> top > docs > PubMed:10449794 > annotations

PubMed:10449794 JSONTXT

Annnotations TAB JSON ListView MergeView

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 89-291 DRI_Background denotes Ataxia-telangiectasia (A-T) is characterized by a markedly increased sensitivity to ionizing radiation, increased incidence of cancer, and neurodegeneration, especially of the cerebellar Purkinje cells.
T2 292-416 DRI_Background denotes Ionizing radiation oxidizes macromolecules and causes tissue damage through the generation of reactive oxygen species (ROS).
T3 417-535 DRI_Challenge denotes We therefore hypothesized that A-T is due to oxidative damage resulting from loss of function of the A-T gene product.
T4 536-635 DRI_Approach denotes To assess this hypothesis, we employed an animal model of A-T, the mouse with a disrupted Atm gene.
T5 636-809 DRI_Outcome denotes We show that organs which develop pathologic changes in the Atm-deficient mice are targets of oxidative damage, and that cerebellar Purkinje cells are particularly affected.
T6 810-938 DRI_Background denotes These observations provide a mechanistic basis for the A-T phenotype and lay a rational foundation for therapeutic intervention.

PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 12-33 DiseaseOrPhenotypicFeature denotes ataxia-telangiectasia 0008840
T2 89-110 DiseaseOrPhenotypicFeature denotes Ataxia-telangiectasia 0008840
T3 158-169 DiseaseOrPhenotypicFeature denotes sensitivity 0000605

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 89-95 HP_0001251 denotes Ataxia
T2 96-110 HP_0001009 denotes telangiectasia
T3 216-222 HP_0002664 denotes cancer
T4 228-245 HP_0002180 denotes neurodegeneration

NCBIDiseaseCorpus

Id Subject Object Predicate Lexical cue
T1 12-33 Modifier:D001260 denotes ataxia-telangiectasia
T2 89-110 SpecificDisease:D001260 denotes Ataxia-telangiectasia
T3 112-115 SpecificDisease:D001260 denotes A-T
T4 216-222 DiseaseClass:D009369 denotes cancer
T5 228-245 DiseaseClass:D019636 denotes neurodegeneration
T6 448-451 SpecificDisease:D001260 denotes A-T
T7 518-521 Modifier:D001260 denotes A-T
T8 594-597 SpecificDisease:D001260 denotes A-T
T9 865-868 Modifier:D001260 denotes A-T

NCBI-Disease-Train

Id Subject Object Predicate Lexical cue database_id
T2544 12-33 Modifier denotes ataxia-telangiectasia D001260
T2545 89-110 SpecificDisease denotes Ataxia-telangiectasia D001260
T2546 112-115 SpecificDisease denotes A-T D001260
T2547 216-222 DiseaseClass denotes cancer D009369
T2548 228-245 DiseaseClass denotes neurodegeneration D019636
T2549 448-451 SpecificDisease denotes A-T D001260
T2550 518-521 Modifier denotes A-T D001260
T2551 594-597 SpecificDisease denotes A-T D001260
T2552 865-868 Modifier denotes A-T D001260

NCBI-Disease-Corpus-All

Id Subject Object Predicate Lexical cue database_id
T2544 12-33 Modifier denotes ataxia-telangiectasia D001260
T2545 89-110 SpecificDisease denotes Ataxia-telangiectasia D001260
T2546 112-115 SpecificDisease denotes A-T D001260
T2547 216-222 DiseaseClass denotes cancer D009369
T2548 228-245 DiseaseClass denotes neurodegeneration D019636
T2549 448-451 SpecificDisease denotes A-T D001260
T2550 518-521 Modifier denotes A-T D001260
T2551 594-597 SpecificDisease denotes A-T D001260
T2552 865-868 Modifier denotes A-T D001260

NCBI-Disease-Corpus-2stage-All

Id Subject Object Predicate Lexical cue
T1 12-33 Modifier denotes ataxia-telangiectasia
T2 89-110 SpecificDisease denotes Ataxia-telangiectasia
T3 112-115 SpecificDisease denotes A-T
T4 216-222 DiseaseClass denotes cancer
T5 448-451 SpecificDisease denotes A-T
T6 518-521 Modifier denotes A-T
T7 594-597 Modifier denotes A-T
T8 696-714 Modifier denotes Atm-deficient mice
T9 865-868 Modifier denotes A-T

NCBI-Disease-Corpus-rezarta-All

Id Subject Object Predicate Lexical cue
T1 12-33 Modifier denotes ataxia-telangiectasia
T2 89-110 SpecificDisease denotes Ataxia-telangiectasia
T3 112-115 SpecificDisease denotes A-T
T4 216-222 DiseaseClass denotes cancer
T5 448-451 SpecificDisease denotes A-T
T6 518-521 Modifier denotes A-T
T7 594-597 SpecificDisease denotes A-T
T8 865-868 SpecificDisease denotes A-T

NCBI-Disease-Corpus-4oGuideline-All

Id Subject Object Predicate Lexical cue
T1 12-33 SpecificDisease denotes ataxia-telangiectasia
T2 89-116 SpecificDisease denotes Ataxia-telangiectasia (A-T)
T3 216-222 DiseaseClass denotes cancer
T4 448-451 SpecificDisease denotes A-T
T5 518-521 SpecificDisease denotes A-T
T6 594-597 SpecificDisease denotes A-T
T7 865-868 SpecificDisease denotes A-T

NCBI-Disease-Corpus-Simple-All

Id Subject Object Predicate Lexical cue
T1 12-33 SpecificDisease denotes ataxia-telangiectasia
T2 89-116 SpecificDisease denotes Ataxia-telangiectasia (A-T)
T3 173-181 Modifier denotes ionizing
T4 216-222 DiseaseClass denotes cancer
T5 228-245 DiseaseClass denotes neurodegeneration
T6 292-300 Modifier denotes Ionizing
T7 346-359 CompositeMention denotes tissue damage
T8 386-394 Modifier denotes reactive
T9 448-451 SpecificDisease denotes A-T
T10 518-521 SpecificDisease denotes A-T
T11 594-597 SpecificDisease denotes A-T
T12 626-629 SpecificDisease denotes Atm
T13 649-688 CompositeMention denotes organs which develop pathologic changes
T14 696-709 Modifier denotes Atm-deficient
T15 865-868 SpecificDisease denotes A-T