PubMed:10438457 / 411-752 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T4	0-341	Sentence	denotes	By using Jurkat and primary human T lymphocytes, we demonstrate that the simultaneous activation of two second messengers of the TCR-initiated signal transduction, protein kinase C (PKC) and calcineurin, results in the synergistic activation of the IkappaBalpha kinase (IKK) complex but not of another putative IkappaBalpha kinase, p90(rsk).
T4	0-341	Sentence	denotes	By using Jurkat and primary human T lymphocytes, we demonstrate that the simultaneous activation of two second messengers of the TCR-initiated signal transduction, protein kinase C (PKC) and calcineurin, results in the synergistic activation of the IkappaBalpha kinase (IKK) complex but not of another putative IkappaBalpha kinase, p90(rsk).

Id	Subject	Object	Predicate	Lexical cue
T4	0-341	Sentence	denotes	By using Jurkat and primary human T lymphocytes, we demonstrate that the simultaneous activation of two second messengers of the TCR-initiated signal transduction, protein kinase C (PKC) and calcineurin, results in the synergistic activation of the IkappaBalpha kinase (IKK) complex but not of another putative IkappaBalpha kinase, p90(rsk).

Id	Subject	Object	Predicate	Lexical cue
T12	9-15	cell_line	denotes	Jurkat
T13	20-47	cell_type	denotes	primary human T lymphocytes
T14	129-132	protein	denotes	TCR
T15	164-180	protein	denotes	protein kinase C
T16	182-185	protein	denotes	PKC
T17	191-202	protein	denotes	calcineurin
T18	249-282	protein	denotes	IkappaBalpha kinase (IKK) complex
T19	302-330	protein	denotes	putative IkappaBalpha kinase
T20	332-340	protein	denotes	p90(rsk)

Id	Subject	Object	Predicate	Lexical cue
C13	100-162	NP	denotes	two second messengers of the TCR-initiated signal transduction
C14	164-202	NP	denotes	protein kinase C (PKC) and calcineurin
C12	69-202	NP	denotes	the simultaneous activation of two second messengers of the TCR-initiated signal transduction, protein kinase C (PKC) and calcineurin
C15	245-282	NP	denotes	the IkappaBalpha kinase (IKK) complex
C16	294-330	NP	denotes	another putative IkappaBalpha kinase
C17	332-340	NP	denotes	p90(rsk)
R6	C14	C13	coref-appos	protein kinase C (PKC) and calcineurin,two second messengers of the TCR-initiated signal transduction
R8	C17	C16	coref-appos	p90(rsk),another putative IkappaBalpha kinase

Id	Subject	Object	Predicate	Lexical cue
E1-ab-3	28-33	cui:C0020114	denotes	human
E2-ab-3	34-47	cui:C0039194	denotes	T lymphocytes
E3-ab-3	73-85	cui:C0521115	denotes	simultaneous
E4-ab-3	100-103	cui:C0205448	denotes	two
E5-ab-3	104-121	cui:C1508748	denotes	second messengers
E6-ab-3	129-132	cui:C0034790	denotes	TCR
E7-ab-3	133-142	cui:C1548602	denotes	initiated
E8-ab-3	143-162	cui:C0037083	denotes	signal transduction
E9-ab-3	164-180	cui:C0033634	denotes	protein kinase C
E10-ab-3	191-202	cui:C0054450	denotes	calcineurin
E11-ab-3	249-268	cui:C0754623	denotes	IkappaBalpha kinase
E12-ab-3	275-282	cui:C0439855	denotes	complex
E13-ab-3	287-290	cui:C1518422	denotes	not
E14-ab-3	311-330	cui:C0754623	denotes	IkappaBalpha kinase
E15-ab-3	332-335	cui:C1619635	denotes	p90
E16-ab-3	336-339	entrez:6195,6196,6197	denotes	rsk
T6	28-47	PART_OF	denotes	human T lymphocytes
T7	86-96	STIMULATES	denotes	activation
R11	E2-ab-3	T6	subjectOf	T lymphocytes,human T lymphocytes
R12	E1-ab-3	T6	objectOf	human,human T lymphocytes
R13	E15-ab-3	T7	subjectOf	p90,activation
R14	E5-ab-3	T7	objectOf	second messengers,activation

Id	Subject	Object	Predicate	Lexical cue
S4	0-341	Sentence	denotes	By using Jurkat and primary human T lymphocytes, we demonstrate that the simultaneous activation of two second messengers of the TCR-initiated signal transduction, protein kinase C (PKC) and calcineurin, results in the synergistic activation of the IkappaBalpha kinase (IKK) complex but not of another putative IkappaBalpha kinase, p90(rsk).

Id	Subject	Object	Predicate	Lexical cue
T15	9-15	cell_line	denotes	Jurkat
T16	20-33	cell_type	denotes	primary human
T17	34-47	cell_type	denotes	T lymphocytes
T18	129-132	protein_family_or_group	denotes	TCR
T19	164-180	protein_molecule	denotes	protein kinase C
T20	182-185	protein_molecule	denotes	PKC
T21	191-202	protein_molecule	denotes	calcineurin
T22	249-261	protein_molecule	denotes	IkappaBalpha
T23	302-310	protein_family_or_group	denotes	putative
T24	311-323	protein_molecule	denotes	IkappaBalpha
T25	332-340	protein_molecule	denotes	p90(rsk)

Id	Subject	Object	Predicate	Lexical cue
T3	165-181	C0033634	denotes	rotein kinase C
T6	35-48	C0039194	denotes	lymphocytes,
T11	192-203	C1149946	denotes	alcineurin,
T29	130-133	C0034790	denotes	CR-
T31	333-340	C0248441	denotes	90(rsk)
T39	105-122	C0036522	denotes	econd messengers
T40	29-34	C0086418	denotes	uman
T48	276-283	C1704241	denotes	omplex
T53	205-212	C2825142	denotes	esults
T59	288-291	C1518422	denotes	ot
T64	4-9	C1524063	denotes	sing
T73	220-231	C2986495	denotes	ynergistic
T75	21-28	C0205225	denotes	rimary
T78	134-143	C1704686	denotes	nitiated
T80	74-86	C0521115	denotes	imultaneous
T81	101-104	C0205448	denotes	wo

Id	Subject	Object	Predicate	Lexical cue	db_id
T1	28-33	OrganismTaxon	denotes	human	9606

Id	Subject	Object	Predicate	Lexical cue	uberon_id
T3	34-47	Body_part	denotes	T lymphocytes	http://purl.obolibrary.org/obo/CL_0000084

Id	Subject	Object	Predicate	Lexical cue	cl_id
T3	34-47	Cell	denotes	T lymphocytes	http://purl.obolibrary.org/obo/CL:0000084