 967-1106 Sentence denotes We have generated cleavage defective PS2 constructs, which accumulate exclusively as full-length polypeptides in transfected Neuro2a cells.
T8 1107-1305 Sentence denotes Functional analysis of such cleavage defective PS2 carrying the FAD mutation Asn-141 --> Ile showed that its Abeta42 producing activity was strongly reduced compared with cleavage-competent FAD PS2.
T9 1306-1432 Sentence denotes In contrast, cleavage defective PS2 was active in rescuing the egg-laying defect of a sel-12 mutant in Caenorhabditis elegans.
T10 1433-1591 Sentence denotes We conclude that PS2 endoproteolytic cleavage is not an absolute requirement for its activities but may rather selectively enhance or stabilize its functions.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 544-549 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T2 1369-1372 http://purl.obolibrary.org/obo/MAT_0000213 denotes egg

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 194-213 HP_0002511 denotes Alzheimer's disease
T2 269-276 HP_0011034 denotes amyloid

DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
10575009-7#77#92#geners63750215 1184-1199 geners63750215 denotes Asn-141 --> Ile
10575009-7#64#67#diseaseC0276496 1171-1174 diseaseC0276496 denotes FAD
10575009-7#190#193#diseaseC0276496 1297-1300 diseaseC0276496 denotes FAD
77#92#geners6375021564#67#diseaseC0276496 10575009-7#77#92#geners63750215 10575009-7#64#67#diseaseC0276496 associated_with Asn-141 --> Ile,FAD
77#92#geners63750215190#193#diseaseC0276496 10575009-7#77#92#geners63750215 10575009-7#190#193#diseaseC0276496 associated_with Asn-141 --> Ile,FAD

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
10575009-0#76#88#gene5664 76-88 gene5664 denotes presenilin 2
10575009-0#47#75#diseaseC0276496 47-75 diseaseC0276496 denotes familial Alzheimer's disease
10575009-0#100#107#diseaseC0002726 100-107 diseaseC0002726 denotes amyloid
10575009-1#137#167#gene351 264-294 gene351 denotes beta-amyloid precursor protein
10575009-1#58#86#diseaseC0276496 185-213 diseaseC0276496 denotes familial Alzheimer's disease
10575009-1#88#91#diseaseC0276496 215-218 diseaseC0276496 denotes FAD
76#88#gene566447#75#diseaseC0276496 10575009-0#76#88#gene5664 10575009-0#47#75#diseaseC0276496 associated_with presenilin 2,familial Alzheimer's disease
76#88#gene5664100#107#diseaseC0002726 10575009-0#76#88#gene5664 10575009-0#100#107#diseaseC0002726 associated_with presenilin 2,amyloid
137#167#gene35158#86#diseaseC0276496 10575009-1#137#167#gene351 10575009-1#58#86#diseaseC0276496 associated_with beta-amyloid precursor protein,familial Alzheimer's disease
137#167#gene35188#91#diseaseC0276496 10575009-1#137#167#gene351 10575009-1#88#91#diseaseC0276496 associated_with beta-amyloid precursor protein,FAD

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 544-549 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T2 1369-1372 Body_part denotes egg http://purl.obolibrary.org/obo/MAT_0000213

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 56-75 Phenotype denotes Alzheimer's disease HP:0002511
T2 194-213 Phenotype denotes Alzheimer's disease HP:0002511

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 47-75 Disease denotes familial Alzheimer's disease http://purl.obolibrary.org/obo/MONDO_0015140
T2 100-107 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T3 185-213 Disease denotes familial Alzheimer's disease http://purl.obolibrary.org/obo/MONDO_0015140
T4 215-218 Disease denotes FAD http://purl.obolibrary.org/obo/MONDO_0015140
T5 269-276 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T6 1171-1174 Disease denotes FAD http://purl.obolibrary.org/obo/MONDO_0015140
T7 1297-1300 Disease denotes FAD http://purl.obolibrary.org/obo/MONDO_0015140

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 538-543 OrganismTaxon denotes mouse 10088|10090
T3 737-742 OrganismTaxon denotes human 9606
T4 1409-1431 OrganismTaxon denotes Caenorhabditis elegans 6239

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 544-549 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T2 1369-1372 Body_part denotes egg http://purl.obolibrary.org/obo/UBERON_0007379