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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 21-27 protein denotes ZAP-70
T2 67-81 protein denotes activated SHP1
T3 127-139 protein denotes SHP1 protein
T4 140-160 protein denotes tyrosine phosphatase
T5 224-247 protein denotes T cell antigen receptor
T6 249-252 protein denotes TCR
T7 298-302 protein denotes SHP1
T8 306-319 cell_type denotes T lymphocytes
T9 398-402 protein denotes SHP1
T10 481-485 protein denotes SHP1
T11 489-492 protein denotes TCR
T12 518-532 protein denotes wild-type SHP1
T13 604-610 protein denotes ZAP-70
T14 615-618 protein denotes Syk
T15 630-634 protein denotes SHP1
T16 672-687 protein denotes endogenous SHP1
T17 689-708 protein denotes Inactive SHP1-D421A
T18 713-727 protein denotes wild-type SHP2
T19 750-785 protein denotes Constitutively active SHP1-DeltaSH2
T20 818-824 protein denotes ZAP-70
T21 829-832 protein denotes Syk
T22 884-897 protein denotes SHP1-DeltaSH2
T23 934-940 protein denotes ZAP-70
T24 945-948 protein denotes Syk
T25 976-1008 protein denotes mitogen-activated protein kinase
T26 1009-1013 protein denotes Erk2
T27 1056-1074 DNA denotes interleukin-2 gene
T28 1113-1126 protein denotes SHP2-DeltaSH2
T29 1329-1343 protein denotes TCR zeta-chain
T30 1347-1368 protein denotes phospholipase Cgamma1
T31 1386-1403 protein denotes Src family kinase
T32 1478-1484 protein denotes ZAP-70
T33 1489-1492 protein denotes Syk
T34 1522-1526 protein denotes SHP1
T35 1561-1572 protein denotes SH2 domains
T36 1576-1580 protein denotes SHP1
T37 1619-1625 protein denotes ZAP-70
T38 1630-1633 protein denotes Syk
T39 1692-1696 protein denotes SHP1
T40 1734-1737 protein denotes TCR
T41 1840-1859 protein denotes inhibitory receptor
T42 1888-1892 protein denotes SHP1
T43 1901-1912 protein denotes SH2 domains
T44 1928-1932 protein denotes SHP1
T45 1964-1967 protein denotes TCR
T46 1983-2002 protein denotes inhibitory receptor
T47 2024-2027 protein denotes TCR

genia-medco-coref

Id Subject Object Predicate Lexical cue
C19 96-110 NP denotes motheaten mice
C20 112-117 NP denotes which
C21 123-160 NP denotes the SHP1 protein tyrosine phosphatase
C22 176-187 NP denotes this enzyme
C5 224-263 NP denotes T cell antigen receptor (TCR) signaling
C2 298-302 NP denotes SHP1
C3 398-402 NP denotes SHP1
C4 481-485 NP denotes SHP1
C6 489-502 NP denotes TCR signaling
C23 518-532 NP denotes wild-type SHP1
C11 604-618 NP denotes ZAP-70 and Syk
C8 630-634 NP denotes SHP1
C24 750-785 NP denotes Constitutively active SHP1-DeltaSH2
C12 818-832 NP denotes ZAP-70 and Syk
C41 884-897 NP denotes SHP1-DeltaSH2
C15 934-948 NP denotes ZAP-70 and Syk
C25 1089-1126 NP denotes a constitutively active SHP2-DeltaSH2
C27 1462-1472 NP denotes the notion
C28 1473-1477 NP denotes that
C17 1478-1492 NP denotes ZAP-70 and Syk
C18 1522-1526 NP denotes SHP1
C32 1530-1542 NP denotes intact cells
C29 1576-1580 NP denotes SHP1
C30 1600-1603 NP denotes its
C31 1619-1633 NP denotes ZAP-70 and Syk
C33 1651-1663 NP denotes intact cells
C34 1692-1696 NP denotes SHP1
C39 1829-1859 NP denotes a distinct inhibitory receptor
C36 1888-1892 NP denotes SHP1
C37 1897-1900 NP denotes its
C38 1928-1932 NP denotes SHP1
C40 1979-2002 NP denotes the inhibitory receptor
R1 C20 C19 coref-relat which,motheaten mice
R2 C22 C21 coref-ident this enzyme,the SHP1 protein tyrosine phosphatase
R3 C3 C2 coref-ident SHP1,SHP1
R4 C4 C3 coref-ident SHP1,SHP1
R5 C6 C5 coref-ident TCR signaling,T cell antigen receptor (TCR) signaling
R6 C8 C23 coref-ident SHP1,wild-type SHP1
R7 C12 C11 coref-ident ZAP-70 and Syk,ZAP-70 and Syk
R8 C41 C24 coref-other SHP1-DeltaSH2,Constitutively active SHP1-DeltaSH2
R9 C15 C12 coref-ident ZAP-70 and Syk,ZAP-70 and Syk
R10 C25 C24 coref-ident a constitutively active SHP2-DeltaSH2,Constitutively active SHP1-DeltaSH2
R11 C28 C27 coref-relat that,the notion
R12 C17 C15 coref-ident ZAP-70 and Syk,ZAP-70 and Syk
R13 C18 C3 coref-ident SHP1,SHP1
R14 C29 C18 coref-ident SHP1,SHP1
R15 C30 C29 coref-pron its,SHP1
R16 C31 C17 coref-ident ZAP-70 and Syk,ZAP-70 and Syk
R17 C33 C32 coref-ident intact cells,intact cells
R18 C34 C29 coref-ident SHP1,SHP1
R19 C36 C34 coref-ident SHP1,SHP1
R20 C37 C36 coref-pron its,SHP1
R21 C38 C36 coref-ident SHP1,SHP1
R22 C40 C39 coref-ident the inhibitory receptor,a distinct inhibitory receptor

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-82 Sentence denotes Dephosphorylation of ZAP-70 and inhibition of T cell activation by activated SHP1.
S2 83-264 Sentence denotes Studies with motheaten mice, which lack the SHP1 protein tyrosine phosphatase, indicate that this enzyme plays an important negative role in T cell antigen receptor (TCR) signaling.
S3 265-369 Sentence denotes The physiological substrates for SHP1 in T lymphocytes, however, have remained unclear or controversial.
S4 370-503 Sentence denotes To define these targets for SHP1 we have compared the effects of constitutively active and inactive mutants of SHP1 on TCR signaling.
S5 504-688 Sentence denotes Expression of wild-type SHP1 had a very small effect on the TCR-induced tyrosine phosphorylation of ZAP-70 and Syk, even when SHP1 was overexpressed 20 - 100-fold over endogenous SHP1.
S6 689-749 Sentence denotes Inactive SHP1-D421A and wild-type SHP2 were without effects.
S7 750-883 Sentence denotes Constitutively active SHP1-DeltaSH2 had a more pronounced effect on ZAP-70 and Syk, even when expressed at near physiological levels.
S8 884-1075 Sentence denotes SHP1-DeltaSH2 also inhibited events downstream of ZAP-70 and Syk, such as activation of the mitogen-activated protein kinase Erk2 and the transcriptional activation of the interleukin-2 gene.
S9 1076-1241 Sentence denotes In contrast, a constitutively active SHP2-DeltaSH2 had no statistically significant effect (although it caused a slight augmentation in some individual experiments).
S10 1242-1424 Sentence denotes None of the constructs influenced the anti-CD3-induced tyrosine phosphorylation of the TCR zeta-chain or phospholipase Cgamma1, indicating that Src family kinase function was intact.
S11 1425-1543 Sentence denotes Taken together, our findings support the notion that ZAP-70 and Syk can be direct substrates for SHP1 in intact cells.
S12 1544-1664 Sentence denotes However, the two SH2 domains of SHP1 did not facilitate its recognition of ZAP-70 and Syk as substrates in intact cells.
S13 1665-1791 Sentence denotes Therefore, we suggest that SHP1 is not actively recruited to inhibit TCR signaling induced by ligation of this receptor alone.
S14 1792-2028 Sentence denotes Instead, we propose that ligation of a distinct inhibitory receptor leads to the recruitment of SHP1 via its SH2 domains, activation of SHP1 and subsequently inhibition of TCR signals if the inhibitory receptor is juxtaposed to the TCR.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-17 other_name denotes Dephosphorylation
T2 21-27 protein_molecule denotes ZAP-70
T3 32-63 other_name denotes inhibition of T cell activation
T4 67-81 protein_molecule denotes activated SHP1
T5 96-110 other_artificial_source denotes motheaten mice
T6 127-131 protein_molecule denotes SHP1
T7 140-148 amino_acid_monomer denotes tyrosine
T8 224-247 protein_family_or_group denotes T cell antigen receptor
T9 249-252 protein_family_or_group denotes TCR
T10 298-302 protein_molecule denotes SHP1
T11 306-319 cell_type denotes T lymphocytes
T12 398-402 protein_molecule denotes SHP1
T13 481-485 protein_molecule denotes SHP1
T14 489-492 protein_family_or_group denotes TCR
T15 518-527 protein_molecule denotes wild-type
T16 528-532 protein_molecule denotes SHP1
T17 564-575 other_name denotes TCR-induced
T18 576-584 amino_acid_monomer denotes tyrosine
T19 604-610 protein_molecule denotes ZAP-70
T20 615-618 protein_molecule denotes Syk
T21 630-634 protein_molecule denotes SHP1
T22 672-682 protein_molecule denotes endogenous
T23 683-687 protein_molecule denotes SHP1
T24 689-697 protein_molecule denotes Inactive
T25 698-702 protein_molecule denotes SHP1
T26 713-727 protein_molecule denotes wild-type SHP2
T27 750-771 protein_complex denotes Constitutively active
T28 772-776 protein_molecule denotes SHP1
T29 818-824 protein_molecule denotes ZAP-70
T30 829-832 protein_molecule denotes Syk
T31 862-882 other_name denotes physiological levels
T32 884-888 protein_molecule denotes SHP1
T33 934-940 protein_molecule denotes ZAP-70
T34 945-948 protein_molecule denotes Syk
T35 976-1008 protein_family_or_group denotes mitogen-activated protein kinase
T36 1009-1013 protein_molecule denotes Erk2
T37 1056-1069 protein_molecule denotes interleukin-2
T38 1113-1126 protein_complex denotes SHP2-DeltaSH2
T39 1280-1296 other_name denotes anti-CD3-induced
T40 1297-1305 amino_acid_monomer denotes tyrosine
T41 1329-1343 protein_subunit denotes TCR zeta-chain
T42 1347-1368 protein_molecule denotes phospholipase Cgamma1
T43 1386-1403 protein_family_or_group denotes Src family kinase
T44 1478-1484 protein_molecule denotes ZAP-70
T45 1489-1492 protein_molecule denotes Syk
T46 1522-1526 protein_molecule denotes SHP1
T47 1561-1572 protein_domain_or_region denotes SH2 domains
T48 1576-1580 protein_molecule denotes SHP1
T49 1619-1625 protein_molecule denotes ZAP-70
T50 1630-1633 protein_molecule denotes Syk
T51 1692-1696 protein_molecule denotes SHP1
T52 1734-1737 protein_family_or_group denotes TCR
T53 1840-1859 protein_family_or_group denotes inhibitory receptor
T54 1888-1892 protein_molecule denotes SHP1
T55 1901-1912 protein_domain_or_region denotes SH2 domains
T56 1928-1932 protein_molecule denotes SHP1
T57 1964-1967 protein_family_or_group denotes TCR
T58 1983-2002 protein_family_or_group denotes inhibitory receptor
T59 2024-2027 protein_family_or_group denotes TCR