PubMed:10561455
Annnotations
Glycan-Motif
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 442-457 | https://glytoucan.org/Structures/Glycans/G00058MO | denotes | polylactosamine |
| T2 | 572-578 | https://glytoucan.org/Structures/Glycans/G00031MO | denotes | core 1 |
| T3 | 713-724 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | sialic acid |
| T4 | 728-734 | https://glytoucan.org/Structures/Glycans/G00031MO | denotes | core 1 |
| T5 | 981-984 | https://glytoucan.org/Structures/Glycans/G20044TD | denotes | SM3 |
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 409-415 | Glycan_Motif | denotes | core 2 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO |
| T2 | 442-457 | Glycan_Motif | denotes | polylactosamine | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00058MO |
| T3 | 572-578 | Glycan_Motif | denotes | core 1 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO |
| T4 | 713-724 | Glycan_Motif | denotes | sialic acid | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY |
| T5 | 728-734 | Glycan_Motif | denotes | core 1 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO |
| T6 | 981-984 | Glycan_Motif | denotes | SM3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G20044TD |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-82 | Sentence | denotes | An alpha2,3 sialyltransferase (ST3Gal I) is elevated in primary breast carcinomas. |
| TextSentencer_T2 | 83-275 | Sentence | denotes | The MUC1 mucin is expressed on the luminal surface of most simple epithelial cells but in carcinomas, especially those of the breast and ovary, MUC1 is upregulated and aberrantly glycosylated. |
| TextSentencer_T3 | 276-465 | Sentence | denotes | MUC1 contains a large amount of O-linked glycans which, in the mucin expressed by normal mammary epithelial cells, consist mainly of core 2 based structures carrying polylactosamine chains. |
| TextSentencer_T4 | 466-854 | Sentence | denotes | However, the mucin expressed by breast carcinomas has shorter side-chains, often consisting of sialylated core 1 (Galbeta1-3GalNAc). in situ hybridization of primary breast tissue showed that a sialyltransferase (ST3Gal I), responsible for adding sialic acid to core 1 thereby terminating chain extension, is elevated in primary breast carcinomas when compared to normal or benign tissue. |
| TextSentencer_T5 | 855-1058 | Sentence | denotes | Furthermore, the level of mRNA expression encoding ST3Gal I is correlated to the intensity of staining seen with the antibody SM3, which specifically recognises underglycosylated, tumour associated MUC1. |
| TextSentencer_T6 | 1059-1192 | Sentence | denotes | Thus, the aberrant glycosylation of MUC1 seen in breast carcinomas appears to be due, at least in part, to the elevation of ST3Gal I. |
| T1 | 0-82 | Sentence | denotes | An alpha2,3 sialyltransferase (ST3Gal I) is elevated in primary breast carcinomas. |
| T2 | 83-275 | Sentence | denotes | The MUC1 mucin is expressed on the luminal surface of most simple epithelial cells but in carcinomas, especially those of the breast and ovary, MUC1 is upregulated and aberrantly glycosylated. |
| T3 | 276-465 | Sentence | denotes | MUC1 contains a large amount of O-linked glycans which, in the mucin expressed by normal mammary epithelial cells, consist mainly of core 2 based structures carrying polylactosamine chains. |
| T4 | 466-854 | Sentence | denotes | However, the mucin expressed by breast carcinomas has shorter side-chains, often consisting of sialylated core 1 (Galbeta1-3GalNAc). in situ hybridization of primary breast tissue showed that a sialyltransferase (ST3Gal I), responsible for adding sialic acid to core 1 thereby terminating chain extension, is elevated in primary breast carcinomas when compared to normal or benign tissue. |
| T5 | 855-1058 | Sentence | denotes | Furthermore, the level of mRNA expression encoding ST3Gal I is correlated to the intensity of staining seen with the antibody SM3, which specifically recognises underglycosylated, tumour associated MUC1. |
| T6 | 1059-1192 | Sentence | denotes | Thus, the aberrant glycosylation of MUC1 seen in breast carcinomas appears to be due, at least in part, to the elevation of ST3Gal I. |
| T1 | 0-82 | Sentence | denotes | An alpha2,3 sialyltransferase (ST3Gal I) is elevated in primary breast carcinomas. |
| T2 | 83-275 | Sentence | denotes | The MUC1 mucin is expressed on the luminal surface of most simple epithelial cells but in carcinomas, especially those of the breast and ovary, MUC1 is upregulated and aberrantly glycosylated. |
| T3 | 276-465 | Sentence | denotes | MUC1 contains a large amount of O-linked glycans which, in the mucin expressed by normal mammary epithelial cells, consist mainly of core 2 based structures carrying polylactosamine chains. |
| T4 | 466-854 | Sentence | denotes | However, the mucin expressed by breast carcinomas has shorter side-chains, often consisting of sialylated core 1 (Galbeta1-3GalNAc). in situ hybridization of primary breast tissue showed that a sialyltransferase (ST3Gal I), responsible for adding sialic acid to core 1 thereby terminating chain extension, is elevated in primary breast carcinomas when compared to normal or benign tissue. |
| T5 | 855-1058 | Sentence | denotes | Furthermore, the level of mRNA expression encoding ST3Gal I is correlated to the intensity of staining seen with the antibody SM3, which specifically recognises underglycosylated, tumour associated MUC1. |
| T6 | 1059-1192 | Sentence | denotes | Thus, the aberrant glycosylation of MUC1 seen in breast carcinomas appears to be due, at least in part, to the elevation of ST3Gal I. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 442-457 | https://glytoucan.org/Structures/Glycans/G00058MO | denotes | polylactosamine |
| T2 | 572-578 | https://glytoucan.org/Structures/Glycans/G00031MO | denotes | core 1 |
| T3 | 713-724 | https://glytoucan.org/Structures/Glycans/G81533KY | denotes | sialic acid |
| T4 | 728-734 | https://glytoucan.org/Structures/Glycans/G00031MO | denotes | core 1 |
| T5 | 981-984 | https://glytoucan.org/Structures/Glycans/G20044TD | denotes | SM3 |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 981-984 | http://www.glycoepitope.jp/epitopes/EP0079 | denotes | SM3 |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 498-515 | HP_0003002 | denotes | breast carcinomas |
| T2 | 795-812 | HP_0003002 | denotes | breast carcinomas |
| T3 | 1035-1041 | HP_0002664 | denotes | tumour |
| T4 | 1108-1125 | HP_0003002 | denotes | breast carcinomas |
GlycoBiology-FMA
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| _T1 | 64-70 | FMAID:97486 | denotes | breast |
| _T2 | 64-70 | FMAID:9601 | denotes | breast |
| _T3 | 118-125 | FMAID:179287 | denotes | luminal |
| _T4 | 118-125 | FMAID:74550 | denotes | luminal |
| _T5 | 126-133 | FMAID:146300 | denotes | surface |
| _T6 | 126-133 | FMAID:50594 | denotes | surface |
| _T7 | 149-165 | FMAID:165731 | denotes | epithelial cells |
| _T8 | 149-165 | FMAID:67799 | denotes | epithelial cells |
| _T9 | 149-165 | FMAID:69075 | denotes | epithelial cells |
| _T10 | 149-165 | FMAID:169653 | denotes | epithelial cells |
| _T11 | 149-165 | FMAID:66768 | denotes | epithelial cells |
| _T12 | 149-165 | FMAID:83514 | denotes | epithelial cells |
| _T13 | 149-165 | FMAID:197786 | denotes | epithelial cells |
| _T14 | 149-165 | FMAID:165528 | denotes | epithelial cells |
| _T15 | 149-165 | FMAID:67559 | denotes | epithelial cells |
| _T16 | 149-165 | FMAID:69074 | denotes | epithelial cells |
| _T17 | 149-165 | FMAID:169652 | denotes | epithelial cells |
| _T18 | 149-165 | FMAID:164922 | denotes | epithelial cells |
| _T19 | 149-169 | FMAID:72289 | denotes | epithelial cells but |
| _T20 | 149-169 | FMAID:174393 | denotes | epithelial cells but |
| _T21 | 160-165 | FMAID:169002 | denotes | cells |
| _T22 | 160-165 | FMAID:68646 | denotes | cells |
| _T23 | 209-215 | FMAID:9601 | denotes | breast |
| _T24 | 209-215 | FMAID:97486 | denotes | breast |
| _T25 | 220-225 | FMAID:7209 | denotes | ovary |
| _T26 | 220-225 | FMAID:93687 | denotes | ovary |
| _T27 | 373-389 | FMAID:66768 | denotes | epithelial cells |
| _T28 | 373-389 | FMAID:164922 | denotes | epithelial cells |
| _T29 | 373-389 | FMAID:169653 | denotes | epithelial cells |
| _T30 | 373-389 | FMAID:169652 | denotes | epithelial cells |
| _T31 | 373-389 | FMAID:69074 | denotes | epithelial cells |
| _T32 | 373-389 | FMAID:83514 | denotes | epithelial cells |
| _T33 | 373-389 | FMAID:197786 | denotes | epithelial cells |
| _T34 | 373-389 | FMAID:69075 | denotes | epithelial cells |
| _T35 | 373-389 | FMAID:67799 | denotes | epithelial cells |
| _T36 | 373-389 | FMAID:165731 | denotes | epithelial cells |
| _T37 | 373-389 | FMAID:67559 | denotes | epithelial cells |
| _T38 | 373-389 | FMAID:165528 | denotes | epithelial cells |
| _T39 | 384-389 | FMAID:68646 | denotes | cells |
| _T40 | 384-389 | FMAID:169002 | denotes | cells |
| _T41 | 498-504 | FMAID:97486 | denotes | breast |
| _T42 | 498-504 | FMAID:9601 | denotes | breast |
| _T43 | 632-638 | FMAID:97486 | denotes | breast |
| _T44 | 632-638 | FMAID:9601 | denotes | breast |
| _T45 | 639-645 | FMAID:256050 | denotes | tissue |
| _T46 | 706-712 | FMAID:177242 | denotes | adding |
| _T47 | 795-801 | FMAID:9601 | denotes | breast |
| _T48 | 795-801 | FMAID:97486 | denotes | breast |
| _T49 | 847-853 | FMAID:256050 | denotes | tissue |
| _T50 | 972-980 | FMAID:167180 | denotes | antibody |
| _T51 | 1108-1114 | FMAID:97486 | denotes | breast |
| _T52 | 1108-1114 | FMAID:9601 | denotes | breast |
uniprot-human
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 31-39 | http://www.uniprot.org/uniprot/Q11201 | denotes | ST3Gal I |
| T2 | 679-687 | http://www.uniprot.org/uniprot/Q11201 | denotes | ST3Gal I |
| T3 | 906-914 | http://www.uniprot.org/uniprot/Q11201 | denotes | ST3Gal I |
| T4 | 1183-1191 | http://www.uniprot.org/uniprot/Q11201 | denotes | ST3Gal I |
| T5 | 87-91 | http://www.uniprot.org/uniprot/Q9BXA4 | denotes | MUC1 |
| T6 | 227-231 | http://www.uniprot.org/uniprot/Q9BXA4 | denotes | MUC1 |
| T7 | 276-280 | http://www.uniprot.org/uniprot/Q9BXA4 | denotes | MUC1 |
| T8 | 1053-1057 | http://www.uniprot.org/uniprot/Q9BXA4 | denotes | MUC1 |
| T9 | 1095-1099 | http://www.uniprot.org/uniprot/Q9BXA4 | denotes | MUC1 |
uniprot-mouse
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 31-39 | http://www.uniprot.org/uniprot/P54751 | denotes | ST3Gal I |
| T2 | 679-687 | http://www.uniprot.org/uniprot/P54751 | denotes | ST3Gal I |
| T3 | 906-914 | http://www.uniprot.org/uniprot/P54751 | denotes | ST3Gal I |
| T4 | 1183-1191 | http://www.uniprot.org/uniprot/P54751 | denotes | ST3Gal I |
GlycoBiology-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 71-81 | http://purl.bioontology.org/ontology/NCBITAXON/166034 | denotes | carcinomas |
| T2 | 160-165 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T3 | 173-183 | http://purl.bioontology.org/ontology/NCBITAXON/166034 | denotes | carcinomas |
| T4 | 384-389 | http://purl.bioontology.org/ontology/STY/T025 | denotes | cells |
| T5 | 505-515 | http://purl.bioontology.org/ontology/NCBITAXON/166034 | denotes | carcinomas |
| T6 | 639-645 | http://purl.bioontology.org/ontology/STY/T024 | denotes | tissue |
| T7 | 802-812 | http://purl.bioontology.org/ontology/NCBITAXON/166034 | denotes | carcinomas |
| T8 | 847-853 | http://purl.bioontology.org/ontology/STY/T024 | denotes | tissue |
| T9 | 1115-1125 | http://purl.bioontology.org/ontology/NCBITAXON/166034 | denotes | carcinomas |
GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 262-274 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylated |
| T2 | 1078-1091 | http://purl.obolibrary.org/obo/GO_0070085 | denotes | glycosylation |
| T3 | 561-571 | http://purl.obolibrary.org/obo/GO_0097503 | denotes | sialylated |
GO-MF
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 972-980 | http://purl.obolibrary.org/obo/GO_0003823 | denotes | antibody |
GO-CC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 160-165 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T2 | 384-389 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T3 | 409-413 | http://purl.obolibrary.org/obo/GO_0019013 | denotes | core |
| T4 | 572-576 | http://purl.obolibrary.org/obo/GO_0019013 | denotes | core |
| T5 | 728-732 | http://purl.obolibrary.org/obo/GO_0019013 | denotes | core |
UBERON-AE
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 64-70 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| T2 | 209-215 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| T3 | 498-504 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| T4 | 632-638 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| T5 | 795-801 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| T6 | 1108-1114 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| T7 | 639-645 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissue |
| T8 | 847-853 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissue |
| T9 | 761-770 | http://purl.obolibrary.org/obo/UBERON_2000106 | denotes | extension |
EDAM-topics
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 743-754 | http://edamontology.org/topic_0749 | denotes | terminating |
EDAM-DFO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 358-364 | http://edamontology.org/operation_3435 | denotes | normal |
| T2 | 422-432 | http://edamontology.org/data_0883 | denotes | structures |
| T3 | 830-836 | http://edamontology.org/operation_3435 | denotes | normal |
| T4 | 918-928 | http://edamontology.org/operation_3465 | denotes | correlated |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 10561455-0#31#39#gene6482 | 31-39 | gene6482 | denotes | ST3Gal I |
| 10561455-0#64#81#diseaseC0678222 | 64-81 | diseaseC0678222 | denotes | breast carcinomas |
| 10561455-5#36#40#gene4582 | 1095-1099 | gene4582 | denotes | MUC1 |
| 10561455-5#49#66#diseaseC0678222 | 1108-1125 | diseaseC0678222 | denotes | breast carcinomas |
| 31#39#gene648264#81#diseaseC0678222 | 10561455-0#31#39#gene6482 | 10561455-0#64#81#diseaseC0678222 | associated_with | ST3Gal I,breast carcinomas |
| 36#40#gene458249#66#diseaseC0678222 | 10561455-5#36#40#gene4582 | 10561455-5#49#66#diseaseC0678222 | associated_with | MUC1,breast carcinomas |
GlycoBiology-Motifs
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 442-457 | http://rdf.glycoinfo.org/glycan/G00058MO | denotes | polylactosamine |
GlycoBiology-Epitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-GlycoEpitope-B_T1 | 981-984 | http://www.glycoepitope.jp/epitopes/EP0079 | denotes | SM3 |
performance-test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-UBERON-AE-B_T1 | 639-645 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissue |
| PD-UBERON-AE-B_T2 | 847-853 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissue |
| PD-UBERON-AE-B_T3 | 761-770 | http://purl.obolibrary.org/obo/UBERON_2000106 | denotes | extension |
| PD-UBERON-AE-B_T4 | 64-70 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| PD-UBERON-AE-B_T5 | 209-215 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| PD-UBERON-AE-B_T6 | 498-504 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| PD-UBERON-AE-B_T7 | 632-638 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| PD-UBERON-AE-B_T8 | 795-801 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
| PD-UBERON-AE-B_T9 | 1108-1114 | http://purl.obolibrary.org/obo/UBERON_0000310 | denotes | breast |
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 31-39 | gene:6482 | denotes | ST3Gal I |
| T1 | 64-81 | disease:C0678222 | denotes | breast carcinomas |
| T2 | 87-91 | gene:4582 | denotes | MUC1 |
| T3 | 173-183 | disease:C0007097 | denotes | carcinomas |
| T4 | 679-687 | gene:6482 | denotes | ST3Gal I |
| T5 | 795-812 | disease:C0678222 | denotes | breast carcinomas |
| T6 | 1183-1191 | gene:6482 | denotes | ST3Gal I |
| T7 | 1108-1125 | disease:C0678222 | denotes | breast carcinomas |
| T8 | 1095-1099 | gene:4582 | denotes | MUC1 |
| T9 | 1108-1125 | disease:C0678222 | denotes | breast carcinomas |
| R1 | T0 | T1 | associated_with | ST3Gal I,breast carcinomas |
| R2 | T2 | T3 | associated_with | MUC1,carcinomas |
| R3 | T4 | T5 | associated_with | ST3Gal I,breast carcinomas |
| R4 | T6 | T7 | associated_with | ST3Gal I,breast carcinomas |
| R5 | T8 | T9 | associated_with | MUC1,breast carcinomas |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 64-81 | Phenotype | denotes | breast carcinomas | HP:0003002 |
| T2 | 173-183 | Phenotype | denotes | carcinomas | HP:0030731 |
| T3 | 498-515 | Phenotype | denotes | breast carcinomas | HP:0003002 |
| T4 | 795-812 | Phenotype | denotes | breast carcinomas | HP:0003002 |
| T5 | 1035-1041 | Phenotype | denotes | tumour | HP:0002664 |
| T6 | 1108-1125 | Phenotype | denotes | breast carcinomas | HP:0003002 |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 64-81 | Disease | denotes | breast carcinomas | http://purl.obolibrary.org/obo/MONDO_0004989 |
| T2 | 173-183 | Disease | denotes | carcinomas | http://purl.obolibrary.org/obo/MONDO_0004993 |
| T3 | 498-515 | Disease | denotes | breast carcinomas | http://purl.obolibrary.org/obo/MONDO_0004989 |
| T4 | 795-812 | Disease | denotes | breast carcinomas | http://purl.obolibrary.org/obo/MONDO_0004989 |
| T5 | 1108-1125 | Disease | denotes | breast carcinomas | http://purl.obolibrary.org/obo/MONDO_0004989 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 409-415 | Glycan | denotes | core 2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO |
| T2 | 572-578 | Glycan | denotes | core 1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
| T3 | 728-734 | Glycan | denotes | core 1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
| T4 | 981-984 | Glycan | denotes | SM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G20044TD |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 981-984 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SM3 | http://www.glycoepitope.jp/epitopes/EP0079 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 64-81 | Phenotype | denotes | breast carcinomas | HP:0003002 |
| T2 | 173-183 | Phenotype | denotes | carcinomas | HP:0030731 |
| T3 | 498-515 | Phenotype | denotes | breast carcinomas | HP:0003002 |
| T4 | 795-812 | Phenotype | denotes | breast carcinomas | HP:0003002 |
| T5 | 1035-1041 | Phenotype | denotes | tumour | HP:0002664 |
| T6 | 1108-1125 | Phenotype | denotes | breast carcinomas | HP:0003002 |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 409-415 | Glycan | denotes | core 2 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO |
| T2 | 572-578 | Glycan | denotes | core 1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
| T3 | 728-734 | Glycan | denotes | core 1 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO |
| T4 | 981-984 | Glycan | denotes | SM3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G20044TD |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 149-165 | Cell | denotes | epithelial cells | http://purl.obolibrary.org/obo/CL:0000066 |
| T2 | 365-389 | Cell | denotes | mammary epithelial cells | http://purl.obolibrary.org/obo/CL:0002327 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 64-70 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
| T2 | 149-165 | Body_part | denotes | epithelial cells | http://purl.obolibrary.org/obo/CL_0000066 |
| T3 | 209-215 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
| T4 | 220-225 | Body_part | denotes | ovary | http://purl.obolibrary.org/obo/UBERON_0000992 |
| T5 | 365-389 | Body_part | denotes | mammary epithelial cells | http://purl.obolibrary.org/obo/CL_0002327 |
| T6 | 498-504 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
| T7 | 632-638 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
| T8 | 639-645 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T9 | 761-770 | Body_part | denotes | extension | http://purl.obolibrary.org/obo/UBERON_2000106 |
| T10 | 795-801 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
| T11 | 847-853 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T12 | 1108-1114 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 64-81 | Disease | denotes | breast carcinomas | MONDO:0004989 |
| T2 | 173-183 | Disease | denotes | carcinomas | MONDO:0004993 |
| T3 | 498-515 | Disease | denotes | breast carcinomas | MONDO:0004989 |
| T4 | 795-812 | Disease | denotes | breast carcinomas | MONDO:0004989 |
| T5 | 1035-1041 | Disease | denotes | tumour | MONDO:0005070 |
| T6 | 1108-1125 | Disease | denotes | breast carcinomas | MONDO:0004989 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-82 | Sentence | denotes | An alpha2,3 sialyltransferase (ST3Gal I) is elevated in primary breast carcinomas. |
| T2 | 83-275 | Sentence | denotes | The MUC1 mucin is expressed on the luminal surface of most simple epithelial cells but in carcinomas, especially those of the breast and ovary, MUC1 is upregulated and aberrantly glycosylated. |
| T3 | 276-465 | Sentence | denotes | MUC1 contains a large amount of O-linked glycans which, in the mucin expressed by normal mammary epithelial cells, consist mainly of core 2 based structures carrying polylactosamine chains. |
| T4 | 466-854 | Sentence | denotes | However, the mucin expressed by breast carcinomas has shorter side-chains, often consisting of sialylated core 1 (Galbeta1-3GalNAc). in situ hybridization of primary breast tissue showed that a sialyltransferase (ST3Gal I), responsible for adding sialic acid to core 1 thereby terminating chain extension, is elevated in primary breast carcinomas when compared to normal or benign tissue. |
| T5 | 855-1058 | Sentence | denotes | Furthermore, the level of mRNA expression encoding ST3Gal I is correlated to the intensity of staining seen with the antibody SM3, which specifically recognises underglycosylated, tumour associated MUC1. |
| T6 | 1059-1192 | Sentence | denotes | Thus, the aberrant glycosylation of MUC1 seen in breast carcinomas appears to be due, at least in part, to the elevation of ST3Gal I. |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 981-984 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SM3 | http://www.glycoepitope.jp/epitopes/EP0079 |
GlyCosmos15-FMA
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 64-70 | Body_part | denotes | breast | FMA:9601 |
| T2 | 149-165 | Body_part | denotes | epithelial cells | FMA:66768 |
| T3 | 209-215 | Body_part | denotes | breast | FMA:9601 |
| T4 | 220-225 | Body_part | denotes | ovary | FMA:7209 |
| T5 | 373-389 | Body_part | denotes | epithelial cells | FMA:66768 |
| T6 | 498-504 | Body_part | denotes | breast | FMA:9601 |
| T7 | 632-638 | Body_part | denotes | breast | FMA:9601 |
| T8 | 639-645 | Body_part | denotes | tissue | FMA:9637 |
| T9 | 795-801 | Body_part | denotes | breast | FMA:9601 |
| T10 | 847-853 | Body_part | denotes | tissue | FMA:9637 |
| T11 | 1108-1114 | Body_part | denotes | breast | FMA:9601 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 64-70 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
| T2 | 149-165 | Body_part | denotes | epithelial cells | http://purl.obolibrary.org/obo/CL_0000066 |
| T3 | 209-215 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
| T4 | 220-225 | Body_part | denotes | ovary | http://purl.obolibrary.org/obo/UBERON_0000992 |
| T5 | 365-389 | Body_part | denotes | mammary epithelial cells | http://purl.obolibrary.org/obo/CL_0002327 |
| T6 | 498-504 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
| T7 | 632-638 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
| T8 | 639-645 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T9 | 761-770 | Body_part | denotes | extension | http://purl.obolibrary.org/obo/UBERON_2000106 |
| T10 | 795-801 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
| T11 | 847-853 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T12 | 1108-1114 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 149-165 | Cell | denotes | epithelial cells | http://purl.obolibrary.org/obo/CL:0000066 |
| T2 | 365-389 | Cell | denotes | mammary epithelial cells | http://purl.obolibrary.org/obo/CL:0002327 |