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PubMed:10491412 JSONTXT

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PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 0-20 DiseaseOrPhenotypicFeature denotes Renal cell carcinoma 0005086|0005549
T3 210-231 DiseaseOrPhenotypicFeature denotes renal cell carcinomas 0005086|0005549
T5 233-237 DiseaseOrPhenotypicFeature denotes RCCs 0005086
T6 294-298 DiseaseOrPhenotypicFeature denotes RCCs 0005086
T7 482-485 DiseaseOrPhenotypicFeature denotes RCC 0005086|0005549|0007763|0044874
T11 726-737 DiseaseOrPhenotypicFeature denotes sensitivity 0000605
T12 891-894 DiseaseOrPhenotypicFeature denotes RCC 0005086|0005549|0007763|0044874
T16 975-978 DiseaseOrPhenotypicFeature denotes RCC 0005086|0005549|0007763|0044874
T20 1205-1210 DiseaseOrPhenotypicFeature denotes tumor 0005070
T21 1286-1290 DiseaseOrPhenotypicFeature denotes RCCs 0005086

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 210-231 HP_0005584 denotes renal cell carcinomas
T2 437-442 HP_0002664 denotes Tumor
T3 1205-1210 HP_0002664 denotes tumor

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 51-72 protein denotes nuclear factor-kappaB
T2 87-94 cell_type denotes T cells
T3 114-156 protein denotes transcription factor nuclear factor-kappaB
T4 158-166 protein denotes NFkappaB
T5 183-190 cell_type denotes T cells
T6 255-262 cell_type denotes T cells
T7 319-327 protein denotes NFkappaB
T8 404-422 protein denotes cytoplasmic factor
T9 423-435 protein denotes IkappaBalpha
T10 437-467 protein denotes Tumor-derived soluble products
T11 503-511 protein denotes NFkappaB
T12 524-531 cell_type denotes T cells
T13 600-612 protein denotes IkappaBalpha
T14 741-754 protein denotes neuraminidase
T15 763-771 protein denotes protease
T16 891-903 cell_type denotes RCC explants
T17 1066-1074 protein denotes NFkappaB
T18 1095-1102 cell_type denotes T cells
T19 1133-1142 protein denotes cytokines
T20 1143-1147 protein denotes IL-2
T21 1152-1161 protein denotes IFN-gamma

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-95 Sentence denotes Renal cell carcinoma-derived gangliosides suppress nuclear factor-kappaB activation in T cells.
S2 96-239 Sentence denotes Activation of the transcription factor nuclear factor-kappaB (NFkappaB) is impaired in T cells from patients with renal cell carcinomas (RCCs).
S3 240-436 Sentence denotes In circulating T cells from a subset of patients with RCCs, the suppression of NFkappaB binding activity is downstream from the stimulus-induced degradation of the cytoplasmic factor IkappaBalpha.
S4 437-640 Sentence denotes Tumor-derived soluble products from cultured RCC explants inhibit NFkappaB activity in T cells from healthy volunteers, despite a normal level of stimulus-induced IkappaBalpha degradation in these cells.
S5 641-836 Sentence denotes The inhibitory agent has several features characteristic of a ganglioside, including sensitivity to neuraminidase but not protease treatment; hydrophobicity; and molecular weight less than 3 kDa.
S6 837-947 Sentence denotes Indeed, we detected gangliosides in supernatants from RCC explants and not from adjacent normal kidney tissue.
S7 948-1162 Sentence denotes Gangliosides prepared from RCC supernatants, as well as the purified bovine gangliosides G(m1) and G(d1a), suppressed NFkappaB binding activity in T cells and reduced expression of the cytokines IL-2 and IFN-gamma.
S8 1163-1291 Sentence denotes Taken together, our findings suggest that tumor-derived gangliosides may blunt antitumor immune responses in patients with RCCs.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 87-94 NP denotes T cells
C2 196-238 NP denotes patients with renal cell carcinomas (RCCs)
C3 280-298 NP denotes patients with RCCs
C4 437-494 NP denotes Tumor-derived soluble products from cultured RCC explants
C5 628-639 NP denotes these cells
C6 641-661 NP denotes The inhibitory agent
C7 1095-1102 NP denotes T cells
C8 1272-1290 NP denotes patients with RCCs
R1 C3 C2 coref-ident patients with RCCs,patients with renal cell carcinomas (RCCs)
R2 C5 C1 coref-ident these cells,T cells
R3 C6 C4 coref-ident The inhibitory agent,Tumor-derived soluble products from cultured RCC explants
R4 C7 C5 coref-ident T cells,these cells
R5 C8 C3 coref-ident patients with RCCs,patients with RCCs

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-41 other_organic_compound denotes Renal cell carcinoma-derived gangliosides
T2 51-72 protein_complex denotes nuclear factor-kappaB
T3 87-94 cell_type denotes T cells
T4 114-156 protein_complex denotes transcription factor nuclear factor-kappaB
T5 158-166 protein_complex denotes NFkappaB
T6 183-190 cell_type denotes T cells
T7 196-204 multi_cell denotes patients
T8 210-231 tissue denotes renal cell carcinomas
T9 233-237 tissue denotes RCCs
T10 255-262 cell_type denotes T cells
T11 280-288 multi_cell denotes patients
T12 294-298 tissue denotes RCCs
T13 319-327 protein_complex denotes NFkappaB
T14 368-396 other_name denotes stimulus-induced degradation
T15 404-422 protein_family_or_group denotes cytoplasmic factor
T16 423-435 protein_molecule denotes IkappaBalpha
T17 437-467 protein_family_or_group denotes Tumor-derived soluble products
T18 473-485 tissue denotes cultured RCC
T19 503-511 protein_complex denotes NFkappaB
T20 524-531 cell_type denotes T cells
T21 537-555 multi_cell denotes healthy volunteers
T22 583-599 other_name denotes stimulus-induced
T23 600-612 protein_molecule denotes IkappaBalpha
T24 703-714 other_organic_compound denotes ganglioside
T25 741-754 protein_molecule denotes neuraminidase
T26 763-771 protein_family_or_group denotes protease
T27 783-797 other_name denotes hydrophobicity
T28 857-869 other_organic_compound denotes gangliosides
T29 891-903 cell_type denotes RCC explants
T30 926-946 tissue denotes normal kidney tissue
T31 948-960 other_organic_compound denotes Gangliosides
T32 975-991 cell_component denotes RCC supernatants
T33 1008-1023 other_organic_compound denotes purified bovine
T34 1024-1036 other_organic_compound denotes gangliosides
T35 1066-1074 protein_complex denotes NFkappaB
T36 1095-1102 cell_type denotes T cells
T37 1133-1142 protein_family_or_group denotes cytokines
T38 1143-1147 protein_molecule denotes IL-2
T39 1152-1161 protein_molecule denotes IFN-gamma
T40 1205-1218 other_organic_compound denotes tumor-derived
T41 1219-1231 other_organic_compound denotes gangliosides
T42 1242-1268 other_name denotes antitumor immune responses
T43 1272-1280 multi_cell denotes patients
T44 1286-1290 tissue denotes RCCs