PubMed:10496602
Annnotations
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
TextSentencer_T1 | 0-117 | Sentence | denotes | Multiple endocrine neoplasia type 1: atypical presentation, clinical course, and genetic analysis of multiple tumors. |
TextSentencer_T2 | 118-281 | Sentence | denotes | Multiple endocrine neoplasia type 1 (MEN1) is characterized by the development of endocrine tumors of the parathyroid and pituitary glands, pancreas, and duodenum. |
TextSentencer_T3 | 282-399 | Sentence | denotes | Less frequently occurring tumors associated with MEN1 include non-endocrine tumors such as lipomas and angiofibromas. |
TextSentencer_T4 | 400-585 | Sentence | denotes | An increased incidence of thyroid neoplasms, leiomyomas, adrenal cortical hyperplasia, hepatic focal nodular hyperplasia, and renal angiomyolipoma has been noted in the MEN1 population. |
TextSentencer_T5 | 586-651 | Sentence | denotes | The pathogenesis of non-neuroendocrine tumors in MEN1 is unknown. |
TextSentencer_T6 | 652-796 | Sentence | denotes | We report a complex clinical course and a detailed morphologic and genetic analysis of a series of tumors that developed in a patient with MEN1. |
TextSentencer_T7 | 797-885 | Sentence | denotes | All tumors were microdissected and analyzed for loss of heterozygosity of the MEN1 gene. |
TextSentencer_T8 | 886-1173 | Sentence | denotes | A germline mutation of the MEN1 gene was detected, and deletions of the MEN1 gene were consistently detected in multiple neuroendocrine tumors involving the parathyroid glands and the pancreas and a hepatic neuroendocrine tumor metastasis, as predicted by Knudson's "two hit" hypothesis. |
TextSentencer_T9 | 1174-1335 | Sentence | denotes | Two hits of the MEN1 gene were also detected in esophageal leiomyoma tissue, suggesting that tumorigenesis was directly related to the patient's underlying MEN1. |
TextSentencer_T10 | 1336-1582 | Sentence | denotes | In contrast, follicular thyroid adenoma, papillary thyroid carcinoma, hepatic focal nodular hyperplasia, and adrenal cortical hyperplasia consistently showed retained heterozygosity of the MEN1 gene with flanking markers and an intragenic marker. |
TextSentencer_T11 | 1583-1710 | Sentence | denotes | Therefore, these tumors appear to develop along pathogenetic pathways that are different from classical MEN1-associated tumors. |
T1 | 0-117 | Sentence | denotes | Multiple endocrine neoplasia type 1: atypical presentation, clinical course, and genetic analysis of multiple tumors. |
T2 | 118-281 | Sentence | denotes | Multiple endocrine neoplasia type 1 (MEN1) is characterized by the development of endocrine tumors of the parathyroid and pituitary glands, pancreas, and duodenum. |
T3 | 282-399 | Sentence | denotes | Less frequently occurring tumors associated with MEN1 include non-endocrine tumors such as lipomas and angiofibromas. |
T4 | 400-585 | Sentence | denotes | An increased incidence of thyroid neoplasms, leiomyomas, adrenal cortical hyperplasia, hepatic focal nodular hyperplasia, and renal angiomyolipoma has been noted in the MEN1 population. |
T5 | 586-651 | Sentence | denotes | The pathogenesis of non-neuroendocrine tumors in MEN1 is unknown. |
T6 | 652-796 | Sentence | denotes | We report a complex clinical course and a detailed morphologic and genetic analysis of a series of tumors that developed in a patient with MEN1. |
T7 | 797-885 | Sentence | denotes | All tumors were microdissected and analyzed for loss of heterozygosity of the MEN1 gene. |
T8 | 886-1173 | Sentence | denotes | A germline mutation of the MEN1 gene was detected, and deletions of the MEN1 gene were consistently detected in multiple neuroendocrine tumors involving the parathyroid glands and the pancreas and a hepatic neuroendocrine tumor metastasis, as predicted by Knudson's "two hit" hypothesis. |
T9 | 1174-1335 | Sentence | denotes | Two hits of the MEN1 gene were also detected in esophageal leiomyoma tissue, suggesting that tumorigenesis was directly related to the patient's underlying MEN1. |
T10 | 1336-1582 | Sentence | denotes | In contrast, follicular thyroid adenoma, papillary thyroid carcinoma, hepatic focal nodular hyperplasia, and adrenal cortical hyperplasia consistently showed retained heterozygosity of the MEN1 gene with flanking markers and an intragenic marker. |
T11 | 1583-1710 | Sentence | denotes | Therefore, these tumors appear to develop along pathogenetic pathways that are different from classical MEN1-associated tumors. |
PubmedHPO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 127-146 | HP_0100568 | denotes | endocrine neoplasia |
T2 | 137-146 | HP_0002664 | denotes | neoplasia |
T3 | 210-216 | HP_0002664 | denotes | tumors |
T4 | 210-235 | HP_0006780 | denotes | tumors of the parathyroid |
T5 | 210-256 | HP_0100733 | denotes | tumors of the parathyroid and pituitary glands |
T6 | 308-314 | HP_0002664 | denotes | tumors |
T7 | 358-364 | HP_0002664 | denotes | tumors |
T8 | 373-380 | HP_0012032 | denotes | lipomas |
T9 | 385-398 | HP_0010615 | denotes | angiofibromas |
T10 | 434-443 | HP_0002664 | denotes | neoplasms |
T11 | 526-546 | HP_0006772 | denotes | renal angiomyolipoma |
T12 | 532-546 | HP_0006772 | denotes | angiomyolipoma |
T13 | 610-631 | HP_0100634 | denotes | neuroendocrine tumors |
T14 | 625-631 | HP_0002664 | denotes | tumors |
T15 | 751-757 | HP_0002664 | denotes | tumors |
T16 | 801-807 | HP_0002664 | denotes | tumors |
T17 | 1007-1028 | HP_0100634 | denotes | neuroendocrine tumors |
T18 | 1022-1028 | HP_0002664 | denotes | tumors |
T19 | 1093-1113 | HP_0100634 | denotes | neuroendocrine tumor |
T20 | 1108-1113 | HP_0002664 | denotes | tumor |
T21 | 1349-1375 | HP_0011774 | denotes | follicular thyroid adenoma |
T22 | 1360-1375 | HP_0000854 | denotes | thyroid adenoma |
T23 | 1377-1404 | HP_0002895 | denotes | papillary thyroid carcinoma |
T24 | 1387-1404 | HP_0002890 | denotes | thyroid carcinoma |
T25 | 1600-1606 | HP_0002664 | denotes | tumors |
T26 | 1703-1709 | HP_0002664 | denotes | tumors |
DisGeNET5_gene_disease
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
10496602-7#72#76#gene4221 | 958-962 | gene4221 | denotes | MEN1 |
10496602-7#121#142#diseaseC0206754 | 1007-1028 | diseaseC0206754 | denotes | neuroendocrine tumors |
10496602-7#199#227#diseaseC1333963 | 1085-1113 | diseaseC1333963 | denotes | hepatic neuroendocrine tumor |
10496602-8#16#20#gene4221 | 1190-1194 | gene4221 | denotes | MEN1 |
10496602-8#48#68#diseaseC0238114 | 1222-1242 | diseaseC0238114 | denotes | esophageal leiomyoma |
10496602-8#156#160#diseaseC0025267 | 1330-1334 | diseaseC0025267 | denotes | MEN1 |
10496602-9#189#193#gene4221 | 1525-1529 | gene4221 | denotes | MEN1 |
10496602-9#109#137#diseaseC0342494 | 1445-1473 | diseaseC0342494 | denotes | adrenal cortical hyperplasia |
72#76#gene4221121#142#diseaseC0206754 | 10496602-7#72#76#gene4221 | 10496602-7#121#142#diseaseC0206754 | associated_with | MEN1,neuroendocrine tumors |
72#76#gene4221199#227#diseaseC1333963 | 10496602-7#72#76#gene4221 | 10496602-7#199#227#diseaseC1333963 | associated_with | MEN1,hepatic neuroendocrine tumor |
16#20#gene422148#68#diseaseC0238114 | 10496602-8#16#20#gene4221 | 10496602-8#48#68#diseaseC0238114 | associated_with | MEN1,esophageal leiomyoma |
16#20#gene4221156#160#diseaseC0025267 | 10496602-8#16#20#gene4221 | 10496602-8#156#160#diseaseC0025267 | associated_with | MEN1,MEN1 |
189#193#gene4221109#137#diseaseC0342494 | 10496602-9#189#193#gene4221 | 10496602-9#109#137#diseaseC0342494 | associated_with | MEN1,adrenal cortical hyperplasia |
performance-test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
PD-UBERON-AE-B_T1 | 1243-1249 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissue |
PD-UBERON-AE-B_T2 | 1043-1061 | http://purl.obolibrary.org/obo/UBERON_0001132 | denotes | parathyroid glands |
PD-UBERON-AE-B_T3 | 250-256 | http://purl.obolibrary.org/obo/UBERON_0002530 | denotes | glands |
PD-UBERON-AE-B_T4 | 1055-1061 | http://purl.obolibrary.org/obo/UBERON_0002530 | denotes | glands |
PD-UBERON-AE-B_T5 | 240-256 | http://purl.obolibrary.org/obo/UBERON_0000007 | denotes | pituitary glands |
PD-UBERON-AE-B_T6 | 258-266 | http://purl.obolibrary.org/obo/UBERON_0001264 | denotes | pancreas |
PD-UBERON-AE-B_T7 | 1070-1078 | http://purl.obolibrary.org/obo/UBERON_0001264 | denotes | pancreas |
PD-UBERON-AE-B_T8 | 272-280 | http://purl.obolibrary.org/obo/UBERON_0002114 | denotes | duodenum |
PubCasesHPO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
AB1 | 373-380 | HP:0012032 | denotes | lipomas |
AB2 | 385-398 | HP:0010615 | denotes | angiofibromas |
AB3 | 434-443 | HP:0002664 | denotes | neoplasms |
AB4 | 526-546 | HP:0006772 | denotes | renal angiomyolipoma |
AB5 | 1360-1375 | HP:0000854 | denotes | thyroid adenoma |
AB6 | 1377-1404 | HP:0002895 | denotes | papillary thyroid carcinoma |
PubCasesORDO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
TI1 | 0-35 | ORDO:652 | denotes | Multiple endocrine neoplasia type 1 |
AB1 | 155-159 | ORDO:652 | denotes | MEN1 |
AB2 | 331-335 | ORDO:652 | denotes | MEN1 |
AB3 | 569-573 | ORDO:652 | denotes | MEN1 |
AB4 | 635-639 | ORDO:652 | denotes | MEN1 |
AB5 | 791-795 | ORDO:652 | denotes | MEN1 |
AB6 | 875-879 | ORDO:652 | denotes | MEN1 |
AB7 | 913-917 | ORDO:652 | denotes | MEN1 |
AB8 | 958-962 | ORDO:652 | denotes | MEN1 |
AB9 | 1157-1160 | ORDO:3325 | denotes | hit |
AB10 | 1178-1182 | ORDO:3325 | denotes | hits |
AB11 | 1190-1194 | ORDO:652 | denotes | MEN1 |
AB12 | 1330-1334 | ORDO:652 | denotes | MEN1 |
AB13 | 1525-1529 | ORDO:652 | denotes | MEN1 |
AB14 | 1687-1691 | ORDO:652 | denotes | MEN1 |
UBERON-AE
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
PD-UBERON-AE-B_T1 | 240-256 | http://purl.obolibrary.org/obo/UBERON_0000007 | denotes | pituitary glands |
PD-UBERON-AE-B_T2 | 250-256 | http://purl.obolibrary.org/obo/UBERON_0002530 | denotes | glands |
PD-UBERON-AE-B_T3 | 1055-1061 | http://purl.obolibrary.org/obo/UBERON_0002530 | denotes | glands |
PD-UBERON-AE-B_T4 | 258-266 | http://purl.obolibrary.org/obo/UBERON_0001264 | denotes | pancreas |
PD-UBERON-AE-B_T5 | 1070-1078 | http://purl.obolibrary.org/obo/UBERON_0001264 | denotes | pancreas |
PD-UBERON-AE-B_T6 | 272-280 | http://purl.obolibrary.org/obo/UBERON_0002114 | denotes | duodenum |
PD-UBERON-AE-B_T7 | 1043-1061 | http://purl.obolibrary.org/obo/UBERON_0001132 | denotes | parathyroid glands |
PD-UBERON-AE-B_T8 | 1243-1249 | http://purl.obolibrary.org/obo/UBERON_0000479 | denotes | tissue |
DisGeNET
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T0 | 331-335 | gene:4221 | denotes | MEN1 |
T1 | 385-398 | disease:C0206731 | denotes | angiofibromas |
T2 | 331-335 | gene:4221 | denotes | MEN1 |
T3 | 373-380 | disease:C0023798 | denotes | lipomas |
T4 | 569-573 | gene:4221 | denotes | MEN1 |
T5 | 526-546 | disease:C0241961 | denotes | renal angiomyolipoma |
T6 | 635-639 | gene:4221 | denotes | MEN1 |
T7 | 610-631 | disease:C0206754 | denotes | neuroendocrine tumors |
R1 | T0 | T1 | associated_with | MEN1,angiofibromas |
R2 | T2 | T3 | associated_with | MEN1,lipomas |
R3 | T4 | T5 | associated_with | MEN1,renal angiomyolipoma |
R4 | T6 | T7 | associated_with | MEN1,neuroendocrine tumors |