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PubMed:10561455 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 442-457 https://glytoucan.org/Structures/Glycans/G00058MO denotes polylactosamine
T2 572-578 https://glytoucan.org/Structures/Glycans/G00031MO denotes core 1
T3 713-724 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T4 728-734 https://glytoucan.org/Structures/Glycans/G00031MO denotes core 1
T5 981-984 https://glytoucan.org/Structures/Glycans/G20044TD denotes SM3

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 409-415 Glycan_Motif denotes core 2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO
T2 442-457 Glycan_Motif denotes polylactosamine https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00058MO
T3 572-578 Glycan_Motif denotes core 1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO
T4 713-724 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T5 728-734 Glycan_Motif denotes core 1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO
T6 981-984 Glycan_Motif denotes SM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G20044TD

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-82 Sentence denotes An alpha2,3 sialyltransferase (ST3Gal I) is elevated in primary breast carcinomas.
TextSentencer_T2 83-275 Sentence denotes The MUC1 mucin is expressed on the luminal surface of most simple epithelial cells but in carcinomas, especially those of the breast and ovary, MUC1 is upregulated and aberrantly glycosylated.
TextSentencer_T3 276-465 Sentence denotes MUC1 contains a large amount of O-linked glycans which, in the mucin expressed by normal mammary epithelial cells, consist mainly of core 2 based structures carrying polylactosamine chains.
TextSentencer_T4 466-854 Sentence denotes However, the mucin expressed by breast carcinomas has shorter side-chains, often consisting of sialylated core 1 (Galbeta1-3GalNAc). in situ hybridization of primary breast tissue showed that a sialyltransferase (ST3Gal I), responsible for adding sialic acid to core 1 thereby terminating chain extension, is elevated in primary breast carcinomas when compared to normal or benign tissue.
TextSentencer_T5 855-1058 Sentence denotes Furthermore, the level of mRNA expression encoding ST3Gal I is correlated to the intensity of staining seen with the antibody SM3, which specifically recognises underglycosylated, tumour associated MUC1.
TextSentencer_T6 1059-1192 Sentence denotes Thus, the aberrant glycosylation of MUC1 seen in breast carcinomas appears to be due, at least in part, to the elevation of ST3Gal I.
T1 0-82 Sentence denotes An alpha2,3 sialyltransferase (ST3Gal I) is elevated in primary breast carcinomas.
T2 83-275 Sentence denotes The MUC1 mucin is expressed on the luminal surface of most simple epithelial cells but in carcinomas, especially those of the breast and ovary, MUC1 is upregulated and aberrantly glycosylated.
T3 276-465 Sentence denotes MUC1 contains a large amount of O-linked glycans which, in the mucin expressed by normal mammary epithelial cells, consist mainly of core 2 based structures carrying polylactosamine chains.
T4 466-854 Sentence denotes However, the mucin expressed by breast carcinomas has shorter side-chains, often consisting of sialylated core 1 (Galbeta1-3GalNAc). in situ hybridization of primary breast tissue showed that a sialyltransferase (ST3Gal I), responsible for adding sialic acid to core 1 thereby terminating chain extension, is elevated in primary breast carcinomas when compared to normal or benign tissue.
T5 855-1058 Sentence denotes Furthermore, the level of mRNA expression encoding ST3Gal I is correlated to the intensity of staining seen with the antibody SM3, which specifically recognises underglycosylated, tumour associated MUC1.
T6 1059-1192 Sentence denotes Thus, the aberrant glycosylation of MUC1 seen in breast carcinomas appears to be due, at least in part, to the elevation of ST3Gal I.
T1 0-82 Sentence denotes An alpha2,3 sialyltransferase (ST3Gal I) is elevated in primary breast carcinomas.
T2 83-275 Sentence denotes The MUC1 mucin is expressed on the luminal surface of most simple epithelial cells but in carcinomas, especially those of the breast and ovary, MUC1 is upregulated and aberrantly glycosylated.
T3 276-465 Sentence denotes MUC1 contains a large amount of O-linked glycans which, in the mucin expressed by normal mammary epithelial cells, consist mainly of core 2 based structures carrying polylactosamine chains.
T4 466-854 Sentence denotes However, the mucin expressed by breast carcinomas has shorter side-chains, often consisting of sialylated core 1 (Galbeta1-3GalNAc). in situ hybridization of primary breast tissue showed that a sialyltransferase (ST3Gal I), responsible for adding sialic acid to core 1 thereby terminating chain extension, is elevated in primary breast carcinomas when compared to normal or benign tissue.
T5 855-1058 Sentence denotes Furthermore, the level of mRNA expression encoding ST3Gal I is correlated to the intensity of staining seen with the antibody SM3, which specifically recognises underglycosylated, tumour associated MUC1.
T6 1059-1192 Sentence denotes Thus, the aberrant glycosylation of MUC1 seen in breast carcinomas appears to be due, at least in part, to the elevation of ST3Gal I.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 442-457 https://glytoucan.org/Structures/Glycans/G00058MO denotes polylactosamine
T2 572-578 https://glytoucan.org/Structures/Glycans/G00031MO denotes core 1
T3 713-724 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T4 728-734 https://glytoucan.org/Structures/Glycans/G00031MO denotes core 1
T5 981-984 https://glytoucan.org/Structures/Glycans/G20044TD denotes SM3

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 981-984 http://www.glycoepitope.jp/epitopes/EP0079 denotes SM3

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 498-515 HP_0003002 denotes breast carcinomas
T2 795-812 HP_0003002 denotes breast carcinomas
T3 1035-1041 HP_0002664 denotes tumour
T4 1108-1125 HP_0003002 denotes breast carcinomas

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 64-70 FMAID:97486 denotes breast
_T2 64-70 FMAID:9601 denotes breast
_T3 118-125 FMAID:179287 denotes luminal
_T4 118-125 FMAID:74550 denotes luminal
_T5 126-133 FMAID:146300 denotes surface
_T6 126-133 FMAID:50594 denotes surface
_T7 149-165 FMAID:165731 denotes epithelial cells
_T8 149-165 FMAID:67799 denotes epithelial cells
_T9 149-165 FMAID:69075 denotes epithelial cells
_T10 149-165 FMAID:169653 denotes epithelial cells
_T11 149-165 FMAID:66768 denotes epithelial cells
_T12 149-165 FMAID:83514 denotes epithelial cells
_T13 149-165 FMAID:197786 denotes epithelial cells
_T14 149-165 FMAID:165528 denotes epithelial cells
_T15 149-165 FMAID:67559 denotes epithelial cells
_T16 149-165 FMAID:69074 denotes epithelial cells
_T17 149-165 FMAID:169652 denotes epithelial cells
_T18 149-165 FMAID:164922 denotes epithelial cells
_T19 149-169 FMAID:72289 denotes epithelial cells but
_T20 149-169 FMAID:174393 denotes epithelial cells but
_T21 160-165 FMAID:169002 denotes cells
_T22 160-165 FMAID:68646 denotes cells
_T23 209-215 FMAID:9601 denotes breast
_T24 209-215 FMAID:97486 denotes breast
_T25 220-225 FMAID:7209 denotes ovary
_T26 220-225 FMAID:93687 denotes ovary
_T27 373-389 FMAID:66768 denotes epithelial cells
_T28 373-389 FMAID:164922 denotes epithelial cells
_T29 373-389 FMAID:169653 denotes epithelial cells
_T30 373-389 FMAID:169652 denotes epithelial cells
_T31 373-389 FMAID:69074 denotes epithelial cells
_T32 373-389 FMAID:83514 denotes epithelial cells
_T33 373-389 FMAID:197786 denotes epithelial cells
_T34 373-389 FMAID:69075 denotes epithelial cells
_T35 373-389 FMAID:67799 denotes epithelial cells
_T36 373-389 FMAID:165731 denotes epithelial cells
_T37 373-389 FMAID:67559 denotes epithelial cells
_T38 373-389 FMAID:165528 denotes epithelial cells
_T39 384-389 FMAID:68646 denotes cells
_T40 384-389 FMAID:169002 denotes cells
_T41 498-504 FMAID:97486 denotes breast
_T42 498-504 FMAID:9601 denotes breast
_T43 632-638 FMAID:97486 denotes breast
_T44 632-638 FMAID:9601 denotes breast
_T45 639-645 FMAID:256050 denotes tissue
_T46 706-712 FMAID:177242 denotes adding
_T47 795-801 FMAID:9601 denotes breast
_T48 795-801 FMAID:97486 denotes breast
_T49 847-853 FMAID:256050 denotes tissue
_T50 972-980 FMAID:167180 denotes antibody
_T51 1108-1114 FMAID:97486 denotes breast
_T52 1108-1114 FMAID:9601 denotes breast

uniprot-human

Id Subject Object Predicate Lexical cue
T1 31-39 http://www.uniprot.org/uniprot/Q11201 denotes ST3Gal I
T2 679-687 http://www.uniprot.org/uniprot/Q11201 denotes ST3Gal I
T3 906-914 http://www.uniprot.org/uniprot/Q11201 denotes ST3Gal I
T4 1183-1191 http://www.uniprot.org/uniprot/Q11201 denotes ST3Gal I
T5 87-91 http://www.uniprot.org/uniprot/Q9BXA4 denotes MUC1
T6 227-231 http://www.uniprot.org/uniprot/Q9BXA4 denotes MUC1
T7 276-280 http://www.uniprot.org/uniprot/Q9BXA4 denotes MUC1
T8 1053-1057 http://www.uniprot.org/uniprot/Q9BXA4 denotes MUC1
T9 1095-1099 http://www.uniprot.org/uniprot/Q9BXA4 denotes MUC1

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 31-39 http://www.uniprot.org/uniprot/P54751 denotes ST3Gal I
T2 679-687 http://www.uniprot.org/uniprot/P54751 denotes ST3Gal I
T3 906-914 http://www.uniprot.org/uniprot/P54751 denotes ST3Gal I
T4 1183-1191 http://www.uniprot.org/uniprot/P54751 denotes ST3Gal I

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 71-81 http://purl.bioontology.org/ontology/NCBITAXON/166034 denotes carcinomas
T2 160-165 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T3 173-183 http://purl.bioontology.org/ontology/NCBITAXON/166034 denotes carcinomas
T4 384-389 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T5 505-515 http://purl.bioontology.org/ontology/NCBITAXON/166034 denotes carcinomas
T6 639-645 http://purl.bioontology.org/ontology/STY/T024 denotes tissue
T7 802-812 http://purl.bioontology.org/ontology/NCBITAXON/166034 denotes carcinomas
T8 847-853 http://purl.bioontology.org/ontology/STY/T024 denotes tissue
T9 1115-1125 http://purl.bioontology.org/ontology/NCBITAXON/166034 denotes carcinomas

GO-BP

Id Subject Object Predicate Lexical cue
T1 262-274 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylated
T2 1078-1091 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T3 561-571 http://purl.obolibrary.org/obo/GO_0097503 denotes sialylated

GO-MF

Id Subject Object Predicate Lexical cue
T1 972-980 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody

GO-CC

Id Subject Object Predicate Lexical cue
T1 160-165 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2 384-389 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3 409-413 http://purl.obolibrary.org/obo/GO_0019013 denotes core
T4 572-576 http://purl.obolibrary.org/obo/GO_0019013 denotes core
T5 728-732 http://purl.obolibrary.org/obo/GO_0019013 denotes core

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 64-70 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
T2 209-215 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
T3 498-504 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
T4 632-638 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
T5 795-801 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
T6 1108-1114 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
T7 639-645 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T8 847-853 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T9 761-770 http://purl.obolibrary.org/obo/UBERON_2000106 denotes extension

EDAM-topics

Id Subject Object Predicate Lexical cue
T1 743-754 http://edamontology.org/topic_0749 denotes terminating

EDAM-DFO

Id Subject Object Predicate Lexical cue
T1 358-364 http://edamontology.org/operation_3435 denotes normal
T2 422-432 http://edamontology.org/data_0883 denotes structures
T3 830-836 http://edamontology.org/operation_3435 denotes normal
T4 918-928 http://edamontology.org/operation_3465 denotes correlated

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
10561455-0#31#39#gene6482 31-39 gene6482 denotes ST3Gal I
10561455-0#64#81#diseaseC0678222 64-81 diseaseC0678222 denotes breast carcinomas
10561455-5#36#40#gene4582 1095-1099 gene4582 denotes MUC1
10561455-5#49#66#diseaseC0678222 1108-1125 diseaseC0678222 denotes breast carcinomas
31#39#gene648264#81#diseaseC0678222 10561455-0#31#39#gene6482 10561455-0#64#81#diseaseC0678222 associated_with ST3Gal I,breast carcinomas
36#40#gene458249#66#diseaseC0678222 10561455-5#36#40#gene4582 10561455-5#49#66#diseaseC0678222 associated_with MUC1,breast carcinomas

GlycoBiology-Motifs

Id Subject Object Predicate Lexical cue
T1 442-457 http://rdf.glycoinfo.org/glycan/G00058MO denotes polylactosamine

GlycoBiology-Epitope

Id Subject Object Predicate Lexical cue
PD-GlycoEpitope-B_T1 981-984 http://www.glycoepitope.jp/epitopes/EP0079 denotes SM3

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 639-645 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T2 847-853 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T3 761-770 http://purl.obolibrary.org/obo/UBERON_2000106 denotes extension
PD-UBERON-AE-B_T4 64-70 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T5 209-215 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T6 498-504 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T7 632-638 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T8 795-801 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T9 1108-1114 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast

DisGeNET

Id Subject Object Predicate Lexical cue
T0 31-39 gene:6482 denotes ST3Gal I
T1 64-81 disease:C0678222 denotes breast carcinomas
T2 87-91 gene:4582 denotes MUC1
T3 173-183 disease:C0007097 denotes carcinomas
T4 679-687 gene:6482 denotes ST3Gal I
T5 795-812 disease:C0678222 denotes breast carcinomas
T6 1183-1191 gene:6482 denotes ST3Gal I
T7 1108-1125 disease:C0678222 denotes breast carcinomas
T8 1095-1099 gene:4582 denotes MUC1
T9 1108-1125 disease:C0678222 denotes breast carcinomas
R1 T0 T1 associated_with ST3Gal I,breast carcinomas
R2 T2 T3 associated_with MUC1,carcinomas
R3 T4 T5 associated_with ST3Gal I,breast carcinomas
R4 T6 T7 associated_with ST3Gal I,breast carcinomas
R5 T8 T9 associated_with MUC1,breast carcinomas

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 64-81 Phenotype denotes breast carcinomas HP:0003002
T2 173-183 Phenotype denotes carcinomas HP:0030731
T3 498-515 Phenotype denotes breast carcinomas HP:0003002
T4 795-812 Phenotype denotes breast carcinomas HP:0003002
T5 1035-1041 Phenotype denotes tumour HP:0002664
T6 1108-1125 Phenotype denotes breast carcinomas HP:0003002

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 64-81 Disease denotes breast carcinomas http://purl.obolibrary.org/obo/MONDO_0004989
T2 173-183 Disease denotes carcinomas http://purl.obolibrary.org/obo/MONDO_0004993
T3 498-515 Disease denotes breast carcinomas http://purl.obolibrary.org/obo/MONDO_0004989
T4 795-812 Disease denotes breast carcinomas http://purl.obolibrary.org/obo/MONDO_0004989
T5 1108-1125 Disease denotes breast carcinomas http://purl.obolibrary.org/obo/MONDO_0004989

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 409-415 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO
T2 572-578 Glycan denotes core 1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO
T3 728-734 Glycan denotes core 1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO
T4 981-984 Glycan denotes SM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G20044TD

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 981-984 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes SM3 http://www.glycoepitope.jp/epitopes/EP0079

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 64-81 Phenotype denotes breast carcinomas HP:0003002
T2 173-183 Phenotype denotes carcinomas HP:0030731
T3 498-515 Phenotype denotes breast carcinomas HP:0003002
T4 795-812 Phenotype denotes breast carcinomas HP:0003002
T5 1035-1041 Phenotype denotes tumour HP:0002664
T6 1108-1125 Phenotype denotes breast carcinomas HP:0003002

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 149-165 Cell denotes epithelial cells http://purl.obolibrary.org/obo/CL:0000066
T2 365-389 Cell denotes mammary epithelial cells http://purl.obolibrary.org/obo/CL:0002327

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 64-70 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T2 149-165 Body_part denotes epithelial cells http://purl.obolibrary.org/obo/CL_0000066
T3 209-215 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T4 220-225 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992
T5 365-389 Body_part denotes mammary epithelial cells http://purl.obolibrary.org/obo/CL_0002327
T6 498-504 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T7 632-638 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T8 639-645 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T9 761-770 Body_part denotes extension http://purl.obolibrary.org/obo/UBERON_2000106
T10 795-801 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T11 847-853 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T12 1108-1114 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-82 Sentence denotes An alpha2,3 sialyltransferase (ST3Gal I) is elevated in primary breast carcinomas.
TextSentencer_T2 83-275 Sentence denotes The MUC1 mucin is expressed on the luminal surface of most simple epithelial cells but in carcinomas, especially those of the breast and ovary, MUC1 is upregulated and aberrantly glycosylated.
TextSentencer_T3 276-465 Sentence denotes MUC1 contains a large amount of O-linked glycans which, in the mucin expressed by normal mammary epithelial cells, consist mainly of core 2 based structures carrying polylactosamine chains.
TextSentencer_T4 466-854 Sentence denotes However, the mucin expressed by breast carcinomas has shorter side-chains, often consisting of sialylated core 1 (Galbeta1-3GalNAc). in situ hybridization of primary breast tissue showed that a sialyltransferase (ST3Gal I), responsible for adding sialic acid to core 1 thereby terminating chain extension, is elevated in primary breast carcinomas when compared to normal or benign tissue.
TextSentencer_T5 855-1058 Sentence denotes Furthermore, the level of mRNA expression encoding ST3Gal I is correlated to the intensity of staining seen with the antibody SM3, which specifically recognises underglycosylated, tumour associated MUC1.
TextSentencer_T6 1059-1192 Sentence denotes Thus, the aberrant glycosylation of MUC1 seen in breast carcinomas appears to be due, at least in part, to the elevation of ST3Gal I.
T1 0-82 Sentence denotes An alpha2,3 sialyltransferase (ST3Gal I) is elevated in primary breast carcinomas.
T2 83-275 Sentence denotes The MUC1 mucin is expressed on the luminal surface of most simple epithelial cells but in carcinomas, especially those of the breast and ovary, MUC1 is upregulated and aberrantly glycosylated.
T3 276-465 Sentence denotes MUC1 contains a large amount of O-linked glycans which, in the mucin expressed by normal mammary epithelial cells, consist mainly of core 2 based structures carrying polylactosamine chains.
T4 466-854 Sentence denotes However, the mucin expressed by breast carcinomas has shorter side-chains, often consisting of sialylated core 1 (Galbeta1-3GalNAc). in situ hybridization of primary breast tissue showed that a sialyltransferase (ST3Gal I), responsible for adding sialic acid to core 1 thereby terminating chain extension, is elevated in primary breast carcinomas when compared to normal or benign tissue.
T5 855-1058 Sentence denotes Furthermore, the level of mRNA expression encoding ST3Gal I is correlated to the intensity of staining seen with the antibody SM3, which specifically recognises underglycosylated, tumour associated MUC1.
T6 1059-1192 Sentence denotes Thus, the aberrant glycosylation of MUC1 seen in breast carcinomas appears to be due, at least in part, to the elevation of ST3Gal I.
T1 0-82 Sentence denotes An alpha2,3 sialyltransferase (ST3Gal I) is elevated in primary breast carcinomas.
T2 83-275 Sentence denotes The MUC1 mucin is expressed on the luminal surface of most simple epithelial cells but in carcinomas, especially those of the breast and ovary, MUC1 is upregulated and aberrantly glycosylated.
T3 276-465 Sentence denotes MUC1 contains a large amount of O-linked glycans which, in the mucin expressed by normal mammary epithelial cells, consist mainly of core 2 based structures carrying polylactosamine chains.
T4 466-854 Sentence denotes However, the mucin expressed by breast carcinomas has shorter side-chains, often consisting of sialylated core 1 (Galbeta1-3GalNAc). in situ hybridization of primary breast tissue showed that a sialyltransferase (ST3Gal I), responsible for adding sialic acid to core 1 thereby terminating chain extension, is elevated in primary breast carcinomas when compared to normal or benign tissue.
T5 855-1058 Sentence denotes Furthermore, the level of mRNA expression encoding ST3Gal I is correlated to the intensity of staining seen with the antibody SM3, which specifically recognises underglycosylated, tumour associated MUC1.
T6 1059-1192 Sentence denotes Thus, the aberrant glycosylation of MUC1 seen in breast carcinomas appears to be due, at least in part, to the elevation of ST3Gal I.

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-82 Sentence denotes An alpha2,3 sialyltransferase (ST3Gal I) is elevated in primary breast carcinomas.
T2 83-275 Sentence denotes The MUC1 mucin is expressed on the luminal surface of most simple epithelial cells but in carcinomas, especially those of the breast and ovary, MUC1 is upregulated and aberrantly glycosylated.
T3 276-465 Sentence denotes MUC1 contains a large amount of O-linked glycans which, in the mucin expressed by normal mammary epithelial cells, consist mainly of core 2 based structures carrying polylactosamine chains.
T4 466-854 Sentence denotes However, the mucin expressed by breast carcinomas has shorter side-chains, often consisting of sialylated core 1 (Galbeta1-3GalNAc). in situ hybridization of primary breast tissue showed that a sialyltransferase (ST3Gal I), responsible for adding sialic acid to core 1 thereby terminating chain extension, is elevated in primary breast carcinomas when compared to normal or benign tissue.
T5 855-1058 Sentence denotes Furthermore, the level of mRNA expression encoding ST3Gal I is correlated to the intensity of staining seen with the antibody SM3, which specifically recognises underglycosylated, tumour associated MUC1.
T6 1059-1192 Sentence denotes Thus, the aberrant glycosylation of MUC1 seen in breast carcinomas appears to be due, at least in part, to the elevation of ST3Gal I.

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 981-984 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes SM3 http://www.glycoepitope.jp/epitopes/EP0079

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 64-81 Disease denotes breast carcinomas MONDO:0004989
T2 173-183 Disease denotes carcinomas MONDO:0004993
T3 498-515 Disease denotes breast carcinomas MONDO:0004989
T4 795-812 Disease denotes breast carcinomas MONDO:0004989
T5 1035-1041 Disease denotes tumour MONDO:0005070
T6 1108-1125 Disease denotes breast carcinomas MONDO:0004989

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 64-70 Body_part denotes breast FMA:9601
T2 149-165 Body_part denotes epithelial cells FMA:66768
T3 209-215 Body_part denotes breast FMA:9601
T4 220-225 Body_part denotes ovary FMA:7209
T5 373-389 Body_part denotes epithelial cells FMA:66768
T6 498-504 Body_part denotes breast FMA:9601
T7 632-638 Body_part denotes breast FMA:9601
T8 639-645 Body_part denotes tissue FMA:9637
T9 795-801 Body_part denotes breast FMA:9601
T10 847-853 Body_part denotes tissue FMA:9637
T11 1108-1114 Body_part denotes breast FMA:9601

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 409-415 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO
T2 572-578 Glycan denotes core 1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO
T3 728-734 Glycan denotes core 1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO
T4 981-984 Glycan denotes SM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G20044TD

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 64-70 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T2 149-165 Body_part denotes epithelial cells http://purl.obolibrary.org/obo/CL_0000066
T3 209-215 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T4 220-225 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992
T5 365-389 Body_part denotes mammary epithelial cells http://purl.obolibrary.org/obo/CL_0002327
T6 498-504 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T7 632-638 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T8 639-645 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T9 761-770 Body_part denotes extension http://purl.obolibrary.org/obo/UBERON_2000106
T10 795-801 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T11 847-853 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T12 1108-1114 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 149-165 Cell denotes epithelial cells http://purl.obolibrary.org/obo/CL:0000066
T2 365-389 Cell denotes mammary epithelial cells http://purl.obolibrary.org/obo/CL:0002327