PubMed:10435586 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	164-186	HP_0004808	denotes	acute myeloid leukemia
T2	170-186	HP_0012324	denotes	myeloid leukemia
T3	178-186	HP_0001909	denotes	leukemia

Id	Subject	Object	Predicate	Lexical cue
T1	41-53	cell_line	denotes	32Dcl3 cells
T2	57-71	DNA	denotes	AML1/ETO(MTG8)
T3	100-105	protein	denotes	Bcl-2
T4	111-125	DNA	denotes	chimeric gene,
T5	126-141	DNA	denotes	AML1/ETO (MTG8)
T6	156-163	DNA	denotes	t(8;21)
T7	214-219	protein	denotes	Bcl-2
T8	281-289	DNA	denotes	AML1/ETO
T9	339-344	protein	denotes	Bcl-2
T10	352-386	cell_line	denotes	murine myeloid precursor cell line
T11	388-394	cell_line	denotes	32Dcl3
T12	416-428	cell_line	denotes	32Dcl3 cells
T13	450-455	protein	denotes	Bcl-2
T14	608-613	protein	denotes	Bcl-2
T15	702-707	protein	denotes	Bcl-2
T16	726-738	cell_line	denotes	32Dcl3 cells
T17	757-765	DNA	denotes	AML1/ETO
T18	852-857	protein	denotes	G-CSF
T19	932-937	protein	denotes	Bcl-2
T20	978-986	DNA	denotes	AML1/ETO

Id	Subject	Object	Predicate	Lexical cue
10435586-1#107#112#gene596	214-219	gene596	denotes	Bcl-2
10435586-1#57#79#diseaseC0023467	164-186	diseaseC0023467	denotes	acute myeloid leukemia
10435586-2#65#68#gene862	286-289	gene862	denotes	ETO
10435586-2#118#123#gene596	339-344	gene596	denotes	Bcl-2
10435586-2#72#86#diseaseC0598766	293-307	diseaseC0598766	denotes	leukemogenesis
107#112#gene59657#79#diseaseC0023467	10435586-1#107#112#gene596	10435586-1#57#79#diseaseC0023467	associated_with	Bcl-2,acute myeloid leukemia
65#68#gene86272#86#diseaseC0598766	10435586-2#65#68#gene862	10435586-2#72#86#diseaseC0598766	associated_with	ETO,leukemogenesis
118#123#gene59672#86#diseaseC0598766	10435586-2#118#123#gene596	10435586-2#72#86#diseaseC0598766	associated_with	Bcl-2,leukemogenesis

Id	Subject	Object	Predicate	Lexical cue
C4	57-71	NP	denotes	AML1/ETO(MTG8)
C1	107-124	NP	denotes	The chimeric gene
C2	126-141	NP	denotes	AML1/ETO (MTG8)
C3	214-219	NP	denotes	Bcl-2
C13	196-219	NP	denotes	the expression of Bcl-2
C5	281-289	NP	denotes	AML1/ETO
C6	339-344	NP	denotes	Bcl-2
C7	348-386	NP	denotes	the murine myeloid precursor cell line
C8	388-394	NP	denotes	32Dcl3
C9	702-707	NP	denotes	Bcl-2
C11	893-911	NP	denotes	the interpretation
C12	912-916	NP	denotes	that
C14	932-948	NP	denotes	Bcl-2 expression
C15	978-986	NP	denotes	AML1/ETO
R1	C2	C1	coref-appos	AML1/ETO (MTG8),The chimeric gene
R2	C5	C4	coref-ident	AML1/ETO,AML1/ETO(MTG8)
R3	C6	C3	coref-ident	Bcl-2,Bcl-2
R4	C8	C7	coref-appos	32Dcl3,the murine myeloid precursor cell line
R5	C9	C6	coref-ident	Bcl-2,Bcl-2
R6	C12	C11	coref-relat	that,the interpretation
R7	C14	C13	coref-ident	Bcl-2 expression,the expression of Bcl-2
R8	C15	C5	coref-ident	AML1/ETO,AML1/ETO

Id	Subject	Object	Predicate	Lexical cue
S1	0-106	Sentence	denotes	Block of granulocytic differentiation of 32Dcl3 cells by AML1/ETO(MTG8) but not by highly expressed Bcl-2.
S2	107-220	Sentence	denotes	The chimeric gene, AML1/ETO (MTG8), generated in t(8;21) acute myeloid leukemia enhances the expression of Bcl-2.
S3	221-410	Sentence	denotes	To evaluate whether this enhancement is the primary role of AML1/ETO in leukemogenesis, effects of over-expression of Bcl-2 in the murine myeloid precursor cell line, 32Dcl3, were examined.
S4	411-542	Sentence	denotes	When 32Dcl3 cells expressing exogenous Bcl-2 were induced to differentiate, the onset of morphological differentiation was delayed.
S5	543-708	Sentence	denotes	However, even the cells expressing very high levels of exogenous Bcl-2 eventually underwent differentiation without a significant decrease in the synthesis of Bcl-2.
S6	709-858	Sentence	denotes	On the contrary, 32Dcl3 cells stably expressing AML1/ETO were completely resistant to differentiation and continued to grow in the presence of G-CSF.
S7	859-987	Sentence	denotes	These results are consistent with the interpretation that stimulation of Bcl-2 expression is not the primary target of AML1/ETO.

Id	Subject	Object	Predicate	Lexical cue
T1	9-37	other_name	denotes	granulocytic differentiation
T2	41-53	cell_line	denotes	32Dcl3 cells
T3	57-71	DNA_domain_or_region	denotes	AML1/ETO(MTG8)
T4	100-105	protein_molecule	denotes	Bcl-2
T5	111-125	DNA_family_or_group	denotes	chimeric gene,
T6	126-141	DNA_domain_or_region	denotes	AML1/ETO (MTG8)
T7	156-163	DNA_domain_or_region	denotes	t(8;21)
T8	164-186	other_name	denotes	acute myeloid leukemia
T9	214-219	protein_molecule	denotes	Bcl-2
T10	281-289	DNA_domain_or_region	denotes	AML1/ETO
T11	293-307	other_name	denotes	leukemogenesis
T12	339-344	protein_molecule	denotes	Bcl-2
T13	352-386	cell_line	denotes	murine myeloid precursor cell line
T14	388-394	cell_line	denotes	32Dcl3
T15	416-428	cell_line	denotes	32Dcl3 cells
T16	450-455	protein_molecule	denotes	Bcl-2
T17	500-529	other_name	denotes	morphological differentiation
T18	608-613	protein_molecule	denotes	Bcl-2
T19	702-707	protein_molecule	denotes	Bcl-2
T20	726-738	cell_line	denotes	32Dcl3 cells
T21	757-765	DNA_domain_or_region	denotes	AML1/ETO
T22	852-857	protein_molecule	denotes	G-CSF
T23	932-937	protein_molecule	denotes	Bcl-2
T24	978-986	DNA_domain_or_region	denotes	AML1/ETO

Id	Subject	Object	Predicate	Lexical cue
T0	214-219	gene:596	denotes	Bcl-2
T1	164-186	disease:C0023467	denotes	acute myeloid leukemia
R1	T0	T1	associated_with	Bcl-2,acute myeloid leukemia