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PubMed:10477599 JSONTXT

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jnlpba-st-training

Id	Subject	Object	Predicate	Lexical cue
T1	43-74	DNA	denotes	C motif-1/lymphotactin promoter
T2	150-184	protein	denotes	nuclear factor of activated T cell
T3	186-223	protein	denotes	Single C motif-1 (SCM-1)/lymphotactin
T4	229-245	protein	denotes	C-type chemokine
T5	330-342	cell_type	denotes	CD8+ T cells
T6	344-370	cell_type	denotes	double-negative thymocytes
T7	372-395	cell_type	denotes	gammadelta-type T cells
T8	401-409	cell_type	denotes	NK cells
T9	443-459	DNA	denotes	homologous genes
T10	469-479	protein	denotes	SCM-1alpha
T11	484-493	protein	denotes	SCM-1beta
T12	544-555	DNA	denotes	SCM-1 genes
T13	561-585	DNA	denotes	luciferase reporter gene
T14	611-629	DNA	denotes	5' flanking region
T15	682-690	protein	denotes	anti-CD3
T16	694-697	protein	denotes	PHA
T17	715-742	cell_line	denotes	SCM-1-producer T cell lines
T18	806-808	DNA	denotes	E1
T19	820-834	DNA	denotes	-108 to -95 nt
T20	985-987	DNA	denotes	E1
T21	1055-1067	cell_line	denotes	B cell lines
T22	1077-1097	protein	denotes	constitutive complex
T23	1105-1114	protein	denotes	complex I
T24	1155-1182	cell_line	denotes	SCM-1-producer T cell lines
T25	1192-1215	protein	denotes	higher mobility complex
T26	1223-1233	protein	denotes	complex II
T27	1265-1274	protein	denotes	complex I
T28	1291-1300	protein	denotes	complex I
T29	1304-1314	protein	denotes	complex II
T30	1328-1355	cell_line	denotes	SCM-1-producer T cell lines
T31	1464-1483	DNA	denotes	NF-AT core sequence
T32	1497-1507	DNA	denotes	E1 element
T33	1543-1554	protein	denotes	anti-NF-ATp
T34	1577-1598	protein	denotes	yeast isolated NF-ATp
T35	1605-1623	protein	denotes	E1 binding protein
T36	1645-1651	protein	denotes	NF-ATp
T37	1657-1675	cell_line	denotes	T and B cell lines
T38	1698-1724	protein	denotes	activation-dependent SCM-1
T39	1787-1793	protein	denotes	NF-ATp
T40	1880-1891	DNA	denotes	SCM-1 genes

FSU-PRGE

Id	Subject	Object	Predicate	Lexical cue
T1	36-52	protein	denotes	single C motif-1
T2	53-65	protein	denotes	lymphotactin
T3	150-184	protein	denotes	nuclear factor of activated T cell
T4	186-202	protein	denotes	Single C motif-1
T5	204-209	protein	denotes	SCM-1
T6	211-223	protein	denotes	lymphotactin
T7	229-245	protein	denotes	C-type chemokine
T8	330-333	protein	denotes	CD8
T9	469-479	protein	denotes	SCM-1alpha
T10	484-493	protein	denotes	SCM-1beta
T11	544-549	protein	denotes	SCM-1
T12	561-571	protein	denotes	luciferase
T13	687-690	protein	denotes	CD3
T14	715-720	protein	denotes	SCM-1
T15	1155-1160	protein	denotes	SCM-1
T16	1328-1333	protein	denotes	SCM-1
T17	1464-1469	protein	denotes	NF-AT
T18	1548-1554	protein	denotes	NF-ATp
T19	1592-1598	protein	denotes	NF-ATp
T20	1645-1651	protein	denotes	NF-ATp
T21	1719-1724	protein	denotes	SCM-1
T22	1787-1793	protein	denotes	NF-ATp
T23	1880-1885	protein	denotes	SCM-1

genia-medco-coref

Id	Subject	Object	Predicate	Lexical cue
C22	227-245	NP	denotes	a C-type chemokine
C23	246-251	NP	denotes	whose
C24	432-493	NP	denotes	two highly homologous genes encoding SCM-1alpha and SCM-1beta
C1	540-555	NP	denotes	the SCM-1 genes
C8	715-742	NP	denotes	SCM-1-producer T cell lines
C25	1075-1114	NP	denotes	a constitutive complex termed complex I
C27	1190-1233	NP	denotes	a higher mobility complex termed complex II
C26	1265-1274	NP	denotes	complex I
C28	1291-1300	NP	denotes	complex I
C29	1304-1314	NP	denotes	complex II
C19	1328-1355	NP	denotes	SCM-1-producer T cell lines
C30	1416-1430	NP	denotes	Both complexes
C12	1592-1598	NP	denotes	NF-ATp
C13	1645-1651	NP	denotes	NF-ATp
C20	1787-1793	NP	denotes	NF-ATp
C21	1876-1891	NP	denotes	the SCM-1 genes
R1	C23	C22	coref-relat	whose,a C-type chemokine
R2	C1	C24	coref-xxx	the SCM-1 genes,two highly homologous genes encoding SCM-1alpha and SCM-1beta
R3	C26	C25	coref-ident	complex I,a constitutive complex termed complex I
R4	C28	C26	coref-ident	complex I,complex I
R5	C29	C27	coref-ident	complex II,a higher mobility complex termed complex II
R6	C19	C8	coref-ident	SCM-1-producer T cell lines,SCM-1-producer T cell lines
R7	C30	C28	coref-whole-part	Both complexes,complex I
R8	C30	C29	coref-whole-part	Both complexes,complex II
R9	C13	C12	coref-ident	NF-ATp,NF-ATp
R10	C20	C13	coref-ident	NF-ATp,NF-ATp
R11	C21	C1	coref-ident	the SCM-1 genes,the SCM-1 genes

pubmed-sentences-benchmark

Id	Subject	Object	Predicate	Lexical cue
S1	0-185	Sentence	denotes	An activation-responsive element in single C motif-1/lymphotactin promoter is a site of constitutive and inducible DNA-protein interactions involving nuclear factor of activated T cell.
S2	186-410	Sentence	denotes	Single C motif-1 (SCM-1)/lymphotactin is a C-type chemokine whose expression is activation dependent, cyclosporin A sensitive and restricted to CD8+ T cells, double-negative thymocytes, gammadelta-type T cells, and NK cells.
S3	411-494	Sentence	denotes	In humans, there are two highly homologous genes encoding SCM-1alpha and SCM-1beta.
S4	495-556	Sentence	denotes	Here we examined the regulatory mechanism of the SCM-1 genes.
S5	557-787	Sentence	denotes	The luciferase reporter gene under the control of the 5' flanking region of 0.7 kb was strongly induced upon activation with anti-CD3 or PHA plus PMA only in SCM-1-producer T cell lines through a cyclosporin A-sensitive mechanism.
S6	788-933	Sentence	denotes	An element termed E1 located at -108 to -95 nt relative to the major transcription start site was found to be critical for the promoter activity.
S7	934-1275	Sentence	denotes	In electrophoretic mobility shift assays using the E1 oligonucleotide as probe, nuclear extracts from unstimulated T and B cell lines formed a constitutive complex termed complex I, while nuclear extracts from stimulated SCM-1-producer T cell lines formed a higher mobility complex termed complex II with a concomitant decrease in complex I.
S8	1276-1415	Sentence	denotes	The shift from complex I to complex II seen only in SCM-1-producer T cell lines upon activation was completely suppressed by cyclosporin A.
S9	1416-1555	Sentence	denotes	Both complexes were critically dependent on the NF-AT core sequence TTTCC in the E1 element and were partially supershifted by anti-NF-ATp.
S10	1556-1743	Sentence	denotes	One-hybrid assays in yeast isolated NF-ATp as an E1 binding protein, and transfection of NF-ATp into T and B cell lines strongly enhanced the activation-dependent SCM-1 promoter activity.
S11	1744-1892	Sentence	denotes	Collectively, a unique mechanism involving NF-ATp appears to regulate the cell type-specific and activation-dependent expression of the SCM-1 genes.

GENIAcorpus

Id	Subject	Object	Predicate	Lexical cue
T1	43-74	DNA_domain_or_region	denotes	C motif-1/lymphotactin promoter
T2	115-139	other_name	denotes	DNA-protein interactions
T3	150-184	protein_molecule	denotes	nuclear factor of activated T cell
T4	186-202	protein_molecule	denotes	Single C motif-1
T5	229-245	protein_family_or_group	denotes	C-type chemokine
T6	266-286	other_name	denotes	activation dependent
T7	288-311	other_name	denotes	cyclosporin A sensitive
T8	330-342	cell_type	denotes	CD8+ T cells
T9	344-370	cell_type	denotes	double-negative thymocytes
T10	372-395	cell_type	denotes	gammadelta-type T cells
T11	401-409	cell_type	denotes	NK cells
T12	443-459	DNA_family_or_group	denotes	homologous genes
T13	469-479	protein_molecule	denotes	SCM-1alpha
T14	484-493	protein_molecule	denotes	SCM-1beta
T15	516-536	other_name	denotes	regulatory mechanism
T16	544-555	DNA_domain_or_region	denotes	SCM-1 genes
T17	561-585	DNA_domain_or_region	denotes	luciferase reporter gene
T18	611-629	DNA_domain_or_region	denotes	5' flanking region
T19	682-690	protein_molecule	denotes	anti-CD3
T20	694-697	protein_molecule	denotes	PHA
T21	703-706	other_organic_compound	denotes	PMA
T22	715-742	cell_line	denotes	SCM-1-producer T cell lines
T23	753-786	other_name	denotes	cyclosporin A-sensitive mechanism
T24	806-808	DNA_domain_or_region	denotes	E1
T25	820-834	DNA_domain_or_region	denotes	-108 to -95 nt
T26	915-932	other_name	denotes	promoter activity
T27	937-974	other_name	denotes	electrophoretic mobility shift assays
T28	985-987	DNA_domain_or_region	denotes	E1
T29	1014-1030	cell_component	denotes	nuclear extracts
T30	1055-1067	cell_line	denotes	B cell lines
T31	1077-1097	protein_complex	denotes	constitutive complex
T32	1105-1114	protein_complex	denotes	complex I
T33	1122-1138	cell_component	denotes	nuclear extracts
T34	1155-1182	cell_line	denotes	SCM-1-producer T cell lines
T35	1192-1215	protein_complex	denotes	higher mobility complex
T36	1223-1233	protein_complex	denotes	complex II
T37	1265-1274	protein_complex	denotes	complex I
T38	1291-1300	protein_complex	denotes	complex I
T39	1304-1314	protein_complex	denotes	complex II
T40	1328-1355	cell_line	denotes	SCM-1-producer T cell lines
T41	1401-1414	other_organic_compound	denotes	cyclosporin A
T42	1464-1483	DNA_domain_or_region	denotes	NF-AT core sequence
T43	1484-1489	polynucleotide	denotes	TTTCC
T44	1497-1499	DNA_domain_or_region	denotes	E1
T45	1543-1554	protein_molecule	denotes	anti-NF-ATp
T46	1577-1598	protein_molecule	denotes	yeast isolated NF-ATp
T47	1605-1607	DNA_domain_or_region	denotes	E1
T48	1645-1651	protein_molecule	denotes	NF-ATp
T49	1698-1724	protein_molecule	denotes	activation-dependent SCM-1
T50	1725-1742	other_name	denotes	promoter activity
T51	1787-1793	protein_molecule	denotes	NF-ATp
T52	1841-1872	other_name	denotes	activation-dependent expression
T53	1880-1891	DNA_domain_or_region	denotes	SCM-1 genes