PubMed:10543260
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/10543260","sourcedb":"PubMed","sourceid":"10543260","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/10543260","text":"Increased serum levels of vascular endothelial growth factor in patients with renal cell carcinoma.\nNeovascularization, an essential event for the growth of solid tumors, is regulated by a number of angiogenic factors. One such factor, vascular endothelial growth factor (VEGF), is considered to exert a potent angiogenic activity, as indicated by immunohistochemical and molecular evidence. In this study we investigated the serum VEGF level (s-VEGF) in patients with renal cell carcinoma (RCC). s-VEGF in peripheral blood samples was analyzed in 40 RCC patients and 40 patients without cancer (controls) using a sandwich enzyme-linked immunoassay. In 20 RCC patients, serum samples were obtained separately from the bilateral renal veins. s-VEGF was also measured before, 4 and 8 weeks after nephrectomy in 11 patients. There were significant differences in s-VEGF between the RCC patients and the controls (207.3+/-32.9 vs. 71.5+/-9.1 pg/ml, mean+/-SE) (P\u003c0.005), between the tumor-bearing renal veins and the contralateral ones (P\u003c0.01), between the pre- and post-nephrectomy situations (P\u003c0.01) and among the various parameters of tumor status such as tumor extent (P\u003c0.001) and existence of metastasis (P\u003c0.001). s-VEGF significantly correlated with the tumor volume obtained by a three-dimensional measurement (r=0.802, P\u003c0.0001). The sensitivity and specificity of s-VEGF at the cut-off level of 100 pg/ml, as determined by the receiver-operating-characteristics curve, were 80.0% and 72.5%, respectively. The results indicate that tumor tissue of RCC liberates VEGF into the systemic blood flow and that s-VEGF is a possible marker for RCC.","tracks":[{"project":"PMID_GLOBAL","denotations":[{"id":"T1","span":{"begin":78,"end":98},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":469,"end":489},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":491,"end":494},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":551,"end":554},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T13","span":{"begin":656,"end":659},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T17","span":{"begin":879,"end":882},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T21","span":{"begin":952,"end":954},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T22","span":{"begin":979,"end":984},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T23","span":{"begin":1136,"end":1141},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T24","span":{"begin":1157,"end":1162},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T25","span":{"begin":1260,"end":1265},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T26","span":{"begin":1342,"end":1353},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T27","span":{"begin":1540,"end":1545},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T28","span":{"begin":1556,"end":1559},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T32","span":{"begin":1645,"end":1648},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0005086"},{"id":"A2","pred":"mondo_id","subj":"T1","obj":"0005549"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0005086"},{"id":"A4","pred":"mondo_id","subj":"T3","obj":"0005549"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"0005086"},{"id":"A6","pred":"mondo_id","subj":"T5","obj":"0005549"},{"id":"A7","pred":"mondo_id","subj":"T5","obj":"0007763"},{"id":"A8","pred":"mondo_id","subj":"T5","obj":"0044874"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"0005086"},{"id":"A10","pred":"mondo_id","subj":"T9","obj":"0005549"},{"id":"A11","pred":"mondo_id","subj":"T9","obj":"0007763"},{"id":"A12","pred":"mondo_id","subj":"T9","obj":"0044874"},{"id":"A13","pred":"mondo_id","subj":"T13","obj":"0005086"},{"id":"A14","pred":"mondo_id","subj":"T13","obj":"0005549"},{"id":"A15","pred":"mondo_id","subj":"T13","obj":"0007763"},{"id":"A16","pred":"mondo_id","subj":"T13","obj":"0044874"},{"id":"A17","pred":"mondo_id","subj":"T17","obj":"0005086"},{"id":"A18","pred":"mondo_id","subj":"T17","obj":"0005549"},{"id":"A19","pred":"mondo_id","subj":"T17","obj":"0007763"},{"id":"A20","pred":"mondo_id","subj":"T17","obj":"0044874"},{"id":"A21","pred":"mondo_id","subj":"T21","obj":"0002125"},{"id":"A22","pred":"mondo_id","subj":"T22","obj":"0005070"},{"id":"A23","pred":"mondo_id","subj":"T23","obj":"0005070"},{"id":"A24","pred":"mondo_id","subj":"T24","obj":"0005070"},{"id":"A25","pred":"mondo_id","subj":"T25","obj":"0005070"},{"id":"A26","pred":"mondo_id","subj":"T26","obj":"0000605"},{"id":"A27","pred":"mondo_id","subj":"T27","obj":"0005070"},{"id":"A28","pred":"mondo_id","subj":"T28","obj":"0005086"},{"id":"A29","pred":"mondo_id","subj":"T28","obj":"0005549"},{"id":"A30","pred":"mondo_id","subj":"T28","obj":"0007763"},{"id":"A31","pred":"mondo_id","subj":"T28","obj":"0044874"},{"id":"A32","pred":"mondo_id","subj":"T32","obj":"0005086"},{"id":"A33","pred":"mondo_id","subj":"T32","obj":"0005549"},{"id":"A34","pred":"mondo_id","subj":"T32","obj":"0007763"},{"id":"A35","pred":"mondo_id","subj":"T32","obj":"0044874"},{"subj":"T1","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T3","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T5","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T9","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T13","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T17","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T21","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T22","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T23","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T24","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T25","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T26","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T27","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T28","pred":"source","obj":"PMID_GLOBAL"},{"subj":"T32","pred":"source","obj":"PMID_GLOBAL"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":163,"end":169},"obj":"HP_0002664"},{"id":"T2","span":{"begin":469,"end":489},"obj":"HP_0005584"},{"id":"T3","span":{"begin":588,"end":594},"obj":"HP_0002664"},{"id":"T4","span":{"begin":979,"end":984},"obj":"HP_0002664"},{"id":"T5","span":{"begin":1136,"end":1141},"obj":"HP_0002664"},{"id":"T6","span":{"begin":1157,"end":1162},"obj":"HP_0002664"},{"id":"T7","span":{"begin":1260,"end":1265},"obj":"HP_0002664"},{"id":"T8","span":{"begin":1540,"end":1545},"obj":"HP_0002664"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"},{"subj":"T4","pred":"source","obj":"PubmedHPO"},{"subj":"T5","pred":"source","obj":"PubmedHPO"},{"subj":"T6","pred":"source","obj":"PubmedHPO"},{"subj":"T7","pred":"source","obj":"PubmedHPO"},{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