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PubMed:10485875 JSONTXT

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PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 680-705 DiseaseOrPhenotypicFeature denotes cutaneous T cell lymphoma 0000607
T2 1823-1832 DiseaseOrPhenotypicFeature denotes sensitive 0000605

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 680-705 HP_0012192 denotes cutaneous T cell lymphoma
T2 690-705 HP_0012190 denotes T cell lymphoma
T3 697-705 HP_0002665 denotes lymphoma

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 14-36 protein denotes protein phosphatase 2A
T2 136-141 protein denotes STAT3
T3 143-193 protein denotes Signal transducers and activators of transcription
T4 195-200 protein denotes STATs
T5 265-273 protein denotes cytokine
T6 278-291 protein denotes growth factor
T7 307-329 protein denotes cell surface receptors
T8 331-336 protein denotes STATs
T9 397-418 protein denotes transcription factors
T10 474-479 protein denotes STATs
T11 518-522 protein denotes STAT
T12 581-610 protein denotes serine/threonine phosphatases
T13 614-619 protein denotes STAT3
T14 633-675 cell_line denotes human antigen-specific CD4(+) T cell lines
T15 680-711 cell_line denotes cutaneous T cell lymphoma lines
T16 751-756 protein denotes STAT3
T17 787-807 protein denotes protein phosphatases
T18 809-812 protein denotes PPs
T19 814-822 protein denotes PP1/PP2A
T20 824-835 protein denotes calyculin A
T21 868-873 protein denotes STAT3
T22 927-932 protein denotes STAT3
T23 1008-1013 protein denotes STAT3
T24 1173-1176 protein denotes PP1
T25 1193-1197 protein denotes PP2B
T26 1311-1322 protein denotes calyculin A
T27 1331-1336 protein denotes STAT3
T28 1376-1400 protein denotes serine/threonine kinases
T29 1410-1482 protein denotes mitogen-activated protein kinase-1 extracellular-regulated kinase-kinase
T30 1484-1520 protein denotes mitogen-activated protein p38 kinase
T31 1526-1555 protein denotes phosphatidylinositol 3-kinase
T32 1606-1610 protein denotes PP2A
T33 1653-1658 protein denotes STAT3
T34 1707-1714 cell_type denotes T cells
T35 1765-1770 protein denotes STAT3
T36 1809-1839 protein denotes staurosporine-sensitive kinase
T37 1847-1851 protein denotes PP2A

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-142 Sentence denotes Inhibition of protein phosphatase 2A induces serine/threonine phosphorylation, subcellular redistribution, and functional inhibition of STAT3.
S2 143-330 Sentence denotes Signal transducers and activators of transcription (STATs) are rapidly phosphorylated on tyrosine residues in response to cytokine and growth factor stimulation of cell surface receptors.
S3 331-419 Sentence denotes STATs hereafter are translocated to the nucleus where they act as transcription factors.
S4 420-551 Sentence denotes Recent reports suggest that serine phosphorylation of STATs also is involved in the regulation of STAT-mediated gene transcription.
S5 552-757 Sentence denotes Here, we studied the role of serine/threonine phosphatases in STAT3 signaling in human antigen-specific CD4(+) T cell lines and cutaneous T cell lymphoma lines, expressing a constitutively activated STAT3.
S6 758-1048 Sentence denotes We show that an inhibitor of protein phosphatases (PPs) PP1/PP2A, calyculin A, induces (i) phosphorylation of STAT3 on serine and threonine residues, (ii) inhibition of STAT3 tyrosine phosphorylation and DNA binding activity, and (iii) relocation of STAT3 from the nucleus to the cytoplasm.
S7 1049-1215 Sentence denotes Similar results were obtained with other PP2A inhibitors (okadaic acid, endothall thioanhydride) but not with inhibitors of PP1 (tautomycin) or PP2B (cyclosporine A).
S8 1216-1565 Sentence denotes Pretreatment with the broad serine/threonine kinase inhibitor staurosporine partly blocked the calyculin A-induced STAT3 phosphorylation, whereas inhibitors of serine/threonine kinases, such as mitogen-activated protein kinase-1 extracellular-regulated kinase-kinase, mitogen-activated protein p38 kinase, and phosphatidylinositol 3-kinase, did not.
S9 1566-1715 Sentence denotes In conclusion, we provide evidence that PP2A plays a crucial role in the regulation of STAT3 phosphorylation and subcellular distribution in T cells.
S10 1716-1852 Sentence denotes Moreover, our findings suggest that the level of STAT3 phosphorylation is balanced between a staurosporine-sensitive kinase(s) and PP2A.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C41 14-36 NP denotes protein phosphatase 2A
C10 136-141 NP denotes STAT3
C1 143-201 NP denotes Signal transducers and activators of transcription (STATs)
C2 331-336 NP denotes STATs
C31 367-378 NP denotes the nucleus
C32 379-384 NP denotes where
C33 385-389 NP denotes they
C3 474-479 NP denotes STATs
C34 518-523 NP denotes STAT-
C11 614-619 NP denotes STAT3
C6 751-756 NP denotes STAT3
C35 771-822 NP denotes an inhibitor of protein phosphatases (PPs) PP1/PP2A
C36 824-835 NP denotes calyculin A
C8 868-873 NP denotes STAT3
C14 1008-1013 NP denotes STAT3
C37 1307-1323 NP denotes the calyculin A-
C38 1592-1600 NP denotes evidence
C39 1601-1605 NP denotes that
C22 1606-1610 NP denotes PP2A
C40 1653-1674 NP denotes STAT3 phosphorylation
C27 1765-1786 NP denotes STAT3 phosphorylation
C25 1847-1851 NP denotes PP2A
R1 C2 C1 coref-ident STATs,Signal transducers and activators of transcription (STATs)
R2 C32 C31 coref-relat where,the nucleus
R3 C33 C2 coref-pron they,STATs
R4 C3 C2 coref-ident STATs,STATs
R5 C34 C3 coref-ident STAT-,STATs
R6 C11 C10 coref-ident STAT3,STAT3
R7 C6 C11 coref-ident STAT3,STAT3
R8 C36 C35 coref-appos calyculin A,an inhibitor of protein phosphatases (PPs) PP1/PP2A
R9 C8 C6 coref-ident STAT3,STAT3
R10 C14 C8 coref-ident STAT3,STAT3
R11 C37 C36 coref-ident the calyculin A-,calyculin A
R12 C39 C38 coref-relat that,evidence
R13 C22 C41 coref-ident PP2A,protein phosphatase 2A
R14 C27 C40 coref-ident STAT3 phosphorylation,STAT3 phosphorylation
R15 C25 C22 coref-ident PP2A,PP2A

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 14-36 protein_molecule denotes protein phosphatase 2A
T2 45-51 amino_acid_monomer denotes serine
T3 51-61 amino_acid_monomer denotes /threonine
T4 136-141 protein_molecule denotes STAT3
T5 143-193 protein_family_or_group denotes Signal transducers and activators of transcription
T6 195-200 protein_family_or_group denotes STATs
T7 265-273 protein_family_or_group denotes cytokine
T8 278-291 protein_family_or_group denotes growth factor
T9 307-329 protein_family_or_group denotes cell surface receptors
T10 331-336 protein_family_or_group denotes STATs
T11 371-378 cell_component denotes nucleus
T12 397-418 protein_family_or_group denotes transcription factors
T13 448-454 amino_acid_monomer denotes serine
T14 474-479 protein_family_or_group denotes STATs
T15 518-522 protein_family_or_group denotes STAT
T16 581-587 amino_acid_monomer denotes serine
T17 587-597 amino_acid_monomer denotes /threonine
T18 614-619 protein_molecule denotes STAT3
T19 633-675 cell_line denotes human antigen-specific CD4(+) T cell lines
T20 680-711 cell_line denotes cutaneous T cell lymphoma lines
T21 751-756 protein_molecule denotes STAT3
T22 787-807 protein_family_or_group denotes protein phosphatases
T23 809-812 protein_family_or_group denotes PPs
T24 814-822 protein_molecule denotes PP1/PP2A
T25 824-835 protein_molecule denotes calyculin A
T26 868-873 protein_molecule denotes STAT3
T27 877-883 amino_acid_monomer denotes serine
T28 888-897 amino_acid_monomer denotes threonine
T29 927-932 protein_molecule denotes STAT3
T30 933-941 amino_acid_monomer denotes tyrosine
T31 1008-1013 protein_molecule denotes STAT3
T32 1023-1030 cell_component denotes nucleus
T33 1038-1047 cell_component denotes cytoplasm
T34 1090-1105 other_organic_compound denotes PP2A inhibitors
T35 1107-1119 other_organic_compound denotes okadaic acid
T36 1121-1144 other_organic_compound denotes endothall thioanhydride
T37 1173-1176 protein_molecule denotes PP1
T38 1178-1188 other_organic_compound denotes tautomycin
T39 1193-1197 protein_molecule denotes PP2B
T40 1199-1213 other_organic_compound denotes cyclosporine A
T41 1244-1250 amino_acid_monomer denotes serine
T42 1250-1260 amino_acid_monomer denotes /threonine
T43 1278-1291 other_organic_compound denotes staurosporine
T44 1311-1322 protein_molecule denotes calyculin A
T45 1331-1336 protein_molecule denotes STAT3
T46 1376-1382 amino_acid_monomer denotes serine
T47 1382-1392 amino_acid_monomer denotes /threonine
T48 1410-1482 protein_molecule denotes mitogen-activated protein kinase-1 extracellular-regulated kinase-kinase
T49 1484-1520 protein_molecule denotes mitogen-activated protein p38 kinase
T50 1526-1555 protein_molecule denotes phosphatidylinositol 3-kinase
T51 1606-1610 protein_molecule denotes PP2A
T52 1653-1658 protein_molecule denotes STAT3
T53 1707-1714 cell_type denotes T cells
T54 1765-1770 protein_molecule denotes STAT3
T55 1809-1822 other_organic_compound denotes staurosporine
T56 1847-1851 protein_molecule denotes PP2A