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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-164 Sentence denotes Enhancing therapeutic glycoprotein production in Chinese hamster ovary cells by metabolic engineering endogenous gene control with antisense DNA and gene targeting.
TextSentencer_T2 165-307 Sentence denotes Recombinant glycoprotein therapeutics have proven to be invaluable pharmaceuticals for the treatment of chronic and life-threatening diseases.
TextSentencer_T3 308-475 Sentence denotes Although these molecules are extraordinarily efficacious, many diseases have high dosage requirements of several hundred milligrams of protein for each administration.
TextSentencer_T4 476-538 Sentence denotes Multiple doses at this level are often required for treatment.
TextSentencer_T5 539-744 Sentence denotes One of the major challenges currently facing the biotechnology industry is the development of large-scale, cost-effective production and manufacturing processes of these biologically synthesized molecules.
TextSentencer_T6 745-928 Sentence denotes Metabolic engineering of animal cell expression hosts promises to address this challenge by substantially enhancing recombinant protein quality, productivity, and biological activity.
TextSentencer_T7 929-1071 Sentence denotes In this report, we describe a novel approach to metabolic engineering in Chinese hamster ovary cells by control of endogenous gene expression.
TextSentencer_T8 1072-1273 Sentence denotes Analysis of the advantages and limitations of using antisense DNA and gene targeting as a means of control are discussed and several gene candidates for regulation with these techniques are identified.
TextSentencer_T9 1274-1480 Sentence denotes Practical considerations for using these technologies to reduce the levels of the CHO cell sialidase (Warner et al., Glycobiology, 3, 455-463, 1993) as a model gene system for regulation are also presented.
T1 0-164 Sentence denotes Enhancing therapeutic glycoprotein production in Chinese hamster ovary cells by metabolic engineering endogenous gene control with antisense DNA and gene targeting.
T2 165-307 Sentence denotes Recombinant glycoprotein therapeutics have proven to be invaluable pharmaceuticals for the treatment of chronic and life-threatening diseases.
T3 308-475 Sentence denotes Although these molecules are extraordinarily efficacious, many diseases have high dosage requirements of several hundred milligrams of protein for each administration.
T4 476-538 Sentence denotes Multiple doses at this level are often required for treatment.
T5 539-744 Sentence denotes One of the major challenges currently facing the biotechnology industry is the development of large-scale, cost-effective production and manufacturing processes of these biologically synthesized molecules.
T6 745-928 Sentence denotes Metabolic engineering of animal cell expression hosts promises to address this challenge by substantially enhancing recombinant protein quality, productivity, and biological activity.
T7 929-1071 Sentence denotes In this report, we describe a novel approach to metabolic engineering in Chinese hamster ovary cells by control of endogenous gene expression.
T8 1072-1273 Sentence denotes Analysis of the advantages and limitations of using antisense DNA and gene targeting as a means of control are discussed and several gene candidates for regulation with these techniques are identified.
T9 1274-1480 Sentence denotes Practical considerations for using these technologies to reduce the levels of the CHO cell sialidase (Warner et al., Glycobiology, 3, 455-463, 1993) as a model gene system for regulation are also presented.
T1 0-164 Sentence denotes Enhancing therapeutic glycoprotein production in Chinese hamster ovary cells by metabolic engineering endogenous gene control with antisense DNA and gene targeting.
T2 165-307 Sentence denotes Recombinant glycoprotein therapeutics have proven to be invaluable pharmaceuticals for the treatment of chronic and life-threatening diseases.
T3 308-475 Sentence denotes Although these molecules are extraordinarily efficacious, many diseases have high dosage requirements of several hundred milligrams of protein for each administration.
T4 476-538 Sentence denotes Multiple doses at this level are often required for treatment.
T5 539-744 Sentence denotes One of the major challenges currently facing the biotechnology industry is the development of large-scale, cost-effective production and manufacturing processes of these biologically synthesized molecules.
T6 745-928 Sentence denotes Metabolic engineering of animal cell expression hosts promises to address this challenge by substantially enhancing recombinant protein quality, productivity, and biological activity.
T7 929-1071 Sentence denotes In this report, we describe a novel approach to metabolic engineering in Chinese hamster ovary cells by control of endogenous gene expression.
T8 1072-1273 Sentence denotes Analysis of the advantages and limitations of using antisense DNA and gene targeting as a means of control are discussed and several gene candidates for regulation with these techniques are identified.
T9 1274-1480 Sentence denotes Practical considerations for using these technologies to reduce the levels of the CHO cell sialidase (Warner et al., Glycobiology, 3, 455-463, 1993) as a model gene system for regulation are also presented.

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 22-34 FMAID:167256 denotes glycoprotein
_T2 22-34 FMAID:62925 denotes glycoprotein
_T3 65-70 FMAID:7209 denotes ovary
_T4 65-70 FMAID:93687 denotes ovary
_T5 71-76 FMAID:169002 denotes cells
_T6 71-76 FMAID:68646 denotes cells
_T7 113-117 FMAID:198663 denotes gene
_T8 149-153 FMAID:198663 denotes gene
_T9 177-189 FMAID:167256 denotes glycoprotein
_T10 177-189 FMAID:62925 denotes glycoprotein
_T11 443-450 FMAID:67257 denotes protein
_T12 443-450 FMAID:165447 denotes protein
_T13 577-583 FMAID:117356 denotes facing
_T14 577-583 FMAID:24728 denotes facing
_T15 837-850 FMAID:188924 denotes substantially
_T16 873-880 FMAID:67257 denotes protein
_T17 873-880 FMAID:165447 denotes protein
_T18 1018-1023 FMAID:7209 denotes ovary
_T19 1018-1023 FMAID:93687 denotes ovary
_T20 1024-1029 FMAID:68646 denotes cells
_T21 1024-1029 FMAID:169002 denotes cells
_T22 1055-1059 FMAID:198663 denotes gene
_T23 1142-1146 FMAID:198663 denotes gene
_T24 1205-1209 FMAID:198663 denotes gene
_T25 1434-1438 FMAID:198663 denotes gene

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 71-76 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T2 366-370 http://purl.bioontology.org/ontology/NCBITAXON/9973 denotes many
T3 577-583 http://purl.bioontology.org/ontology/NCBITAXON/1240355 denotes facing
T4 1024-1029 http://purl.bioontology.org/ontology/STY/T025 denotes cells

GO-BP

Id Subject Object Predicate Lexical cue
T1 80-89 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolic
T2 745-754 http://purl.obolibrary.org/obo/GO_0008152 denotes Metabolic
T3 618-629 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T4 1055-1070 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T5 1225-1235 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T6 1450-1460 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T7 1356-1359 http://purl.obolibrary.org/obo/GO_0043848 denotes CHO
T8 1383-1385 http://purl.obolibrary.org/obo/GO_0004306 denotes et

GO-CC

Id Subject Object Predicate Lexical cue
T1 71-76 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2 777-781 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3 1360-1364 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T4 793-798 http://purl.obolibrary.org/obo/GO_0018995 denotes hosts

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 639-644 http://purl.obolibrary.org/obo/UBERON_0002542 denotes scale

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 577-583 http://purl.obolibrary.org/obo/UBERON_0001456 denotes facing
PD-UBERON-AE-B_T2 639-644 http://purl.obolibrary.org/obo/UBERON_0002542 denotes scale

Lectin

Id Subject Object Predicate Lexical cue
Lectin_T1 1386-1388 https://acgg.asia/db/lfdb/LfDB0344 denotes al

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 49-64 OrganismTaxon denotes Chinese hamster 10029
T2 1002-1017 OrganismTaxon denotes Chinese hamster 10029

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 65-70 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992
T2 639-644 Body_part denotes scale http://purl.obolibrary.org/obo/UBERON_0002542
T3 1018-1023 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992