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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-117 Sentence denotes Multiple endocrine neoplasia type 1: atypical presentation, clinical course, and genetic analysis of multiple tumors.
TextSentencer_T2 118-281 Sentence denotes Multiple endocrine neoplasia type 1 (MEN1) is characterized by the development of endocrine tumors of the parathyroid and pituitary glands, pancreas, and duodenum.
TextSentencer_T3 282-399 Sentence denotes Less frequently occurring tumors associated with MEN1 include non-endocrine tumors such as lipomas and angiofibromas.
TextSentencer_T4 400-585 Sentence denotes An increased incidence of thyroid neoplasms, leiomyomas, adrenal cortical hyperplasia, hepatic focal nodular hyperplasia, and renal angiomyolipoma has been noted in the MEN1 population.
TextSentencer_T5 586-651 Sentence denotes The pathogenesis of non-neuroendocrine tumors in MEN1 is unknown.
TextSentencer_T6 652-796 Sentence denotes We report a complex clinical course and a detailed morphologic and genetic analysis of a series of tumors that developed in a patient with MEN1.
TextSentencer_T7 797-885 Sentence denotes All tumors were microdissected and analyzed for loss of heterozygosity of the MEN1 gene.
TextSentencer_T8 886-1173 Sentence denotes A germline mutation of the MEN1 gene was detected, and deletions of the MEN1 gene were consistently detected in multiple neuroendocrine tumors involving the parathyroid glands and the pancreas and a hepatic neuroendocrine tumor metastasis, as predicted by Knudson's "two hit" hypothesis.
TextSentencer_T9 1174-1335 Sentence denotes Two hits of the MEN1 gene were also detected in esophageal leiomyoma tissue, suggesting that tumorigenesis was directly related to the patient's underlying MEN1.
TextSentencer_T10 1336-1582 Sentence denotes In contrast, follicular thyroid adenoma, papillary thyroid carcinoma, hepatic focal nodular hyperplasia, and adrenal cortical hyperplasia consistently showed retained heterozygosity of the MEN1 gene with flanking markers and an intragenic marker.
TextSentencer_T11 1583-1710 Sentence denotes Therefore, these tumors appear to develop along pathogenetic pathways that are different from classical MEN1-associated tumors.
T1 0-117 Sentence denotes Multiple endocrine neoplasia type 1: atypical presentation, clinical course, and genetic analysis of multiple tumors.
T2 118-281 Sentence denotes Multiple endocrine neoplasia type 1 (MEN1) is characterized by the development of endocrine tumors of the parathyroid and pituitary glands, pancreas, and duodenum.
T3 282-399 Sentence denotes Less frequently occurring tumors associated with MEN1 include non-endocrine tumors such as lipomas and angiofibromas.
T4 400-585 Sentence denotes An increased incidence of thyroid neoplasms, leiomyomas, adrenal cortical hyperplasia, hepatic focal nodular hyperplasia, and renal angiomyolipoma has been noted in the MEN1 population.
T5 586-651 Sentence denotes The pathogenesis of non-neuroendocrine tumors in MEN1 is unknown.
T6 652-796 Sentence denotes We report a complex clinical course and a detailed morphologic and genetic analysis of a series of tumors that developed in a patient with MEN1.
T7 797-885 Sentence denotes All tumors were microdissected and analyzed for loss of heterozygosity of the MEN1 gene.
T8 886-1173 Sentence denotes A germline mutation of the MEN1 gene was detected, and deletions of the MEN1 gene were consistently detected in multiple neuroendocrine tumors involving the parathyroid glands and the pancreas and a hepatic neuroendocrine tumor metastasis, as predicted by Knudson's "two hit" hypothesis.
T9 1174-1335 Sentence denotes Two hits of the MEN1 gene were also detected in esophageal leiomyoma tissue, suggesting that tumorigenesis was directly related to the patient's underlying MEN1.
T10 1336-1582 Sentence denotes In contrast, follicular thyroid adenoma, papillary thyroid carcinoma, hepatic focal nodular hyperplasia, and adrenal cortical hyperplasia consistently showed retained heterozygosity of the MEN1 gene with flanking markers and an intragenic marker.
T11 1583-1710 Sentence denotes Therefore, these tumors appear to develop along pathogenetic pathways that are different from classical MEN1-associated tumors.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 127-146 HP_0100568 denotes endocrine neoplasia
T2 137-146 HP_0002664 denotes neoplasia
T3 210-216 HP_0002664 denotes tumors
T4 210-235 HP_0006780 denotes tumors of the parathyroid
T5 210-256 HP_0100733 denotes tumors of the parathyroid and pituitary glands
T6 308-314 HP_0002664 denotes tumors
T7 358-364 HP_0002664 denotes tumors
T8 373-380 HP_0012032 denotes lipomas
T9 385-398 HP_0010615 denotes angiofibromas
T10 434-443 HP_0002664 denotes neoplasms
T11 526-546 HP_0006772 denotes renal angiomyolipoma
T12 532-546 HP_0006772 denotes angiomyolipoma
T13 610-631 HP_0100634 denotes neuroendocrine tumors
T14 625-631 HP_0002664 denotes tumors
T15 751-757 HP_0002664 denotes tumors
T16 801-807 HP_0002664 denotes tumors
T17 1007-1028 HP_0100634 denotes neuroendocrine tumors
T18 1022-1028 HP_0002664 denotes tumors
T19 1093-1113 HP_0100634 denotes neuroendocrine tumor
T20 1108-1113 HP_0002664 denotes tumor
T21 1349-1375 HP_0011774 denotes follicular thyroid adenoma
T22 1360-1375 HP_0000854 denotes thyroid adenoma
T23 1377-1404 HP_0002895 denotes papillary thyroid carcinoma
T24 1387-1404 HP_0002890 denotes thyroid carcinoma
T25 1600-1606 HP_0002664 denotes tumors
T26 1703-1709 HP_0002664 denotes tumors

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
10496602-7#72#76#gene4221 958-962 gene4221 denotes MEN1
10496602-7#121#142#diseaseC0206754 1007-1028 diseaseC0206754 denotes neuroendocrine tumors
10496602-7#199#227#diseaseC1333963 1085-1113 diseaseC1333963 denotes hepatic neuroendocrine tumor
10496602-8#16#20#gene4221 1190-1194 gene4221 denotes MEN1
10496602-8#48#68#diseaseC0238114 1222-1242 diseaseC0238114 denotes esophageal leiomyoma
10496602-8#156#160#diseaseC0025267 1330-1334 diseaseC0025267 denotes MEN1
10496602-9#189#193#gene4221 1525-1529 gene4221 denotes MEN1
10496602-9#109#137#diseaseC0342494 1445-1473 diseaseC0342494 denotes adrenal cortical hyperplasia
72#76#gene4221121#142#diseaseC0206754 10496602-7#72#76#gene4221 10496602-7#121#142#diseaseC0206754 associated_with MEN1,neuroendocrine tumors
72#76#gene4221199#227#diseaseC1333963 10496602-7#72#76#gene4221 10496602-7#199#227#diseaseC1333963 associated_with MEN1,hepatic neuroendocrine tumor
16#20#gene422148#68#diseaseC0238114 10496602-8#16#20#gene4221 10496602-8#48#68#diseaseC0238114 associated_with MEN1,esophageal leiomyoma
16#20#gene4221156#160#diseaseC0025267 10496602-8#16#20#gene4221 10496602-8#156#160#diseaseC0025267 associated_with MEN1,MEN1
189#193#gene4221109#137#diseaseC0342494 10496602-9#189#193#gene4221 10496602-9#109#137#diseaseC0342494 associated_with MEN1,adrenal cortical hyperplasia

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1243-1249 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T2 1043-1061 http://purl.obolibrary.org/obo/UBERON_0001132 denotes parathyroid glands
PD-UBERON-AE-B_T3 250-256 http://purl.obolibrary.org/obo/UBERON_0002530 denotes glands
PD-UBERON-AE-B_T4 1055-1061 http://purl.obolibrary.org/obo/UBERON_0002530 denotes glands
PD-UBERON-AE-B_T5 240-256 http://purl.obolibrary.org/obo/UBERON_0000007 denotes pituitary glands
PD-UBERON-AE-B_T6 258-266 http://purl.obolibrary.org/obo/UBERON_0001264 denotes pancreas
PD-UBERON-AE-B_T7 1070-1078 http://purl.obolibrary.org/obo/UBERON_0001264 denotes pancreas
PD-UBERON-AE-B_T8 272-280 http://purl.obolibrary.org/obo/UBERON_0002114 denotes duodenum

PubCasesHPO

Id Subject Object Predicate Lexical cue
AB1 373-380 HP:0012032 denotes lipomas
AB2 385-398 HP:0010615 denotes angiofibromas
AB3 434-443 HP:0002664 denotes neoplasms
AB4 526-546 HP:0006772 denotes renal angiomyolipoma
AB5 1360-1375 HP:0000854 denotes thyroid adenoma
AB6 1377-1404 HP:0002895 denotes papillary thyroid carcinoma

PubCasesORDO

Id Subject Object Predicate Lexical cue
TI1 0-35 ORDO:652 denotes Multiple endocrine neoplasia type 1
AB1 155-159 ORDO:652 denotes MEN1
AB2 331-335 ORDO:652 denotes MEN1
AB3 569-573 ORDO:652 denotes MEN1
AB4 635-639 ORDO:652 denotes MEN1
AB5 791-795 ORDO:652 denotes MEN1
AB6 875-879 ORDO:652 denotes MEN1
AB7 913-917 ORDO:652 denotes MEN1
AB8 958-962 ORDO:652 denotes MEN1
AB9 1157-1160 ORDO:3325 denotes hit
AB10 1178-1182 ORDO:3325 denotes hits
AB11 1190-1194 ORDO:652 denotes MEN1
AB12 1330-1334 ORDO:652 denotes MEN1
AB13 1525-1529 ORDO:652 denotes MEN1
AB14 1687-1691 ORDO:652 denotes MEN1

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 240-256 http://purl.obolibrary.org/obo/UBERON_0000007 denotes pituitary glands
PD-UBERON-AE-B_T2 250-256 http://purl.obolibrary.org/obo/UBERON_0002530 denotes glands
PD-UBERON-AE-B_T3 1055-1061 http://purl.obolibrary.org/obo/UBERON_0002530 denotes glands
PD-UBERON-AE-B_T4 258-266 http://purl.obolibrary.org/obo/UBERON_0001264 denotes pancreas
PD-UBERON-AE-B_T5 1070-1078 http://purl.obolibrary.org/obo/UBERON_0001264 denotes pancreas
PD-UBERON-AE-B_T6 272-280 http://purl.obolibrary.org/obo/UBERON_0002114 denotes duodenum
PD-UBERON-AE-B_T7 1043-1061 http://purl.obolibrary.org/obo/UBERON_0001132 denotes parathyroid glands
PD-UBERON-AE-B_T8 1243-1249 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue

DisGeNET

Id Subject Object Predicate Lexical cue
T0 331-335 gene:4221 denotes MEN1
T1 385-398 disease:C0206731 denotes angiofibromas
T2 331-335 gene:4221 denotes MEN1
T3 373-380 disease:C0023798 denotes lipomas
T4 569-573 gene:4221 denotes MEN1
T5 526-546 disease:C0241961 denotes renal angiomyolipoma
T6 635-639 gene:4221 denotes MEN1
T7 610-631 disease:C0206754 denotes neuroendocrine tumors
R1 T0 T1 associated_with MEN1,angiofibromas
R2 T2 T3 associated_with MEN1,lipomas
R3 T4 T5 associated_with MEN1,renal angiomyolipoma
R4 T6 T7 associated_with MEN1,neuroendocrine tumors