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PubmedHPO

Id Subject Object Predicate Lexical cue
T1 485-500 HP_0002621 denotes atherosclerosis
T2 721-726 HP_0002664 denotes tumor

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 15-23 protein denotes TNFalpha
T2 33-41 protein denotes NFkappaB
T3 124-127 protein denotes IKK
T4 131-143 cell_line denotes ECV304 cells
T5 407-428 protein denotes nuclear factor-kappaB
T6 430-438 protein denotes NFkappaB
T7 534-542 protein denotes NFkappaB
T8 647-655 protein denotes NFkappaB
T9 674-681 protein denotes IkappaB
T10 693-705 cell_line denotes ECV304 cells
T11 721-748 protein denotes tumor necrosis factor-alpha
T12 750-758 protein denotes TNFalpha
T13 834-848 protein denotes IkappaB kinase
T14 850-853 protein denotes IKK
T15 1026-1029 protein denotes IKK
T16 1078-1090 protein denotes IkappaBalpha
T17 1095-1106 protein denotes IkappaBbeta
T18 1188-1196 protein denotes NFkappaB
T19 1258-1270 cell_line denotes ECV304 cells
T20 1386-1394 protein denotes NFkappaB
T21 1394-1402 protein denotes /IkappaB

genia-medco-coref

Id Subject Object Predicate Lexical cue
C14 54-63 NP denotes myricetin
C9 108-127 NP denotes the activity of IKK
C7 131-143 NP denotes ECV304 cells
C1 145-155 NP denotes Flavonoids
C3 354-364 NP denotes flavonoids
C4 403-439 NP denotes the nuclear factor-kappaB (NFkappaB)
C5 534-542 NP denotes NFkappaB
C6 633-643 NP denotes flavonoids
C20 647-689 NP denotes NFkappaB/inhibitor-kappaB (IkappaB) system
C8 693-705 NP denotes ECV304 cells
C12 816-830 NP denotes six flavonoids
C10 834-863 NP denotes IkappaB kinase (IKK) activity
C11 865-958 NP denotes an enzyme recently found to phosphorylate critical serine residues of IkappaB for degradation
C13 963-984 NP denotes six flavonoids tested
C15 986-995 NP denotes myricetin
C16 1026-1045 NP denotes IKK kinase activity
C17 1152-1161 NP denotes myricetin
C18 1258-1270 NP denotes ECV304 cells
C19 1299-1309 NP denotes flavonoids
C21 1386-1409 NP denotes NFkappaB/IkappaB system
R1 C3 C1 coref-ident flavonoids,Flavonoids
R2 C5 C4 coref-ident NFkappaB,the nuclear factor-kappaB (NFkappaB)
R3 C6 C3 coref-ident flavonoids,flavonoids
R4 C8 C7 coref-ident ECV304 cells,ECV304 cells
R5 C10 C9 coref-ident IkappaB kinase (IKK) activity,the activity of IKK
R6 C11 C10 coref-appos an enzyme recently found to phosphorylate critical serine residues of IkappaB for degradation,IkappaB kinase (IKK) activity
R7 C13 C12 coref-ident six flavonoids tested,six flavonoids
R8 C15 C14 coref-ident myricetin,myricetin
R9 C16 C10 coref-ident IKK kinase activity,IkappaB kinase (IKK) activity
R10 C17 C15 coref-ident myricetin,myricetin
R11 C18 C8 coref-ident ECV304 cells,ECV304 cells
R12 C19 C6 coref-ident flavonoids,flavonoids
R13 C21 C20 coref-ident NFkappaB/IkappaB system,NFkappaB/inhibitor-kappaB (IkappaB) system

semrep-sample

Id Subject Object Predicate Lexical cue
E1-ti-1 0-11 cui:C0439181 denotes Suppression
E2-ti-1 15-23 cui:C1448177 denotes TNFalpha
E3-ti-1 24-32 cui:C0086597 denotes mediated
E4-ti-1 33-41 cui:C0521447 denotes NFkappaB
E5-ti-1 42-50 cui:C0439167 denotes activity
E6-ti-1 54-63 cui:C0067067 denotes myricetin
E7-ti-1 74-84 cui:C0596577 denotes flavonoids
E8-ti-1 112-120 cui:C0439167 denotes activity
E9-ti-1 138-143 cui:C0007634 denotes cells
T1 54-84 ISA denotes myricetin and other flavonoids
T2 54-84 ISA denotes myricetin and other flavonoids
T3 128-130 LOCATION_OF denotes in
T4 128-130 LOCATION_OF denotes in
T5 54-84 LOCATION_OF denotes myricetin and other flavonoids
T6 54-84 LOCATION_OF denotes myricetin and other flavonoids
E1-ab-1 145-155 cui:C0596577 denotes Flavonoids
E2-ab-1 162-167 cui:C0441833 denotes group
E3-ab-1 191-199 cui:C0359916 denotes phenolic
E4-ab-1 200-209 cui:C0205198 denotes compounds
E5-ab-1 217-222 cui:C0032098 denotes plant
E6-ab-1 241-251 cui:C0596577 denotes flavonoids
E7-ab-1 267-275 cui:C0005847 denotes vascular
E8-ab-1 276-286 cui:C0033613 denotes protective
E9-ab-1 287-297 cui:C0871161 denotes properties
E1-ab-2 320-330 cui:C0033613 denotes protective
E2-ab-2 331-339 cui:C0871261 denotes response
E3-ab-2 354-364 cui:C0596577 denotes flavonoids
E4-ab-2 368-371 cui:C1518422 denotes not
E5-ab-2 372-376 cui:C0205170 denotes well
E1-ab-3 395-399 cui:C0449911 denotes view
E2-ab-3 407-414 cui:C0521447 denotes nuclear
E3-ab-3 415-421 cui:C1521761 denotes factor
E4-ab-3 451-458 cui:C0205099 denotes central
E5-ab-3 459-463 cui:C0035820 denotes role
E6-ab-3 485-500 cui:C0004153 denotes atherosclerosis
E7-ab-3 502-512 cui:C0687732 denotes prevention
E8-ab-3 534-542 cui:C0521447 denotes NFkappaB
E9-ab-3 534-542 cui:C1521761 denotes NFkappaB
E10-ab-3 567-571 cui:C0035820 denotes role
E11-ab-3 586-601 cui:C0178324 denotes vascular injury
T7 572-574 COEXISTS_WITH denotes in
E1-ab-4 611-616 cui:C0008972 denotes study
E2-ab-4 622-629 cui:C1280500 denotes effects
E3-ab-4 633-643 cui:C0596577 denotes flavonoids
E4-ab-4 647-655 cui:C0521447 denotes NFkappaB
E5-ab-4 647-655 cui:C1521761 denotes NFkappaB
E6-ab-4 656-665 cui:C0243077 denotes inhibitor
E7-ab-4 683-689 cui:C0449913 denotes system
E8-ab-4 700-705 cui:C0007634 denotes cells
E9-ab-4 721-748 cui:C1448177 denotes tumor necrosis factor-alpha
T8 690-692 LOCATION_OF denotes in
T9 706-715 STIMULATES denotes activated
E1-ab-5 795-805 cui:C0243077 denotes inhibitory
E2-ab-5 816-819 cui:C0205452 denotes six
E3-ab-5 820-830 cui:C0596577 denotes flavonoids
E4-ab-5 834-841 cui:C0243077 denotes IkappaB
E5-ab-5 842-848 cui:C0031727 denotes kinase
E6-ab-5 855-863 cui:C0439167 denotes activity
E7-ab-5 868-874 cui:C0014442 denotes enzyme
E8-ab-5 875-883 cui:C0332185 denotes recently
E9-ab-5 907-915 cui:C1511545 denotes critical
E10-ab-5 916-922 cui:C0036720 denotes serine
E11-ab-5 923-931 cui:C1609982 denotes residues
E12-ab-5 935-942 cui:C0243077 denotes IkappaB
E13-ab-5 947-958 cui:C0243125 denotes degradation
E1-ab-6 963-966 cui:C0205452 denotes six
E2-ab-6 967-977 cui:C0596577 denotes flavonoids
E3-ab-6 986-995 cui:C0067067 denotes myricetin
E4-ab-6 1030-1045 cui:C1150423 denotes kinase activity
E5-ab-6 1063-1074 cui:C0243125 denotes degradation
E6-ab-6 1078-1090 cui:C0126732 denotes IkappaBalpha
E7-ab-6 1095-1106 cui:C0166033 denotes IkappaBbeta
E8-ab-6 1110-1119 cui:C1515877 denotes activated
E9-ab-6 1120-1137 cui:C0225336 denotes endothelial cells
T10 1107-1109 LOCATION_OF denotes in
T11 1107-1109 LOCATION_OF denotes in
E1-ab-7 1152-1161 cui:C0067067 denotes myricetin
E2-ab-7 1188-1196 cui:C0521447 denotes NFkappaB
E3-ab-7 1188-1196 cui:C1521761 denotes NFkappaB
E4-ab-7 1197-1205 cui:C0439167 denotes activity
E5-ab-7 1222-1233 cui:C0439181 denotes suppression
E6-ab-7 1237-1245 cui:C0026473 denotes monocyte
E7-ab-7 1246-1254 cui:C0001511 denotes adhesion
E8-ab-7 1265-1270 cui:C0007634 denotes cells
T12 1222-1233 DISRUPTS denotes suppression
T13 1237-1254 LOCATION_OF denotes monocyte adhesion
E1-ab-8 1299-1309 cui:C0596577 denotes flavonoids
E2-ab-8 1320-1331 cui:C0302350 denotes therapeutic
E3-ab-8 1342-1358 cui:C0042373 denotes vascular disease
E4-ab-8 1367-1382 cui:C0013081 denotes down regulation
E5-ab-8 1386-1394 cui:C0521447 denotes NFkappaB
E6-ab-8 1386-1394 cui:C1521761 denotes NFkappaB
E7-ab-8 1395-1402 cui:C0243077 denotes IkappaB
E8-ab-8 1403-1409 cui:C0449913 denotes system
R1 E6-ti-1 T1 subjectOf myricetin,myricetin and other flavonoids
R2 E7-ti-1 T1 objectOf flavonoids,myricetin and other flavonoids
R3 E7-ti-1 T2 subjectOf flavonoids,myricetin and other flavonoids
R4 E6-ti-1 T2 objectOf myricetin,myricetin and other flavonoids
R5 E9-ti-1 T3 subjectOf cells,in
R6 E7-ti-1 T3 objectOf flavonoids,in
R7 E9-ti-1 T4 subjectOf cells,in
R8 E6-ti-1 T4 objectOf myricetin,in
R9 E9-ti-1 T5 subjectOf cells,myricetin and other flavonoids
R10 E6-ti-1 T5 objectOf myricetin,myricetin and other flavonoids
R11 E9-ti-1 T6 subjectOf cells,myricetin and other flavonoids
R12 E7-ti-1 T6 objectOf flavonoids,myricetin and other flavonoids
R13 E6-ab-3 T7 subjectOf atherosclerosis,in
R14 E11-ab-3 T7 objectOf vascular injury,in
R15 E8-ab-4 T8 subjectOf cells,in
R16 E3-ab-4 T8 objectOf flavonoids,in
R17 E9-ab-4 T9 subjectOf tumor necrosis factor-alpha,activated
R18 E3-ab-4 T9 objectOf flavonoids,activated
R19 E9-ab-6 T10 subjectOf endothelial cells,in
R20 E7-ab-6 T10 objectOf IkappaBbeta,in
R21 E9-ab-6 T11 subjectOf endothelial cells,in
R22 E6-ab-6 T11 objectOf IkappaBalpha,in
R23 E1-ab-7 T12 subjectOf myricetin,suppression
R24 E7-ab-7 T12 objectOf adhesion,suppression
R25 E6-ab-7 T13 subjectOf monocyte,monocyte adhesion
R26 E7-ab-7 T13 objectOf adhesion,monocyte adhesion

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-144 Sentence denotes Suppression of TNFalpha-mediated NFkappaB activity by myricetin and other flavonoids through downregulating the activity of IKK in ECV304 cells.
S2 145-298 Sentence denotes Flavonoids are a group of naturally-occurring phenolic compounds in the plant kingdom, and many flavonoids are found with vascular protective properties.
S3 299-391 Sentence denotes Nevertheless how the protective response is exerted by flavonoids is not well characterized.
S4 392-602 Sentence denotes In view of the nuclear factor-kappaB (NFkappaB) may play a central role in the initiation of atherosclerosis, prevention of the activation of NFkappaB represents an important role in protecting vascular injury.
S5 603-774 Sentence denotes In this study, the effects of flavonoids on NFkappaB/inhibitor-kappaB (IkappaB) system in ECV304 cells activated with tumor necrosis factor-alpha (TNFalpha) were examined.
S6 775-959 Sentence denotes We investigated the inhibitory action of six flavonoids on IkappaB kinase (IKK) activity, an enzyme recently found to phosphorylate critical serine residues of IkappaB for degradation.
S7 960-1138 Sentence denotes Of six flavonoids tested, myricetin was found to strongly inhibit IKK kinase activity, and prevent the degradation of IkappaBalpha and IkappaBbeta in activated endothelial cells.
S8 1139-1271 Sentence denotes Furthermore, myricetin was also found to inhibit NFkappaB activity correlated with suppression of monocyte adhesion to ECV304 cells.
S9 1272-1410 Sentence denotes Therefore we conclude that flavonoids may be of therapeutic value for vascular disease through down regulation of NFkappaB/IkappaB system.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 15-23 protein_molecule denotes TNFalpha
T2 33-41 protein_complex denotes NFkappaB
T3 54-63 other_organic_compound denotes myricetin
T4 74-84 other_organic_compound denotes flavonoids
T5 124-127 protein_molecule denotes IKK
T6 131-143 cell_line denotes ECV304 cells
T7 145-155 other_organic_compound denotes Flavonoids
T8 171-209 other_organic_compound denotes naturally-occurring phenolic compounds
T9 241-251 other_organic_compound denotes flavonoids
T10 267-297 other_name denotes vascular protective properties
T11 354-364 other_organic_compound denotes flavonoids
T12 407-428 protein_complex denotes nuclear factor-kappaB
T13 430-438 protein_complex denotes NFkappaB
T14 485-500 other_name denotes atherosclerosis
T15 534-542 protein_complex denotes NFkappaB
T16 586-601 other_name denotes vascular injury
T17 633-643 other_organic_compound denotes flavonoids
T18 647-655 protein_complex denotes NFkappaB
T19 674-681 protein_molecule denotes IkappaB
T20 693-705 cell_line denotes ECV304 cells
T21 721-748 protein_molecule denotes tumor necrosis factor-alpha
T22 750-758 protein_molecule denotes TNFalpha
T23 820-830 other_organic_compound denotes flavonoids
T24 834-848 protein_molecule denotes IkappaB kinase
T25 850-853 protein_molecule denotes IKK
T26 916-922 amino_acid_monomer denotes serine
T27 967-977 other_organic_compound denotes flavonoids
T28 986-995 other_organic_compound denotes myricetin
T29 1026-1029 protein_molecule denotes IKK
T30 1078-1090 protein_molecule denotes IkappaBalpha
T31 1095-1106 protein_molecule denotes IkappaBbeta
T32 1152-1161 other_organic_compound denotes myricetin
T33 1188-1196 protein_complex denotes NFkappaB
T34 1258-1270 cell_line denotes ECV304 cells
T35 1299-1309 other_organic_compound denotes flavonoids
T36 1386-1394 protein_complex denotes NFkappaB
T37 1394-1402 protein_molecule denotes /IkappaB

metamap-sample

Id Subject Object Predicate Lexical cue
T1 722-749 C1456820 denotes umor necrosis factor-alpha
T2 16-24 C1456820 denotes NFalpha-
T3 1300-1310 C0596577 denotes lavonoids
T4 968-978 C0596577 denotes lavonoids
T5 821-831 C0596577 denotes lavonoids
T6 634-644 C0596577 denotes lavonoids
T7 355-365 C0596577 denotes lavonoids
T8 146-156 C0596577 denotes lavonoids
T9 242-252 C0596577 denotes lavonoids
T10 75-85 C0596577 denotes lavonoids
T11 1153-1162 C0067067 denotes yricetin
T12 987-996 C0067067 denotes yricetin
T13 55-64 C0067067 denotes yricetin
T14 1189-1197 C0079904 denotes FkappaB
T15 535-543 C0079904 denotes FkappaB
T16 408-429 C0079904 denotes uclear factor-kappaB
T17 1266-1271 C0007634 denotes ells.
T18 701-706 C0007634 denotes ells
T19 139-144 C0007634 denotes ells.
T20 1198-1206 C1561536 denotes ctivity
T21 856-864 C1561536 denotes ctivity,
T22 1027-1030 C1150571 denotes KK
T23 851-854 C1150571 denotes KK)
T24 125-128 C1150571 denotes KK
T25 1223-1234 C0301625 denotes uppression
T26 1-12 C0301625 denotes uppression
T27 69-73 C0205394 denotes ther
T28 16-24 C2003941 denotes NFalpha-
T29 25-33 C0127400 denotes ediated
T30 1387-1403 C0126732 denotes FkappaB/IkappaB
T31 1079-1090 C0126732 denotes kappaBalpha
T32 648-666 C0126732 denotes FkappaB/inhibitor-
T33 1286-1294 C0917903 denotes onclude
T34 1181-1188 C0018790 denotes nhibit
T35 1019-1026 C0018790 denotes nhibit
T36 1238-1245 C0026473 denotes onocyte
T37 1247-1255 C0001511 denotes dhesion
T38 486-501 C0004153 denotes therosclerosis,
T39 1172-1177 C0150312 denotes ound
T40 1001-1006 C0150312 denotes ound
T41 885-890 C0150312 denotes ound
T42 257-262 C0150312 denotes ound
T43 1368-1383 C0013081 denotes own regulation
T44 1064-1075 C0699900 denotes egradation
T45 948-959 C0699900 denotes egradation.
T46 843-849 C0031727 denotes inase
T47 1096-1107 C0166033 denotes kappaBbeta
T48 796-806 C3463820 denotes nhibitory
T49 917-923 C0036720 denotes erine
T50 1178-1180 C1883351 denotes o
T51 1007-1008 C1883351 denotes o
T52 891-893 C1883351 denotes o
T53 1111-1120 C1879547 denotes ctivated
T54 707-716 C1879547 denotes ctivated
T55 521-531 C1879547 denotes ctivation
T56 163-168 C1257890 denotes roup
T57 1121-1138 C0225336 denotes ndothelial cells.
T58 587-602 C0178324 denotes ascular injury.
T59 1343-1359 C0042373 denotes ascular disease
T60 1404-1410 C0449913 denotes ystem.
T61 684-690 C0449913 denotes ystem
T62 964-967 C0205452 denotes ix
T63 817-820 C0205452 denotes ix
T64 869-875 C0014442 denotes nzyme
T65 268-276 C0005847 denotes ascular
T66 218-222 C0032098 denotes lant
T67 445-449 C0600138 denotes lay
T68 766-774 C0332128 denotes xamined.
T69 779-791 C1292732 denotes nvestigated
T70 1052-1059 C0309872 denotes revent
T71 544-554 C1882932 denotes epresents
T72 612-617 C2603343 denotes tudy,
T73 979-985 C0392366 denotes ested,
T74 1031-1046 C1150423 denotes inase activity,
T75 224-231 C1708611 denotes ingdom,
T76 332-340 C0871261 denotes esponse
T77 378-391 C1880022 denotes haracterized.
T78 373-376 C0205170 denotes ell
T79 344-351 C0015264 denotes xerted
T80 161-168 C0441835 denotes group
T81 623-630 C1280500 denotes ffects
T82 1315-1317 C2987476 denotes e
T83 1333-1338 C1522609 denotes alue
T84 1321-1332 C0039796 denotes herapeutic
T85 288-298 C0871161 denotes roperties.
T86 807-813 C0441472 denotes ction
T87 1207-1217 C1707520 denotes orrelated
T88 503-513 C0199176 denotes revention
T89 924-932 C1709915 denotes esidues
T90 876-884 C0332185 denotes ecently
T91 369-372 C1518422 denotes ot
T92 908-916 C1511545 denotes ritical
T93 192-200 C0359916 denotes henolic
T94 452-458 C1879652 denotes entral
T95 472-482 C1158830 denotes nitiation
T96 201-210 C1706082 denotes ompounds
T97 182-191 C2745955 denotes ccurring