PubMed:10437913 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	117-122	HP_0002664	denotes	Tumor
T2	151-165	HP_0009919	denotes	retinoblastoma

Id	Subject	Object	Predicate	Lexical cue
T1	51-56	protein	denotes	Oct-1
T2	91-104	protein	denotes	interleukin-8
T3	151-170	DNA	denotes	retinoblastoma gene
T4	200-218	DNA	denotes	HLA class II genes
T5	234-243	protein	denotes	IFN-gamma
T6	288-290	protein	denotes	Rb
T7	317-330	DNA	denotes	class II gene
T8	379-381	protein	denotes	Rb
T9	396-410	DNA	denotes	class II genes
T10	454-456	protein	denotes	Rb
T11	506-513	DNA	denotes	HLA-DRA
T12	519-542	DNA	denotes	prototype class II gene
T13	544-549	protein	denotes	Oct-1
T14	553-584	protein	denotes	POU domain transcription factor
T15	619-626	DNA	denotes	HLA-DRA
T16	652-670	cell_type	denotes	Rb-defective cells
T17	672-674	protein	denotes	Rb
T18	712-717	protein	denotes	Oct-1
T19	757-762	protein	denotes	Oct-1
T20	794-807	protein	denotes	interleukin 8
T21	861-866	protein	denotes	Oct-1
T22	895-920	cell_line	denotes	Rb-transformed cell lines
T23	922-935	protein	denotes	interleukin 8

Id	Subject	Object	Predicate	Lexical cue
C14	91-115	NP	denotes	interleukin-8 expression
C1	196-218	NP	denotes	the HLA class II genes
C2	392-410	NP	denotes	the class II genes
C7	454-467	NP	denotes	Rb expression
C3	506-513	NP	denotes	HLA-DRA
C4	515-542	NP	denotes	the prototype class II gene
C5	544-549	NP	denotes	Oct-1
C6	551-584	NP	denotes	a POU domain transcription factor
C12	652-655	NP	denotes	Rb-
C8	672-685	NP	denotes	Rb expression
C9	712-717	NP	denotes	Oct-1
C10	734-737	NP	denotes	its
C11	757-762	NP	denotes	Oct-1
C13	895-898	NP	denotes	Rb-
C15	922-946	NP	denotes	interleukin 8 expression
R1	C2	C1	coref-ident	the class II genes,the HLA class II genes
R2	C4	C3	coref-appos	the prototype class II gene,HLA-DRA
R3	C6	C5	coref-appos	a POU domain transcription factor,Oct-1
R4	C8	C7	coref-ident	Rb expression,Rb expression
R5	C9	C5	coref-ident	Oct-1,Oct-1
R6	C10	C8	coref-pron	its,Rb expression
R7	C11	C9	coref-ident	Oct-1,Oct-1
R8	C13	C12	coref-ident	Rb-,Rb-
R9	C15	C14	coref-ident	interleukin 8 expression,interleukin-8 expression

Id	Subject	Object	Predicate	Lexical cue
S1	0-116	Sentence	denotes	Retinoblastoma protein expression leads to reduced Oct-1 DNA binding activity and enhances interleukin-8 expression.
S2	117-342	Sentence	denotes	Tumor cell lines with a defective retinoblastoma gene are unable to transcribe the HLA class II genes in response to IFN-gamma treatment, and reconstitution of functional Rb rescues IFN-gamma-induced class II gene expression.
S3	343-422	Sentence	denotes	However, the molecular mechanism of Rb rescue of the class II genes is unknown.
S4	423-543	Sentence	denotes	We have examined the effect of Rb expression on the activation of the promoter for HLA-DRA, the prototype class II gene.
S5	544-671	Sentence	denotes	Oct-1, a POU domain transcription factor, was identified as a repressor of HLA-DRA promoter activity in the Rb-defective cells.
S6	672-756	Sentence	denotes	Rb expression led to phosphorylation of Oct-1, thus relieving its repressive effect.
S7	757-826	Sentence	denotes	Oct-1 has also been shown to repress interleukin 8 promoter activity.
S8	827-977	Sentence	denotes	Consistent with reduced levels of Oct-1 DNA binding activity in the Rb-transformed cell lines, interleukin 8 expression is higher in these cell lines.

Id	Subject	Object	Predicate	Lexical cue
T1	51-56	protein_molecule	denotes	Oct-1
T2	91-104	protein_molecule	denotes	interleukin-8
T3	151-165	other_name	denotes	retinoblastoma
T4	200-218	DNA_family_or_group	denotes	HLA class II genes
T5	234-243	protein_molecule	denotes	IFN-gamma
T6	288-290	protein_molecule	denotes	Rb
T7	299-316	other_name	denotes	IFN-gamma-induced
T8	317-330	DNA_family_or_group	denotes	class II gene
T9	379-381	protein_molecule	denotes	Rb
T10	396-410	DNA_family_or_group	denotes	class II genes
T11	454-456	protein_molecule	denotes	Rb
T12	506-513	DNA_domain_or_region	denotes	HLA-DRA
T13	519-542	DNA_domain_or_region	denotes	prototype class II gene
T14	544-549	protein_molecule	denotes	Oct-1
T15	553-584	protein_family_or_group	denotes	POU domain transcription factor
T16	619-626	DNA_domain_or_region	denotes	HLA-DRA
T17	652-670	cell_type	denotes	Rb-defective cells
T18	672-674	protein_molecule	denotes	Rb
T19	712-717	protein_molecule	denotes	Oct-1
T20	757-762	protein_molecule	denotes	Oct-1
T21	794-807	protein_molecule	denotes	interleukin 8
T22	861-866	protein_molecule	denotes	Oct-1
T23	895-920	cell_line	denotes	Rb-transformed cell lines
T24	922-935	protein_molecule	denotes	interleukin 8