PubMed:10567373
Annnotations
Goldhamster2_CellLineAnn
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 527-532 | CellLine | denotes | ES2Y) |
T2 | 1005-1010 | CellLine | denotes | ES2Y |
T3 | 1161-1166 | CellLine | denotes | ISK9) |
GlyCosmos6-Glycan-Motif-Image
Id | Subject | Object | Predicate | Lexical cue | image |
---|---|---|---|---|---|
T1 | 14-21 | Glycan_Motif | denotes | glucose | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG |
T2 | 755-762 | Glycan_Motif | denotes | glucose | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG |
T3 | 1331-1338 | Glycan_Motif | denotes | glucose | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-174 | Sentence | denotes | Engineering a glucose-responsive human insulin-secreting cell line from islets of Langerhans isolated from a patient with persistent hyperinsulinemic hypoglycemia of infancy. |
T2 | 175-345 | Sentence | denotes | Persistent hyperinsulinemic hypoglycemia of infancy (PHHI) is a neonatal disease characterized by dysregulation of insulin secretion accompanied by profound hypoglycemia. |
T3 | 346-497 | Sentence | denotes | We have discovered that islet cells, isolated from the pancreas of a PHHI patient, proliferate in culture while maintaining a beta cell-like phenotype. |
T4 | 498-763 | Sentence | denotes | The PHHI-derived cell line (NES2Y) exhibits insulin secretory characteristics typical of islet cells derived from these patients, i.e. they have no K(ATP) channel activity and as a consequence secrete insulin at constitutively high levels in the absence of glucose. |
T5 | 764-979 | Sentence | denotes | In addition, they exhibit impaired expression of the homeodomain transcription factor PDX1, which is a key component of the signaling pathway linking nutrient metabolism to the regulation of insulin gene expression. |
T6 | 980-1128 | Sentence | denotes | To repair these defects NES2Y cells were triple-transfected with cDNAs encoding the two components of the K(ATP) channel (SUR1 and Kir6.2) and PDX1. |
T7 | 1129-1354 | Sentence | denotes | One selected clonal cell line (NISK9) had normal K(ATP) channel activity, and as a result of changes in intracellular Ca(2+) homeostasis ([Ca(2+)](i)) secreted insulin within the physiological range of glucose concentrations. |
T8 | 1355-1548 | Sentence | denotes | This approach to engineering PHHI-derived islet cells may be of use in gene therapy for PHHI and in cell engineering techniques for administering insulin for the treatment of diabetes mellitus. |
GlyCosmos6-Glycan-Motif-Structure
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 14-21 | https://glytoucan.org/Structures/Glycans/G15021LG | denotes | glucose |
T2 | 755-762 | https://glytoucan.org/Structures/Glycans/G15021LG | denotes | glucose |
T3 | 1331-1338 | https://glytoucan.org/Structures/Glycans/G15021LG | denotes | glucose |
Glycosmos6-MAT
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 72-92 | http://purl.obolibrary.org/obo/MAT_0000076 | denotes | islets of Langerhans |
T2 | 401-409 | http://purl.obolibrary.org/obo/MAT_0000075 | denotes | pancreas |
PubmedHPO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 186-215 | HP_0000825 | denotes | hyperinsulinemic hypoglycemia |
T2 | 203-215 | HP_0001943 | denotes | hypoglycemia |
T3 | 332-344 | HP_0001943 | denotes | hypoglycemia |
T4 | 1530-1547 | HP_0000819 | denotes | diabetes mellitus |
DisGeNET
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T0 | 39-46 | gene:3630 | denotes | insulin |
T1 | 122-173 | disease:C2931834 | denotes | persistent hyperinsulinemic hypoglycemia of infancy |
T2 | 39-46 | gene:3630 | denotes | insulin |
T3 | 122-173 | disease:C2931833 | denotes | persistent hyperinsulinemic hypoglycemia of infancy |
T4 | 39-46 | gene:3630 | denotes | insulin |
T5 | 122-173 | disease:C0027773 | denotes | persistent hyperinsulinemic hypoglycemia of infancy |
T6 | 39-46 | gene:723961 | denotes | insulin |
T7 | 122-173 | disease:C2931834 | denotes | persistent hyperinsulinemic hypoglycemia of infancy |
T8 | 39-46 | gene:723961 | denotes | insulin |
T9 | 122-173 | disease:C2931833 | denotes | persistent hyperinsulinemic hypoglycemia of infancy |
T10 | 39-46 | gene:723961 | denotes | insulin |
T11 | 122-173 | disease:C0027773 | denotes | persistent hyperinsulinemic hypoglycemia of infancy |
T12 | 290-297 | gene:3630 | denotes | insulin |
T13 | 175-226 | disease:C0027773 | denotes | Persistent hyperinsulinemic hypoglycemia of infancy |
T14 | 290-297 | gene:723961 | denotes | insulin |
T15 | 175-226 | disease:C0027773 | denotes | Persistent hyperinsulinemic hypoglycemia of infancy |
T16 | 290-297 | gene:723961 | denotes | insulin |
T17 | 175-226 | disease:C2931834 | denotes | Persistent hyperinsulinemic hypoglycemia of infancy |
T18 | 290-297 | gene:3630 | denotes | insulin |
T19 | 175-226 | disease:C2931833 | denotes | Persistent hyperinsulinemic hypoglycemia of infancy |
T20 | 290-297 | gene:723961 | denotes | insulin |
T21 | 175-226 | disease:C2931833 | denotes | Persistent hyperinsulinemic hypoglycemia of infancy |
T22 | 290-297 | gene:3630 | denotes | insulin |
T23 | 175-226 | disease:C2931834 | denotes | Persistent hyperinsulinemic hypoglycemia of infancy |
T24 | 290-297 | gene:723961 | denotes | insulin |
T25 | 228-232 | disease:C2931833 | denotes | PHHI |
T26 | 290-297 | gene:723961 | denotes | insulin |
T27 | 228-232 | disease:C0027773 | denotes | PHHI |
T28 | 290-297 | gene:3630 | denotes | insulin |
T29 | 332-344 | disease:C0020615 | denotes | hypoglycemia |
T30 | 290-297 | gene:3630 | denotes | insulin |
T31 | 228-232 | disease:C2931833 | denotes | PHHI |
T32 | 290-297 | gene:3630 | denotes | insulin |
T33 | 228-232 | disease:C0027773 | denotes | PHHI |
T34 | 290-297 | gene:3630 | denotes | insulin |
T35 | 228-232 | disease:C2931834 | denotes | PHHI |
T36 | 290-297 | gene:723961 | denotes | insulin |
T37 | 239-255 | disease:C0021290 | denotes | neonatal disease |
T38 | 290-297 | gene:3630 | denotes | insulin |
T39 | 239-255 | disease:C0021290 | denotes | neonatal disease |
T40 | 290-297 | gene:723961 | denotes | insulin |
T41 | 332-344 | disease:C0020615 | denotes | hypoglycemia |
T42 | 290-297 | gene:723961 | denotes | insulin |
T43 | 228-232 | disease:C2931834 | denotes | PHHI |
T44 | 542-549 | gene:3630 | denotes | insulin |
T45 | 502-506 | disease:C2931834 | denotes | PHHI |
T46 | 542-549 | gene:3630 | denotes | insulin |
T47 | 502-506 | disease:C0027773 | denotes | PHHI |
T48 | 542-549 | gene:3630 | denotes | insulin |
T49 | 502-506 | disease:C2931833 | denotes | PHHI |
T50 | 542-549 | gene:723961 | denotes | insulin |
T51 | 502-506 | disease:C2931834 | denotes | PHHI |
T52 | 542-549 | gene:723961 | denotes | insulin |
T53 | 502-506 | disease:C0027773 | denotes | PHHI |
T54 | 542-549 | gene:723961 | denotes | insulin |
T55 | 502-506 | disease:C2931833 | denotes | PHHI |
R1 | T0 | T1 | associated_with | insulin,persistent hyperinsulinemic hypoglycemia of infancy |
R2 | T2 | T3 | associated_with | insulin,persistent hyperinsulinemic hypoglycemia of infancy |
R3 | T4 | T5 | associated_with | insulin,persistent hyperinsulinemic hypoglycemia of infancy |
R4 | T6 | T7 | associated_with | insulin,persistent hyperinsulinemic hypoglycemia of infancy |
R5 | T8 | T9 | associated_with | insulin,persistent hyperinsulinemic hypoglycemia of infancy |
R6 | T10 | T11 | associated_with | insulin,persistent hyperinsulinemic hypoglycemia of infancy |
R7 | T12 | T13 | associated_with | insulin,Persistent hyperinsulinemic hypoglycemia of infancy |
R8 | T14 | T15 | associated_with | insulin,Persistent hyperinsulinemic hypoglycemia of infancy |
R9 | T16 | T17 | associated_with | insulin,Persistent hyperinsulinemic hypoglycemia of infancy |
R10 | T18 | T19 | associated_with | insulin,Persistent hyperinsulinemic hypoglycemia of infancy |
R11 | T20 | T21 | associated_with | insulin,Persistent hyperinsulinemic hypoglycemia of infancy |
R12 | T22 | T23 | associated_with | insulin,Persistent hyperinsulinemic hypoglycemia of infancy |
R13 | T24 | T25 | associated_with | insulin,PHHI |
R14 | T26 | T27 | associated_with | insulin,PHHI |
R15 | T28 | T29 | associated_with | insulin,hypoglycemia |
R16 | T30 | T31 | associated_with | insulin,PHHI |
R17 | T32 | T33 | associated_with | insulin,PHHI |
R18 | T34 | T35 | associated_with | insulin,PHHI |
R19 | T36 | T37 | associated_with | insulin,neonatal disease |
R20 | T38 | T39 | associated_with | insulin,neonatal disease |
R21 | T40 | T41 | associated_with | insulin,hypoglycemia |
R22 | T42 | T43 | associated_with | insulin,PHHI |
R23 | T44 | T45 | associated_with | insulin,PHHI |
R24 | T46 | T47 | associated_with | insulin,PHHI |
R25 | T48 | T49 | associated_with | insulin,PHHI |
R26 | T50 | T51 | associated_with | insulin,PHHI |
R27 | T52 | T53 | associated_with | insulin,PHHI |
R28 | T54 | T55 | associated_with | insulin,PHHI |
Anatomy-MAT
Id | Subject | Object | Predicate | Lexical cue | mat_id |
---|---|---|---|---|---|
T1 | 72-92 | Body_part | denotes | islets of Langerhans | http://purl.obolibrary.org/obo/MAT_0000076 |
T2 | 401-409 | Body_part | denotes | pancreas | http://purl.obolibrary.org/obo/MAT_0000075 |
mondo_disease
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 122-173 | Disease | denotes | persistent hyperinsulinemic hypoglycemia of infancy | http://purl.obolibrary.org/obo/MONDO_0009734|http://purl.obolibrary.org/obo/MONDO_0011153|http://purl.obolibrary.org/obo/MONDO_0019010 |
T4 | 175-226 | Disease | denotes | Persistent hyperinsulinemic hypoglycemia of infancy | http://purl.obolibrary.org/obo/MONDO_0009734|http://purl.obolibrary.org/obo/MONDO_0011153|http://purl.obolibrary.org/obo/MONDO_0019010 |
T7 | 228-232 | Disease | denotes | PHHI | http://purl.obolibrary.org/obo/MONDO_0019010 |
T8 | 332-344 | Disease | denotes | hypoglycemia | http://purl.obolibrary.org/obo/MONDO_0004946 |
T9 | 401-409 | Disease | denotes | pancreas | http://purl.obolibrary.org/obo/MONDO_0021040 |
T10 | 415-419 | Disease | denotes | PHHI | http://purl.obolibrary.org/obo/MONDO_0019010 |
T11 | 502-506 | Disease | denotes | PHHI | http://purl.obolibrary.org/obo/MONDO_0019010 |
T12 | 1384-1388 | Disease | denotes | PHHI | http://purl.obolibrary.org/obo/MONDO_0019010 |
T13 | 1443-1447 | Disease | denotes | PHHI | http://purl.obolibrary.org/obo/MONDO_0019010 |
T14 | 1530-1547 | Disease | denotes | diabetes mellitus | http://purl.obolibrary.org/obo/MONDO_0005015 |
NCBITAXON
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 33-38 | OrganismTaxon | denotes | human | 9606 |
T2 | 109-116 | OrganismTaxon | denotes | patient | 9606 |
T3 | 420-427 | OrganismTaxon | denotes | patient | 9606 |
Anatomy-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 39-61 | Body_part | denotes | insulin-secreting cell | http://purl.obolibrary.org/obo/CL_0000169 |
T2 | 72-92 | Body_part | denotes | islets of Langerhans | http://purl.obolibrary.org/obo/UBERON_0000006 |
T3 | 401-409 | Body_part | denotes | pancreas | http://purl.obolibrary.org/obo/UBERON_0001264|http://purl.obolibrary.org/obo/UBERON_3011040 |
T5 | 472-481 | Body_part | denotes | beta cell | http://purl.obolibrary.org/obo/CL_0000169 |
T6 | 1233-1246 | Body_part | denotes | intracellular | http://purl.obolibrary.org/obo/GO_0005622 |
HP-phenotype
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T1 | 133-162 | Phenotype | denotes | hyperinsulinemic hypoglycemia | HP:0000825 |
T2 | 186-215 | Phenotype | denotes | hyperinsulinemic hypoglycemia | HP:0000825 |
T3 | 332-344 | Phenotype | denotes | hypoglycemia | HP:0001943 |
T4 | 1530-1547 | Phenotype | denotes | diabetes mellitus | HP:0000819 |
CL-cell
Id | Subject | Object | Predicate | Lexical cue | cl_id |
---|---|---|---|---|---|
T1 | 39-61 | Cell | denotes | insulin-secreting cell | http://purl.obolibrary.org/obo/CL:0000169 |
T2 | 472-481 | Cell | denotes | beta cell | http://purl.obolibrary.org/obo/CL:0000169|http://purl.obolibrary.org/obo/CL:0000639 |