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PubMed:10446999 JSONTXT

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PubmedHPO

Id Subject Object Predicate Lexical cue
T1 158-180 HP_0004808 denotes acute myeloid leukemia
T2 164-180 HP_0012324 denotes myeloid leukemia
T3 172-180 HP_0001909 denotes leukemia
T4 840-862 HP_0004808 denotes acute myeloid leukemia
T5 846-862 HP_0012324 denotes myeloid leukemia
T6 854-862 HP_0001909 denotes leukemia

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 26-44 protein denotes vitamin D receptor
T2 109-137 cell_line denotes M2-type leukemic blast cells
T3 158-192 cell_type denotes acute myeloid leukemia blast cells
T4 289-309 cell_line denotes M0/M1 leukemic cells
T5 363-380 cell_line denotes M3 leukemic cells
T6 483-506 cell_line denotes M2 leukemic blast cells
T7 657-679 cell_type denotes M2-type leukemic cells
T8 792-806 cell_line denotes M2 blast cells
T9 821-835 cell_line denotes Kasumi-1 cells
T10 840-880 cell_line denotes acute myeloid leukemia M2-type cell line
T11 975-986 protein denotes VD receptor
T12 988-991 protein denotes VDR
T13 1033-1036 protein denotes VDR
T14 1076-1090 cell_line denotes Kasumi-1 cells
T15 1135-1154 protein denotes retinoid X receptor
T16 1167-1204 DNA denotes DR3-type vitamin D-responsive element
T17 1243-1295 DNA denotes vitamin D-responsive element-regulated reporter gene
T18 1329-1348 DNA denotes VD-responsive genes
T19 1382-1396 cell_line denotes Kasumi-1 cells
T20 1571-1574 protein denotes VDR
T21 1632-1648 cell_line denotes M2 leukemic cell

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 13-44 NP denotes a functional vitamin D receptor
C2 109-137 NP denotes M2-type leukemic blast cells
C4 237-267 NP denotes all-trans-retinoic acid (ATRA)
C5 272-287 NP denotes vitamin D3 (VD)
C3 237-287 NP denotes all-trans-retinoic acid (ATRA) and vitamin D3 (VD)
C6 479-481 NP denotes VD
C7 483-506 NP denotes M2 leukemic blast cells
C8 534-538 NP denotes they
C9 578-611 NP denotes both the differentiation inducers
C11 765-769 NP denotes ATRA
C12 774-776 NP denotes VD
C10 765-776 NP denotes ATRA and VD
C13 821-881 NP denotes Kasumi-1 cells (an acute myeloid leukemia M2-type cell line)
C15 909-913 NP denotes ATRA
C16 925-927 NP denotes VD
C14 909-927 NP denotes ATRA as well as VD
C17 975-992 NP denotes VD receptor (VDR)
C18 1006-1031 NP denotes monocytic differentiation
C19 1033-1036 NP denotes VDR
C20 1099-1101 NP denotes it
C21 1382-1396 NP denotes Kasumi-1 cells
C22 1445-1470 NP denotes monocytic differentiation
C23 1485-1508 NP denotes The molecular mechanism
C24 1512-1517 NP denotes which
C25 1518-1522 NP denotes ATRA
C26 1558-1574 NP denotes a functional VDR
C27 1679-1704 NP denotes monocytic differentiation
R1 C6 C5 coref-ident VD,vitamin D3 (VD)
R2 C7 C2 coref-ident M2 leukemic blast cells,M2-type leukemic blast cells
R3 C8 C7 coref-pron they,M2 leukemic blast cells
R4 C9 C3 coref-ident both the differentiation inducers,all-trans-retinoic acid (ATRA) and vitamin D3 (VD)
R5 C11 C4 coref-ident ATRA,all-trans-retinoic acid (ATRA)
R6 C12 C6 coref-ident VD,VD
R7 C10 C9 coref-ident ATRA and VD,both the differentiation inducers
R8 C15 C11 coref-ident ATRA,ATRA
R9 C16 C12 coref-ident VD,VD
R10 C14 C10 coref-ident ATRA as well as VD,ATRA and VD
R11 C19 C17 coref-ident VDR,VD receptor (VDR)
R12 C20 C19 coref-pron it,VDR
R13 C21 C13 coref-ident Kasumi-1 cells,Kasumi-1 cells (an acute myeloid leukemia M2-type cell line)
R14 C22 C18 coref-ident monocytic differentiation,monocytic differentiation
R15 C24 C23 coref-relat which,The molecular mechanism
R16 C25 C15 coref-ident ATRA,ATRA
R17 C26 C1 coref-ident a functional VDR,a functional vitamin D receptor
R18 C27 C22 coref-ident monocytic differentiation,monocytic differentiation

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-138 Sentence denotes Induction of a functional vitamin D receptor in all-trans-retinoic acid-induced monocytic differentiation of M2-type leukemic blast cells.
S2 139-288 Sentence denotes Different types of acute myeloid leukemia blast cells were induced to differentiate in vitro with all-trans-retinoic acid (ATRA) and vitamin D3 (VD).
S3 289-482 Sentence denotes M0/M1 leukemic cells are not sensitive to differentiating agents, whereas M3 leukemic cells are induced to undergo granulocytic differentiation after ATRA treatment but are not sensitive to VD.
S4 483-612 Sentence denotes M2 leukemic blast cells behave differently because they undergo monocytic differentiation with both the differentiation inducers.
S5 613-882 Sentence denotes To gain some insight into the maturation of M2-type leukemic cells, we studied the molecular mechanisms underlying monocytic differentiation induced by ATRA and VD in spontaneous M2 blast cells as well as in Kasumi-1 cells (an acute myeloid leukemia M2-type cell line).
S6 883-1032 Sentence denotes Our results indicate that ATRA as well as VD efficiently increases the nuclear abundance of VD receptor (VDR) and promotes monocytic differentiation.
S7 1033-1296 Sentence denotes VDR is functionally active in ATRA-treated Kasumi-1 cells because it efficiently heterodimerizes with retinoid X receptor, binds to a DR3-type vitamin D-responsive element, and activates the transcription of a vitamin D-responsive element-regulated reporter gene.
S8 1297-1484 Sentence denotes Consistent with these findings, VD-responsive genes are induced by ATRA treatment of Kasumi-1 cells, suggesting that the genetic program underlying monocytic differentiation is activated.
S9 1485-1705 Sentence denotes The molecular mechanism by which ATRA increases the nuclear abundance of a functional VDR is still unknown, but our data clearly indicate that the M2 leukemic cell context is only permissive of monocytic differentiation.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 26-44 protein_family_or_group denotes vitamin D receptor
T2 48-71 other_organic_compound denotes all-trans-retinoic acid
T3 109-137 cell_line denotes M2-type leukemic blast cells
T4 158-192 cell_type denotes acute myeloid leukemia blast cells
T5 237-260 other_organic_compound denotes all-trans-retinoic acid
T6 262-266 other_organic_compound denotes ATRA
T7 272-282 lipid denotes vitamin D3
T8 284-286 lipid denotes VD
T9 289-309 cell_line denotes M0/M1 leukemic cells
T10 331-353 other_organic_compound denotes differentiating agents
T11 363-380 cell_line denotes M3 leukemic cells
T12 404-432 other_name denotes granulocytic differentiation
T13 439-443 other_organic_compound denotes ATRA
T14 479-481 lipid denotes VD
T15 483-506 cell_line denotes M2 leukemic blast cells
T16 547-572 other_name denotes monocytic differentiation
T17 657-679 cell_type denotes M2-type leukemic cells
T18 728-753 other_name denotes monocytic differentiation
T19 765-769 other_organic_compound denotes ATRA
T20 774-776 lipid denotes VD
T21 792-806 cell_line denotes M2 blast cells
T22 821-835 cell_line denotes Kasumi-1 cells
T23 840-880 cell_line denotes acute myeloid leukemia M2-type cell line
T24 909-913 other_organic_compound denotes ATRA
T25 925-927 lipid denotes VD
T26 975-977 lipid denotes VD
T27 988-991 protein_family_or_group denotes VDR
T28 1033-1036 protein_family_or_group denotes VDR
T29 1063-1067 other_organic_compound denotes ATRA
T30 1076-1090 cell_line denotes Kasumi-1 cells
T31 1135-1154 protein_molecule denotes retinoid X receptor
T32 1167-1204 DNA_domain_or_region denotes DR3-type vitamin D-responsive element
T33 1243-1295 DNA_domain_or_region denotes vitamin D-responsive element-regulated reporter gene
T34 1329-1331 lipid denotes VD
T35 1364-1368 other_organic_compound denotes ATRA
T36 1382-1396 cell_line denotes Kasumi-1 cells
T37 1489-1508 other_name denotes molecular mechanism
T38 1518-1522 other_organic_compound denotes ATRA
T39 1571-1574 protein_family_or_group denotes VDR
T40 1632-1648 cell_line denotes M2 leukemic cell
T41 1679-1704 other_name denotes monocytic differentiation