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PubMed:10455130 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 14-20 Glycan_Motif denotes core 2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO
T2 478-484 Glycan_Motif denotes core 2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO
T3 531-537 Glycan_Motif denotes core 2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO
T4 791-795 Glycan_Motif denotes SM-3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G20044TD
T5 1080-1094 Glycan_Motif denotes sialyl Lewis x https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO
T6 1087-1094 Glycan_Motif denotes Lewis x https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G01187XC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00051MO
T8 1303-1307 Glycan_Motif denotes SM-3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G20044TD
T9 1362-1373 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T10 1420-1426 Glycan_Motif denotes core 2 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00033MO

sentences

Id Subject Object Predicate Lexical cue
T1 0-165 Sentence denotes Expression of core 2 beta-1,6-N-acetylglucosaminyltransferase in a human pancreatic cancer cell line results in altered expression of MUC1 tumor-associated epitopes.
T2 166-342 Sentence denotes Many tumor-associated epitopes possess carbohydrate as a key component, and thus changes in the activity of glycosyltransferases could play a role in generating these epitopes.
T3 343-576 Sentence denotes In this report we describe the stable transfection of a human pancreatic adenocarcinoma cell line, Panc1-MUC1, with the cDNA for mucin core 2 GlcNAc-transferase (C2GnT), which creates the core 2 beta-1,6 branch in mucin-type glycans.
T4 577-662 Sentence denotes These cells lack endogenous C2GnT activity but express a recombinant human MUC1 cDNA.
T5 663-839 Sentence denotes C2GnT-transfected clones expressing different levels of C2GnT were characterized using monoclonal antibodies CC49, CSLEX-1, and SM-3, which recognize tumor-associated epitopes.
T6 840-1017 Sentence denotes Increased C2GnT expression led to greatly diminished expression of the CC49 epitope, which we identified as NeuAcalpha2,6(Galbeta1,3)GalNAcalpha-Ser/Thr in the Panc1-MUC1 cells.
T7 1018-1172 Sentence denotes This was accompanied by the emergence of the CSLEX-1 epitope, sialyl Lewis x (NeuAcalpha2,3Galbeta1,4(Fucalpha1,3)GlcNAc-R), an important selectin ligand.
T8 1173-1248 Sentence denotes Despite this, however, the C2GnT transfectants could not bind to selectins.
T9 1249-1456 Sentence denotes Increased C2GnT expression also led to masking of the SM-3 peptide epitope, which persisted after the removal of sialic acid, further suggesting greater complexity of the core 2-associated O-glycans on MUC1.
T10 1457-1586 Sentence denotes The results of this study suggest that C2GnT could play a regulatory role in the expression of certain tumor-associated epitopes.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 791-795 https://glytoucan.org/Structures/Glycans/G20044TD denotes SM-3
T2 1080-1094 https://glytoucan.org/Structures/Glycans/G00054MO denotes sialyl Lewis x
T3 1087-1094 https://glytoucan.org/Structures/Glycans/G00051MO denotes Lewis x
T4 1087-1094 https://glytoucan.org/Structures/Glycans/G01187XC denotes Lewis x
T5 1303-1307 https://glytoucan.org/Structures/Glycans/G20044TD denotes SM-3
T6 1362-1373 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 772-776 http://www.glycoepitope.jp/epitopes/AN0086 denotes CC49
T2 911-915 http://www.glycoepitope.jp/epitopes/AN0086 denotes CC49
T3 1080-1094 http://www.glycoepitope.jp/epitopes/EP0012 denotes sialyl Lewis x
T4 1087-1094 http://www.glycoepitope.jp/epitopes/EP0011 denotes Lewis x

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 171-176 HP_0002664 denotes tumor
T2 405-430 HP_0006725 denotes pancreatic adenocarcinoma
T3 813-818 HP_0002664 denotes tumor
T4 1560-1565 HP_0002664 denotes tumor

NGLY1-deficiency

Id Subject Object Predicate Lexical cue
PD-NGLY1-deficiency-B_T1 485-491 chem:24139 denotes GlcNAc
PD-NGLY1-deficiency-B_T2 1132-1138 chem:24139 denotes GlcNAc

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
10455130-0#21#61#gene2650 21-61 gene2650 denotes beta-1,6-N-acetylglucosaminyltransferase
10455130-0#21#61#gene140687 21-61 gene140687 denotes beta-1,6-N-acetylglucosaminyltransferase
10455130-0#73#90#diseaseC0235974 73-90 diseaseC0235974 denotes pancreatic cancer
10455130-0#73#90#diseaseC0346647 73-90 diseaseC0346647 denotes pancreatic cancer
10455130-0#73#90#diseaseC0235974 73-90 diseaseC0235974 denotes pancreatic cancer
10455130-0#73#90#diseaseC0346647 73-90 diseaseC0346647 denotes pancreatic cancer
21#61#gene265073#90#diseaseC0235974 10455130-0#21#61#gene2650 10455130-0#73#90#diseaseC0235974 associated_with "beta-1,6-N-acetylglucosaminyltransferase",pancreatic cancer
21#61#gene265073#90#diseaseC0346647 10455130-0#21#61#gene2650 10455130-0#73#90#diseaseC0346647 associated_with "beta-1,6-N-acetylglucosaminyltransferase",pancreatic cancer
21#61#gene265073#90#diseaseC0235974 10455130-0#21#61#gene2650 10455130-0#73#90#diseaseC0235974 associated_with "beta-1,6-N-acetylglucosaminyltransferase",pancreatic cancer
21#61#gene265073#90#diseaseC0346647 10455130-0#21#61#gene2650 10455130-0#73#90#diseaseC0346647 associated_with "beta-1,6-N-acetylglucosaminyltransferase",pancreatic cancer
21#61#gene14068773#90#diseaseC0235974 10455130-0#21#61#gene140687 10455130-0#73#90#diseaseC0235974 associated_with "beta-1,6-N-acetylglucosaminyltransferase",pancreatic cancer
21#61#gene14068773#90#diseaseC0346647 10455130-0#21#61#gene140687 10455130-0#73#90#diseaseC0346647 associated_with "beta-1,6-N-acetylglucosaminyltransferase",pancreatic cancer
21#61#gene14068773#90#diseaseC0235974 10455130-0#21#61#gene140687 10455130-0#73#90#diseaseC0235974 associated_with "beta-1,6-N-acetylglucosaminyltransferase",pancreatic cancer
21#61#gene14068773#90#diseaseC0346647 10455130-0#21#61#gene140687 10455130-0#73#90#diseaseC0346647 associated_with "beta-1,6-N-acetylglucosaminyltransferase",pancreatic cancer

DisGeNET

Id Subject Object Predicate Lexical cue
T0 21-61 gene:140687 denotes beta-1,6-N-acetylglucosaminyltransferase
T1 73-90 disease:C0235974 denotes pancreatic cancer
T2 21-61 gene:140687 denotes beta-1,6-N-acetylglucosaminyltransferase
T3 73-90 disease:C0346647 denotes pancreatic cancer
T4 21-61 gene:2650 denotes beta-1,6-N-acetylglucosaminyltransferase
T5 73-90 disease:C0235974 denotes pancreatic cancer
T6 21-61 gene:2650 denotes beta-1,6-N-acetylglucosaminyltransferase
T7 73-90 disease:C0346647 denotes pancreatic cancer
R1 T0 T1 associated_with "beta-1,6-N-acetylglucosaminyltransferase",pancreatic cancer
R2 T2 T3 associated_with "beta-1,6-N-acetylglucosaminyltransferase",pancreatic cancer
R3 T4 T5 associated_with "beta-1,6-N-acetylglucosaminyltransferase",pancreatic cancer
R4 T6 T7 associated_with "beta-1,6-N-acetylglucosaminyltransferase",pancreatic cancer

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 14-20 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO
T2 478-484 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO
T3 531-537 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO
T4 791-795 Glycan denotes SM-3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G20044TD
T5 1080-1094 Glycan denotes sialyl Lewis x https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO
T6 1303-1307 Glycan denotes SM-3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G20044TD
T7 1420-1426 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 73-90 Disease denotes pancreatic cancer http://purl.obolibrary.org/obo/MONDO_0005192|http://purl.obolibrary.org/obo/MONDO_0009831
T3 139-144 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T4 171-176 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T5 405-430 Disease denotes pancreatic adenocarcinoma http://purl.obolibrary.org/obo/MONDO_0006047
T6 813-818 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T7 1560-1565 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 73-90 Phenotype denotes pancreatic cancer HP:0002894
T2 139-144 Phenotype denotes tumor HP:0002664
T3 171-176 Phenotype denotes tumor HP:0002664
T4 405-430 Phenotype denotes pancreatic adenocarcinoma HP:0006725
T5 813-818 Phenotype denotes tumor HP:0002664
T6 1560-1565 Phenotype denotes tumor HP:0002664

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 14-20 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO
T2 478-484 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO
T3 531-537 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO
T4 1080-1094 Glycan denotes sialyl Lewis x https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO
T5 1420-1426 Glycan denotes core 2 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00033MO

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 772-776 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes CC49 http://www.glycoepitope.jp/epitopes/AN0086
T2 911-915 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes CC49 http://www.glycoepitope.jp/epitopes/AN0086
T3 1080-1094 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes sialyl Lewis x http://www.glycoepitope.jp/epitopes/EP0012

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 73-90 Phenotype denotes pancreatic cancer HP:0002894
T2 139-144 Phenotype denotes tumor HP:0002664
T3 171-176 Phenotype denotes tumor HP:0002664
T4 405-430 Phenotype denotes pancreatic adenocarcinoma HP:0006725
T5 813-818 Phenotype denotes tumor HP:0002664
T6 1560-1565 Phenotype denotes tumor HP:0002664

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 84-95 Cell denotes cancer cell http://purl.obolibrary.org/obo/CL:0001064

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 73-90 Disease denotes pancreatic cancer MONDO:0005192|MONDO:0009831
T3 139-144 Disease denotes tumor MONDO:0005070
T4 171-176 Disease denotes tumor MONDO:0005070
T5 405-430 Disease denotes pancreatic adenocarcinoma MONDO:0006047
T6 813-818 Disease denotes tumor MONDO:0005070
T7 1560-1565 Disease denotes tumor MONDO:0005070

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 772-776 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes CC49 http://www.glycoepitope.jp/epitopes/AN0086
T2 911-915 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes CC49 http://www.glycoepitope.jp/epitopes/AN0086
T3 1080-1094 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes sialyl Lewis x http://www.glycoepitope.jp/epitopes/EP0012

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 67-72 Organism denotes human 9606
T2 399-404 Organism denotes human 9606
T3 646-651 Organism denotes human 9606

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-165 Sentence denotes Expression of core 2 beta-1,6-N-acetylglucosaminyltransferase in a human pancreatic cancer cell line results in altered expression of MUC1 tumor-associated epitopes.
T2 166-342 Sentence denotes Many tumor-associated epitopes possess carbohydrate as a key component, and thus changes in the activity of glycosyltransferases could play a role in generating these epitopes.
T3 343-576 Sentence denotes In this report we describe the stable transfection of a human pancreatic adenocarcinoma cell line, Panc1-MUC1, with the cDNA for mucin core 2 GlcNAc-transferase (C2GnT), which creates the core 2 beta-1,6 branch in mucin-type glycans.
T4 577-662 Sentence denotes These cells lack endogenous C2GnT activity but express a recombinant human MUC1 cDNA.
T5 663-839 Sentence denotes C2GnT-transfected clones expressing different levels of C2GnT were characterized using monoclonal antibodies CC49, CSLEX-1, and SM-3, which recognize tumor-associated epitopes.
T6 840-1017 Sentence denotes Increased C2GnT expression led to greatly diminished expression of the CC49 epitope, which we identified as NeuAcalpha2,6(Galbeta1,3)GalNAcalpha-Ser/Thr in the Panc1-MUC1 cells.
T7 1018-1172 Sentence denotes This was accompanied by the emergence of the CSLEX-1 epitope, sialyl Lewis x (NeuAcalpha2,3Galbeta1,4(Fucalpha1,3)GlcNAc-R), an important selectin ligand.
T8 1173-1248 Sentence denotes Despite this, however, the C2GnT transfectants could not bind to selectins.
T9 1249-1456 Sentence denotes Increased C2GnT expression also led to masking of the SM-3 peptide epitope, which persisted after the removal of sialic acid, further suggesting greater complexity of the core 2-associated O-glycans on MUC1.
T10 1457-1586 Sentence denotes The results of this study suggest that C2GnT could play a regulatory role in the expression of certain tumor-associated epitopes.

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 67-72 OrganismTaxon denotes human 9606
T2 399-404 OrganismTaxon denotes human 9606
T3 646-651 OrganismTaxon denotes human 9606

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 84-95 Cell denotes cancer cell http://purl.obolibrary.org/obo/CL:0001064