PubMed:10468560
Annnotations
PMID_GLOBAL
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 433-436 | DiseaseOrPhenotypicFeature | denotes | HS3 | 0007466|0010053 |
| T3 | 781-784 | DiseaseOrPhenotypicFeature | denotes | HS2 | 0000913 |
| T4 | 791-794 | DiseaseOrPhenotypicFeature | denotes | HS3 | 0007466|0010053 |
| T6 | 845-848 | DiseaseOrPhenotypicFeature | denotes | HS2 | 0000913 |
| T7 | 893-896 | DiseaseOrPhenotypicFeature | denotes | HS3 | 0007466|0010053 |
| T9 | 1000-1003 | DiseaseOrPhenotypicFeature | denotes | HS3 | 0007466|0010053 |
| T11 | 1061-1069 | DiseaseOrPhenotypicFeature | denotes | leukemia | 0004355|0005059 |
| T13 | 1110-1113 | DiseaseOrPhenotypicFeature | denotes | HS2 | 0000913 |
| T14 | 1187-1195 | DiseaseOrPhenotypicFeature | denotes | leukemia | 0004355|0005059 |
| T16 | 1276-1279 | DiseaseOrPhenotypicFeature | denotes | HS3 | 0007466|0010053 |
| T18 | 1313-1315 | DiseaseOrPhenotypicFeature | denotes | HS | 0019395 |
| T19 | 1361-1363 | DiseaseOrPhenotypicFeature | denotes | HS | 0019395 |
| T20 | 1413-1416 | DiseaseOrPhenotypicFeature | denotes | HS3 | 0007466|0010053 |
| T22 | 1446-1449 | DiseaseOrPhenotypicFeature | denotes | HS2 | 0000913 |
| T23 | 1483-1486 | DiseaseOrPhenotypicFeature | denotes | HS2 | 0000913 |
| T24 | 1508-1511 | DiseaseOrPhenotypicFeature | denotes | HS3 | 0007466|0010053 |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1061-1069 | HP_0001909 | denotes | leukemia |
| T2 | 1187-1195 | HP_0001909 | denotes | leukemia |
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 4-24 | DNA | denotes | beta-globin promoter |
| T2 | 57-86 | protein | denotes | erythroid Krüppel-like factor |
| T3 | 94-114 | DNA | denotes | locus control region |
| T4 | 118-133 | cell_type | denotes | erythroid cells |
| T5 | 135-164 | protein | denotes | Erythroid Krüppel-like factor |
| T6 | 166-170 | protein | denotes | EKLF |
| T7 | 209-229 | DNA | denotes | beta-globin promoter |
| T8 | 269-285 | DNA | denotes | beta-globin gene |
| T9 | 289-310 | cell_type | denotes | adult erythroid cells |
| T10 | 346-350 | protein | denotes | EKLF |
| T11 | 392-424 | DNA | denotes | beta-globin locus control region |
| T12 | 426-429 | DNA | denotes | LCR |
| T13 | 431-436 | DNA | denotes | 5'HS3 |
| T14 | 470-473 | DNA | denotes | LCR |
| T15 | 482-502 | DNA | denotes | beta-globin promoter |
| T16 | 515-536 | cell_type | denotes | adult erythroid cells |
| T17 | 642-646 | protein | denotes | EKLF |
| T18 | 667-670 | DNA | denotes | LCR |
| T19 | 771-775 | protein | denotes | EKLF |
| T20 | 779-784 | DNA | denotes | 5'HS2 |
| T21 | 789-794 | DNA | denotes | 5'HS3 |
| T22 | 802-805 | DNA | denotes | LCR |
| T23 | 835-839 | protein | denotes | EKLF |
| T24 | 843-848 | DNA | denotes | 5'HS2 |
| T25 | 862-870 | DNA | denotes | TATA box |
| T26 | 891-896 | DNA | denotes | 5'HS3 |
| T27 | 922-932 | DNA | denotes | TATA boxes |
| T28 | 940-960 | DNA | denotes | beta-globin promoter |
| T29 | 990-994 | protein | denotes | EKLF |
| T30 | 998-1003 | DNA | denotes | 5'HS3 |
| T31 | 1021-1075 | cell_type | denotes | beta-globin-expressing murine erythroid leukemia cells |
| T32 | 1100-1104 | protein | denotes | EKLF |
| T33 | 1108-1113 | DNA | denotes | 5'HS2 |
| T34 | 1131-1165 | cell_line | denotes | gamma-globin-expressing K562 cells |
| T35 | 1170-1201 | cell_type | denotes | murine erythroid leukemia cells |
| T36 | 1210-1214 | protein | denotes | EKLF |
| T37 | 1216-1219 | protein | denotes | Sp1 |
| T38 | 1274-1279 | DNA | denotes | 5'HS3 |
| T39 | 1311-1315 | DNA | denotes | 5'HS |
| T40 | 1343-1347 | protein | denotes | EKLF |
| T41 | 1359-1363 | DNA | denotes | 5'HS |
| T42 | 1403-1407 | protein | denotes | EKLF |
| T43 | 1411-1416 | DNA | denotes | 5'HS3 |
| T44 | 1444-1449 | DNA | denotes | 5'HS2 |
| T45 | 1481-1486 | DNA | denotes | 5'HS2 |
| T46 | 1506-1511 | DNA | denotes | 5'HS3 |
| T47 | 1577-1581 | protein | denotes | EKLF |
| T48 | 1606-1623 | DNA | denotes | beta-globin locus |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 10468560-6#28#32#gene10661 | 990-994 | gene10661 | denotes | EKLF |
| 10468560-6#138#142#gene10661 | 1100-1104 | gene10661 | denotes | EKLF |
| 10468560-6#169#181#gene3047 | 1131-1143 | gene3047 | denotes | gamma-globin |
| 10468560-6#99#107#diseaseC0023418 | 1061-1069 | diseaseC0023418 | denotes | leukemia |
| 10468560-6#225#233#diseaseC0023418 | 1187-1195 | diseaseC0023418 | denotes | leukemia |
| 28#32#gene1066199#107#diseaseC0023418 | 10468560-6#28#32#gene10661 | 10468560-6#99#107#diseaseC0023418 | associated_with | EKLF,leukemia |
| 28#32#gene10661225#233#diseaseC0023418 | 10468560-6#28#32#gene10661 | 10468560-6#225#233#diseaseC0023418 | associated_with | EKLF,leukemia |
| 138#142#gene1066199#107#diseaseC0023418 | 10468560-6#138#142#gene10661 | 10468560-6#99#107#diseaseC0023418 | associated_with | EKLF,leukemia |
| 138#142#gene10661225#233#diseaseC0023418 | 10468560-6#138#142#gene10661 | 10468560-6#225#233#diseaseC0023418 | associated_with | EKLF,leukemia |
| 169#181#gene304799#107#diseaseC0023418 | 10468560-6#169#181#gene3047 | 10468560-6#99#107#diseaseC0023418 | associated_with | gamma-globin,leukemia |
| 169#181#gene3047225#233#diseaseC0023418 | 10468560-6#169#181#gene3047 | 10468560-6#225#233#diseaseC0023418 | associated_with | gamma-globin,leukemia |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C35 | 0-24 | NP | denotes | The beta-globin promoter |
| C1 | 135-171 | NP | denotes | Erythroid Krüppel-like factor (EKLF) |
| C34 | 173-178 | NP | denotes | which |
| C36 | 205-229 | NP | denotes | the beta-globin promoter |
| C8 | 289-310 | NP | denotes | adult erythroid cells |
| C2 | 346-350 | NP | denotes | EKLF |
| C5 | 388-436 | NP | denotes | the beta-globin locus control region (LCR) 5'HS3 |
| C6 | 470-473 | NP | denotes | LCR |
| C20 | 478-502 | NP | denotes | the beta-globin promoter |
| C9 | 515-536 | NP | denotes | adult erythroid cells |
| C37 | 542-585 | NP | denotes | the network of protein-protein interactions |
| C38 | 586-590 | NP | denotes | that |
| C39 | 606-624 | NP | denotes | these two elements |
| C10 | 642-646 | NP | denotes | EKLF |
| C11 | 663-670 | NP | denotes | the LCR |
| C40 | 771-775 | NP | denotes | EKLF |
| C41 | 779-784 | NP | denotes | 5'HS2 |
| C14 | 789-794 | NP | denotes | 5'HS3 |
| C44 | 752-794 | NP | denotes | the recruitment of EKLF to 5'HS2 and 5'HS3 |
| C15 | 798-805 | NP | denotes | the LCR |
| C42 | 835-839 | NP | denotes | EKLF |
| C43 | 843-848 | NP | denotes | 5'HS2 |
| C45 | 820-848 | NP | denotes | recruitment of EKLF to 5'HS2 |
| C19 | 891-896 | NP | denotes | 5'HS3 |
| C46 | 876-896 | NP | denotes | recruitment to 5'HS3 |
| C47 | 936-960 | NP | denotes | the beta-globin promoter |
| C48 | 990-994 | NP | denotes | EKLF |
| C49 | 998-1003 | NP | denotes | 5'HS3 |
| C22 | 975-1003 | NP | denotes | recruitment of EKLF to 5'HS3 |
| C24 | 1021-1075 | NP | denotes | beta-globin-expressing murine erythroid leukemia cells |
| C50 | 1100-1104 | NP | denotes | EKLF |
| C51 | 1108-1113 | NP | denotes | 5'HS2 |
| C23 | 1085-1113 | NP | denotes | recruitment of EKLF to 5'HS2 |
| C25 | 1170-1201 | NP | denotes | murine erythroid leukemia cells |
| C52 | 1210-1214 | NP | denotes | EKLF |
| C53 | 1216-1219 | NP | denotes | Sp1 |
| C54 | 1221-1226 | NP | denotes | which |
| C28 | 1274-1279 | NP | denotes | 5'HS3 |
| C55 | 1343-1347 | NP | denotes | EKLF |
| C56 | 1403-1407 | NP | denotes | EKLF |
| C57 | 1411-1416 | NP | denotes | 5'HS3 |
| C27 | 1384-1416 | NP | denotes | the recruitment of EKLF to 5'HS3 |
| C29 | 1444-1449 | NP | denotes | 5'HS2 |
| C30 | 1481-1486 | NP | denotes | 5'HS2 |
| C58 | 1462-1486 | NP | denotes | the recruitment to 5'HS2 |
| C31 | 1506-1511 | NP | denotes | 5'HS3 |
| C59 | 1548-1555 | NP | denotes | a model |
| C60 | 1556-1560 | NP | denotes | that |
| C32 | 1577-1581 | NP | denotes | EKLF |
| R1 | C34 | C1 | coref-relat | which,Erythroid Krüppel-like factor (EKLF) |
| R2 | C36 | C35 | coref-ident | the beta-globin promoter,The beta-globin promoter |
| R3 | C2 | C1 | coref-ident | EKLF,Erythroid Krüppel-like factor (EKLF) |
| R4 | C6 | C5 | coref-xxx | LCR,the beta-globin locus control region (LCR) 5'HS3 |
| R5 | C20 | C36 | coref-xxx | the beta-globin promoter,the beta-globin promoter |
| R6 | C9 | C8 | coref-ident | adult erythroid cells,adult erythroid cells |
| R7 | C38 | C37 | coref-relat | that,the network of protein-protein interactions |
| R8 | C39 | C6 | coref-whole-part | these two elements,LCR |
| R9 | C39 | C20 | coref-whole-part | these two elements,the beta-globin promoter |
| R10 | C10 | C2 | coref-ident | EKLF,EKLF |
| R11 | C11 | C6 | coref-ident | the LCR,LCR |
| R12 | C40 | C10 | coref-ident | EKLF,EKLF |
| R13 | C14 | C5 | coref-ident | 5'HS3,the beta-globin locus control region (LCR) 5'HS3 |
| R14 | C15 | C11 | coref-ident | the LCR,the LCR |
| R15 | C42 | C40 | coref-ident | EKLF,EKLF |
| R16 | C43 | C41 | coref-ident | 5'HS2,5'HS2 |
| R17 | C45 | C44 | coref-part-whole | recruitment of EKLF to 5'HS2,the recruitment of EKLF to 5'HS2 and 5'HS3 |
| R18 | C19 | C14 | coref-ident | 5'HS3,5'HS3 |
| R19 | C46 | C44 | coref-ident | recruitment to 5'HS3,the recruitment of EKLF to 5'HS2 and 5'HS3 |
| R20 | C47 | C20 | coref-ident | the beta-globin promoter,the beta-globin promoter |
| R21 | C48 | C42 | coref-ident | EKLF,EKLF |
| R22 | C49 | C19 | coref-ident | 5'HS3,5'HS3 |
| R23 | C22 | C46 | coref-ident | recruitment of EKLF to 5'HS3,recruitment to 5'HS3 |
| R24 | C50 | C48 | coref-ident | EKLF,EKLF |
| R25 | C51 | C43 | coref-ident | 5'HS2,5'HS2 |
| R26 | C23 | C45 | coref-ident | recruitment of EKLF to 5'HS2,recruitment of EKLF to 5'HS2 |
| R27 | C25 | C24 | coref-other | murine erythroid leukemia cells,beta-globin-expressing murine erythroid leukemia cells |
| R28 | C52 | C50 | coref-ident | EKLF,EKLF |
| R29 | C54 | C53 | coref-relat | which,Sp1 |
| R30 | C28 | C19 | coref-ident | 5'HS3,5'HS3 |
| R31 | C55 | C52 | coref-ident | EKLF,EKLF |
| R32 | C56 | C55 | coref-ident | EKLF,EKLF |
| R33 | C57 | C28 | coref-ident | 5'HS3,5'HS3 |
| R34 | C27 | C22 | coref-ident | the recruitment of EKLF to 5'HS3,recruitment of EKLF to 5'HS3 |
| R35 | C29 | C51 | coref-ident | 5'HS2,5'HS2 |
| R36 | C30 | C29 | coref-ident | 5'HS2,5'HS2 |
| R37 | C58 | C23 | coref-ident | the recruitment to 5'HS2,recruitment of EKLF to 5'HS2 |
| R38 | C31 | C57 | coref-ident | 5'HS3,5'HS3 |
| R39 | C60 | C59 | coref-relat | that,a model |
| R40 | C32 | C56 | coref-ident | EKLF,EKLF |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-134 | Sentence | denotes | The beta-globin promoter is important for recruitment of erythroid Krüppel-like factor to the locus control region in erythroid cells. |
| S2 | 135-311 | Sentence | denotes | Erythroid Krüppel-like factor (EKLF), which binds to the CACCC box in the beta-globin promoter, is required for the expression of the beta-globin gene in adult erythroid cells. |
| S3 | 312-437 | Sentence | denotes | It was recently demonstrated that EKLF is also required for the activity of the beta-globin locus control region (LCR) 5'HS3. |
| S4 | 438-671 | Sentence | denotes | Some evidence suggests that the LCR and the beta-globin promoter interact in adult erythroid cells, and the network of protein-protein interactions that exists between these two elements may regulate how EKLF is recruited to the LCR. |
| S5 | 672-806 | Sentence | denotes | In this report, we use the PIN*POINT assay to study the role of the promoter on the recruitment of EKLF to 5'HS2 and 5'HS3 of the LCR. |
| S6 | 807-961 | Sentence | denotes | We find that recruitment of EKLF to 5'HS2 requires the TATA box, but recruitment to 5'HS3 depends on the CACCC and TATA boxes of the beta-globin promoter. |
| S7 | 962-1202 | Sentence | denotes | Furthermore, recruitment of EKLF to 5'HS3 only occurred in beta-globin-expressing murine erythroid leukemia cells, whereas recruitment of EKLF to 5'HS2 occurred in both gamma-globin-expressing K562 cells and murine erythroid leukemia cells. |
| S8 | 1203-1280 | Sentence | denotes | Unlike EKLF, Sp1, which also binds to CACCC boxes, is not recruited to 5'HS3. |
| S9 | 1281-1364 | Sentence | denotes | We have also examined how one 5'HS affects the recruitment of EKLF to another 5'HS. |
| S10 | 1365-1512 | Sentence | denotes | We have found that the recruitment of EKLF to 5'HS3 depends on the presence of 5'HS2 in cis, but the recruitment to 5'HS2 does not depend on 5'HS3. |
| S11 | 1513-1624 | Sentence | denotes | Based on these results, we present a model that illustrates how EKLF may be recruited to the beta-globin locus. |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 4-24 | DNA_domain_or_region | denotes | beta-globin promoter |
| T2 | 57-86 | protein_molecule | denotes | erythroid Krüppel-like factor |
| T3 | 94-114 | DNA_domain_or_region | denotes | locus control region |
| T4 | 118-133 | cell_type | denotes | erythroid cells |
| T5 | 135-164 | protein_molecule | denotes | Erythroid Krüppel-like factor |
| T6 | 166-170 | protein_molecule | denotes | EKLF |
| T7 | 209-229 | DNA_domain_or_region | denotes | beta-globin promoter |
| T8 | 269-285 | DNA_domain_or_region | denotes | beta-globin gene |
| T9 | 289-310 | cell_type | denotes | adult erythroid cells |
| T10 | 346-350 | protein_molecule | denotes | EKLF |
| T11 | 392-424 | DNA_domain_or_region | denotes | beta-globin locus control region |
| T12 | 426-429 | DNA_domain_or_region | denotes | LCR |
| T13 | 431-436 | DNA_domain_or_region | denotes | 5'HS3 |
| T14 | 470-473 | DNA_domain_or_region | denotes | LCR |
| T15 | 482-502 | DNA_domain_or_region | denotes | beta-globin promoter |
| T16 | 515-536 | cell_type | denotes | adult erythroid cells |
| T17 | 557-585 | other_name | denotes | protein-protein interactions |
| T18 | 642-646 | protein_molecule | denotes | EKLF |
| T19 | 667-670 | DNA_domain_or_region | denotes | LCR |
| T20 | 699-714 | other_name | denotes | PIN*POINT assay |
| T21 | 771-775 | protein_molecule | denotes | EKLF |
| T22 | 779-784 | DNA_domain_or_region | denotes | 5'HS2 |
| T23 | 789-794 | DNA_domain_or_region | denotes | 5'HS3 |
| T24 | 802-805 | DNA_domain_or_region | denotes | LCR |
| T25 | 835-839 | protein_molecule | denotes | EKLF |
| T26 | 843-848 | DNA_domain_or_region | denotes | 5'HS2 |
| T27 | 862-870 | DNA_domain_or_region | denotes | TATA box |
| T28 | 891-896 | DNA_domain_or_region | denotes | 5'HS3 |
| T29 | 912-917 | polynucleotide | denotes | CACCC |
| T30 | 922-932 | DNA_domain_or_region | denotes | TATA boxes |
| T31 | 940-960 | DNA_domain_or_region | denotes | beta-globin promoter |
| T32 | 990-994 | protein_molecule | denotes | EKLF |
| T33 | 998-1003 | DNA_domain_or_region | denotes | 5'HS3 |
| T34 | 1021-1075 | cell_type | denotes | beta-globin-expressing murine erythroid leukemia cells |
| T35 | 1100-1104 | protein_molecule | denotes | EKLF |
| T36 | 1108-1113 | DNA_domain_or_region | denotes | 5'HS2 |
| T37 | 1131-1165 | cell_line | denotes | gamma-globin-expressing K562 cells |
| T38 | 1170-1201 | cell_type | denotes | murine erythroid leukemia cells |
| T39 | 1210-1214 | protein_molecule | denotes | EKLF |
| T40 | 1216-1219 | protein_molecule | denotes | Sp1 |
| T41 | 1241-1246 | polynucleotide | denotes | CACCC |
| T42 | 1274-1279 | DNA_domain_or_region | denotes | 5'HS3 |
| T43 | 1311-1315 | DNA_domain_or_region | denotes | 5'HS |
| T44 | 1343-1347 | protein_molecule | denotes | EKLF |
| T45 | 1359-1363 | DNA_domain_or_region | denotes | 5'HS |
| T46 | 1403-1407 | protein_molecule | denotes | EKLF |
| T47 | 1411-1416 | DNA_domain_or_region | denotes | 5'HS3 |
| T48 | 1444-1449 | DNA_domain_or_region | denotes | 5'HS2 |
| T49 | 1481-1486 | DNA_domain_or_region | denotes | 5'HS2 |
| T50 | 1506-1511 | DNA_domain_or_region | denotes | 5'HS3 |
| T51 | 1577-1581 | protein_molecule | denotes | EKLF |
| T52 | 1606-1623 | DNA_domain_or_region | denotes | beta-globin locus |
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 990-994 | gene:10661 | denotes | EKLF |
| T1 | 1061-1069 | disease:C0023418 | denotes | leukemia |
| R1 | T0 | T1 | associated_with | EKLF,leukemia |