PubMed:10485906
Annnotations
PMID_GLOBAL
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-111 | Sentence | denotes | Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression. |
| T2 | 112-194 | Sentence | denotes | Interferons (IFNs) inhibit induction by IL-4 of multiple genes in human monocytes. |
| T3 | 195-277 | Sentence | denotes | However, the mechanism by which IFNs mediate this inhibition has not been defined. |
| T4 | 278-486 | Sentence | denotes | IL-4 activates gene expression by inducing tyrosine phosphorylation, homodimerization, and nuclear translocation of the latent transcription factor, STAT6 (signal transducer and activator of transcription-6). |
| T5 | 487-585 | Sentence | denotes | STAT6-responsive elements are characteristically present in the promoters of IL-4-inducible genes. |
| T6 | 586-776 | Sentence | denotes | Because STAT6 activation is essential for IL-4-induced gene expression, we examined the ability of type I and type II IFNs to regulate activation of STAT6 by IL-4 in primary human monocytes. |
| T7 | 777-1019 | Sentence | denotes | Pretreatment of monocytes with IFN-beta or IFN-gamma, but not IL-1, IL-2, macrophage colony-stimulating factor, granulocyte/macrophage colony-stimulating factor, IL-6, or transforming growth factor beta suppressed activation of STAT6 by IL-4. |
| T8 | 1020-1232 | Sentence | denotes | This inhibition was associated with decreased tyrosine phosphorylation and nuclear translocation of STAT6 and was not evident unless the cells were preincubated with IFN for at least 1 hr before IL-4 stimulation. |
| T9 | 1233-1396 | Sentence | denotes | Furthermore, inhibition by IFN could be blocked by cotreatment with actinomycin D and correlated temporally with induction of the JAK/STAT inhibitory gene, SOCS-1. |
| T10 | 1397-1589 | Sentence | denotes | Forced expression of SOCS-1 in a macrophage cell line, RAW264, markedly suppressed trans-activation of an IL-4-inducible reporter as well as IL-6- and IFN-gamma-induced reporter gene activity. |
| T11 | 1590-1756 | Sentence | denotes | These findings demonstrate that IFNs inhibit IL-4-induced activation of STAT6 and STAT6-dependent gene expression, at least in part, by inducing expression of SOCS-1. |
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 34-39 | protein | denotes | STAT6 |
| T2 | 43-56 | protein | denotes | interleukin 4 |
| T3 | 60-75 | cell_type | denotes | human monocytes |
| T4 | 88-99 | DNA | denotes | SOCS-1 gene |
| T5 | 112-123 | protein | denotes | Interferons |
| T6 | 125-129 | protein | denotes | IFNs |
| T7 | 152-156 | protein | denotes | IL-4 |
| T8 | 178-193 | cell_type | denotes | human monocytes |
| T9 | 227-231 | protein | denotes | IFNs |
| T10 | 278-282 | protein | denotes | IL-4 |
| T11 | 398-425 | protein | denotes | latent transcription factor |
| T12 | 427-432 | protein | denotes | STAT6 |
| T13 | 434-484 | protein | denotes | signal transducer and activator of transcription-6 |
| T14 | 487-492 | protein | denotes | STAT6 |
| T15 | 551-560 | DNA | denotes | promoters |
| T16 | 564-584 | DNA | denotes | IL-4-inducible genes |
| T17 | 594-599 | protein | denotes | STAT6 |
| T18 | 628-632 | protein | denotes | IL-4 |
| T19 | 704-708 | protein | denotes | IFNs |
| T20 | 735-740 | protein | denotes | STAT6 |
| T21 | 744-748 | protein | denotes | IL-4 |
| T22 | 752-775 | cell_type | denotes | primary human monocytes |
| T23 | 793-802 | cell_type | denotes | monocytes |
| T24 | 808-816 | protein | denotes | IFN-beta |
| T25 | 820-829 | protein | denotes | IFN-gamma |
| T26 | 839-843 | protein | denotes | IL-1 |
| T27 | 845-849 | protein | denotes | IL-2 |
| T28 | 851-887 | protein | denotes | macrophage colony-stimulating factor |
| T29 | 889-937 | protein | denotes | granulocyte/macrophage colony-stimulating factor |
| T30 | 939-943 | protein | denotes | IL-6 |
| T31 | 1005-1010 | protein | denotes | STAT6 |
| T32 | 1014-1018 | protein | denotes | IL-4 |
| T33 | 1120-1125 | protein | denotes | STAT6 |
| T34 | 1186-1189 | protein | denotes | IFN |
| T35 | 1215-1219 | protein | denotes | IL-4 |
| T36 | 1260-1263 | protein | denotes | IFN |
| T37 | 1363-1387 | DNA | denotes | JAK/STAT inhibitory gene |
| T38 | 1389-1395 | DNA | denotes | SOCS-1 |
| T39 | 1418-1424 | DNA | denotes | SOCS-1 |
| T40 | 1430-1450 | cell_line | denotes | macrophage cell line |
| T41 | 1452-1458 | cell_line | denotes | RAW264 |
| T42 | 1503-1526 | DNA | denotes | IL-4-inducible reporter |
| T43 | 1622-1626 | protein | denotes | IFNs |
| T44 | 1635-1639 | protein | denotes | IL-4 |
| T45 | 1662-1667 | protein | denotes | STAT6 |
| T46 | 1672-1677 | protein | denotes | STAT6 |
| T47 | 1749-1755 | DNA | denotes | SOCS-1 |
semrep-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| E1-ti-1 | 0-11 | cui:C0021747 | denotes | Interferons |
| E2-ti-1 | 34-39 | cui:C1335877 | denotes | STAT6 |
| E3-ti-1 | 43-56 | cui:C0021758 | denotes | interleukin 4 |
| E4-ti-1 | 60-65 | cui:C0020114 | denotes | human |
| E5-ti-1 | 66-75 | cui:C0026473 | denotes | monocytes |
| E6-ti-1 | 79-87 | cui:C0205263 | denotes | inducing |
| E7-ti-1 | 88-99 | cui:C1332762 | denotes | SOCS-1 gene |
| E8-ti-1 | 100-110 | cui:C0185117 | denotes | expression |
| T1 | 20-30 | STIMULATES | denotes | activation |
| T2 | 60-75 | PART_OF | denotes | human monocytes |
| T3 | 57-59 | LOCATION_OF | denotes | in |
| E1-ab-1 | 112-123 | cui:C0021747 | denotes | Interferons |
| E2-ab-1 | 139-148 | cui:C0857127 | denotes | induction |
| E3-ab-1 | 152-156 | cui:C0021758 | denotes | IL-4 |
| E4-ab-1 | 160-168 | cui:C0439064 | denotes | multiple |
| E5-ab-1 | 169-174 | cui:C0017337 | denotes | genes |
| E6-ab-1 | 178-183 | cui:C0020114 | denotes | human |
| E7-ab-1 | 184-193 | cui:C0026473 | denotes | monocytes |
| T4 | 178-193 | PART_OF | denotes | human monocytes |
| T5 | 175-177 | LOCATION_OF | denotes | in |
| E1-ab-2 | 208-217 | cui:C0441712 | denotes | mechanism |
| E2-ab-2 | 227-231 | cui:C0021747 | denotes | IFNs |
| E3-ab-2 | 260-263 | cui:C1518422 | denotes | not |
| E1-ab-3 | 278-282 | cui:C0021758 | denotes | IL-4 |
| E2-ab-3 | 293-308 | cui:C0017262 | denotes | gene expression |
| E3-ab-3 | 312-320 | cui:C0205263 | denotes | inducing |
| E4-ab-3 | 321-345 | cui:C1519726 | denotes | tyrosine phosphorylation |
| E5-ab-3 | 347-363 | cui:C1512485 | denotes | homodimerization |
| E6-ab-3 | 369-390 | cui:C1518440 | denotes | nuclear translocation |
| E7-ab-3 | 398-404 | cui:C0205275 | denotes | latent |
| E8-ab-3 | 405-425 | cui:C0040648 | denotes | transcription factor |
| E9-ab-3 | 427-432 | cui:C1335877 | denotes | STAT6 |
| E10-ab-3 | 441-451 | cui:C0040661 | denotes | transducer |
| E11-ab-3 | 469-482 | cui:C0040649 | denotes | transcription |
| T6 | 283-292 | AUGMENTS | denotes | activates |
| E1-ab-4 | 487-492 | cui:C1335877 | denotes | STAT6 |
| E2-ab-4 | 493-503 | cui:C0205342 | denotes | responsive |
| E3-ab-4 | 504-512 | cui:C0013879 | denotes | elements |
| E4-ab-4 | 551-560 | cui:C0086860 | denotes | promoters |
| E5-ab-4 | 564-584 | cui:C1334119 | denotes | IL-4-inducible genes |
| E1-ab-5 | 594-599 | cui:C1335877 | denotes | STAT6 |
| E2-ab-5 | 614-623 | cui:C0205224 | denotes | essential |
| E3-ab-5 | 633-640 | cui:C0205263 | denotes | induced |
| E4-ab-5 | 628-645 | cui:C1334119 | denotes | IL-4-induced gene |
| E5-ab-5 | 646-656 | cui:C0185117 | denotes | expression |
| E6-ab-5 | 674-681 | cui:C0085732 | denotes | ability |
| E7-ab-5 | 685-689 | cui:C1547052 | denotes | type |
| E8-ab-5 | 696-708 | cui:C0021745 | denotes | type II IFNs |
| E9-ab-5 | 735-740 | cui:C1335877 | denotes | STAT6 |
| E10-ab-5 | 744-748 | cui:C0021758 | denotes | IL-4 |
| E11-ab-5 | 760-765 | cui:C0020114 | denotes | human |
| E12-ab-5 | 766-775 | cui:C0026473 | denotes | monocytes |
| T7 | 600-610 | STIMULATES | denotes | activation |
| T8 | 721-731 | STIMULATES | denotes | activation |
| T9 | 760-775 | PART_OF | denotes | human monocytes |
| T10 | 749-751 | LOCATION_OF | denotes | in |
| E1-ab-6 | 777-789 | cui:C1550147 | denotes | Pretreatment |
| E2-ab-6 | 793-802 | cui:C0026473 | denotes | monocytes |
| E3-ab-6 | 808-816 | cui:C0015980 | denotes | IFN-beta |
| E4-ab-6 | 820-823 | cui:C0733470 | denotes | IFN |
| E5-ab-6 | 835-838 | cui:C1518422 | denotes | not |
| E6-ab-6 | 839-843 | cui:C0600251 | denotes | IL-1 |
| E7-ab-6 | 845-849 | cui:C0879590 | denotes | IL-2 |
| E8-ab-6 | 851-887 | cui:C0079784 | denotes | macrophage colony-stimulating factor |
| E9-ab-6 | 889-937 | cui:C0079460 | denotes | granulocyte/macrophage colony-stimulating factor |
| E10-ab-6 | 939-943 | cui:C0021760 | denotes | IL-6 |
| E11-ab-6 | 948-979 | cui:C0040690 | denotes | transforming growth factor beta |
| E12-ab-6 | 1005-1010 | cui:C1335877 | denotes | STAT6 |
| E13-ab-6 | 1014-1018 | cui:C0021758 | denotes | IL-4 |
| T11 | 803-807 | PART_OF | denotes | with |
| T12 | 803-807 | PART_OF | denotes | with |
| T13 | 991-1001 | STIMULATES | denotes | activation |
| E1-ab-7 | 1056-1065 | cui:C0205216 | denotes | decreased |
| E2-ab-7 | 1066-1090 | cui:C1519726 | denotes | tyrosine phosphorylation |
| E3-ab-7 | 1095-1116 | cui:C1518440 | denotes | nuclear translocation |
| E4-ab-7 | 1120-1125 | cui:C1335877 | denotes | STAT6 |
| E5-ab-7 | 1134-1137 | cui:C1518422 | denotes | not |
| E6-ab-7 | 1157-1162 | cui:C0007634 | denotes | cells |
| E7-ab-7 | 1186-1189 | cui:C0733470 | denotes | IFN |
| E8-ab-7 | 1215-1219 | cui:C0021758 | denotes | IL-4 |
| E9-ab-7 | 1220-1231 | cui:C1292856 | denotes | stimulation |
| T14 | 1181-1185 | PART_OF | denotes | with |
| T15 | 1220-1231 | STIMULATES | denotes | stimulation |
| E1-ab-8 | 1260-1263 | cui:C0733470 | denotes | IFN |
| E2-ab-8 | 1284-1295 | cui:C0009429 | denotes | cotreatment |
| E3-ab-8 | 1301-1314 | cui:C0010934 | denotes | actinomycin D |
| E4-ab-8 | 1346-1355 | cui:C0857127 | denotes | induction |
| E5-ab-8 | 1372-1382 | cui:C0243077 | denotes | inhibitory |
| E6-ab-8 | 1383-1387 | cui:C0017337 | denotes | gene |
| E7-ab-8 | 1389-1395 | cui:C0299250 | denotes | SOCS-1 |
| T16 | 1296-1300 | USES | denotes | with |
| E1-ab-9 | 1397-1403 | cui:C0443221 | denotes | Forced |
| E2-ab-9 | 1404-1414 | cui:C0185117 | denotes | expression |
| E3-ab-9 | 1418-1424 | cui:C0299250 | denotes | SOCS-1 |
| E4-ab-9 | 1430-1440 | cui:C0024432 | denotes | macrophage |
| E5-ab-9 | 1441-1450 | cui:C0007600 | denotes | cell line |
| E6-ab-9 | 1460-1468 | cui:C0522501 | denotes | markedly |
| E7-ab-9 | 1469-1479 | cui:C1260953 | denotes | suppressed |
| E8-ab-9 | 1503-1507 | cui:C0021758 | denotes | IL-4 |
| E9-ab-9 | 1518-1526 | cui:C0335038 | denotes | reporter |
| E10-ab-9 | 1538-1542 | cui:C0021760 | denotes | IL-6 |
| E11-ab-9 | 1548-1551 | cui:C0733470 | denotes | IFN |
| E12-ab-9 | 1558-1565 | cui:C0205263 | denotes | induced |
| E13-ab-9 | 1566-1579 | cui:C0206414 | denotes | reporter gene |
| E14-ab-9 | 1580-1588 | cui:C0439167 | denotes | activity |
| T17 | 1404-1414 | PART_OF | denotes | expression |
| E1-ab-10 | 1596-1604 | cui:C0243095 | denotes | findings |
| E2-ab-10 | 1622-1626 | cui:C0021747 | denotes | IFNs |
| E3-ab-10 | 1635-1639 | cui:C0021758 | denotes | IL-4 |
| E4-ab-10 | 1640-1647 | cui:C0205263 | denotes | induced |
| E5-ab-10 | 1662-1667 | cui:C1335877 | denotes | STAT6 |
| E6-ab-10 | 1672-1677 | cui:C1335877 | denotes | STAT6 |
| E7-ab-10 | 1688-1703 | cui:C0017262 | denotes | gene expression |
| E8-ab-10 | 1717-1721 | cui:C0449719 | denotes | part |
| E9-ab-10 | 1726-1734 | cui:C0205263 | denotes | inducing |
| E10-ab-10 | 1735-1745 | cui:C0185117 | denotes | expression |
| E11-ab-10 | 1749-1755 | cui:C0299250 | denotes | SOCS-1 |
| T18 | 1648-1658 | STIMULATES | denotes | activation |
| T19 | 1648-1658 | STIMULATES | denotes | activation |
| R1 | E3-ti-1 | T1 | subjectOf | interleukin 4,activation |
| R2 | E2-ti-1 | T1 | objectOf | STAT6,activation |
| R3 | E5-ti-1 | T2 | subjectOf | monocytes,human monocytes |
| R4 | E4-ti-1 | T2 | objectOf | human,human monocytes |
| R5 | E5-ti-1 | T3 | subjectOf | monocytes,in |
| R6 | E3-ti-1 | T3 | objectOf | interleukin 4,in |
| R7 | E7-ab-1 | T4 | subjectOf | monocytes,human monocytes |
| R8 | E6-ab-1 | T4 | objectOf | human,human monocytes |
| R9 | E7-ab-1 | T5 | subjectOf | monocytes,in |
| R10 | E3-ab-1 | T5 | objectOf | IL-4,in |
| R11 | E1-ab-3 | T6 | subjectOf | IL-4,activates |
| R12 | E2-ab-3 | T6 | objectOf | gene expression,activates |
| R13 | E8-ab-5 | T7 | subjectOf | type II IFNs,activation |
| R14 | E1-ab-5 | T7 | objectOf | STAT6,activation |
| R15 | E10-ab-5 | T8 | subjectOf | IL-4,activation |
| R16 | E9-ab-5 | T8 | objectOf | STAT6,activation |
| R17 | E12-ab-5 | T9 | subjectOf | monocytes,human monocytes |
| R18 | E11-ab-5 | T9 | objectOf | human,human monocytes |
| R19 | E12-ab-5 | T10 | subjectOf | monocytes,in |
| R20 | E10-ab-5 | T10 | objectOf | IL-4,in |
| R21 | E3-ab-6 | T11 | subjectOf | IFN-beta,with |
| R22 | E2-ab-6 | T11 | objectOf | monocytes,with |
| R23 | E4-ab-6 | T12 | subjectOf | IFN,with |
| R24 | E2-ab-6 | T12 | objectOf | monocytes,with |
| R25 | E13-ab-6 | T13 | subjectOf | IL-4,activation |
| R26 | E12-ab-6 | T13 | objectOf | STAT6,activation |
| R27 | E7-ab-7 | T14 | subjectOf | IFN,with |
| R28 | E6-ab-7 | T14 | objectOf | cells,with |
| R29 | E4-ab-7 | T15 | subjectOf | STAT6,stimulation |
| R30 | E8-ab-7 | T15 | objectOf | IL-4,stimulation |
| R31 | E2-ab-8 | T16 | subjectOf | cotreatment,with |
| R32 | E3-ab-8 | T16 | objectOf | actinomycin D,with |
| R33 | E3-ab-9 | T17 | subjectOf | SOCS-1,expression |
| R34 | E5-ab-9 | T17 | objectOf | cell line,expression |
| R35 | E11-ab-10 | T18 | subjectOf | SOCS-1,activation |
| R36 | E5-ab-10 | T18 | objectOf | STAT6,activation |
| R37 | E11-ab-10 | T19 | subjectOf | SOCS-1,activation |
| R38 | E6-ab-10 | T19 | objectOf | STAT6,activation |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-111 | Sentence | denotes | Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression. |
| S2 | 112-194 | Sentence | denotes | Interferons (IFNs) inhibit induction by IL-4 of multiple genes in human monocytes. |
| S3 | 195-277 | Sentence | denotes | However, the mechanism by which IFNs mediate this inhibition has not been defined. |
| S4 | 278-486 | Sentence | denotes | IL-4 activates gene expression by inducing tyrosine phosphorylation, homodimerization, and nuclear translocation of the latent transcription factor, STAT6 (signal transducer and activator of transcription-6). |
| S5 | 487-585 | Sentence | denotes | STAT6-responsive elements are characteristically present in the promoters of IL-4-inducible genes. |
| S6 | 586-776 | Sentence | denotes | Because STAT6 activation is essential for IL-4-induced gene expression, we examined the ability of type I and type II IFNs to regulate activation of STAT6 by IL-4 in primary human monocytes. |
| S7 | 777-1019 | Sentence | denotes | Pretreatment of monocytes with IFN-beta or IFN-gamma, but not IL-1, IL-2, macrophage colony-stimulating factor, granulocyte/macrophage colony-stimulating factor, IL-6, or transforming growth factor beta suppressed activation of STAT6 by IL-4. |
| S8 | 1020-1232 | Sentence | denotes | This inhibition was associated with decreased tyrosine phosphorylation and nuclear translocation of STAT6 and was not evident unless the cells were preincubated with IFN for at least 1 hr before IL-4 stimulation. |
| S9 | 1233-1396 | Sentence | denotes | Furthermore, inhibition by IFN could be blocked by cotreatment with actinomycin D and correlated temporally with induction of the JAK/STAT inhibitory gene, SOCS-1. |
| S10 | 1397-1589 | Sentence | denotes | Forced expression of SOCS-1 in a macrophage cell line, RAW264, markedly suppressed trans-activation of an IL-4-inducible reporter as well as IL-6- and IFN-gamma-induced reporter gene activity. |
| S11 | 1590-1756 | Sentence | denotes | These findings demonstrate that IFNs inhibit IL-4-induced activation of STAT6 and STAT6-dependent gene expression, at least in part, by inducing expression of SOCS-1. |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C2 | 0-11 | NP | denotes | Interferons |
| C41 | 34-39 | NP | denotes | STAT6 |
| C42 | 43-56 | NP | denotes | interleukin 4 |
| C16 | 60-75 | NP | denotes | human monocytes |
| C39 | 88-110 | NP | denotes | SOCS-1 gene expression |
| C1 | 112-130 | NP | denotes | Interferons (IFNs) |
| C4 | 152-156 | NP | denotes | IL-4 |
| C15 | 178-193 | NP | denotes | human monocytes |
| C43 | 204-217 | NP | denotes | the mechanism |
| C44 | 221-226 | NP | denotes | which |
| C3 | 227-231 | NP | denotes | IFNs |
| C5 | 278-282 | NP | denotes | IL-4 |
| C7 | 427-485 | NP | denotes | STAT6 (signal transducer and activator of transcription-6) |
| C8 | 487-493 | NP | denotes | STAT6- |
| C9 | 564-569 | NP | denotes | IL-4- |
| C11 | 628-633 | NP | denotes | IL-4- |
| C46 | 685-708 | NP | denotes | type I and type II IFNs |
| C13 | 735-740 | NP | denotes | STAT6 |
| C14 | 744-748 | NP | denotes | IL-4 |
| C17 | 752-775 | NP | denotes | primary human monocytes |
| C27 | 820-829 | NP | denotes | IFN-gamma |
| C51 | 939-943 | NP | denotes | IL-6 |
| C18 | 1005-1010 | NP | denotes | STAT6 |
| C19 | 1014-1018 | NP | denotes | IL-4 |
| C20 | 1120-1125 | NP | denotes | STAT6 |
| C32 | 1186-1189 | NP | denotes | IFN |
| C23 | 1260-1263 | NP | denotes | IFN |
| C24 | 1359-1387 | NP | denotes | the JAK/STAT inhibitory gene |
| C48 | 1389-1395 | NP | denotes | SOCS-1 |
| C25 | 1418-1424 | NP | denotes | SOCS-1 |
| C49 | 1428-1450 | NP | denotes | a macrophage cell line |
| C50 | 1452-1458 | NP | denotes | RAW264 |
| C26 | 1503-1508 | NP | denotes | IL-4- |
| C52 | 1538-1543 | NP | denotes | IL-6- |
| C28 | 1548-1558 | NP | denotes | IFN-gamma- |
| C30 | 1622-1626 | NP | denotes | IFNs |
| C33 | 1635-1640 | NP | denotes | IL-4- |
| C34 | 1662-1667 | NP | denotes | STAT6 |
| C35 | 1672-1678 | NP | denotes | STAT6- |
| C36 | 1749-1755 | NP | denotes | SOCS-1 |
| C45 | 1735-1755 | NP | denotes | expression of SOCS-1 |
| R1 | C1 | C2 | coref-ident | Interferons (IFNs),Interferons |
| R2 | C4 | C42 | coref-ident | IL-4,interleukin 4 |
| R3 | C15 | C16 | coref-ident | human monocytes,human monocytes |
| R4 | C44 | C43 | coref-relat | which,the mechanism |
| R5 | C3 | C1 | coref-ident | IFNs,Interferons (IFNs) |
| R6 | C5 | C4 | coref-ident | IL-4,IL-4 |
| R7 | C7 | C41 | coref-ident | STAT6 (signal transducer and activator of transcription-6),STAT6 |
| R8 | C8 | C7 | coref-other | STAT6-,STAT6 (signal transducer and activator of transcription-6) |
| R9 | C9 | C5 | coref-other | IL-4-,IL-4 |
| R10 | C11 | C9 | coref-other | IL-4-,IL-4- |
| R11 | C46 | C1 | coref-part-whole | type I and type II IFNs,Interferons (IFNs) |
| R12 | C13 | C8 | coref-ident | STAT6,STAT6- |
| R13 | C14 | C11 | coref-ident | IL-4,IL-4- |
| R14 | C17 | C15 | coref-part-whole | primary human monocytes,human monocytes |
| R15 | C18 | C13 | coref-ident | STAT6,STAT6 |
| R16 | C19 | C14 | coref-ident | IL-4,IL-4 |
| R17 | C20 | C18 | coref-ident | STAT6,STAT6 |
| R18 | C23 | C32 | coref-ident | IFN,IFN |
| R19 | C48 | C24 | coref-appos | SOCS-1,the JAK/STAT inhibitory gene |
| R20 | C25 | C48 | coref-ident | SOCS-1,SOCS-1 |
| R21 | C50 | C49 | coref-appos | RAW264,a macrophage cell line |
| R22 | C26 | C19 | coref-other | IL-4-,IL-4 |
| R23 | C52 | C51 | coref-ident | IL-6-,IL-6 |
| R24 | C28 | C27 | coref-other | IFN-gamma-,IFN-gamma |
| R25 | C30 | C3 | coref-ident | IFNs,IFNs |
| R26 | C33 | C26 | coref-other | IL-4-,IL-4- |
| R27 | C34 | C20 | coref-ident | STAT6,STAT6 |
| R28 | C35 | C34 | coref-other | STAT6-,STAT6 |
| R29 | C36 | C25 | coref-ident | SOCS-1,SOCS-1 |
| R30 | C45 | C39 | coref-ident | expression of SOCS-1,SOCS-1 gene expression |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 34-39 | protein_molecule | denotes | STAT6 |
| T2 | 43-56 | protein_molecule | denotes | interleukin 4 |
| T3 | 60-75 | cell_type | denotes | human monocytes |
| T4 | 88-99 | DNA_domain_or_region | denotes | SOCS-1 gene |
| T5 | 112-123 | protein_family_or_group | denotes | Interferons |
| T6 | 125-129 | protein_family_or_group | denotes | IFNs |
| T7 | 152-156 | protein_molecule | denotes | IL-4 |
| T8 | 178-193 | cell_type | denotes | human monocytes |
| T9 | 227-231 | protein_family_or_group | denotes | IFNs |
| T10 | 278-282 | protein_molecule | denotes | IL-4 |
| T11 | 293-308 | other_name | denotes | gene expression |
| T12 | 321-329 | amino_acid_monomer | denotes | tyrosine |
| T13 | 347-363 | other_name | denotes | homodimerization |
| T14 | 369-390 | other_name | denotes | nuclear translocation |
| T15 | 398-425 | protein_family_or_group | denotes | latent transcription factor |
| T16 | 427-432 | protein_molecule | denotes | STAT6 |
| T17 | 434-484 | protein_molecule | denotes | signal transducer and activator of transcription-6 |
| T18 | 487-492 | protein_molecule | denotes | STAT6 |
| T19 | 551-560 | DNA_domain_or_region | denotes | promoters |
| T20 | 564-568 | protein_molecule | denotes | IL-4 |
| T21 | 594-599 | protein_molecule | denotes | STAT6 |
| T22 | 628-632 | protein_molecule | denotes | IL-4 |
| T23 | 641-656 | other_name | denotes | gene expression |
| T24 | 704-708 | protein_family_or_group | denotes | IFNs |
| T25 | 735-740 | protein_molecule | denotes | STAT6 |
| T26 | 744-748 | protein_molecule | denotes | IL-4 |
| T27 | 752-759 | cell_type | denotes | primary |
| T28 | 760-775 | cell_type | denotes | human monocytes |
| T29 | 793-802 | cell_type | denotes | monocytes |
| T30 | 808-816 | protein_molecule | denotes | IFN-beta |
| T31 | 820-829 | protein_molecule | denotes | IFN-gamma |
| T32 | 839-843 | protein_molecule | denotes | IL-1 |
| T33 | 845-849 | protein_molecule | denotes | IL-2 |
| T34 | 851-887 | protein_family_or_group | denotes | macrophage colony-stimulating factor |
| T35 | 889-937 | protein_family_or_group | denotes | granulocyte/macrophage colony-stimulating factor |
| T36 | 939-943 | protein_molecule | denotes | IL-6 |
| T37 | 1005-1010 | protein_molecule | denotes | STAT6 |
| T38 | 1014-1018 | protein_molecule | denotes | IL-4 |
| T39 | 1066-1074 | amino_acid_monomer | denotes | tyrosine |
| T40 | 1095-1116 | other_name | denotes | nuclear translocation |
| T41 | 1120-1125 | protein_molecule | denotes | STAT6 |
| T42 | 1186-1189 | protein_family_or_group | denotes | IFN |
| T43 | 1215-1219 | protein_molecule | denotes | IL-4 |
| T44 | 1260-1263 | protein_family_or_group | denotes | IFN |
| T45 | 1301-1314 | other_organic_compound | denotes | actinomycin D |
| T46 | 1363-1387 | DNA_family_or_group | denotes | JAK/STAT inhibitory gene |
| T47 | 1389-1395 | DNA_domain_or_region | denotes | SOCS-1 |
| T48 | 1418-1424 | DNA_domain_or_region | denotes | SOCS-1 |
| T49 | 1430-1450 | cell_line | denotes | macrophage cell line |
| T50 | 1452-1458 | cell_line | denotes | RAW264 |
| T51 | 1480-1496 | other_name | denotes | trans-activation |
| T52 | 1503-1507 | protein_molecule | denotes | IL-4 |
| T53 | 1622-1626 | protein_family_or_group | denotes | IFNs |
| T54 | 1635-1639 | protein_molecule | denotes | IL-4 |
| T55 | 1662-1667 | protein_molecule | denotes | STAT6 |
| T56 | 1672-1677 | protein_molecule | denotes | STAT6 |
| T57 | 1688-1703 | other_name | denotes | gene expression |
| T58 | 1749-1755 | DNA_domain_or_region | denotes | SOCS-1 |
metamap-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 761-766 | C0086418 | denotes | uman |
| T2 | 179-183 | C0086418 | denotes | uman |
| T3 | 61-66 | C0086418 | denotes | uman |
| T4 | 44-57 | C0021758 | denotes | nterleukin 4 |
| T5 | 794-802 | C0026473 | denotes | onocytes |
| T6 | 767-776 | C0026473 | denotes | onocytes. |
| T7 | 185-194 | C0026473 | denotes | onocytes. |
| T8 | 67-76 | C0026473 | denotes | onocytes |
| T9 | 1121-1126 | C0297890 | denotes | TAT6 |
| T10 | 1006-1011 | C0297890 | denotes | TAT6 |
| T11 | 488-493 | C0297890 | denotes | TAT6- |
| T12 | 428-433 | C0297890 | denotes | TAT6 |
| T13 | 35-40 | C0297890 | denotes | TAT6 |
| T14 | 1628-1635 | C0018790 | denotes | nhibit |
| T15 | 132-139 | C0018790 | denotes | nhibit |
| T16 | 13-20 | C0018790 | denotes | nhibit |
| T17 | 1689-1704 | C0017262 | denotes | ene expression, |
| T18 | 294-309 | C0017262 | denotes | ene expression |
| T19 | 96-111 | C0017262 | denotes | ene expression. |
| T20 | 1623-1627 | C1522537 | denotes | FNs |
| T21 | 228-232 | C1522537 | denotes | FNs |
| T22 | 113-124 | C1522537 | denotes | nterferons |
| T23 | 1-12 | C1522537 | denotes | nterferons |
| T24 | 1750-1756 | C1426208 | denotes | OCS-1. |
| T25 | 1419-1425 | C1426208 | denotes | OCS-1 |
| T26 | 1390-1396 | C1426208 | denotes | OCS-1. |
| T27 | 89-95 | C1426208 | denotes | OCS-1 |
| T28 | 1649-1659 | C1879547 | denotes | ctivation |
| T29 | 1487-1497 | C1879547 | denotes | ctivation |
| T30 | 992-1002 | C1879547 | denotes | ctivation |
| T31 | 21-31 | C1879547 | denotes | ctivation |
| T32 | 1641-1648 | C0205263 | denotes | nduced |
| T33 | 1727-1734 | C0205263 | denotes | nducing |
| T34 | 1559-1566 | C0205263 | denotes | nduced |
| T35 | 634-641 | C0205263 | denotes | nduced |
| T36 | 313-321 | C0205263 | denotes | nducing |
| T37 | 140-149 | C0205263 | denotes | nduction |
| T38 | 80-88 | C0205263 | denotes | nducing |
| T39 | 1636-1638 | C0021764 | denotes | L- |
| T40 | 1504-1506 | C0021764 | denotes | L- |
| T41 | 1216-1218 | C0021764 | denotes | L- |
| T42 | 1015-1017 | C0021764 | denotes | L- |
| T43 | 745-747 | C0021764 | denotes | L- |
| T44 | 279-281 | C0021764 | denotes | L- |
| T45 | 1509-1518 | C0669372 | denotes | nducible |
| T46 | 570-579 | C0669372 | denotes | nducible |
| T47 | 890-938 | C0079460 | denotes | ranulocyte/macrophage colony-stimulating factor, |
| T48 | 809-817 | C0015980 | denotes | FN-beta |
| T49 | 697-709 | C0021745 | denotes | ype II IFNs |
| T50 | 840-844 | C0600251 | denotes | L-1, |
| T51 | 1567-1579 | C0206414 | denotes | eporter gene |
| T52 | 1302-1315 | C0010934 | denotes | ctinomycin D |
| T53 | 675-682 | C0085732 | denotes | bility |
| T54 | 1076-1091 | C0031715 | denotes | hosphorylation |
| T55 | 1373-1383 | C3463820 | denotes | nhibitory |
| T56 | 1431-1441 | C0024432 | denotes | acrophage |
| T57 | 1247-1257 | C1628982 | denotes | nhibition |
| T58 | 1026-1036 | C1628982 | denotes | nhibition |
| T59 | 246-256 | C1628982 | denotes | nhibition |
| T60 | 1135-1138 | C1518422 | denotes | ot |
| T61 | 836-839 | C1518422 | denotes | ot |
| T62 | 261-263 | C1518422 | denotes | ot |
| T63 | 1736-1746 | C0185117 | denotes | xpression |
| T64 | 1405-1415 | C0185117 | denotes | xpression |
| T65 | 647-657 | C0185117 | denotes | xpression, |
| T66 | 1539-1543 | C1334122 | denotes | L-6- |
| T67 | 940-944 | C1334122 | denotes | L-6, |
| T68 | 1539-1543 | C2983957 | denotes | L-6- |
| T69 | 940-944 | C2983957 | denotes | L-6, |
| T70 | 1442-1451 | C0007600 | denotes | ell line, |
| T71 | 442-452 | C0040661 | denotes | ransducer |
| T72 | 406-426 | C0040648 | denotes | ranscription factor, |
| T73 | 1096-1117 | C1518440 | denotes | uclear translocation |
| T74 | 370-391 | C1518440 | denotes | uclear translocation |
| T75 | 1709-1714 | C0547044 | denotes | east |
| T76 | 1198-1203 | C0547044 | denotes | east |
| T77 | 1470-1480 | C1260953 | denotes | uppressed |
| T78 | 981-991 | C1260953 | denotes | uppressed |
| T79 | 1553-1558 | C1552644 | denotes | amma- |
| T80 | 825-830 | C1552644 | denotes | amma, |
| T81 | 1067-1091 | C1519726 | denotes | yrosine phosphorylation |
| T82 | 505-513 | C0013879 | denotes | lements |
| T83 | 1285-1296 | C0009429 | denotes | otreatment |
| T84 | 1158-1163 | C0007634 | denotes | ells |
| T85 | 1320-1330 | C1707520 | denotes | orrelated |
| T86 | 270-277 | C1704788 | denotes | efined. |
| T87 | 662-670 | C0332128 | denotes | xamined |
| T88 | 348-364 | C1512485 | denotes | omodimerization, |
| T89 | 846-850 | C0879590 | denotes | L-2, |
| T90 | 233-240 | C0086597 | denotes | ediate |
| T91 | 1718-1722 | C0449719 | denotes | art, |
| T92 | 284-293 | C1515877 | denotes | ctivates |
| T93 | 1597-1605 | C2607943 | denotes | indings |
| T94 | 435-441 | C1710082 | denotes | ignal |
| T95 | 494-504 | C0205342 | denotes | esponsive |
| T96 | 1221-1232 | C1292856 | denotes | timulation. |
| T97 | 1041-1056 | C0332281 | denotes | ssociated with |
| T98 | 1057-1075 | C1291165 | denotes | ecreased tyrosine |
| T99 | 1581-1589 | C1561536 | denotes | ctivity. |
| T100 | 1274-1281 | C0028778 | denotes | locked |
| T101 | 778-790 | C1550147 | denotes | retreatment |
| T102 | 1285-1296 | C0814472 | denotes | otreatment |
| T103 | 778-790 | C2709094 | denotes | retreatment |
| T104 | 1139-1146 | C0332120 | denotes | vident |
| T105 | 1057-1066 | C0205216 | denotes | ecreased |
| T106 | 209-218 | C0441712 | denotes | echanism |
| T107 | 615-624 | C0205224 | denotes | ssential |
| T108 | 1364-1367 | C1150611 | denotes | AK/ |
| T109 | 537-544 | C0150312 | denotes | resent |
| T110 | 552-561 | C0086860 | denotes | romoters |
| T111 | 1368-1372 | C0205548 | denotes | TAT |
| T112 | 1481-1486 | C2826298 | denotes | rans- |
| T113 | 753-760 | C0205225 | denotes | rimary |
| T114 | 1679-1688 | C0851827 | denotes | ependent |
| T115 | 686-692 | C0441729 | denotes | ype I |
| T116 | 1398-1404 | C0441722 | denotes | orced |
| T117 | 399-404 | C0205275 | denotes | atent |
| T118 | 161-169 | C0439064 | denotes | ultiple |
| T119 | 1461-1469 | C0522501 | denotes | arkedly |
| T120 | 1519-1527 | C1709908 | denotes | eporter |