> top > docs > PubMed:10438487 > annotations

PubMed:10438487 JSONTXT

Annnotations TAB JSON ListView MergeView

GlyCosmos15-Species-PubTator

Id Subject Object Predicate Lexical cue db_id
23 693-696 Species denotes rat 10116

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 24-27 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T3 241-244 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T5 246-249 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T7 564-567 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T9 653-656 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T11 898-901 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T13 1042-1045 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T15 1167-1170 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T17 1228-1231 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T19 1339-1342 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ
T21 1581-1584 Glycan_Motif denotes GD3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G98544DH|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81928IQ

sentences

Id Subject Object Predicate Lexical cue
T1 0-87 Sentence denotes Apoptogenic ganglioside GD3 directly induces the mitochondrial permeability transition.
T2 88-245 Sentence denotes Early events in apoptotic cascades initiated by ceramides or by activation of the surface receptor CD95 (Fas/APO-1) include the formation of ganglioside GD3.
T3 246-345 Sentence denotes GD3 appears to be both necessary and sufficient to propagate this lipid-mediated apoptotic pathway.
T4 346-545 Sentence denotes Later events common to many apoptotic pathways include induction of the mitochondrial permeability transition (PT) and cytochrome c release, which in turn triggers downstream caspases and cell death.
T5 546-625 Sentence denotes The links between GD3 formation and downstream stages of apoptosis are unknown.
T6 626-852 Sentence denotes We report that ganglioside GD3 directly induces the PT in isolated rat liver mitochondria at 30-100 microM in the presence of exogenous substrate (succinate) and at approximately 3 microM in the absence of exogenous substrate.
T7 853-1041 Sentence denotes In contrast, other gangliosides tested (e.g. GM1) have only weak stimulatory effects in the presence of succinate and protect against PT induction in the absence of respiratory substrates.
T8 1042-1166 Sentence denotes GD3-mediated induction of PT was antagonized by known PT inhibitors, namely cyclosporin A, ADP, trifluoperazine, and Mg(2+).
T9 1167-1326 Sentence denotes GD3 induced PT even in the presence of submicromolar Ca(2+); GD3 is therefore the first biological PT inducer identified that does not require elevated Ca(2+).
T10 1327-1390 Sentence denotes Exposure to GD3 also led to mitochondrial cytochrome c release.
T11 1391-1548 Sentence denotes In contrast, C(2)-ceramide, which can initiate the lipid-mediated apoptotic cascade in susceptible cells, failed to either induce PT or release cytochrome c.
T12 1549-1650 Sentence denotes These observations suggest that GD3 propagates apoptosis by inducing the PT and cytochrome c release.
T13 1651-1771 Sentence denotes This model provides a mechanistic link between the earlier and later stages of CD95-induced/ceramide-mediated apoptosis.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 24-27 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T2 24-27 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T3 241-244 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T4 241-244 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T5 246-249 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T6 246-249 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T7 564-567 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T8 564-567 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T9 653-656 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T10 653-656 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T11 898-901 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T12 898-901 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T13 1042-1045 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T14 1042-1045 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T15 1167-1170 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T16 1167-1170 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T17 1228-1231 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T18 1228-1231 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T19 1339-1342 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T20 1339-1342 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3
T21 1581-1584 https://glytoucan.org/Structures/Glycans/G81928IQ denotes GD3
T22 1581-1584 https://glytoucan.org/Structures/Glycans/G98544DH denotes GD3

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 346-351 http://purl.obolibrary.org/obo/MAT_0000488 denotes Later
T2 697-702 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T3 1710-1719 http://purl.obolibrary.org/obo/MAT_0000488 denotes and later

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 898-901 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 418-431 HP_0001427 denotes mitochondrial
T2 1355-1368 HP_0001427 denotes mitochondrial

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 24-27 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T2 241-244 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T3 246-249 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T4 564-567 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T5 653-656 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T6 898-901 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T7 1042-1045 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T8 1167-1170 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T9 1228-1231 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T10 1339-1342 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T11 1581-1584 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 346-351 Body_part denotes Later http://purl.obolibrary.org/obo/MAT_0000488
T2 697-702 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T3 1714-1719 Body_part denotes later http://purl.obolibrary.org/obo/MAT_0000488

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 24-27 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T2 241-244 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T3 246-249 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T4 564-567 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T5 653-656 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T6 898-901 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T7 1042-1045 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T8 1167-1170 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T9 1228-1231 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T10 1339-1342 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH
T11 1581-1584 Glycan denotes GD3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 898-901 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 693-696 OrganismTaxon denotes rat 10114|10116

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 697-702 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-87 Sentence denotes Apoptogenic ganglioside GD3 directly induces the mitochondrial permeability transition.
T2 88-245 Sentence denotes Early events in apoptotic cascades initiated by ceramides or by activation of the surface receptor CD95 (Fas/APO-1) include the formation of ganglioside GD3.
T3 246-345 Sentence denotes GD3 appears to be both necessary and sufficient to propagate this lipid-mediated apoptotic pathway.
T4 346-545 Sentence denotes Later events common to many apoptotic pathways include induction of the mitochondrial permeability transition (PT) and cytochrome c release, which in turn triggers downstream caspases and cell death.
T5 546-625 Sentence denotes The links between GD3 formation and downstream stages of apoptosis are unknown.
T6 626-852 Sentence denotes We report that ganglioside GD3 directly induces the PT in isolated rat liver mitochondria at 30-100 microM in the presence of exogenous substrate (succinate) and at approximately 3 microM in the absence of exogenous substrate.
T7 853-1041 Sentence denotes In contrast, other gangliosides tested (e.g. GM1) have only weak stimulatory effects in the presence of succinate and protect against PT induction in the absence of respiratory substrates.
T8 1042-1166 Sentence denotes GD3-mediated induction of PT was antagonized by known PT inhibitors, namely cyclosporin A, ADP, trifluoperazine, and Mg(2+).
T9 1167-1326 Sentence denotes GD3 induced PT even in the presence of submicromolar Ca(2+); GD3 is therefore the first biological PT inducer identified that does not require elevated Ca(2+).
T10 1327-1390 Sentence denotes Exposure to GD3 also led to mitochondrial cytochrome c release.
T11 1391-1548 Sentence denotes In contrast, C(2)-ceramide, which can initiate the lipid-mediated apoptotic cascade in susceptible cells, failed to either induce PT or release cytochrome c.
T12 1549-1650 Sentence denotes These observations suggest that GD3 propagates apoptosis by inducing the PT and cytochrome c release.
T13 1651-1771 Sentence denotes This model provides a mechanistic link between the earlier and later stages of CD95-induced/ceramide-mediated apoptosis.

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 898-901 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 697-702 Body_part denotes liver FMA:7197

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 346-351 Body_part denotes Later http://purl.obolibrary.org/obo/MAT_0000488
T2 697-702 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T3 1714-1719 Body_part denotes later http://purl.obolibrary.org/obo/MAT_0000488

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 693-696 OrganismTaxon denotes rat 10114|10116

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 697-702 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107