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c_corpus

Id Subject Object Predicate Lexical cue
T1 30-36 UBERON:0027368 denotes matrix
T3 30-56 P14780 denotes matrix metalloproteinase-9
T4 30-56 P41246 denotes matrix metalloproteinase-9
T5 30-56 P41245 denotes matrix metalloproteinase-9
T6 30-56 P50282 denotes matrix metalloproteinase-9
T7 30-56 PR:000010491 denotes matrix metalloproteinase-9
T8 30-56 P52176 denotes matrix metalloproteinase-9
T9 30-56 O18733 denotes matrix metalloproteinase-9
T2 30-56 D020780 denotes matrix metalloproteinase-9
T10 61-80 UBERON:0000120 denotes blood-brain barrier
T13 95-99 PR:000005054 denotes mice
T15 95-99 O89094 denotes mice
T14 95-99 D051379 denotes mice
T16 95-99 10095 denotes mice
T17 112-129 D002545 denotes cerebral ischemia
T18 112-129 D002545 denotes cerebral ischemia
T21 153-158 UBERON:6110636 denotes brain
T22 153-158 UBERON:0000955 denotes brain
T23 168-171 UBERON:0000120 denotes BBB
T24 245-253 D007511 denotes ischemia
T25 245-253 D007511 denotes ischemia
T26 267-292 D020782 denotes Matrix metalloproteinases
T28 294-298 D020782 denotes MMPs
T29 316-335 D010447 denotes proteolytic enzymes
T31 379-399 GO:0031012 denotes extracellular matrix
T32 393-399 UBERON:0027368 denotes matrix
T35 425-437 P08253 denotes Gelatinase A
T36 425-437 Q90611 denotes Gelatinase A
T38 425-437 PR:000010479 denotes Gelatinase A
T39 425-437 P33436 denotes Gelatinase A
T40 425-437 P33434 denotes Gelatinase A
T41 425-437 P50757 denotes Gelatinase A
T37 425-437 D020778 denotes Gelatinase A
T42 439-442 CHEBI:340824 denotes MMP
T45 439-442 CHEBI:59761 denotes MMP
T46 439-444 PR:P08253 denotes MMP-2
T47 439-444 Q9GLE5 denotes MMP-2
T48 439-444 P08253 denotes MMP-2
T49 439-444 Q90611 denotes MMP-2
T51 439-444 PR:Q8MPP3 denotes MMP-2
T52 439-444 P33436 denotes MMP-2
T53 439-444 PR:Q90611 denotes MMP-2
T54 439-444 PR:P33436 denotes MMP-2
T55 439-444 PR:000010479 denotes MMP-2
T56 439-444 PR:P33434 denotes MMP-2
T57 439-444 P33434 denotes MMP-2
T58 439-444 P50757 denotes MMP-2
T50 439-444 GO:0004228 denotes MMP-2
T62 450-462 P14780 denotes gelatinase B
T63 450-462 P41246 denotes gelatinase B
T64 450-462 P41245 denotes gelatinase B
T65 450-462 P50282 denotes gelatinase B
T66 450-462 PR:000010491 denotes gelatinase B
T67 450-462 P52176 denotes gelatinase B
T68 450-462 O18733 denotes gelatinase B
T61 450-462 D020780 denotes gelatinase B
T69 464-467 CHEBI:340824 denotes MMP
T72 464-467 CHEBI:59761 denotes MMP
T73 464-469 PR:P50282 denotes MMP-9
T74 464-469 PR:P14780 denotes MMP-9
T75 464-469 P14780 denotes MMP-9
T76 464-469 PR:P41245 denotes MMP-9
T77 464-469 P41246 denotes MMP-9
T78 464-469 P41245 denotes MMP-9
T79 464-469 PR:P52176 denotes MMP-9
T80 464-469 P50282 denotes MMP-9
T82 464-469 PR:000010491 denotes MMP-9
T83 464-469 P52176 denotes MMP-9
T84 464-469 O18733 denotes MMP-9
T81 464-469 GO:0004229 denotes MMP-9
T85 506-518 GO:0005604 denotes basal lamina
T86 506-518 UBERON:0000482 denotes basal lamina
T90 560-563 UBERON:0000120 denotes BBB
T91 640-651 D018093 denotes gelatinases
T92 685-702 D002545 denotes cerebral ischemia
T93 685-702 D002545 denotes cerebral ischemia
T96 712-716 PR:000005054 denotes mice
T98 712-716 O89094 denotes mice
T97 712-716 D051379 denotes mice
T99 712-716 10095 denotes mice
T100 724-728 UBERON:0003101 denotes male
T101 724-728 CHEBI:30780 denotes male
T102 729-732 PR:000001838 denotes CD1
T103 729-732 Q188R7 denotes CD1
T104 733-737 PR:000005054 denotes mice
T106 733-737 O89094 denotes mice
T105 733-737 D051379 denotes mice
T107 733-737 10095 denotes mice
T108 759-762 CVCL_E777 denotes min
T112 852-859 PR:000000001 denotes protein
T110 852-859 CHEBI:36080 denotes protein
T111 852-859 CHEBI:11122 denotes protein
T113 852-859 SO:0000104 denotes protein
T109 852-859 GO:0003675 denotes protein
T114 883-892 D003902 denotes detergent
T115 883-892 CHEBI:27780 denotes detergent
T116 883-892 D003902 denotes detergent
T117 939-942 CHEBI:340824 denotes MMP
T120 939-942 CHEBI:59761 denotes MMP
T121 939-944 PR:P50282 denotes MMP-9
T122 939-944 PR:P14780 denotes MMP-9
T123 939-944 P14780 denotes MMP-9
T124 939-944 PR:P41245 denotes MMP-9
T125 939-944 P41246 denotes MMP-9
T126 939-944 P41245 denotes MMP-9
T127 939-944 PR:P52176 denotes MMP-9
T128 939-944 P50282 denotes MMP-9
T130 939-944 PR:000010491 denotes MMP-9
T131 939-944 P52176 denotes MMP-9
T132 939-944 O18733 denotes MMP-9
T129 939-944 GO:0004229 denotes MMP-9
T133 1034-1040 UBERON:0000479 denotes tissue
T134 1041-1051 CHEBI:35222 denotes inhibitors
T135 1055-1074 GO:0051405 denotes metalloproteinase-1
T136 1091-1098 SO:0001031 denotes reverse
T137 1115-1118 UBERON:0000120 denotes BBB
T138 1119-1126 UBERON:0004111 denotes opening
T139 1148-1158 D005070 denotes Evans blue
T140 1148-1158 D005070 denotes Evans blue
T141 1148-1158 CHEBI:82467 denotes Evans blue
T142 1202-1205 CHEBI:340824 denotes MMP
T145 1202-1205 CHEBI:59761 denotes MMP
T146 1202-1207 PR:P50282 denotes MMP-9
T147 1202-1207 PR:P14780 denotes MMP-9
T148 1202-1207 P14780 denotes MMP-9
T149 1202-1207 PR:P41245 denotes MMP-9
T150 1202-1207 P41246 denotes MMP-9
T151 1202-1207 P41245 denotes MMP-9
T152 1202-1207 PR:P52176 denotes MMP-9
T153 1202-1207 P50282 denotes MMP-9
T155 1202-1207 PR:000010491 denotes MMP-9
T156 1202-1207 P52176 denotes MMP-9
T157 1202-1207 O18733 denotes MMP-9
T154 1202-1207 GO:0004229 denotes MMP-9
T158 1285-1293 D007511 denotes ischemia
T159 1285-1293 D007511 denotes ischemia
T160 1333-1336 UBERON:0000120 denotes BBB
T161 1390-1395 UBERON:6110636 denotes brain
T162 1390-1395 UBERON:0000955 denotes brain
T163 1402-1405 CVCL_N817 denotes pro
T167 1402-1405 SO:0001439 denotes pro
T164 1402-1405 CHEBI:32871 denotes pro
T165 1402-1405 CHEBI:32865 denotes pro
T166 1402-1405 CHEBI:50342 denotes pro
T168 1402-1405 CHEBI:32866 denotes pro
T169 1406-1409 CHEBI:340824 denotes MMP
T172 1406-1409 CHEBI:59761 denotes MMP
T173 1406-1411 PR:P50282 denotes MMP-9
T174 1406-1411 PR:P14780 denotes MMP-9
T175 1406-1411 P14780 denotes MMP-9
T176 1406-1411 PR:P41245 denotes MMP-9
T177 1406-1411 P41246 denotes MMP-9
T178 1406-1411 P41245 denotes MMP-9
T179 1406-1411 PR:P52176 denotes MMP-9
T180 1406-1411 P50282 denotes MMP-9
T182 1406-1411 PR:000010491 denotes MMP-9
T183 1406-1411 P52176 denotes MMP-9
T184 1406-1411 O18733 denotes MMP-9
T181 1406-1411 GO:0004229 denotes MMP-9
T185 1425-1428 CVCL_N817 denotes pro
T189 1425-1428 SO:0001439 denotes pro
T191 1425-1434 C069860 denotes pro-MMP-2
T196 1429-1434 PR:P08253 denotes MMP-2
T197 1429-1434 Q9GLE5 denotes MMP-2
T198 1429-1434 P08253 denotes MMP-2
T199 1429-1434 Q90611 denotes MMP-2
T201 1429-1434 PR:Q8MPP3 denotes MMP-2
T202 1429-1434 P33436 denotes MMP-2
T203 1429-1434 PR:Q90611 denotes MMP-2
T204 1429-1434 PR:P33436 denotes MMP-2
T205 1429-1434 PR:000010479 denotes MMP-2
T206 1429-1434 PR:P33434 denotes MMP-2
T207 1429-1434 P33434 denotes MMP-2
T208 1429-1434 P50757 denotes MMP-2
T200 1429-1434 GO:0004228 denotes MMP-2
T209 1546-1549 CHEBI:340824 denotes MMP
T212 1546-1549 CHEBI:59761 denotes MMP
T213 1546-1551 PR:P50282 denotes MMP-9
T214 1546-1551 PR:P14780 denotes MMP-9
T215 1546-1551 P14780 denotes MMP-9
T216 1546-1551 PR:P41245 denotes MMP-9
T217 1546-1551 P41246 denotes MMP-9
T218 1546-1551 P41245 denotes MMP-9
T219 1546-1551 PR:P52176 denotes MMP-9
T220 1546-1551 P50282 denotes MMP-9
T222 1546-1551 PR:000010491 denotes MMP-9
T223 1546-1551 P52176 denotes MMP-9
T224 1546-1551 O18733 denotes MMP-9
T221 1546-1551 GO:0004229 denotes MMP-9
T225 1656-1659 CHEBI:340824 denotes MMP
T228 1656-1659 CHEBI:59761 denotes MMP
T229 1656-1661 PR:P50282 denotes MMP-9
T230 1656-1661 PR:P14780 denotes MMP-9
T231 1656-1661 P14780 denotes MMP-9
T232 1656-1661 PR:P41245 denotes MMP-9
T233 1656-1661 P41246 denotes MMP-9
T234 1656-1661 P41245 denotes MMP-9
T235 1656-1661 PR:P52176 denotes MMP-9
T236 1656-1661 P50282 denotes MMP-9
T238 1656-1661 PR:000010491 denotes MMP-9
T239 1656-1661 P52176 denotes MMP-9
T240 1656-1661 O18733 denotes MMP-9
T237 1656-1661 GO:0004229 denotes MMP-9
T241 1691-1694 UBERON:0000120 denotes BBB
T242 1748-1751 CHEBI:340824 denotes MMP
T245 1748-1751 CHEBI:59761 denotes MMP
T246 1748-1753 PR:P50282 denotes MMP-9
T247 1748-1753 PR:P14780 denotes MMP-9
T248 1748-1753 P14780 denotes MMP-9
T249 1748-1753 PR:P41245 denotes MMP-9
T250 1748-1753 P41246 denotes MMP-9
T251 1748-1753 P41245 denotes MMP-9
T252 1748-1753 PR:P52176 denotes MMP-9
T253 1748-1753 P50282 denotes MMP-9
T255 1748-1753 PR:000010491 denotes MMP-9
T256 1748-1753 P52176 denotes MMP-9
T257 1748-1753 O18733 denotes MMP-9
T254 1748-1753 GO:0004229 denotes MMP-9
T258 1779-1788 GO:0009058 denotes formation
T259 1802-1807 D004487 denotes edema
T260 1802-1807 D004487 denotes edema

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 685-702 HP_0002637 denotes cerebral ischemia
T2 1802-1807 HP_0000969 denotes edema

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T13 1519-1621 DRI_Background denotes A significant induction of MMP-9 was confirmed by both immunohistochemistry and Western blot analysis.
T1 0-146 DRI_Background denotes Early appearance of activated matrix metalloproteinase-9 and blood-brain barrier disruption in mice after focal cerebral ischemia and reperfusion.
T2 147-266 DRI_Outcome denotes Blood-brain barrier (BBB) disruption is thought to play a critical role in the pathophysiology of ischemia/reperfusion.
T3 267-424 DRI_Approach denotes Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that can degrade all the components of the extracellular matrix when they are activated.
T4 425-579 DRI_Approach denotes Gelatinase A (MMP-2) and gelatinase B (MMP-9) are able to digest the endothelial basal lamina, which plays a major role in maintaining BBB impermeability.
T5 580-717 DRI_Background denotes The present study examined the expression and activation of gelatinases before and after transient focal cerebral ischemia (FCI) in mice.
T6 718-783 DRI_Background denotes Adult male CD1 mice were subjected to 60 min FCI and reperfusion.
T7 784-938 DRI_Approach denotes Zymography was performed from 1 to 23 h after reperfusion using the protein extraction method with detergent extraction and affinity-support purification.
T8 939-1110 DRI_Background denotes MMP-9 expression was also examined by both immunohistochemistry and Western blot analysis, and tissue inhibitors to metalloproteinase-1 was measured by reverse zymography.
T9 1111-1180 DRI_Approach denotes The BBB opening was evaluated by the Evans blue extravasation method.
T10 1181-1308 DRI_Background denotes The 88-kDa activated MMP-9 was absent from the control specimens, while it appeared 3 h after transient ischemia by zymography.
T11 1309-1396 DRI_Approach denotes At this time point, the BBB permeability alteration was detected in the ischemic brain.
T12 1397-1518 DRI_Background denotes Both pro-MMP-9 (96 kDa) and pro-MMP-2 (72 kDa) were seen in the control specimens, and were markedly increased after FCI.
T14 1622-1828 DRI_Challenge denotes The early appearance of activated MMP-9, associated with evidence of BBB permeability alteration, suggests that activation of MMP-9 contributes to the early formation of vasogenic edema after transient FCI.

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 147-266 DRI_Outcome denotes Blood-brain barrier (BBB) disruption is thought to play a critical role in the pathophysiology of ischemia/reperfusion.
T2 267-424 DRI_Approach denotes Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that can degrade all the components of the extracellular matrix when they are activated.
T3 425-579 DRI_Approach denotes Gelatinase A (MMP-2) and gelatinase B (MMP-9) are able to digest the endothelial basal lamina, which plays a major role in maintaining BBB impermeability.
T4 580-717 DRI_Background denotes The present study examined the expression and activation of gelatinases before and after transient focal cerebral ischemia (FCI) in mice.
T5 718-783 DRI_Background denotes Adult male CD1 mice were subjected to 60 min FCI and reperfusion.
T6 784-938 DRI_Approach denotes Zymography was performed from 1 to 23 h after reperfusion using the protein extraction method with detergent extraction and affinity-support purification.
T7 939-1110 DRI_Background denotes MMP-9 expression was also examined by both immunohistochemistry and Western blot analysis, and tissue inhibitors to metalloproteinase-1 was measured by reverse zymography.
T8 1111-1180 DRI_Approach denotes The BBB opening was evaluated by the Evans blue extravasation method.
T9 1181-1308 DRI_Background denotes The 88-kDa activated MMP-9 was absent from the control specimens, while it appeared 3 h after transient ischemia by zymography.
T10 1309-1396 DRI_Approach denotes At this time point, the BBB permeability alteration was detected in the ischemic brain.
T11 1397-1518 DRI_Background denotes Both pro-MMP-9 (96 kDa) and pro-MMP-2 (72 kDa) were seen in the control specimens, and were markedly increased after FCI.
T12 1519-1621 DRI_Background denotes A significant induction of MMP-9 was confirmed by both immunohistochemistry and Western blot analysis.
T13 1622-1828 DRI_Challenge denotes The early appearance of activated MMP-9, associated with evidence of BBB permeability alteration, suggests that activation of MMP-9 contributes to the early formation of vasogenic edema after transient FCI.