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PubMed:10567373 JSONTXT

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Goldhamster2_CellLineAnn

Id Subject Object Predicate Lexical cue
T1 527-532 CellLine denotes ES2Y)
T2 1005-1010 CellLine denotes ES2Y
T3 1161-1166 CellLine denotes ISK9)

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 14-21 Glycan_Motif denotes glucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T2 755-762 Glycan_Motif denotes glucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T3 1331-1338 Glycan_Motif denotes glucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG

sentences

Id Subject Object Predicate Lexical cue
T1 0-174 Sentence denotes Engineering a glucose-responsive human insulin-secreting cell line from islets of Langerhans isolated from a patient with persistent hyperinsulinemic hypoglycemia of infancy.
T2 175-345 Sentence denotes Persistent hyperinsulinemic hypoglycemia of infancy (PHHI) is a neonatal disease characterized by dysregulation of insulin secretion accompanied by profound hypoglycemia.
T3 346-497 Sentence denotes We have discovered that islet cells, isolated from the pancreas of a PHHI patient, proliferate in culture while maintaining a beta cell-like phenotype.
T4 498-763 Sentence denotes The PHHI-derived cell line (NES2Y) exhibits insulin secretory characteristics typical of islet cells derived from these patients, i.e. they have no K(ATP) channel activity and as a consequence secrete insulin at constitutively high levels in the absence of glucose.
T5 764-979 Sentence denotes In addition, they exhibit impaired expression of the homeodomain transcription factor PDX1, which is a key component of the signaling pathway linking nutrient metabolism to the regulation of insulin gene expression.
T6 980-1128 Sentence denotes To repair these defects NES2Y cells were triple-transfected with cDNAs encoding the two components of the K(ATP) channel (SUR1 and Kir6.2) and PDX1.
T7 1129-1354 Sentence denotes One selected clonal cell line (NISK9) had normal K(ATP) channel activity, and as a result of changes in intracellular Ca(2+) homeostasis ([Ca(2+)](i)) secreted insulin within the physiological range of glucose concentrations.
T8 1355-1548 Sentence denotes This approach to engineering PHHI-derived islet cells may be of use in gene therapy for PHHI and in cell engineering techniques for administering insulin for the treatment of diabetes mellitus.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 14-21 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose
T2 755-762 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose
T3 1331-1338 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 72-92 http://purl.obolibrary.org/obo/MAT_0000076 denotes islets of Langerhans
T2 401-409 http://purl.obolibrary.org/obo/MAT_0000075 denotes pancreas

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 186-215 HP_0000825 denotes hyperinsulinemic hypoglycemia
T2 203-215 HP_0001943 denotes hypoglycemia
T3 332-344 HP_0001943 denotes hypoglycemia
T4 1530-1547 HP_0000819 denotes diabetes mellitus

DisGeNET

Id Subject Object Predicate Lexical cue
T0 39-46 gene:3630 denotes insulin
T1 122-173 disease:C2931834 denotes persistent hyperinsulinemic hypoglycemia of infancy
T2 39-46 gene:3630 denotes insulin
T3 122-173 disease:C2931833 denotes persistent hyperinsulinemic hypoglycemia of infancy
T4 39-46 gene:3630 denotes insulin
T5 122-173 disease:C0027773 denotes persistent hyperinsulinemic hypoglycemia of infancy
T6 39-46 gene:723961 denotes insulin
T7 122-173 disease:C2931834 denotes persistent hyperinsulinemic hypoglycemia of infancy
T8 39-46 gene:723961 denotes insulin
T9 122-173 disease:C2931833 denotes persistent hyperinsulinemic hypoglycemia of infancy
T10 39-46 gene:723961 denotes insulin
T11 122-173 disease:C0027773 denotes persistent hyperinsulinemic hypoglycemia of infancy
T12 290-297 gene:3630 denotes insulin
T13 175-226 disease:C0027773 denotes Persistent hyperinsulinemic hypoglycemia of infancy
T14 290-297 gene:723961 denotes insulin
T15 175-226 disease:C0027773 denotes Persistent hyperinsulinemic hypoglycemia of infancy
T16 290-297 gene:723961 denotes insulin
T17 175-226 disease:C2931834 denotes Persistent hyperinsulinemic hypoglycemia of infancy
T18 290-297 gene:3630 denotes insulin
T19 175-226 disease:C2931833 denotes Persistent hyperinsulinemic hypoglycemia of infancy
T20 290-297 gene:723961 denotes insulin
T21 175-226 disease:C2931833 denotes Persistent hyperinsulinemic hypoglycemia of infancy
T22 290-297 gene:3630 denotes insulin
T23 175-226 disease:C2931834 denotes Persistent hyperinsulinemic hypoglycemia of infancy
T24 290-297 gene:723961 denotes insulin
T25 228-232 disease:C2931833 denotes PHHI
T26 290-297 gene:723961 denotes insulin
T27 228-232 disease:C0027773 denotes PHHI
T28 290-297 gene:3630 denotes insulin
T29 332-344 disease:C0020615 denotes hypoglycemia
T30 290-297 gene:3630 denotes insulin
T31 228-232 disease:C2931833 denotes PHHI
T32 290-297 gene:3630 denotes insulin
T33 228-232 disease:C0027773 denotes PHHI
T34 290-297 gene:3630 denotes insulin
T35 228-232 disease:C2931834 denotes PHHI
T36 290-297 gene:723961 denotes insulin
T37 239-255 disease:C0021290 denotes neonatal disease
T38 290-297 gene:3630 denotes insulin
T39 239-255 disease:C0021290 denotes neonatal disease
T40 290-297 gene:723961 denotes insulin
T41 332-344 disease:C0020615 denotes hypoglycemia
T42 290-297 gene:723961 denotes insulin
T43 228-232 disease:C2931834 denotes PHHI
T44 542-549 gene:3630 denotes insulin
T45 502-506 disease:C2931834 denotes PHHI
T46 542-549 gene:3630 denotes insulin
T47 502-506 disease:C0027773 denotes PHHI
T48 542-549 gene:3630 denotes insulin
T49 502-506 disease:C2931833 denotes PHHI
T50 542-549 gene:723961 denotes insulin
T51 502-506 disease:C2931834 denotes PHHI
T52 542-549 gene:723961 denotes insulin
T53 502-506 disease:C0027773 denotes PHHI
T54 542-549 gene:723961 denotes insulin
T55 502-506 disease:C2931833 denotes PHHI
R1 T0 T1 associated_with insulin,persistent hyperinsulinemic hypoglycemia of infancy
R2 T2 T3 associated_with insulin,persistent hyperinsulinemic hypoglycemia of infancy
R3 T4 T5 associated_with insulin,persistent hyperinsulinemic hypoglycemia of infancy
R4 T6 T7 associated_with insulin,persistent hyperinsulinemic hypoglycemia of infancy
R5 T8 T9 associated_with insulin,persistent hyperinsulinemic hypoglycemia of infancy
R6 T10 T11 associated_with insulin,persistent hyperinsulinemic hypoglycemia of infancy
R7 T12 T13 associated_with insulin,Persistent hyperinsulinemic hypoglycemia of infancy
R8 T14 T15 associated_with insulin,Persistent hyperinsulinemic hypoglycemia of infancy
R9 T16 T17 associated_with insulin,Persistent hyperinsulinemic hypoglycemia of infancy
R10 T18 T19 associated_with insulin,Persistent hyperinsulinemic hypoglycemia of infancy
R11 T20 T21 associated_with insulin,Persistent hyperinsulinemic hypoglycemia of infancy
R12 T22 T23 associated_with insulin,Persistent hyperinsulinemic hypoglycemia of infancy
R13 T24 T25 associated_with insulin,PHHI
R14 T26 T27 associated_with insulin,PHHI
R15 T28 T29 associated_with insulin,hypoglycemia
R16 T30 T31 associated_with insulin,PHHI
R17 T32 T33 associated_with insulin,PHHI
R18 T34 T35 associated_with insulin,PHHI
R19 T36 T37 associated_with insulin,neonatal disease
R20 T38 T39 associated_with insulin,neonatal disease
R21 T40 T41 associated_with insulin,hypoglycemia
R22 T42 T43 associated_with insulin,PHHI
R23 T44 T45 associated_with insulin,PHHI
R24 T46 T47 associated_with insulin,PHHI
R25 T48 T49 associated_with insulin,PHHI
R26 T50 T51 associated_with insulin,PHHI
R27 T52 T53 associated_with insulin,PHHI
R28 T54 T55 associated_with insulin,PHHI

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 72-92 Body_part denotes islets of Langerhans http://purl.obolibrary.org/obo/MAT_0000076
T2 401-409 Body_part denotes pancreas http://purl.obolibrary.org/obo/MAT_0000075

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 122-173 Disease denotes persistent hyperinsulinemic hypoglycemia of infancy http://purl.obolibrary.org/obo/MONDO_0009734|http://purl.obolibrary.org/obo/MONDO_0011153|http://purl.obolibrary.org/obo/MONDO_0019010
T4 175-226 Disease denotes Persistent hyperinsulinemic hypoglycemia of infancy http://purl.obolibrary.org/obo/MONDO_0009734|http://purl.obolibrary.org/obo/MONDO_0011153|http://purl.obolibrary.org/obo/MONDO_0019010
T7 228-232 Disease denotes PHHI http://purl.obolibrary.org/obo/MONDO_0019010
T8 332-344 Disease denotes hypoglycemia http://purl.obolibrary.org/obo/MONDO_0004946
T9 401-409 Disease denotes pancreas http://purl.obolibrary.org/obo/MONDO_0021040
T10 415-419 Disease denotes PHHI http://purl.obolibrary.org/obo/MONDO_0019010
T11 502-506 Disease denotes PHHI http://purl.obolibrary.org/obo/MONDO_0019010
T12 1384-1388 Disease denotes PHHI http://purl.obolibrary.org/obo/MONDO_0019010
T13 1443-1447 Disease denotes PHHI http://purl.obolibrary.org/obo/MONDO_0019010
T14 1530-1547 Disease denotes diabetes mellitus http://purl.obolibrary.org/obo/MONDO_0005015

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 33-38 OrganismTaxon denotes human 9606
T2 109-116 OrganismTaxon denotes patient 9606
T3 420-427 OrganismTaxon denotes patient 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 39-61 Body_part denotes insulin-secreting cell http://purl.obolibrary.org/obo/CL_0000169
T2 72-92 Body_part denotes islets of Langerhans http://purl.obolibrary.org/obo/UBERON_0000006
T3 401-409 Body_part denotes pancreas http://purl.obolibrary.org/obo/UBERON_0001264|http://purl.obolibrary.org/obo/UBERON_3011040
T5 472-481 Body_part denotes beta cell http://purl.obolibrary.org/obo/CL_0000169
T6 1233-1246 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 133-162 Phenotype denotes hyperinsulinemic hypoglycemia HP:0000825
T2 186-215 Phenotype denotes hyperinsulinemic hypoglycemia HP:0000825
T3 332-344 Phenotype denotes hypoglycemia HP:0001943
T4 1530-1547 Phenotype denotes diabetes mellitus HP:0000819

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 39-61 Cell denotes insulin-secreting cell http://purl.obolibrary.org/obo/CL:0000169
T2 472-481 Cell denotes beta cell http://purl.obolibrary.org/obo/CL:0000169|http://purl.obolibrary.org/obo/CL:0000639