PubMed:10438913
Annnotations
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-4 | protein | denotes | IL-2 |
| T2 | 49-62 | cell_type | denotes | human T cells |
| T3 | 74-78 | protein | denotes | CD28 |
| T4 | 101-105 | protein | denotes | CD28 |
| T5 | 297-301 | protein | denotes | CD28 |
| T6 | 329-338 | protein | denotes | cytokines |
| T7 | 348-352 | protein | denotes | IL-2 |
| T8 | 406-410 | protein | denotes | CD28 |
| T9 | 444-463 | protein | denotes | natural ligand CD80 |
| T10 | 509-513 | protein | denotes | IL-2 |
| T11 | 536-544 | protein | denotes | cytokine |
| T12 | 560-573 | DNA | denotes | IL-2 promoter |
| T13 | 612-616 | protein | denotes | CD28 |
| T14 | 643-652 | protein | denotes | NF-kappaB |
| T15 | 657-661 | protein | denotes | AP-1 |
| T16 | 674-679 | protein | denotes | NF-AT |
| T17 | 694-707 | DNA | denotes | IL-2 promoter |
| T18 | 902-905 | protein | denotes | Abs |
| T19 | 914-918 | protein | denotes | IL-2 |
| T20 | 927-940 | protein | denotes | IL-2 receptor |
| T21 | 991-995 | protein | denotes | CD28 |
| T22 | 1015-1019 | protein | denotes | IL-2 |
| T23 | 1069-1082 | cell_type | denotes | T cell blasts |
| T24 | 1088-1092 | protein | denotes | CD80 |
| T25 | 1150-1154 | protein | denotes | IL-2 |
| T26 | 1188-1192 | protein | denotes | CD28 |
| T27 | 1268-1272 | protein | denotes | IL-2 |
| T28 | 1295-1309 | protein | denotes | soluble factor |
| T29 | 1325-1330 | protein | denotes | NF-AT |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 0-5 | NP | denotes | IL-2- |
| C2 | 74-78 | NP | denotes | CD28 |
| C3 | 101-105 | NP | denotes | CD28 |
| C4 | 153-167 | NP | denotes | the mechanisms |
| C5 | 171-176 | NP | denotes | which |
| C6 | 177-179 | NP | denotes | it |
| C7 | 187-190 | NP | denotes | its |
| C8 | 297-301 | NP | denotes | CD28 |
| C10 | 348-352 | NP | denotes | IL-2 |
| C20 | 357-377 | NP | denotes | T cell proliferation |
| C9 | 406-410 | NP | denotes | CD28 |
| C12 | 395-463 | NP | denotes | a model of CD28 costimulation using PMA plus the natural ligand CD80 |
| C13 | 464-468 | NP | denotes | that |
| C11 | 509-513 | NP | denotes | IL-2 |
| C14 | 612-617 | NP | denotes | CD28- |
| C15 | 722-742 | NP | denotes | T cell proliferation |
| C16 | 838-858 | NP | denotes | T cell proliferation |
| C17 | 914-918 | NP | denotes | IL-2 |
| C18 | 991-995 | NP | denotes | CD28 |
| C25 | 961-995 | NP | denotes | this form of costimulation by CD28 |
| C19 | 1015-1019 | NP | denotes | IL-2 |
| C22 | 1150-1154 | NP | denotes | IL-2 |
| C26 | 1188-1206 | NP | denotes | CD28 costimulation |
| C23 | 1268-1272 | NP | denotes | IL-2 |
| C24 | 1274-1279 | NP | denotes | which |
| R1 | C3 | C2 | coref-ident | CD28,CD28 |
| R2 | C5 | C4 | coref-relat | which,the mechanisms |
| R3 | C6 | C3 | coref-pron | it,CD28 |
| R4 | C7 | C3 | coref-pron | its,CD28 |
| R5 | C8 | C3 | coref-ident | CD28,CD28 |
| R6 | C10 | C1 | coref-ident | IL-2,IL-2- |
| R7 | C9 | C8 | coref-ident | CD28,CD28 |
| R8 | C13 | C12 | coref-relat | that,a model of CD28 costimulation using PMA plus the natural ligand CD80 |
| R9 | C11 | C10 | coref-ident | IL-2,IL-2 |
| R10 | C14 | C9 | coref-ident | CD28-,CD28 |
| R11 | C15 | C20 | coref-ident | T cell proliferation,T cell proliferation |
| R12 | C16 | C15 | coref-ident | T cell proliferation,T cell proliferation |
| R13 | C17 | C11 | coref-ident | IL-2,IL-2 |
| R14 | C18 | C14 | coref-ident | CD28,CD28- |
| R15 | C19 | C17 | coref-ident | IL-2,IL-2 |
| R16 | C22 | C19 | coref-ident | IL-2,IL-2 |
| R17 | C26 | C25 | coref-ident | CD28 costimulation,this form of costimulation by CD28 |
| R18 | C23 | C22 | coref-ident | IL-2,IL-2 |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-79 | Sentence | denotes | IL-2-independent activation and proliferation in human T cells induced by CD28. |
| S2 | 80-228 | Sentence | denotes | Although the role of CD28 in T cell costimulation is firmly established, the mechanisms by which it exerts its costimulatory actions are less clear. |
| S3 | 229-378 | Sentence | denotes | In many circumstances it is difficult to distinguish the effects of CD28 from subsequent actions of cytokines, such as IL-2, on T cell proliferation. |
| S4 | 379-586 | Sentence | denotes | Here, we report a model of CD28 costimulation using PMA plus the natural ligand CD80 that resulted in very limited stimulation of IL-2, as evidenced by both cytokine production and IL-2 promoter stimulation. |
| S5 | 587-708 | Sentence | denotes | Promoter assays revealed CD28-dependent effects on both NF-kappaB and AP-1, but not on NF-AT or the intact IL-2 promoter. |
| S6 | 709-828 | Sentence | denotes | In addition, T cell proliferation was completely resistant to the actions of the immunosuppressant cyclosporin A (CsA). |
| S7 | 829-1020 | Sentence | denotes | Moreover T cell proliferation was unaffected by the addition of blocking Abs to both IL-2 and the IL-2 receptor, demonstrating that this form of costimulation by CD28 was independent of IL-2. |
| S8 | 1021-1170 | Sentence | denotes | We also investigated the effects of stimulating T cell blasts with CD80 alone and found that there was a limited requirement for IL-2 in this system. |
| S9 | 1171-1347 | Sentence | denotes | We conclude that CD28 costimulation can cause substantial T cell proliferation in the absence of IL-2, which is driven by a soluble factor independent of NF-AT transactivation. |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-4 | protein_molecule | denotes | IL-2 |
| T2 | 49-62 | cell_type | denotes | human T cells |
| T3 | 74-78 | protein_molecule | denotes | CD28 |
| T4 | 101-105 | protein_molecule | denotes | CD28 |
| T5 | 109-129 | other_name | denotes | T cell costimulation |
| T6 | 297-301 | protein_molecule | denotes | CD28 |
| T7 | 329-338 | protein_family_or_group | denotes | cytokines |
| T8 | 348-352 | protein_molecule | denotes | IL-2 |
| T9 | 357-377 | other_name | denotes | T cell proliferation |
| T10 | 406-410 | protein_molecule | denotes | CD28 |
| T11 | 431-434 | other_organic_compound | denotes | PMA |
| T12 | 444-463 | protein_molecule | denotes | natural ligand CD80 |
| T13 | 509-513 | protein_molecule | denotes | IL-2 |
| T14 | 536-544 | protein_family_or_group | denotes | cytokine |
| T15 | 560-564 | protein_molecule | denotes | IL-2 |
| T16 | 612-616 | protein_molecule | denotes | CD28 |
| T17 | 643-652 | protein_complex | denotes | NF-kappaB |
| T18 | 657-661 | protein_molecule | denotes | AP-1 |
| T19 | 674-679 | protein_molecule | denotes | NF-AT |
| T20 | 694-698 | protein_molecule | denotes | IL-2 |
| T21 | 722-742 | other_name | denotes | T cell proliferation |
| T22 | 790-821 | other_organic_compound | denotes | immunosuppressant cyclosporin A |
| T23 | 823-826 | other_organic_compound | denotes | CsA |
| T24 | 838-858 | other_name | denotes | T cell proliferation |
| T25 | 902-905 | protein_family_or_group | denotes | Abs |
| T26 | 914-918 | protein_molecule | denotes | IL-2 |
| T27 | 927-931 | protein_molecule | denotes | IL-2 |
| T28 | 991-995 | protein_molecule | denotes | CD28 |
| T29 | 1015-1019 | protein_molecule | denotes | IL-2 |
| T30 | 1069-1082 | cell_type | denotes | T cell blasts |
| T31 | 1088-1092 | protein_molecule | denotes | CD80 |
| T32 | 1150-1154 | protein_molecule | denotes | IL-2 |
| T33 | 1188-1192 | protein_molecule | denotes | CD28 |
| T34 | 1229-1249 | other_name | denotes | T cell proliferation |
| T35 | 1268-1272 | protein_molecule | denotes | IL-2 |
| T36 | 1295-1309 | protein_family_or_group | denotes | soluble factor |
| T37 | 1325-1330 | protein_molecule | denotes | NF-AT |