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PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 112-373 OBJECTIVE denotes To determine the levels of mRNAs encoding markers of fibrosis in lens epithelial cells (LECs) from patients with anterior polar cataracts and to test whether transforming growth factor (TGF)-beta enhances the expression of mRNAs for mesenchymal markers in LECs.
T2 383-933 METHODS denotes LECs attached to the anterior capsules of patients with nuclear or anterior polar cataracts were analyzed by reverse transcription-polymerase chain reaction (RT-PCR) for the expression of mRNAs encoding pathologic extracellular matrix proteins, a marker of myofibroblast transformation, growth factors, and growth factor receptors, and by western blot analysis for the proteins encoded by these mRNAs. Bovine lens epithelial explants and intact rabbit lenses cultured with or without TGF-beta1 were also subjected to RT-PCR and western blot analysis.
T3 943-1709 RESULTS denotes The levels of fibronectin, type I collagen, and alpha-smooth muscle actin (SMA) mRNAs were higher in LECs from patients with anterior polar cataracts than in those from patients with nuclear cataracts. Expression of mRNAs for TGF-beta1, TGF-beta2, TGF-beta receptor type II, and connective tissue growth factor (CTGF) was significantly greater in anterior polar type than in nuclear type cataracts. In contrast, expression of mRNAs for epidermal growth factor (EGF), epidermal growth factor receptor (EGFR), fibroblast growth factor (FGF)-2, and FGF receptor-1 was similar in LECs from the two types of cataracts. TGF-beta1 markedly increased the levels of fibronectin, type I collagen, and alpha-SMA mRNA in bovine lens epithelial explants and intact rabbit lenses.
T4 1723-2183 CONCLUSIONS denotes This is the first finding showing altered mRNA expression in LECs from anterior polar cataracts. Enhanced expression of TGF-beta and the TGF-beta receptor suggests that TGF-beta derived from LECs may function in an autocrine fashion as the prime mediator of transdifferentiation and pathogenesis in human LECs. Elevated levels of CTGF mRNA suggest that this growth factor may play a role in the increased deposition of extracellular matrix in metaplastic LECs.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 225-249 HP_0001134 denotes anterior polar cataracts
T2 234-249 HP_0010696 denotes polar cataracts
T3 240-249 HP_0000518 denotes cataracts

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
10440257-4#14#25#gene2335 957-968 gene2335 denotes fibronectin
10440257-4#140#149#diseaseC0086543 1083-1092 diseaseC0086543 denotes cataracts
10440257-4#140#149#diseaseC0521707 1083-1092 diseaseC0521707 denotes cataracts
10440257-4#191#200#diseaseC0086543 1134-1143 diseaseC0086543 denotes cataracts
10440257-4#191#200#diseaseC0521707 1134-1143 diseaseC0521707 denotes cataracts
10440257-5#35#44#gene7042 1180-1189 gene7042 denotes TGF-beta2
10440257-5#77#108#gene1490 1222-1253 gene1490 denotes connective tissue growth factor
10440257-5#110#114#gene1490 1255-1259 gene1490 denotes CTGF
10440257-5#186#195#diseaseC0086543 1331-1340 diseaseC0086543 denotes cataracts
10440257-5#186#195#diseaseC0521707 1331-1340 diseaseC0521707 denotes cataracts
10440257-5#186#195#diseaseC0086543 1331-1340 diseaseC0086543 denotes cataracts
10440257-5#186#195#diseaseC0521707 1331-1340 diseaseC0521707 denotes cataracts
10440257-5#186#195#diseaseC0086543 1331-1340 diseaseC0086543 denotes cataracts
10440257-5#186#195#diseaseC0521707 1331-1340 diseaseC0521707 denotes cataracts
10440257-6#37#60#gene1950 1379-1402 gene1950 denotes epidermal growth factor
10440257-6#62#65#gene1950 1404-1407 gene1950 denotes EGF
10440257-6#68#100#gene1956 1410-1442 gene1956 denotes epidermal growth factor receptor
10440257-6#102#106#gene1956 1444-1448 gene1956 denotes EGFR
10440257-6#204#213#diseaseC0086543 1546-1555 diseaseC0086543 denotes cataracts
10440257-6#204#213#diseaseC0521707 1546-1555 diseaseC0521707 denotes cataracts
10440257-6#204#213#diseaseC0086543 1546-1555 diseaseC0086543 denotes cataracts
10440257-6#204#213#diseaseC0521707 1546-1555 diseaseC0521707 denotes cataracts
10440257-6#204#213#diseaseC0086543 1546-1555 diseaseC0086543 denotes cataracts
10440257-6#204#213#diseaseC0521707 1546-1555 diseaseC0521707 denotes cataracts
10440257-6#204#213#diseaseC0086543 1546-1555 diseaseC0086543 denotes cataracts
10440257-6#204#213#diseaseC0521707 1546-1555 diseaseC0521707 denotes cataracts
14#25#gene2335140#149#diseaseC0086543 10440257-4#14#25#gene2335 10440257-4#140#149#diseaseC0086543 associated_with fibronectin,cataracts
14#25#gene2335140#149#diseaseC0521707 10440257-4#14#25#gene2335 10440257-4#140#149#diseaseC0521707 associated_with fibronectin,cataracts
14#25#gene2335191#200#diseaseC0086543 10440257-4#14#25#gene2335 10440257-4#191#200#diseaseC0086543 associated_with fibronectin,cataracts
14#25#gene2335191#200#diseaseC0521707 10440257-4#14#25#gene2335 10440257-4#191#200#diseaseC0521707 associated_with fibronectin,cataracts
35#44#gene7042186#195#diseaseC0086543 10440257-5#35#44#gene7042 10440257-5#186#195#diseaseC0086543 associated_with TGF-beta2,cataracts
35#44#gene7042186#195#diseaseC0521707 10440257-5#35#44#gene7042 10440257-5#186#195#diseaseC0521707 associated_with TGF-beta2,cataracts
35#44#gene7042186#195#diseaseC0086543 10440257-5#35#44#gene7042 10440257-5#186#195#diseaseC0086543 associated_with TGF-beta2,cataracts
35#44#gene7042186#195#diseaseC0521707 10440257-5#35#44#gene7042 10440257-5#186#195#diseaseC0521707 associated_with TGF-beta2,cataracts
35#44#gene7042186#195#diseaseC0086543 10440257-5#35#44#gene7042 10440257-5#186#195#diseaseC0086543 associated_with TGF-beta2,cataracts
35#44#gene7042186#195#diseaseC0521707 10440257-5#35#44#gene7042 10440257-5#186#195#diseaseC0521707 associated_with TGF-beta2,cataracts
77#108#gene1490186#195#diseaseC0086543 10440257-5#77#108#gene1490 10440257-5#186#195#diseaseC0086543 associated_with connective tissue growth factor,cataracts
77#108#gene1490186#195#diseaseC0521707 10440257-5#77#108#gene1490 10440257-5#186#195#diseaseC0521707 associated_with connective tissue growth factor,cataracts
77#108#gene1490186#195#diseaseC0086543 10440257-5#77#108#gene1490 10440257-5#186#195#diseaseC0086543 associated_with connective tissue growth factor,cataracts
77#108#gene1490186#195#diseaseC0521707 10440257-5#77#108#gene1490 10440257-5#186#195#diseaseC0521707 associated_with connective tissue growth factor,cataracts
77#108#gene1490186#195#diseaseC0086543 10440257-5#77#108#gene1490 10440257-5#186#195#diseaseC0086543 associated_with connective tissue growth factor,cataracts
77#108#gene1490186#195#diseaseC0521707 10440257-5#77#108#gene1490 10440257-5#186#195#diseaseC0521707 associated_with connective tissue growth factor,cataracts
110#114#gene1490186#195#diseaseC0086543 10440257-5#110#114#gene1490 10440257-5#186#195#diseaseC0086543 associated_with CTGF,cataracts
110#114#gene1490186#195#diseaseC0521707 10440257-5#110#114#gene1490 10440257-5#186#195#diseaseC0521707 associated_with CTGF,cataracts
110#114#gene1490186#195#diseaseC0086543 10440257-5#110#114#gene1490 10440257-5#186#195#diseaseC0086543 associated_with CTGF,cataracts
110#114#gene1490186#195#diseaseC0521707 10440257-5#110#114#gene1490 10440257-5#186#195#diseaseC0521707 associated_with CTGF,cataracts
110#114#gene1490186#195#diseaseC0086543 10440257-5#110#114#gene1490 10440257-5#186#195#diseaseC0086543 associated_with CTGF,cataracts
110#114#gene1490186#195#diseaseC0521707 10440257-5#110#114#gene1490 10440257-5#186#195#diseaseC0521707 associated_with CTGF,cataracts
37#60#gene1950204#213#diseaseC0086543 10440257-6#37#60#gene1950 10440257-6#204#213#diseaseC0086543 associated_with epidermal growth factor,cataracts
37#60#gene1950204#213#diseaseC0521707 10440257-6#37#60#gene1950 10440257-6#204#213#diseaseC0521707 associated_with epidermal growth factor,cataracts
37#60#gene1950204#213#diseaseC0086543 10440257-6#37#60#gene1950 10440257-6#204#213#diseaseC0086543 associated_with epidermal growth factor,cataracts
37#60#gene1950204#213#diseaseC0521707 10440257-6#37#60#gene1950 10440257-6#204#213#diseaseC0521707 associated_with epidermal growth factor,cataracts
37#60#gene1950204#213#diseaseC0086543 10440257-6#37#60#gene1950 10440257-6#204#213#diseaseC0086543 associated_with epidermal growth factor,cataracts
37#60#gene1950204#213#diseaseC0521707 10440257-6#37#60#gene1950 10440257-6#204#213#diseaseC0521707 associated_with epidermal growth factor,cataracts
37#60#gene1950204#213#diseaseC0086543 10440257-6#37#60#gene1950 10440257-6#204#213#diseaseC0086543 associated_with epidermal growth factor,cataracts
37#60#gene1950204#213#diseaseC0521707 10440257-6#37#60#gene1950 10440257-6#204#213#diseaseC0521707 associated_with epidermal growth factor,cataracts
62#65#gene1950204#213#diseaseC0086543 10440257-6#62#65#gene1950 10440257-6#204#213#diseaseC0086543 associated_with EGF,cataracts
62#65#gene1950204#213#diseaseC0521707 10440257-6#62#65#gene1950 10440257-6#204#213#diseaseC0521707 associated_with EGF,cataracts
62#65#gene1950204#213#diseaseC0086543 10440257-6#62#65#gene1950 10440257-6#204#213#diseaseC0086543 associated_with EGF,cataracts
62#65#gene1950204#213#diseaseC0521707 10440257-6#62#65#gene1950 10440257-6#204#213#diseaseC0521707 associated_with EGF,cataracts
62#65#gene1950204#213#diseaseC0086543 10440257-6#62#65#gene1950 10440257-6#204#213#diseaseC0086543 associated_with EGF,cataracts
62#65#gene1950204#213#diseaseC0521707 10440257-6#62#65#gene1950 10440257-6#204#213#diseaseC0521707 associated_with EGF,cataracts
62#65#gene1950204#213#diseaseC0086543 10440257-6#62#65#gene1950 10440257-6#204#213#diseaseC0086543 associated_with EGF,cataracts
62#65#gene1950204#213#diseaseC0521707 10440257-6#62#65#gene1950 10440257-6#204#213#diseaseC0521707 associated_with EGF,cataracts
68#100#gene1956204#213#diseaseC0086543 10440257-6#68#100#gene1956 10440257-6#204#213#diseaseC0086543 associated_with epidermal growth factor receptor,cataracts
68#100#gene1956204#213#diseaseC0521707 10440257-6#68#100#gene1956 10440257-6#204#213#diseaseC0521707 associated_with epidermal growth factor receptor,cataracts
68#100#gene1956204#213#diseaseC0086543 10440257-6#68#100#gene1956 10440257-6#204#213#diseaseC0086543 associated_with epidermal growth factor receptor,cataracts
68#100#gene1956204#213#diseaseC0521707 10440257-6#68#100#gene1956 10440257-6#204#213#diseaseC0521707 associated_with epidermal growth factor receptor,cataracts
68#100#gene1956204#213#diseaseC0086543 10440257-6#68#100#gene1956 10440257-6#204#213#diseaseC0086543 associated_with epidermal growth factor receptor,cataracts
68#100#gene1956204#213#diseaseC0521707 10440257-6#68#100#gene1956 10440257-6#204#213#diseaseC0521707 associated_with epidermal growth factor receptor,cataracts
68#100#gene1956204#213#diseaseC0086543 10440257-6#68#100#gene1956 10440257-6#204#213#diseaseC0086543 associated_with epidermal growth factor receptor,cataracts
68#100#gene1956204#213#diseaseC0521707 10440257-6#68#100#gene1956 10440257-6#204#213#diseaseC0521707 associated_with epidermal growth factor receptor,cataracts
102#106#gene1956204#213#diseaseC0086543 10440257-6#102#106#gene1956 10440257-6#204#213#diseaseC0086543 associated_with EGFR,cataracts
102#106#gene1956204#213#diseaseC0521707 10440257-6#102#106#gene1956 10440257-6#204#213#diseaseC0521707 associated_with EGFR,cataracts
102#106#gene1956204#213#diseaseC0086543 10440257-6#102#106#gene1956 10440257-6#204#213#diseaseC0086543 associated_with EGFR,cataracts
102#106#gene1956204#213#diseaseC0521707 10440257-6#102#106#gene1956 10440257-6#204#213#diseaseC0521707 associated_with EGFR,cataracts
102#106#gene1956204#213#diseaseC0086543 10440257-6#102#106#gene1956 10440257-6#204#213#diseaseC0086543 associated_with EGFR,cataracts
102#106#gene1956204#213#diseaseC0521707 10440257-6#102#106#gene1956 10440257-6#204#213#diseaseC0521707 associated_with EGFR,cataracts
102#106#gene1956204#213#diseaseC0086543 10440257-6#102#106#gene1956 10440257-6#204#213#diseaseC0086543 associated_with EGFR,cataracts
102#106#gene1956204#213#diseaseC0521707 10440257-6#102#106#gene1956 10440257-6#204#213#diseaseC0521707 associated_with EGFR,cataracts

DisGeNET

Id Subject Object Predicate Lexical cue
T0 957-968 gene:2335 denotes fibronectin
T1 1083-1092 disease:C0086543 denotes cataracts
T2 957-968 gene:2335 denotes fibronectin
T3 1083-1092 disease:C0521707 denotes cataracts
T4 957-968 gene:2335 denotes fibronectin
T5 1134-1143 disease:C0086543 denotes cataracts
T6 957-968 gene:2335 denotes fibronectin
T7 1134-1143 disease:C0521707 denotes cataracts
T8 1180-1189 gene:7042 denotes TGF-beta2
T9 1331-1340 disease:C0086543 denotes cataracts
T10 1180-1189 gene:7042 denotes TGF-beta2
T11 1331-1340 disease:C0521707 denotes cataracts
T12 1222-1253 gene:1490 denotes connective tissue growth factor
T13 1331-1340 disease:C0086543 denotes cataracts
T14 1222-1253 gene:1490 denotes connective tissue growth factor
T15 1331-1340 disease:C0521707 denotes cataracts
T16 1255-1259 gene:1490 denotes CTGF
T17 1331-1340 disease:C0086543 denotes cataracts
T18 1255-1259 gene:1490 denotes CTGF
T19 1331-1340 disease:C0521707 denotes cataracts
T20 1379-1402 gene:1950 denotes epidermal growth factor
T21 1546-1555 disease:C0086543 denotes cataracts
T22 1379-1402 gene:1950 denotes epidermal growth factor
T23 1546-1555 disease:C0521707 denotes cataracts
T24 1404-1407 gene:1950 denotes EGF
T25 1546-1555 disease:C0086543 denotes cataracts
T26 1404-1407 gene:1950 denotes EGF
T27 1546-1555 disease:C0521707 denotes cataracts
T28 1444-1448 gene:1956 denotes EGFR
T29 1546-1555 disease:C0086543 denotes cataracts
T30 1444-1448 gene:1956 denotes EGFR
T31 1546-1555 disease:C0521707 denotes cataracts
T32 1489-1501 gene:2263 denotes FGF receptor
T33 1546-1555 disease:C0086543 denotes cataracts
T34 1489-1501 gene:2263 denotes FGF receptor
T35 1546-1555 disease:C0521707 denotes cataracts
R1 T0 T1 associated_with fibronectin,cataracts
R2 T2 T3 associated_with fibronectin,cataracts
R3 T4 T5 associated_with fibronectin,cataracts
R4 T6 T7 associated_with fibronectin,cataracts
R5 T8 T9 associated_with TGF-beta2,cataracts
R6 T10 T11 associated_with TGF-beta2,cataracts
R7 T12 T13 associated_with connective tissue growth factor,cataracts
R8 T14 T15 associated_with connective tissue growth factor,cataracts
R9 T16 T17 associated_with CTGF,cataracts
R10 T18 T19 associated_with CTGF,cataracts
R11 T20 T21 associated_with epidermal growth factor,cataracts
R12 T22 T23 associated_with epidermal growth factor,cataracts
R13 T24 T25 associated_with EGF,cataracts
R14 T26 T27 associated_with EGF,cataracts
R15 T28 T29 associated_with EGFR,cataracts
R16 T30 T31 associated_with EGFR,cataracts
R17 T32 T33 associated_with FGF receptor,cataracts
R18 T34 T35 associated_with FGF receptor,cataracts