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sentences

Id Subject Object Predicate Lexical cue
T1 0-121 Sentence denotes Identification of human asparaginyl endopeptidase (legumain) as an inhibitor of osteoclast formation and bone resorption.
T2 122-319 Sentence denotes We screened a human osteoclast (OCL) cDNA expression library for OCL inhibitory factors and identified a clone that blocked both human and murine OCL formation and bone resorption by more than 60%.
T3 320-389 Sentence denotes This clone was identical to human legumain, a cysteine endopeptidase.
T4 390-688 Sentence denotes Legumain significantly inhibited OCL-like multinucleated cell formation induced by 1,25-dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)) and parathyroid hormone-related protein (PTHrP) in mouse and human bone marrow cultures, and bone resorption in the fetal rat long bone assay in a dose-dependent manner.
T5 689-813 Sentence denotes Legumain was detected in freshly isolated marrow plasma from normal donors and conditioned media from human marrow cultures.
T6 814-978 Sentence denotes Furthermore, treatment of human marrow cultures with an antibody to legumain induced OCL formation to levels that were as high as those induced by 1,25-(OH)(2)D(3).
T7 979-1322 Sentence denotes Implantation in nude mice of 293 cells transfected with the legumain cDNA and constitutively expressing high levels of the protein significantly reduced hypercalcemia induced by PTHrP by about 50%, and significantly inhibited the increase in OCL surface and in OCL number expressed per mm(2) bone area and per mm bone surface induced by PTHrP.
T8 1323-1468 Sentence denotes These results suggest that legumain may be a physiologic local regulator of OCL activity that can negatively modulate OCL formation and activity.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 105-109 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone
T2 286-290 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone
T3 523-534 http://purl.obolibrary.org/obo/MAT_0000082 denotes parathyroid
T4 586-597 http://purl.obolibrary.org/obo/MAT_0000084 denotes bone marrow
T5 586-590 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone
T6 612-616 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone
T7 650-654 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone
T8 1271-1275 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone
T9 1292-1296 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 1132-1145 HP_0003072 denotes hypercalcemia

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
10488118-6#60#68#gene5641 1039-1047 gene5641 denotes legumain
10488118-6#153#166#diseaseC0020437 1132-1145 diseaseC0020437 denotes hypercalcemia
60#68#gene5641153#166#diseaseC0020437 10488118-6#60#68#gene5641 10488118-6#153#166#diseaseC0020437 associated_with legumain,hypercalcemia

2015-BEL-Sample-2

Id Subject Object Predicate Lexical cue
BEL:20029346 0-1460 cat(p(HGNC:ANXA2)) increases bp(GOBP:"osteoclast differentiation") denotes Identification of human asparaginyl endopeptidase (legumain) as an inhibitor of osteoclast formation and bone resorption. We screened a human osteoclast (OCL) cDNA expression library for OCL inhibitory factors and identified a clone that blocked both human and murine OCL formation and bone resorption by more than 60%. This clone was identical to human legumain, a cysteine endopeptidase. Legumain significantly inhibited OCL-like multinucleated cell formation induced by 1,25-dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)) and parathyroid hormone-related protein (PTHrP) in mouse and human bone marrow cultures, and bone resorption in the fetal rat long bone assay in a dose-dependent manner. Legumain was detected in freshly isolated marrow plasma from normal donors and conditioned media from human marrow cultures. Furthermore, treatment of human marrow cultures with an antibody to legumain induced OCL formation to levels that were as high as those induced by 1,25-(OH)(2)D(3). Implantation in nude mice of 293 cells transfected with the legumain cDNA and constitutively expressing high levels of the protein significantly reduced hypercalcemia induced by PTHrP by about 50%, and significantly inhibited the increase in OCL surface and in OCL number expressed per mm(2) bone area and per mm bone surface induced by PTHrP. These results suggest that legumain may be a physiologic local regulator of OCL activity that can negatively modulate OCL formation and a
BEL:20029380 0-1460 cat(p(HGNC:ATXN1)) decreases bp(GOBP:"osteoclast differentiation") denotes Identification of human asparaginyl endopeptidase (legumain) as an inhibitor of osteoclast formation and bone resorption. We screened a human osteoclast (OCL) cDNA expression library for OCL inhibitory factors and identified a clone that blocked both human and murine OCL formation and bone resorption by more than 60%. This clone was identical to human legumain, a cysteine endopeptidase. Legumain significantly inhibited OCL-like multinucleated cell formation induced by 1,25-dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)) and parathyroid hormone-related protein (PTHrP) in mouse and human bone marrow cultures, and bone resorption in the fetal rat long bone assay in a dose-dependent manner. Legumain was detected in freshly isolated marrow plasma from normal donors and conditioned media from human marrow cultures. Furthermore, treatment of human marrow cultures with an antibody to legumain induced OCL formation to levels that were as high as those induced by 1,25-(OH)(2)D(3). Implantation in nude mice of 293 cells transfected with the legumain cDNA and constitutively expressing high levels of the protein significantly reduced hypercalcemia induced by PTHrP by about 50%, and significantly inhibited the increase in OCL surface and in OCL number expressed per mm(2) bone area and per mm bone surface induced by PTHrP. These results suggest that legumain may be a physiologic local regulator of OCL activity that can negatively modulate OCL formation and a

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1039-1047 gene:5641 denotes legumain
T1 1132-1145 disease:C0020437 denotes hypercalcemia
T2 1157-1162 gene:5744 denotes PTHrP
T3 1132-1145 disease:C0020437 denotes hypercalcemia
T4 1316-1321 gene:5744 denotes PTHrP
T5 1132-1145 disease:C0020437 denotes hypercalcemia
R1 T0 T1 associated_with legumain,hypercalcemia
R2 T2 T3 associated_with PTHrP,hypercalcemia
R3 T4 T5 associated_with PTHrP,hypercalcemia

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 105-109 Body_part denotes bone http://purl.obolibrary.org/obo/MAT_0000299
T2 286-290 Body_part denotes bone http://purl.obolibrary.org/obo/MAT_0000299
T3 523-534 Body_part denotes parathyroid http://purl.obolibrary.org/obo/MAT_0000082
T4 586-597 Body_part denotes bone marrow http://purl.obolibrary.org/obo/MAT_0000084
T5 612-616 Body_part denotes bone http://purl.obolibrary.org/obo/MAT_0000299
T6 650-654 Body_part denotes bone http://purl.obolibrary.org/obo/MAT_0000299
T7 1271-1275 Body_part denotes bone http://purl.obolibrary.org/obo/MAT_0000299
T8 1292-1296 Body_part denotes bone http://purl.obolibrary.org/obo/MAT_0000299

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1132-1145 Disease denotes hypercalcemia http://purl.obolibrary.org/obo/MONDO_0001566

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 18-23 OrganismTaxon denotes human 9606
T2 136-141 OrganismTaxon denotes human 9606
T3 251-256 OrganismTaxon denotes human 9606
T4 348-353 OrganismTaxon denotes human 9606
T5 570-575 OrganismTaxon denotes mouse 10088|10090
T7 580-585 OrganismTaxon denotes human 9606
T8 641-644 OrganismTaxon denotes rat 10114|10116
T10 791-796 OrganismTaxon denotes human 9606
T11 840-845 OrganismTaxon denotes human 9606
T12 1000-1004 OrganismTaxon denotes mice 10088

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T4 142-152 Body_part denotes osteoclast http://purl.obolibrary.org/obo/CL_0000092
T5 154-157 Body_part denotes OCL http://purl.obolibrary.org/obo/CL_0000092
T6 187-190 Body_part denotes OCL http://purl.obolibrary.org/obo/CL_0000092
T7 268-271 Body_part denotes OCL http://purl.obolibrary.org/obo/CL_0000092
T8 286-290 Body_part denotes bone http://purl.obolibrary.org/obo/UBERON_0001474|http://purl.obolibrary.org/obo/UBERON_0002481
T10 423-426 Body_part denotes OCL http://purl.obolibrary.org/obo/CL_0000092
T11 432-451 Body_part denotes multinucleated cell http://purl.obolibrary.org/obo/CL_0000228
T12 523-534 Body_part denotes parathyroid http://purl.obolibrary.org/obo/UBERON_0001132
T13 586-597 Body_part denotes bone marrow http://purl.obolibrary.org/obo/UBERON_0002371
T14 612-616 Body_part denotes bone http://purl.obolibrary.org/obo/UBERON_0001474|http://purl.obolibrary.org/obo/UBERON_0002481
T16 645-654 Body_part denotes long bone http://purl.obolibrary.org/obo/UBERON_0002495
T17 738-744 Body_part denotes plasma http://purl.obolibrary.org/obo/UBERON_0001969
T18 899-902 Body_part denotes OCL http://purl.obolibrary.org/obo/CL_0000092
T19 1221-1224 Body_part denotes OCL http://purl.obolibrary.org/obo/CL_0000092
T20 1240-1243 Body_part denotes OCL http://purl.obolibrary.org/obo/CL_0000092
T21 1271-1275 Body_part denotes bone http://purl.obolibrary.org/obo/UBERON_0001474|http://purl.obolibrary.org/obo/UBERON_0002481
T23 1292-1304 Body_part denotes bone surface http://purl.obolibrary.org/obo/UBERON_4200230
T24 1399-1402 Body_part denotes OCL http://purl.obolibrary.org/obo/CL_0000092
T25 1441-1444 Body_part denotes OCL http://purl.obolibrary.org/obo/CL_0000092
T1 80-90 Body_part denotes osteoclast http://purl.obolibrary.org/obo/CL_0000092
T2 105-109 Body_part denotes bone http://purl.obolibrary.org/obo/UBERON_0001474|http://purl.obolibrary.org/obo/UBERON_0002481