PubMed:10526099
Annnotations
c_corpus
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 30-36 | UBERON:0027368 | denotes | matrix |
T3 | 30-56 | P14780 | denotes | matrix metalloproteinase-9 |
T4 | 30-56 | P41246 | denotes | matrix metalloproteinase-9 |
T5 | 30-56 | P41245 | denotes | matrix metalloproteinase-9 |
T6 | 30-56 | P50282 | denotes | matrix metalloproteinase-9 |
T7 | 30-56 | PR:000010491 | denotes | matrix metalloproteinase-9 |
T8 | 30-56 | P52176 | denotes | matrix metalloproteinase-9 |
T9 | 30-56 | O18733 | denotes | matrix metalloproteinase-9 |
T2 | 30-56 | D020780 | denotes | matrix metalloproteinase-9 |
T10 | 61-80 | UBERON:0000120 | denotes | blood-brain barrier |
T13 | 95-99 | PR:000005054 | denotes | mice |
T15 | 95-99 | O89094 | denotes | mice |
T14 | 95-99 | D051379 | denotes | mice |
T16 | 95-99 | 10095 | denotes | mice |
T17 | 112-129 | D002545 | denotes | cerebral ischemia |
T18 | 112-129 | D002545 | denotes | cerebral ischemia |
T21 | 153-158 | UBERON:6110636 | denotes | brain |
T22 | 153-158 | UBERON:0000955 | denotes | brain |
T23 | 168-171 | UBERON:0000120 | denotes | BBB |
T24 | 245-253 | D007511 | denotes | ischemia |
T25 | 245-253 | D007511 | denotes | ischemia |
T26 | 267-292 | D020782 | denotes | Matrix metalloproteinases |
T28 | 294-298 | D020782 | denotes | MMPs |
T29 | 316-335 | D010447 | denotes | proteolytic enzymes |
T31 | 379-399 | GO:0031012 | denotes | extracellular matrix |
T32 | 393-399 | UBERON:0027368 | denotes | matrix |
T35 | 425-437 | P08253 | denotes | Gelatinase A |
T36 | 425-437 | Q90611 | denotes | Gelatinase A |
T38 | 425-437 | PR:000010479 | denotes | Gelatinase A |
T39 | 425-437 | P33436 | denotes | Gelatinase A |
T40 | 425-437 | P33434 | denotes | Gelatinase A |
T41 | 425-437 | P50757 | denotes | Gelatinase A |
T37 | 425-437 | D020778 | denotes | Gelatinase A |
T42 | 439-442 | CHEBI:340824 | denotes | MMP |
T45 | 439-442 | CHEBI:59761 | denotes | MMP |
T46 | 439-444 | PR:P08253 | denotes | MMP-2 |
T47 | 439-444 | Q9GLE5 | denotes | MMP-2 |
T48 | 439-444 | P08253 | denotes | MMP-2 |
T49 | 439-444 | Q90611 | denotes | MMP-2 |
T51 | 439-444 | PR:Q8MPP3 | denotes | MMP-2 |
T52 | 439-444 | P33436 | denotes | MMP-2 |
T53 | 439-444 | PR:Q90611 | denotes | MMP-2 |
T54 | 439-444 | PR:P33436 | denotes | MMP-2 |
T55 | 439-444 | PR:000010479 | denotes | MMP-2 |
T56 | 439-444 | PR:P33434 | denotes | MMP-2 |
T57 | 439-444 | P33434 | denotes | MMP-2 |
T58 | 439-444 | P50757 | denotes | MMP-2 |
T50 | 439-444 | GO:0004228 | denotes | MMP-2 |
T62 | 450-462 | P14780 | denotes | gelatinase B |
T63 | 450-462 | P41246 | denotes | gelatinase B |
T64 | 450-462 | P41245 | denotes | gelatinase B |
T65 | 450-462 | P50282 | denotes | gelatinase B |
T66 | 450-462 | PR:000010491 | denotes | gelatinase B |
T67 | 450-462 | P52176 | denotes | gelatinase B |
T68 | 450-462 | O18733 | denotes | gelatinase B |
T61 | 450-462 | D020780 | denotes | gelatinase B |
T69 | 464-467 | CHEBI:340824 | denotes | MMP |
T72 | 464-467 | CHEBI:59761 | denotes | MMP |
T73 | 464-469 | PR:P50282 | denotes | MMP-9 |
T74 | 464-469 | PR:P14780 | denotes | MMP-9 |
T75 | 464-469 | P14780 | denotes | MMP-9 |
T76 | 464-469 | PR:P41245 | denotes | MMP-9 |
T77 | 464-469 | P41246 | denotes | MMP-9 |
T78 | 464-469 | P41245 | denotes | MMP-9 |
T79 | 464-469 | PR:P52176 | denotes | MMP-9 |
T80 | 464-469 | P50282 | denotes | MMP-9 |
T82 | 464-469 | PR:000010491 | denotes | MMP-9 |
T83 | 464-469 | P52176 | denotes | MMP-9 |
T84 | 464-469 | O18733 | denotes | MMP-9 |
T81 | 464-469 | GO:0004229 | denotes | MMP-9 |
T85 | 506-518 | GO:0005604 | denotes | basal lamina |
T86 | 506-518 | UBERON:0000482 | denotes | basal lamina |
T90 | 560-563 | UBERON:0000120 | denotes | BBB |
T91 | 640-651 | D018093 | denotes | gelatinases |
T92 | 685-702 | D002545 | denotes | cerebral ischemia |
T93 | 685-702 | D002545 | denotes | cerebral ischemia |
T96 | 712-716 | PR:000005054 | denotes | mice |
T98 | 712-716 | O89094 | denotes | mice |
T97 | 712-716 | D051379 | denotes | mice |
T99 | 712-716 | 10095 | denotes | mice |
T100 | 724-728 | UBERON:0003101 | denotes | male |
T101 | 724-728 | CHEBI:30780 | denotes | male |
T102 | 729-732 | PR:000001838 | denotes | CD1 |
T103 | 729-732 | Q188R7 | denotes | CD1 |
T104 | 733-737 | PR:000005054 | denotes | mice |
T106 | 733-737 | O89094 | denotes | mice |
T105 | 733-737 | D051379 | denotes | mice |
T107 | 733-737 | 10095 | denotes | mice |
T108 | 759-762 | CVCL_E777 | denotes | min |
T112 | 852-859 | PR:000000001 | denotes | protein |
T110 | 852-859 | CHEBI:36080 | denotes | protein |
T111 | 852-859 | CHEBI:11122 | denotes | protein |
T113 | 852-859 | SO:0000104 | denotes | protein |
T109 | 852-859 | GO:0003675 | denotes | protein |
T114 | 883-892 | D003902 | denotes | detergent |
T115 | 883-892 | CHEBI:27780 | denotes | detergent |
T116 | 883-892 | D003902 | denotes | detergent |
T117 | 939-942 | CHEBI:340824 | denotes | MMP |
T120 | 939-942 | CHEBI:59761 | denotes | MMP |
T121 | 939-944 | PR:P50282 | denotes | MMP-9 |
T122 | 939-944 | PR:P14780 | denotes | MMP-9 |
T123 | 939-944 | P14780 | denotes | MMP-9 |
T124 | 939-944 | PR:P41245 | denotes | MMP-9 |
T125 | 939-944 | P41246 | denotes | MMP-9 |
T126 | 939-944 | P41245 | denotes | MMP-9 |
T127 | 939-944 | PR:P52176 | denotes | MMP-9 |
T128 | 939-944 | P50282 | denotes | MMP-9 |
T130 | 939-944 | PR:000010491 | denotes | MMP-9 |
T131 | 939-944 | P52176 | denotes | MMP-9 |
T132 | 939-944 | O18733 | denotes | MMP-9 |
T129 | 939-944 | GO:0004229 | denotes | MMP-9 |
T133 | 1034-1040 | UBERON:0000479 | denotes | tissue |
T134 | 1041-1051 | CHEBI:35222 | denotes | inhibitors |
T135 | 1055-1074 | GO:0051405 | denotes | metalloproteinase-1 |
T136 | 1091-1098 | SO:0001031 | denotes | reverse |
T137 | 1115-1118 | UBERON:0000120 | denotes | BBB |
T138 | 1119-1126 | UBERON:0004111 | denotes | opening |
T139 | 1148-1158 | D005070 | denotes | Evans blue |
T140 | 1148-1158 | D005070 | denotes | Evans blue |
T141 | 1148-1158 | CHEBI:82467 | denotes | Evans blue |
T142 | 1202-1205 | CHEBI:340824 | denotes | MMP |
T145 | 1202-1205 | CHEBI:59761 | denotes | MMP |
T146 | 1202-1207 | PR:P50282 | denotes | MMP-9 |
T147 | 1202-1207 | PR:P14780 | denotes | MMP-9 |
T148 | 1202-1207 | P14780 | denotes | MMP-9 |
T149 | 1202-1207 | PR:P41245 | denotes | MMP-9 |
T150 | 1202-1207 | P41246 | denotes | MMP-9 |
T151 | 1202-1207 | P41245 | denotes | MMP-9 |
T152 | 1202-1207 | PR:P52176 | denotes | MMP-9 |
T153 | 1202-1207 | P50282 | denotes | MMP-9 |
T155 | 1202-1207 | PR:000010491 | denotes | MMP-9 |
T156 | 1202-1207 | P52176 | denotes | MMP-9 |
T157 | 1202-1207 | O18733 | denotes | MMP-9 |
T154 | 1202-1207 | GO:0004229 | denotes | MMP-9 |
T158 | 1285-1293 | D007511 | denotes | ischemia |
T159 | 1285-1293 | D007511 | denotes | ischemia |
T160 | 1333-1336 | UBERON:0000120 | denotes | BBB |
T161 | 1390-1395 | UBERON:6110636 | denotes | brain |
T162 | 1390-1395 | UBERON:0000955 | denotes | brain |
T163 | 1402-1405 | CVCL_N817 | denotes | pro |
T167 | 1402-1405 | SO:0001439 | denotes | pro |
T164 | 1402-1405 | CHEBI:32871 | denotes | pro |
T165 | 1402-1405 | CHEBI:32865 | denotes | pro |
T166 | 1402-1405 | CHEBI:50342 | denotes | pro |
T168 | 1402-1405 | CHEBI:32866 | denotes | pro |
T169 | 1406-1409 | CHEBI:340824 | denotes | MMP |
T172 | 1406-1409 | CHEBI:59761 | denotes | MMP |
T173 | 1406-1411 | PR:P50282 | denotes | MMP-9 |
T174 | 1406-1411 | PR:P14780 | denotes | MMP-9 |
T175 | 1406-1411 | P14780 | denotes | MMP-9 |
T176 | 1406-1411 | PR:P41245 | denotes | MMP-9 |
T177 | 1406-1411 | P41246 | denotes | MMP-9 |
T178 | 1406-1411 | P41245 | denotes | MMP-9 |
T179 | 1406-1411 | PR:P52176 | denotes | MMP-9 |
T180 | 1406-1411 | P50282 | denotes | MMP-9 |
T182 | 1406-1411 | PR:000010491 | denotes | MMP-9 |
T183 | 1406-1411 | P52176 | denotes | MMP-9 |
T184 | 1406-1411 | O18733 | denotes | MMP-9 |
T181 | 1406-1411 | GO:0004229 | denotes | MMP-9 |
T185 | 1425-1428 | CVCL_N817 | denotes | pro |
T189 | 1425-1428 | SO:0001439 | denotes | pro |
T191 | 1425-1434 | C069860 | denotes | pro-MMP-2 |
T196 | 1429-1434 | PR:P08253 | denotes | MMP-2 |
T197 | 1429-1434 | Q9GLE5 | denotes | MMP-2 |
T198 | 1429-1434 | P08253 | denotes | MMP-2 |
T199 | 1429-1434 | Q90611 | denotes | MMP-2 |
T201 | 1429-1434 | PR:Q8MPP3 | denotes | MMP-2 |
T202 | 1429-1434 | P33436 | denotes | MMP-2 |
T203 | 1429-1434 | PR:Q90611 | denotes | MMP-2 |
T204 | 1429-1434 | PR:P33436 | denotes | MMP-2 |
T205 | 1429-1434 | PR:000010479 | denotes | MMP-2 |
T206 | 1429-1434 | PR:P33434 | denotes | MMP-2 |
T207 | 1429-1434 | P33434 | denotes | MMP-2 |
T208 | 1429-1434 | P50757 | denotes | MMP-2 |
T200 | 1429-1434 | GO:0004228 | denotes | MMP-2 |
T209 | 1546-1549 | CHEBI:340824 | denotes | MMP |
T212 | 1546-1549 | CHEBI:59761 | denotes | MMP |
T213 | 1546-1551 | PR:P50282 | denotes | MMP-9 |
T214 | 1546-1551 | PR:P14780 | denotes | MMP-9 |
T215 | 1546-1551 | P14780 | denotes | MMP-9 |
T216 | 1546-1551 | PR:P41245 | denotes | MMP-9 |
T217 | 1546-1551 | P41246 | denotes | MMP-9 |
T218 | 1546-1551 | P41245 | denotes | MMP-9 |
T219 | 1546-1551 | PR:P52176 | denotes | MMP-9 |
T220 | 1546-1551 | P50282 | denotes | MMP-9 |
T222 | 1546-1551 | PR:000010491 | denotes | MMP-9 |
T223 | 1546-1551 | P52176 | denotes | MMP-9 |
T224 | 1546-1551 | O18733 | denotes | MMP-9 |
T221 | 1546-1551 | GO:0004229 | denotes | MMP-9 |
T225 | 1656-1659 | CHEBI:340824 | denotes | MMP |
T228 | 1656-1659 | CHEBI:59761 | denotes | MMP |
T229 | 1656-1661 | PR:P50282 | denotes | MMP-9 |
T230 | 1656-1661 | PR:P14780 | denotes | MMP-9 |
T231 | 1656-1661 | P14780 | denotes | MMP-9 |
T232 | 1656-1661 | PR:P41245 | denotes | MMP-9 |
T233 | 1656-1661 | P41246 | denotes | MMP-9 |
T234 | 1656-1661 | P41245 | denotes | MMP-9 |
T235 | 1656-1661 | PR:P52176 | denotes | MMP-9 |
T236 | 1656-1661 | P50282 | denotes | MMP-9 |
T238 | 1656-1661 | PR:000010491 | denotes | MMP-9 |
T239 | 1656-1661 | P52176 | denotes | MMP-9 |
T240 | 1656-1661 | O18733 | denotes | MMP-9 |
T237 | 1656-1661 | GO:0004229 | denotes | MMP-9 |
T241 | 1691-1694 | UBERON:0000120 | denotes | BBB |
T242 | 1748-1751 | CHEBI:340824 | denotes | MMP |
T245 | 1748-1751 | CHEBI:59761 | denotes | MMP |
T246 | 1748-1753 | PR:P50282 | denotes | MMP-9 |
T247 | 1748-1753 | PR:P14780 | denotes | MMP-9 |
T248 | 1748-1753 | P14780 | denotes | MMP-9 |
T249 | 1748-1753 | PR:P41245 | denotes | MMP-9 |
T250 | 1748-1753 | P41246 | denotes | MMP-9 |
T251 | 1748-1753 | P41245 | denotes | MMP-9 |
T252 | 1748-1753 | PR:P52176 | denotes | MMP-9 |
T253 | 1748-1753 | P50282 | denotes | MMP-9 |
T255 | 1748-1753 | PR:000010491 | denotes | MMP-9 |
T256 | 1748-1753 | P52176 | denotes | MMP-9 |
T257 | 1748-1753 | O18733 | denotes | MMP-9 |
T254 | 1748-1753 | GO:0004229 | denotes | MMP-9 |
T258 | 1779-1788 | GO:0009058 | denotes | formation |
T259 | 1802-1807 | D004487 | denotes | edema |
T260 | 1802-1807 | D004487 | denotes | edema |
PubmedHPO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 685-702 | HP_0002637 | denotes | cerebral ischemia |
T2 | 1802-1807 | HP_0000969 | denotes | edema |
UseCases_ArguminSci_Discourse
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T13 | 1519-1621 | DRI_Background | denotes | A significant induction of MMP-9 was confirmed by both immunohistochemistry and Western blot analysis. |
T1 | 0-146 | DRI_Background | denotes | Early appearance of activated matrix metalloproteinase-9 and blood-brain barrier disruption in mice after focal cerebral ischemia and reperfusion. |
T2 | 147-266 | DRI_Outcome | denotes | Blood-brain barrier (BBB) disruption is thought to play a critical role in the pathophysiology of ischemia/reperfusion. |
T3 | 267-424 | DRI_Approach | denotes | Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that can degrade all the components of the extracellular matrix when they are activated. |
T4 | 425-579 | DRI_Approach | denotes | Gelatinase A (MMP-2) and gelatinase B (MMP-9) are able to digest the endothelial basal lamina, which plays a major role in maintaining BBB impermeability. |
T5 | 580-717 | DRI_Background | denotes | The present study examined the expression and activation of gelatinases before and after transient focal cerebral ischemia (FCI) in mice. |
T6 | 718-783 | DRI_Background | denotes | Adult male CD1 mice were subjected to 60 min FCI and reperfusion. |
T7 | 784-938 | DRI_Approach | denotes | Zymography was performed from 1 to 23 h after reperfusion using the protein extraction method with detergent extraction and affinity-support purification. |
T8 | 939-1110 | DRI_Background | denotes | MMP-9 expression was also examined by both immunohistochemistry and Western blot analysis, and tissue inhibitors to metalloproteinase-1 was measured by reverse zymography. |
T9 | 1111-1180 | DRI_Approach | denotes | The BBB opening was evaluated by the Evans blue extravasation method. |
T10 | 1181-1308 | DRI_Background | denotes | The 88-kDa activated MMP-9 was absent from the control specimens, while it appeared 3 h after transient ischemia by zymography. |
T11 | 1309-1396 | DRI_Approach | denotes | At this time point, the BBB permeability alteration was detected in the ischemic brain. |
T12 | 1397-1518 | DRI_Background | denotes | Both pro-MMP-9 (96 kDa) and pro-MMP-2 (72 kDa) were seen in the control specimens, and were markedly increased after FCI. |
T14 | 1622-1828 | DRI_Challenge | denotes | The early appearance of activated MMP-9, associated with evidence of BBB permeability alteration, suggests that activation of MMP-9 contributes to the early formation of vasogenic edema after transient FCI. |
PubMed_ArguminSci
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 147-266 | DRI_Outcome | denotes | Blood-brain barrier (BBB) disruption is thought to play a critical role in the pathophysiology of ischemia/reperfusion. |
T2 | 267-424 | DRI_Approach | denotes | Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that can degrade all the components of the extracellular matrix when they are activated. |
T3 | 425-579 | DRI_Approach | denotes | Gelatinase A (MMP-2) and gelatinase B (MMP-9) are able to digest the endothelial basal lamina, which plays a major role in maintaining BBB impermeability. |
T4 | 580-717 | DRI_Background | denotes | The present study examined the expression and activation of gelatinases before and after transient focal cerebral ischemia (FCI) in mice. |
T5 | 718-783 | DRI_Background | denotes | Adult male CD1 mice were subjected to 60 min FCI and reperfusion. |
T6 | 784-938 | DRI_Approach | denotes | Zymography was performed from 1 to 23 h after reperfusion using the protein extraction method with detergent extraction and affinity-support purification. |
T7 | 939-1110 | DRI_Background | denotes | MMP-9 expression was also examined by both immunohistochemistry and Western blot analysis, and tissue inhibitors to metalloproteinase-1 was measured by reverse zymography. |
T8 | 1111-1180 | DRI_Approach | denotes | The BBB opening was evaluated by the Evans blue extravasation method. |
T9 | 1181-1308 | DRI_Background | denotes | The 88-kDa activated MMP-9 was absent from the control specimens, while it appeared 3 h after transient ischemia by zymography. |
T10 | 1309-1396 | DRI_Approach | denotes | At this time point, the BBB permeability alteration was detected in the ischemic brain. |
T11 | 1397-1518 | DRI_Background | denotes | Both pro-MMP-9 (96 kDa) and pro-MMP-2 (72 kDa) were seen in the control specimens, and were markedly increased after FCI. |
T12 | 1519-1621 | DRI_Background | denotes | A significant induction of MMP-9 was confirmed by both immunohistochemistry and Western blot analysis. |
T13 | 1622-1828 | DRI_Challenge | denotes | The early appearance of activated MMP-9, associated with evidence of BBB permeability alteration, suggests that activation of MMP-9 contributes to the early formation of vasogenic edema after transient FCI. |