PubMed:10438934 JSONTXT

{"project":"Lectin_function","denotations":[{"id":"T1","span":{"begin":0,"end":4},"obj":"GL_001101"},{"id":"T2","span":{"begin":13,"end":17},"obj":"GX_000020"},{"id":"T3","span":{"begin":27,"end":40},"obj":"GL_000114"},{"id":"T4","span":{"begin":27,"end":40},"obj":"GL_000115"},{"id":"T5","span":{"begin":34,"end":40},"obj":"GX_000027"},{"id":"T6","span":{"begin":34,"end":40},"obj":"GX_000045"},{"id":"T7","span":{"begin":179,"end":194},"obj":"GL_000114"},{"id":"T8","span":{"begin":179,"end":194},"obj":"GL_000115"},{"id":"T9","span":{"begin":188,"end":194},"obj":"GX_000027"},{"id":"T10","span":{"begin":188,"end":194},"obj":"GX_000045"},{"id":"T11","span":{"begin":229,"end":233},"obj":"GX_000020"},{"id":"T12","span":{"begin":421,"end":427},"obj":"GX_000027"},{"id":"T13","span":{"begin":421,"end":427},"obj":"GX_000045"},{"id":"T14","span":{"begin":498,"end":502},"obj":"GX_000020"},{"id":"T15","span":{"begin":667,"end":671},"obj":"GX_000020"},{"id":"T16","span":{"begin":759,"end":763},"obj":"GX_000020"},{"id":"T17","span":{"begin":873,"end":877},"obj":"GX_000020"},{"id":"T18","span":{"begin":897,"end":903},"obj":"GX_000027"},{"id":"T19","span":{"begin":897,"end":903},"obj":"GX_000045"},{"id":"T20","span":{"begin":1076,"end":1080},"obj":"GX_000020"},{"id":"T21","span":{"begin":1170,"end":1174},"obj":"GX_000020"},{"id":"T22","span":{"begin":1269,"end":1273},"obj":"GL_001647"},{"id":"T23","span":{"begin":1302,"end":1306},"obj":"GX_000020"},{"id":"T24","span":{"begin":1417,"end":1421},"obj":"GX_000020"},{"id":"T25","span":{"begin":1518,"end":1522},"obj":"GX_000020"}],"text":"APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif.\nWe have identified a novel member of the calcium-dependent (C-type) lectin family. This molecule, designated DCIR (for dendritic cell (DC) immunoreceptor), is a type II membrane glycoprotein of 237 aa with a single carbohydrate recognition domain (CRD), closest in homology to those of the macrophage lectin and hepatic asialoglycoprotein receptors. The intracellular domain of DCIR contains a consensus immunoreceptor tyrosine-based inhibitory motif. A mouse cDNA, encoding a homologous protein has been identified. Northern blot analysis showed DCIR mRNA to be predominantly transcribed in hematopoietic tissues. The gene encoding human DCIR was localized to chromosome 12p13, in a region close to the NK gene complex. Unlike members of this complex, DCIR displays a typical lectin CRD rather than an NK cell type extracellular domain, and was expressed on DC, monocytes, macrophages, B lymphocytes, and granulocytes, but not detected on NK and T cells. DCIR was strongly expressed by DC derived from blood monocytes cultured with GM-CSF and IL-4. DCIR was mostly expressed by monocyte-related rather than Langerhans cell related DC obtained from CD34+ progenitor cells. Finally, DCIR expression was down-regulated by signals inducing DC maturation such as CD40 ligand, LPS, or TNF-alpha. Thus, DCIR is differentially expressed on DC depending on their origin and stage of maturation/activation. DCIR represents a novel surface molecule expressed by Ag presenting cells, and of potential importance in regulation of DC function."}