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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-135 Sentence denotes Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyte-endothelial cell interaction.
T2 136-393 Sentence denotes An early event in acute and chronic inflammation and associated diseases such as atherosclerosis and rheumatoid arthritis is the induced expression of specific adhesion molecules on the surface of endothelial cells (ECs), which subsequently bind leukocytes.
T3 394-682 Sentence denotes Peroxisome proliferator-activated receptors (PPARs), members of the nuclear receptor superfamily of transcription factors, are activated by fatty acid metabolites, peroxisome proliferators, and thiazolidinediones and are now recognized as important mediators in the inflammatory response.
T4 683-762 Sentence denotes Whether PPAR activators influence the inflammatory responses of ECs is unknown.
T5 763-1160 Sentence denotes We show that the PPAR activators 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), Wyeth 14643, ciglitazone, and troglitazone, but not BRL 49653, partially inhibit the induced expression of vascular cell adhesion molecule-1 (VCAM-1), as measured by ELISA, and monocyte binding to human aortic endothelial cells (HAECs) activated by phorbol 12-myristate 13-acetate (PMA) or lipopolysaccharide.
T6 1161-1389 Sentence denotes The "natural" PPAR activator 15d-PGJ(2) had the greatest potency and was the only tested molecule capable of partially inhibiting the induced expression of E-selectin and neutrophil-like HL60 cell binding to PMA-activated HAECs.
T7 1390-1487 Sentence denotes Intracellular adhesion molecule-1 induction by PMA was unaffected by any of the molecules tested.
T8 1488-1731 Sentence denotes Both PPAR-alpha and PPAR-gamma mRNAs were detected in HAECs by using reverse transcription-polymerase chain reaction and a ribonuclease protection assay; however, we have yet to determine which, if any, of the PPARs are mediating this process.
T9 1732-1935 Sentence denotes These results suggest that certain PPAR activators may help limit chronic inflammation mediated by VCAM-1 and monocytes without affecting acute inflammation mediated by E-selectin and neutrophil binding.
T1 0-135 Sentence denotes Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyte-endothelial cell interaction.
T2 136-393 Sentence denotes An early event in acute and chronic inflammation and associated diseases such as atherosclerosis and rheumatoid arthritis is the induced expression of specific adhesion molecules on the surface of endothelial cells (ECs), which subsequently bind leukocytes.
T3 394-682 Sentence denotes Peroxisome proliferator-activated receptors (PPARs), members of the nuclear receptor superfamily of transcription factors, are activated by fatty acid metabolites, peroxisome proliferators, and thiazolidinediones and are now recognized as important mediators in the inflammatory response.
T4 683-762 Sentence denotes Whether PPAR activators influence the inflammatory responses of ECs is unknown.
T5 763-1160 Sentence denotes We show that the PPAR activators 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), Wyeth 14643, ciglitazone, and troglitazone, but not BRL 49653, partially inhibit the induced expression of vascular cell adhesion molecule-1 (VCAM-1), as measured by ELISA, and monocyte binding to human aortic endothelial cells (HAECs) activated by phorbol 12-myristate 13-acetate (PMA) or lipopolysaccharide.
T6 1161-1389 Sentence denotes The "natural" PPAR activator 15d-PGJ(2) had the greatest potency and was the only tested molecule capable of partially inhibiting the induced expression of E-selectin and neutrophil-like HL60 cell binding to PMA-activated HAECs.
T7 1390-1487 Sentence denotes Intracellular adhesion molecule-1 induction by PMA was unaffected by any of the molecules tested.
T8 1488-1731 Sentence denotes Both PPAR-alpha and PPAR-gamma mRNAs were detected in HAECs by using reverse transcription-polymerase chain reaction and a ribonuclease protection assay; however, we have yet to determine which, if any, of the PPARs are mediating this process.
T9 1732-1935 Sentence denotes These results suggest that certain PPAR activators may help limit chronic inflammation mediated by VCAM-1 and monocytes without affecting acute inflammation mediated by E-selectin and neutrophil binding.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 217-232 HP_0002621 denotes atherosclerosis
T2 237-257 HP_0001370 denotes rheumatoid arthritis
T3 248-257 HP_0001369 denotes arthritis

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-53 protein denotes Peroxisome proliferator-activated receptor activators
T2 61-84 cell_type denotes human endothelial cells
T3 96-105 cell_type denotes leukocyte
T4 105-122 cell_type denotes -endothelial cell
T5 296-314 protein denotes adhesion molecules
T6 333-350 cell_type denotes endothelial cells
T7 352-355 cell_type denotes ECs
T8 382-392 cell_type denotes leukocytes
T9 394-437 protein denotes Peroxisome proliferator-activated receptors
T10 439-444 protein denotes PPARs
T11 462-490 protein denotes nuclear receptor superfamily
T12 494-515 protein denotes transcription factors
T13 747-750 cell_type denotes ECs
T14 958-991 protein denotes vascular cell adhesion molecule-1
T15 993-999 protein denotes VCAM-1
T16 1048-1078 cell_type denotes human aortic endothelial cells
T17 1080-1085 cell_type denotes HAECs
T18 1317-1327 protein denotes E-selectin
T19 1348-1357 cell_line denotes HL60 cell
T20 1383-1388 cell_type denotes HAECs
T21 1493-1524 RNA denotes PPAR-alpha and PPAR-gamma mRNAs
T22 1542-1547 cell_type denotes HAECs
T23 1611-1623 protein denotes ribonuclease
T24 1698-1703 protein denotes PPARs
T25 1831-1837 protein denotes VCAM-1
T26 1842-1851 cell_type denotes monocytes
T27 1901-1911 protein denotes E-selectin
T28 1916-1926 cell_type denotes neutrophil

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-135 Sentence denotes Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyte-endothelial cell interaction.
S2 136-393 Sentence denotes An early event in acute and chronic inflammation and associated diseases such as atherosclerosis and rheumatoid arthritis is the induced expression of specific adhesion molecules on the surface of endothelial cells (ECs), which subsequently bind leukocytes.
S3 394-682 Sentence denotes Peroxisome proliferator-activated receptors (PPARs), members of the nuclear receptor superfamily of transcription factors, are activated by fatty acid metabolites, peroxisome proliferators, and thiazolidinediones and are now recognized as important mediators in the inflammatory response.
S4 683-762 Sentence denotes Whether PPAR activators influence the inflammatory responses of ECs is unknown.
S5 763-1160 Sentence denotes We show that the PPAR activators 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), Wyeth 14643, ciglitazone, and troglitazone, but not BRL 49653, partially inhibit the induced expression of vascular cell adhesion molecule-1 (VCAM-1), as measured by ELISA, and monocyte binding to human aortic endothelial cells (HAECs) activated by phorbol 12-myristate 13-acetate (PMA) or lipopolysaccharide.
S6 1161-1389 Sentence denotes The "natural" PPAR activator 15d-PGJ(2) had the greatest potency and was the only tested molecule capable of partially inhibiting the induced expression of E-selectin and neutrophil-like HL60 cell binding to PMA-activated HAECs.
S7 1390-1487 Sentence denotes Intracellular adhesion molecule-1 induction by PMA was unaffected by any of the molecules tested.
S8 1488-1731 Sentence denotes Both PPAR-alpha and PPAR-gamma mRNAs were detected in HAECs by using reverse transcription-polymerase chain reaction and a ribonuclease protection assay; however, we have yet to determine which, if any, of the PPARs are mediating this process.
S9 1732-1935 Sentence denotes These results suggest that certain PPAR activators may help limit chronic inflammation mediated by VCAM-1 and monocytes without affecting acute inflammation mediated by E-selectin and neutrophil binding.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C27 0-53 NP denotes Peroxisome proliferator-activated receptor activators
C30 61-84 NP denotes human endothelial cells
C28 154-208 NP denotes acute and chronic inflammation and associated diseases
C29 217-257 NP denotes atherosclerosis and rheumatoid arthritis
C3 333-356 NP denotes endothelial cells (ECs)
C31 358-363 NP denotes which
C1 394-445 NP denotes Peroxisome proliferator-activated receptors (PPARs)
C32 447-515 NP denotes members of the nuclear receptor superfamily of transcription factors
C33 656-681 NP denotes the inflammatory response
C2 691-695 NP denotes PPAR
C14 691-706 NP denotes PPAR activators
C4 747-750 NP denotes ECs
C34 717-750 NP denotes the inflammatory responses of ECs
C16 776-849 NP denotes the PPAR activators 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2))
C20 958-1000 NP denotes vascular cell adhesion molecule-1 (VCAM-1)
C7 1100-1137 NP denotes phorbol 12-myristate 13-acetate (PMA)
C10 1048-1140 NP denotes human aortic endothelial cells (HAECs) activated by phorbol 12-myristate 13-acetate (PMA) or
C35 1161-1200 NP denotes The "natural" PPAR activator 15d-PGJ(2)
C8 1369-1373 NP denotes PMA-
C17 1369-1388 NP denotes PMA-activated HAECs
C9 1437-1440 NP denotes PMA
C18 1542-1547 NP denotes HAECs
C19 1694-1703 NP denotes the PPARs
C13 1759-1782 NP denotes certain PPAR activators
C21 1831-1837 NP denotes VCAM-1
R1 C29 C28 coref-part-whole atherosclerosis and rheumatoid arthritis,acute and chronic inflammation and associated diseases
R2 C3 C30 coref-ident endothelial cells (ECs),human endothelial cells
R3 C31 C3 coref-relat which,endothelial cells (ECs)
R4 C32 C1 coref-appos members of the nuclear receptor superfamily of transcription factors,Peroxisome proliferator-activated receptors (PPARs)
R5 C2 C1 coref-ident PPAR,Peroxisome proliferator-activated receptors (PPARs)
R6 C14 C27 coref-xxx PPAR activators,Peroxisome proliferator-activated receptor activators
R7 C4 C3 coref-ident ECs,endothelial cells (ECs)
R8 C34 C33 coref-ident the inflammatory responses of ECs,the inflammatory response
R9 C16 C14 coref-other "the PPAR activators 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2))",PPAR activators
R10 C35 C16 coref-ident "The ""natural"" PPAR activator 15d-PGJ(2)","the PPAR activators 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2))"
R11 C8 C7 coref-ident PMA-,phorbol 12-myristate 13-acetate (PMA)
R12 C17 C10 coref-ident PMA-activated HAECs,human aortic endothelial cells (HAECs) activated by phorbol 12-myristate 13-acetate (PMA) or
R13 C9 C8 coref-ident PMA,PMA-
R14 C18 C17 coref-ident HAECs,PMA-activated HAECs
R15 C19 C1 coref-ident the PPARs,Peroxisome proliferator-activated receptors (PPARs)
R16 C13 C14 coref-other certain PPAR activators,PPAR activators
R17 C21 C20 coref-ident VCAM-1,vascular cell adhesion molecule-1 (VCAM-1)

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-10 cell_component denotes Peroxisome
T2 61-84 cell_type denotes human endothelial cells
T3 96-105 cell_type denotes leukocyte
T4 105-122 cell_type denotes -endothelial cell
T5 217-232 other_name denotes atherosclerosis
T6 237-257 other_name denotes rheumatoid arthritis
T7 265-283 other_name denotes induced expression
T8 296-314 protein_family_or_group denotes adhesion molecules
T9 333-350 cell_type denotes endothelial cells
T10 352-355 cell_type denotes ECs
T11 382-392 cell_type denotes leukocytes
T12 394-404 cell_component denotes Peroxisome
T13 439-444 protein_family_or_group denotes PPARs
T14 462-490 protein_family_or_group denotes nuclear receptor superfamily
T15 494-515 protein_family_or_group denotes transcription factors
T16 534-556 lipid denotes fatty acid metabolites
T17 558-568 cell_component denotes peroxisome
T18 588-606 other_organic_compound denotes thiazolidinediones
T19 660-681 other_name denotes inflammatory response
T20 691-706 other_organic_compound denotes PPAR activators
T21 721-743 other_name denotes inflammatory responses
T22 747-750 cell_type denotes ECs
T23 780-795 other_organic_compound denotes PPAR activators
T24 796-836 other_organic_compound denotes 15-deoxy-Delta(12,14)-prostaglandin J(2)
T25 838-848 other_organic_compound denotes 15d-PGJ(2)
T26 851-862 other_organic_compound denotes Wyeth 14643
T27 864-875 other_organic_compound denotes ciglitazone
T28 881-893 other_organic_compound denotes troglitazone
T29 903-912 other_organic_compound denotes BRL 49653
T30 936-954 other_name denotes induced expression
T31 958-991 protein_molecule denotes vascular cell adhesion molecule-1
T32 993-999 protein_molecule denotes VCAM-1
T33 1017-1022 other_name denotes ELISA
T34 1028-1044 other_name denotes monocyte binding
T35 1048-1078 cell_type denotes human aortic endothelial cells
T36 1080-1085 cell_type denotes HAECs
T37 1100-1131 other_organic_compound denotes phorbol 12-myristate 13-acetate
T38 1133-1136 other_organic_compound denotes PMA
T39 1141-1159 lipid denotes lipopolysaccharide
T40 1175-1189 other_organic_compound denotes PPAR activator
T41 1190-1200 other_organic_compound denotes 15d-PGJ(2)
T42 1295-1313 other_name denotes induced expression
T43 1317-1327 protein_molecule denotes E-selectin
T44 1348-1357 cell_line denotes HL60 cell
T45 1369-1372 other_organic_compound denotes PMA
T46 1383-1388 cell_type denotes HAECs
T47 1390-1423 protein_N/A denotes Intracellular adhesion molecule-1
T48 1437-1440 other_organic_compound denotes PMA
T49 1493-1503 RNA_molecule denotes PPAR-alpha
T50 1508-1524 RNA_molecule denotes PPAR-gamma mRNAs
T51 1542-1547 cell_type denotes HAECs
T52 1557-1604 other_name denotes reverse transcription-polymerase chain reaction
T53 1611-1623 protein_molecule denotes ribonuclease
T54 1698-1703 protein_family_or_group denotes PPARs
T55 1767-1782 other_organic_compound denotes PPAR activators
T56 1806-1818 other_name denotes inflammation
T57 1831-1837 protein_molecule denotes VCAM-1
T58 1842-1851 cell_type denotes monocytes
T59 1876-1888 other_name denotes inflammation
T60 1901-1911 protein_molecule denotes E-selectin
T61 1916-1926 cell_type denotes neutrophil