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PubMed:10464302 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-107 Sentence denotes Association of the Ras to mitogen-activated protein kinase signal transduction pathway with microfilaments.
T2 108-261 Sentence denotes Evidence for a p185(neu)-containing cell surface signal transduction particle linking the mitogenic pathway to a membrane-microfilament association site.
T3 262-480 Sentence denotes Microvilli of the aggressive 13762 ascites mammary adenocarcinoma contain a large, microfilament-associated signal transduction particle whose scaffolding is a stable glycoprotein complex (Li, Y., Hua, F., Carraway, K.
T4 481-501 Sentence denotes L., and Carraway, C.
T5 502-504 Sentence denotes A.
T6 505-517 Sentence denotes C. (1999) J.
T7 518-523 Sentence denotes Biol.
T8 524-529 Sentence denotes Chem.
T9 530-601 Sentence denotes 274, 25651-25658) associated with the growth factor receptor p185(neu).
T10 602-797 Sentence denotes The receptor is constitutively tyrosine-phosphorylated in the cells and microvilli, predicting that it should recruit mitogenic pathway components to this membrane-microfilament interaction site.
T11 798-1043 Sentence denotes Immunoprecipitation of cell lysates with anti-phosphotyrosine and immunoblotting showed phosphorylated forms of the mitogenic pathway proteins Shc and MAPK in addition to p185(neu), suggesting that the Ras to MAPK mitogenic pathway is activated.
T12 1044-1363 Sentence denotes Immunoblotting of p185(neu)-containing microvillar fractions revealed the presence in each of stably associated Shc, Grb-2, Sos, Ras, Raf, mitogen-activated protein kinase kinase, and mitogen-activated protein kinase/extracellular signal-regulated kinase, as well as the transcription factor-phosphorylating kinase Rsk.
T13 1364-1526 Sentence denotes All of these pathway components co-immunoprecipitated with p185(neu) from cleared lysates of microvilli solubilized under microfilament-depolymerizing conditions.
T14 1527-1825 Sentence denotes The recruitment of constitutively phosphorylated p185(neu) and the activated mitogenic pathway proteins to this membrane-microfilament interaction site provides a physical model for integrating the assembly of the mitogenic pathway with the transmission of growth factor signal to the cytoskeleton.
T15 1826-1931 Sentence denotes This linkage is probably a requisite step in the global cytoskeleton remodeling accompanying mitogenesis.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 280-290 HP_0000718 denotes aggressive
T2 297-304 HP_0001541 denotes ascites

FSU-PRGE

Id Subject Object Predicate Lexical cue
T1 19-22 protein denotes Ras
T2 26-58 protein denotes mitogen-activated protein kinase
T3 123-132 protein denotes p185(neu)
T4 568-590 protein denotes growth factor receptor
T5 591-600 protein denotes p185(neu)
T6 941-944 protein denotes Shc
T7 949-953 protein denotes MAPK
T8 969-978 protein denotes p185(neu)
T9 1000-1003 protein denotes Ras
T10 1007-1011 protein denotes MAPK
T11 1062-1071 protein denotes p185(neu)
T12 1156-1159 protein denotes Shc
T13 1161-1166 protein denotes Grb-2
T14 1168-1171 protein denotes Sos
T15 1173-1176 protein denotes Ras
T16 1178-1181 protein denotes Raf
T17 1183-1222 protein denotes mitogen-activated protein kinase kinase
T18 1228-1260 protein denotes mitogen-activated protein kinase
T19 1261-1298 protein denotes extracellular signal-regulated kinase
T20 1315-1335 protein denotes transcription factor
T21 1359-1362 protein denotes Rsk
T22 1423-1432 protein denotes p185(neu)
T23 1576-1585 protein denotes p185(neu)
T24 1784-1797 protein denotes growth factor

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 305-327 Disease denotes mammary adenocarcinoma http://purl.obolibrary.org/obo/MONDO_0004988

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 280-290 Phenotype denotes aggressive HP:0000718
T2 297-304 Phenotype denotes ascites HP:0001541

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 459-462 OrganismTaxon denotes Hua 124939|147129

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 92-106 Body_part denotes microfilaments http://purl.obolibrary.org/obo/GO_0005884
T2 221-229 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T5 230-243 Body_part denotes microfilament http://purl.obolibrary.org/obo/GO_0005884
T6 262-272 Body_part denotes Microvilli http://purl.obolibrary.org/obo/GO_0005902|http://purl.obolibrary.org/obo/UBERON_0012423
T8 297-304 Body_part denotes ascites http://purl.obolibrary.org/obo/UBERON_0007795
T9 345-358 Body_part denotes microfilament http://purl.obolibrary.org/obo/GO_0005884
T10 674-684 Body_part denotes microvilli http://purl.obolibrary.org/obo/GO_0005902|http://purl.obolibrary.org/obo/UBERON_0012423
T12 757-765 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T15 766-779 Body_part denotes microfilament http://purl.obolibrary.org/obo/GO_0005884
T16 1261-1274 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T17 1457-1467 Body_part denotes microvilli http://purl.obolibrary.org/obo/GO_0005902|http://purl.obolibrary.org/obo/UBERON_0012423
T19 1486-1499 Body_part denotes microfilament http://purl.obolibrary.org/obo/GO_0005884
T20 1639-1647 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T23 1648-1661 Body_part denotes microfilament http://purl.obolibrary.org/obo/GO_0005884
T24 1812-1824 Body_part denotes cytoskeleton http://purl.obolibrary.org/obo/GO_0005856
T25 1882-1894 Body_part denotes cytoskeleton http://purl.obolibrary.org/obo/GO_0005856