PubMed:10497131 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	119-147	protein	denotes	calcium-mobilizing receptors
T2	151-209	DNA	denotes	nuclear factor of activated T cells (NFAT)-dependent genes
T3	261-272	protein	denotes	phosphatase
T4	273-284	protein	denotes	calcineurin
T5	293-313	protein	denotes	transcription factor
T6	314-318	protein	denotes	NFAT
T7	336-347	protein	denotes	calcineurin
T8	427-452	protein	denotes	calcineurin docking motif
T9	456-460	protein	denotes	NFAT
T10	494-498	protein	denotes	NFAT
T11	514-518	protein	denotes	NFAT
T12	543-568	DNA	denotes	endogenous cytokine genes
T13	572-579	cell_type	denotes	T cells
T14	623-632	protein	denotes	cytokines
T15	646-657	protein	denotes	calcineurin
T16	666-670	protein	denotes	NFAT
T17	736-760	protein	denotes	calcineurin docking site
T18	775-786	protein	denotes	calcineurin
T19	805-809	protein	denotes	NFAT
T20	857-868	protein	denotes	calcineurin
T21	868-873	protein	denotes	-NFAT
T22	904-915	protein	denotes	calcineurin
T23	916-927	protein	denotes	phosphatase

Id	Subject	Object	Predicate	Lexical cue
S1	0-89	Sentence	denotes	Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A.
S2	90-319	Sentence	denotes	The flow of information from calcium-mobilizing receptors to nuclear factor of activated T cells (NFAT)-dependent genes is critically dependent on interaction between the phosphatase calcineurin and the transcription factor NFAT.
S3	320-461	Sentence	denotes	A high-affinity calcineurin-binding peptide was selected from combinatorial peptide libraries based on the calcineurin docking motif of NFAT.
S4	462-671	Sentence	denotes	This peptide potently inhibited NFAT activation and NFAT-dependent expression of endogenous cytokine genes in T cells, without affecting the expression of other cytokines that require calcineurin but not NFAT.
S5	672-810	Sentence	denotes	Substitution of the optimized peptide sequence into the natural calcineurin docking site increased the calcineurin responsiveness of NFAT.
S6	811-1012	Sentence	denotes	Compounds that interfere selectively with the calcineurin-NFAT interaction without affecting calcineurin phosphatase activity may be useful as therapeutic agents that are less toxic than current drugs.

Id	Subject	Object	Predicate	Lexical cue
C10	151-194	NP	denotes	nuclear factor of activated T cells (NFAT)-
C12	289-318	NP	denotes	the transcription factor NFAT
C27	320-363	NP	denotes	A high-affinity calcineurin-binding peptide
C3	456-460	NP	denotes	NFAT
C25	462-474	NP	denotes	This peptide
C13	514-519	NP	denotes	NFAT-
C28	617-632	NP	denotes	other cytokines
C29	633-637	NP	denotes	that
C6	666-670	NP	denotes	NFAT
C7	805-809	NP	denotes	NFAT
C30	811-820	NP	denotes	Compounds
C31	821-825	NP	denotes	that
C32	954-972	NP	denotes	therapeutic agents
C33	973-977	NP	denotes	that
R1	C12	C10	coref-ident	the transcription factor NFAT,nuclear factor of activated T cells (NFAT)-
R2	C3	C12	coref-xxx	NFAT,the transcription factor NFAT
R3	C25	C27	coref-ident	This peptide,A high-affinity calcineurin-binding peptide
R4	C13	C3	coref-ident	NFAT-,NFAT
R5	C29	C28	coref-relat	that,other cytokines
R6	C6	C3	coref-ident	NFAT,NFAT
R7	C7	C6	coref-ident	NFAT,NFAT
R8	C31	C30	coref-relat	that,Compounds
R9	C33	C32	coref-relat	that,therapeutic agents

Id	Subject	Object	Predicate	Lexical cue
T1	0-33	other_name	denotes	Affinity-driven peptide selection
T2	40-54	other_organic_compound	denotes	NFAT inhibitor
T3	75-88	other_organic_compound	denotes	cyclosporin A
T4	119-147	protein_family_or_group	denotes	calcium-mobilizing receptors
T5	151-186	protein_molecule	denotes	nuclear factor of activated T cells
T6	188-192	protein_molecule	denotes	NFAT
T7	261-272	protein_family_or_group	denotes	phosphatase
T8	273-284	protein_molecule	denotes	calcineurin
T9	293-313	protein_family_or_group	denotes	transcription factor
T10	314-318	protein_molecule	denotes	NFAT
T11	322-335	peptide	denotes	high-affinity
T12	336-347	protein_molecule	denotes	calcineurin
T13	396-413	other_name	denotes	peptide libraries
T14	427-438	protein_molecule	denotes	calcineurin
T15	456-460	protein_molecule	denotes	NFAT
T16	494-498	protein_molecule	denotes	NFAT
T17	514-518	protein_molecule	denotes	NFAT
T18	543-568	DNA_family_or_group	denotes	endogenous cytokine genes
T19	572-579	cell_type	denotes	T cells
T20	623-632	protein_family_or_group	denotes	cytokines
T21	646-657	protein_molecule	denotes	calcineurin
T22	666-670	protein_molecule	denotes	NFAT
T23	702-718	other_name	denotes	peptide sequence
T24	736-747	protein_molecule	denotes	calcineurin
T25	775-786	protein_molecule	denotes	calcineurin
T26	805-809	protein_molecule	denotes	NFAT
T27	857-868	protein_molecule	denotes	calcineurin
T28	868-873	protein_molecule	denotes	-NFAT
T29	904-915	protein_molecule	denotes	calcineurin
T30	916-927	protein_family_or_group	denotes	phosphatase
T31	954-972	other_name	denotes	therapeutic agents