PubMed:10473568
Annnotations
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 1129-1139 | Cell | denotes | fibroblast | http://purl.obolibrary.org/obo/CL:0000057 |
ggdb-test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 67-98 | https://acgg.asia/db/ggdb/info/gg077 | denotes | beta1,4-galactosyltransferase I |
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 997-1006 | Glycan_Motif | denotes | galactose | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE |
GGDB-2020
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 67-98 | https://acgg.asia/db/ggdb/info/gg077 | denotes | beta1,4-galactosyltransferase I |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-99 | Sentence | denotes | Cloning and expression of a proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I. |
| T2 | 100-170 | Sentence | denotes | A seventh member of the human beta4-galactosyltransferase gene family. |
| T3 | 171-310 | Sentence | denotes | A seventh member of the human beta4-galactosyltransferase family, beta4Gal-T7, was identified by BLAST analysis of expressed sequence tags. |
| T4 | 311-590 | Sentence | denotes | The coding region of beta4Gal-T7 depicts a type II transmembrane protein with sequence similarity to beta4-galactosyltransferases, but the sequence was distinct in known motifs and did not contain the cysteine residues conserved in the other six members of the beta4Gal-T family. |
| T5 | 591-671 | Sentence | denotes | The genomic organization of beta4Gal-T7 was different from previous beta4Gal-Ts. |
| T6 | 672-848 | Sentence | denotes | Expression of beta4Gal-T7 in insect cells showed that the gene product had beta1,4-galactosyltransferase activity with beta-xylosides, and the linkage formed was Galbeta1-4Xyl. |
| T7 | 849-1088 | Sentence | denotes | Thus, beta4Gal-T7 represents galactosyltransferase I enzyme (xylosylprotein beta1, 4-galactosyltransferase; EC 2.4.1.133), which attaches the first galactose in the proteoglycan linkage region GlcAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser. |
| T8 | 1089-1363 | Sentence | denotes | Sequence analysis of beta4Gal-T7 from a fibroblast cell line of a patient with a progeroid syndrome and signs of the Ehlers-Danlos syndrome, previously shown to exhibit reduced galactosyltransferase I activity (Quentin, E., Gladen, A., Rodén, L., and Kresse, H. (1990) Proc. |
| T9 | 1364-1369 | Sentence | denotes | Natl. |
| T10 | 1370-1375 | Sentence | denotes | Acad. |
| T11 | 1376-1380 | Sentence | denotes | Sci. |
| T12 | 1381-1383 | Sentence | denotes | U. |
| T13 | 1384-1386 | Sentence | denotes | S. |
| T14 | 1387-1389 | Sentence | denotes | A. |
| T15 | 1390-1725 | Sentence | denotes | 87, 1342-1346), revealed two inherited allelic variants, beta4Gal-T7(186D) and beta4Gal-T7(206P), each with a single missense substitution in the putative catalytic domain of the enzyme. beta4Gal-T7(186D) exhibited a 4-fold elevated K(m) for the donor substrate, whereas essentially no activity was demonstrated with beta4Gal-T7(206P). |
| T16 | 1726-1911 | Sentence | denotes | Molecular cloning of beta4Gal-T7 should facilitate general studies of its pathogenic role in progeroid syndromes and connective tissue disorders with affected proteoglycan biosynthesis. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 997-1006 | https://glytoucan.org/Structures/Glycans/G65889KE | denotes | galactose |
| T2 | 997-1006 | https://glytoucan.org/Structures/Glycans/G68158BT | denotes | galactose |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1843-1860 | http://purl.obolibrary.org/obo/MAT_0000301 | denotes | connective tissue |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1843-1870 | HP_0003549 | denotes | connective tissue disorders |
glycogenes
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-GlycoGenes20190927-B_T1 | 359-361 | https://acgg.asia/db/ggdb/info/gg111 | denotes | II |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 1170-1188 | Disease | denotes | progeroid syndrome | http://purl.obolibrary.org/obo/MONDO_0015333 |
| T2 | 1206-1228 | Disease | denotes | Ehlers-Danlos syndrome | http://purl.obolibrary.org/obo/MONDO_0020066 |
| T3 | 1819-1838 | Disease | denotes | progeroid syndromes | http://purl.obolibrary.org/obo/MONDO_0015333 |
| T4 | 1843-1870 | Disease | denotes | connective tissue disorders | http://purl.obolibrary.org/obo/MONDO_0003900 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 124-129 | OrganismTaxon | denotes | human | 9606 |
| T2 | 195-200 | OrganismTaxon | denotes | human | 9606 |
| T3 | 1155-1162 | OrganismTaxon | denotes | patient | 9606 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 362-375 | Body_part | denotes | transmembrane | http://purl.obolibrary.org/obo/GO_0016020 |
| T2 | 1129-1139 | Body_part | denotes | fibroblast | http://purl.obolibrary.org/obo/CL_0000057 |
| T3 | 1843-1860 | Body_part | denotes | connective tissue | http://purl.obolibrary.org/obo/UBERON_0002384 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 1843-1860 | Body_part | denotes | connective tissue | http://purl.obolibrary.org/obo/MAT_0000301 |