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PubMed:10455134 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-135 Sentence denotes AML1 (CBFalpha2) cooperates with B cell-specific activating protein (BSAP/PAX5) in activation of the B cell-specific BLK gene promoter.
T2 136-333 Sentence denotes AML1 plays a critical role during hematopoiesis and chromosomal translocations involving AML1 are commonly associated with different forms of leukemia, including pre-B acute lymphoblastic leukemia.
T3 334-603 Sentence denotes To understand the function of AML1 during B cell differentiation, we analyzed regulatory regions of B cell-specific genes for potential AML1-binding sites and have identified a putative AML1-binding site in the promoter of the B cell-specific tyrosine kinase gene, blk.
T4 604-799 Sentence denotes Gel mobility shift assays and transient transfection assays demonstrate that AML1 binds specifically to this site in the blk promoter and this binding site is important for blk promoter activity.
T5 800-990 Sentence denotes Furthermore, in vitro binding analysis revealed that the AML1 runt DNA-binding domain physically interacts with the paired DNA-binding domain of BSAP, a B cell-specific transcription factor.
T6 991-1085 Sentence denotes BSAP has been shown previously to be important for B cell-specific regulation of the blk gene.
T7 1086-1283 Sentence denotes Physical interaction of AML1 with BSAP correlates with functional cooperativity in transfection studies where AML1 and BSAP synergistically activate blk promoter transcription by more than 50-fold.
T8 1284-1466 Sentence denotes These results demonstrate physical and functional interactions between AML1 and BSAP and suggest that AML1 is an important factor for regulating a critical B cell-specific gene, blk.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 278-286 HP_0001909 denotes leukemia
T2 304-332 HP_0006721 denotes acute lymphoblastic leukemia
T3 324-332 HP_0001909 denotes leukemia

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-16 protein denotes AML1 (CBFalpha2)
T2 33-79 protein denotes B cell-specific activating protein (BSAP/PAX5)
T3 101-134 DNA denotes B cell-specific BLK gene promoter
T4 136-140 protein denotes AML1
T5 225-229 protein denotes AML1
T6 364-368 protein denotes AML1
T7 376-382 cell_type denotes B cell
T8 412-430 DNA denotes regulatory regions
T9 434-455 DNA denotes B cell-specific genes
T10 470-488 DNA denotes AML1-binding sites
T11 520-537 DNA denotes AML1-binding site
T12 561-602 DNA denotes B cell-specific tyrosine kinase gene, blk
T13 681-685 protein denotes AML1
T14 725-737 DNA denotes blk promoter
T15 777-780 DNA denotes blk
T16 857-885 DNA denotes AML1 runt DNA-binding domain
T17 916-941 DNA denotes paired DNA-binding domain
T18 945-949 protein denotes BSAP
T19 953-989 protein denotes B cell-specific transcription factor
T20 991-995 protein denotes BSAP
T21 1076-1079 DNA denotes blk
T22 1110-1114 protein denotes AML1
T23 1120-1124 protein denotes BSAP
T24 1196-1200 protein denotes AML1
T25 1205-1209 protein denotes BSAP
T26 1235-1238 DNA denotes blk
T27 1355-1359 protein denotes AML1
T28 1364-1368 protein denotes BSAP
T29 1386-1390 protein denotes AML1
T30 1440-1460 DNA denotes B cell-specific gene
T31 1462-1465 DNA denotes blk

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 0-16 NP denotes AML1 (CBFalpha2)
C2 136-140 NP denotes AML1
C3 225-229 NP denotes AML1
C4 364-368 NP denotes AML1
C30 557-597 NP denotes the B cell-specific tyrosine kinase gene
C33 599-602 NP denotes blk
C34 541-602 NP denotes the promoter of the B cell-specific tyrosine kinase gene, blk
C7 509-602 NP denotes a putative AML1-binding site in the promoter of the B cell-specific tyrosine kinase gene, blk
C10 681-685 NP denotes AML1
C13 721-737 NP denotes the blk promoter
C11 708-737 NP denotes this site in the blk promoter
C12 742-759 NP denotes this binding site
C16 853-861 NP denotes the AML1
C17 945-949 NP denotes BSAP
C15 951-989 NP denotes a B cell-specific transcription factor
C18 991-995 NP denotes BSAP
C31 1072-1084 NP denotes the blk gene
C20 1110-1114 NP denotes AML1
C21 1120-1124 NP denotes BSAP
C22 1196-1200 NP denotes AML1
C23 1205-1209 NP denotes BSAP
C25 1355-1359 NP denotes AML1
C26 1364-1368 NP denotes BSAP
C27 1386-1390 NP denotes AML1
C29 1429-1460 NP denotes a critical B cell-specific gene
C32 1462-1465 NP denotes blk
R1 C2 C1 coref-ident AML1,AML1 (CBFalpha2)
R2 C3 C2 coref-ident AML1,AML1
R3 C4 C3 coref-ident AML1,AML1
R4 C33 C30 coref-appos blk,the B cell-specific tyrosine kinase gene
R5 C10 C4 coref-ident AML1,AML1
R6 C13 C34 coref-ident the blk promoter,"the promoter of the B cell-specific tyrosine kinase gene, blk"
R7 C11 C7 coref-ident this site in the blk promoter,"a putative AML1-binding site in the promoter of the B cell-specific tyrosine kinase gene, blk"
R8 C12 C11 coref-ident this binding site,this site in the blk promoter
R9 C16 C10 coref-ident the AML1,AML1
R10 C15 C17 coref-appos a B cell-specific transcription factor,BSAP
R11 C18 C17 coref-ident BSAP,BSAP
R12 C31 C30 coref-ident the blk gene,the B cell-specific tyrosine kinase gene
R13 C20 C16 coref-ident AML1,the AML1
R14 C21 C18 coref-ident BSAP,BSAP
R15 C22 C20 coref-ident AML1,AML1
R16 C23 C21 coref-ident BSAP,BSAP
R17 C25 C22 coref-ident AML1,AML1
R18 C26 C23 coref-ident BSAP,BSAP
R19 C27 C25 coref-ident AML1,AML1
R20 C32 C29 coref-appos blk,a critical B cell-specific gene

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-135 Sentence denotes AML1 (CBFalpha2) cooperates with B cell-specific activating protein (BSAP/PAX5) in activation of the B cell-specific BLK gene promoter.
S2 136-333 Sentence denotes AML1 plays a critical role during hematopoiesis and chromosomal translocations involving AML1 are commonly associated with different forms of leukemia, including pre-B acute lymphoblastic leukemia.
S3 334-603 Sentence denotes To understand the function of AML1 during B cell differentiation, we analyzed regulatory regions of B cell-specific genes for potential AML1-binding sites and have identified a putative AML1-binding site in the promoter of the B cell-specific tyrosine kinase gene, blk.
S4 604-799 Sentence denotes Gel mobility shift assays and transient transfection assays demonstrate that AML1 binds specifically to this site in the blk promoter and this binding site is important for blk promoter activity.
S5 800-990 Sentence denotes Furthermore, in vitro binding analysis revealed that the AML1 runt DNA-binding domain physically interacts with the paired DNA-binding domain of BSAP, a B cell-specific transcription factor.
S6 991-1085 Sentence denotes BSAP has been shown previously to be important for B cell-specific regulation of the blk gene.
S7 1086-1283 Sentence denotes Physical interaction of AML1 with BSAP correlates with functional cooperativity in transfection studies where AML1 and BSAP synergistically activate blk promoter transcription by more than 50-fold.
S8 1284-1466 Sentence denotes These results demonstrate physical and functional interactions between AML1 and BSAP and suggest that AML1 is an important factor for regulating a critical B cell-specific gene, blk.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-4 protein_molecule denotes AML1
T2 6-15 protein_molecule denotes CBFalpha2
T3 33-69 protein_molecule denotes B cell-specific activating protein (
T4 69-78 protein_molecule denotes BSAP/PAX5
T5 101-134 DNA_domain_or_region denotes B cell-specific BLK gene promoter
T6 136-140 protein_molecule denotes AML1
T7 170-183 other_name denotes hematopoiesis
T8 188-214 other_name denotes chromosomal translocations
T9 225-229 protein_molecule denotes AML1
T10 278-286 other_name denotes leukemia
T11 298-332 other_name denotes pre-B acute lymphoblastic leukemia
T12 364-368 protein_molecule denotes AML1
T13 376-382 cell_type denotes B cell
T14 412-430 DNA_domain_or_region denotes regulatory regions
T15 434-455 DNA_family_or_group denotes B cell-specific genes
T16 470-474 protein_molecule denotes AML1
T17 520-524 protein_molecule denotes AML1
T18 561-602 DNA_domain_or_region denotes B cell-specific tyrosine kinase gene, blk
T19 604-629 other_name denotes Gel mobility shift assays
T20 634-656 other_name denotes transient transfection
T21 681-685 protein_molecule denotes AML1
T22 725-728 DNA_domain_or_region denotes blk
T23 777-780 DNA_domain_or_region denotes blk
T24 813-838 other_name denotes in vitro binding analysis
T25 857-861 protein_molecule denotes AML1
T26 916-941 DNA_domain_or_region denotes paired DNA-binding domain
T27 945-949 protein_molecule denotes BSAP
T28 953-959 cell_type denotes B cell
T29 991-995 protein_molecule denotes BSAP
T30 1042-1068 other_name denotes B cell-specific regulation
T31 1076-1079 DNA_domain_or_region denotes blk
T32 1110-1114 protein_molecule denotes AML1
T33 1120-1124 protein_molecule denotes BSAP
T34 1169-1181 other_name denotes transfection
T35 1196-1200 protein_molecule denotes AML1
T36 1205-1209 protein_molecule denotes BSAP
T37 1235-1238 DNA_domain_or_region denotes blk
T38 1355-1359 protein_molecule denotes AML1
T39 1364-1368 protein_molecule denotes BSAP
T40 1386-1390 protein_molecule denotes AML1
T41 1440-1460 DNA_family_or_group denotes B cell-specific gene
T42 1462-1465 DNA_domain_or_region denotes blk

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 278-286 Phenotype denotes leukemia HP:0001909
T2 302-332 Phenotype denotes B acute lymphoblastic leukemia HP:0004812

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 278-286 Disease denotes leukemia http://purl.obolibrary.org/obo/MONDO_0005059
T2 302-332 Disease denotes B acute lymphoblastic leukemia http://purl.obolibrary.org/obo/MONDO_0000814|http://purl.obolibrary.org/obo/MONDO_0000872|http://purl.obolibrary.org/obo/MONDO_0020511

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 33-39 Body_part denotes B cell http://purl.obolibrary.org/obo/CL_0000236
T2 101-107 Body_part denotes B cell http://purl.obolibrary.org/obo/CL_0000236
T3 376-382 Body_part denotes B cell http://purl.obolibrary.org/obo/CL_0000236
T4 434-440 Body_part denotes B cell http://purl.obolibrary.org/obo/CL_0000236
T5 561-567 Body_part denotes B cell http://purl.obolibrary.org/obo/CL_0000236
T6 953-959 Body_part denotes B cell http://purl.obolibrary.org/obo/CL_0000236
T7 1042-1048 Body_part denotes B cell http://purl.obolibrary.org/obo/CL_0000236
T8 1440-1446 Body_part denotes B cell http://purl.obolibrary.org/obo/CL_0000236

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 33-39 Cell denotes B cell http://purl.obolibrary.org/obo/CL:0000236
T2 101-107 Cell denotes B cell http://purl.obolibrary.org/obo/CL:0000236
T3 310-323 Cell denotes lymphoblastic http://purl.obolibrary.org/obo/CL:0017005
T4 376-382 Cell denotes B cell http://purl.obolibrary.org/obo/CL:0000236
T5 434-440 Cell denotes B cell http://purl.obolibrary.org/obo/CL:0000236
T6 561-567 Cell denotes B cell http://purl.obolibrary.org/obo/CL:0000236
T7 951-959 Cell denotes a B cell http://purl.obolibrary.org/obo/CL:4023097
T8 953-959 Cell denotes B cell http://purl.obolibrary.org/obo/CL:0000236
T9 1042-1048 Cell denotes B cell http://purl.obolibrary.org/obo/CL:0000236
T10 1440-1446 Cell denotes B cell http://purl.obolibrary.org/obo/CL:0000236