PubMed:10433370 JSONTXT

Annnotations TAB JSON ListView MergeView

    jnlpba-st-training

    {"project":"jnlpba-st-training","denotations":[{"id":"T1","span":{"begin":34,"end":74},"obj":"protein"},{"id":"T2","span":{"begin":78,"end":93},"obj":"cell_type"},{"id":"T3","span":{"begin":125,"end":141},"obj":"protein"},{"id":"T4","span":{"begin":143,"end":152},"obj":"protein"},{"id":"T5","span":{"begin":158,"end":172},"obj":"protein"},{"id":"T6","span":{"begin":174,"end":179},"obj":"protein"},{"id":"T7","span":{"begin":213,"end":224},"obj":"cell_type"},{"id":"T8","span":{"begin":360,"end":405},"obj":"protein"},{"id":"T9","span":{"begin":422,"end":425},"obj":"DNA"},{"id":"T10","span":{"begin":443,"end":464},"obj":"protein"},{"id":"T11","span":{"begin":483,"end":501},"obj":"DNA"},{"id":"T12","span":{"begin":532,"end":548},"obj":"protein"},{"id":"T13","span":{"begin":573,"end":588},"obj":"DNA"},{"id":"T14","span":{"begin":596,"end":606},"obj":"DNA"},{"id":"T15","span":{"begin":616,"end":641},"obj":"protein"},{"id":"T16","span":{"begin":646,"end":651},"obj":"protein"},{"id":"T17","span":{"begin":682,"end":687},"obj":"protein"},{"id":"T18","span":{"begin":698,"end":707},"obj":"protein"},{"id":"T19","span":{"begin":716,"end":720},"obj":"protein"},{"id":"T20","span":{"begin":740,"end":765},"obj":"protein"},{"id":"T21","span":{"begin":839,"end":848},"obj":"protein"},{"id":"T22","span":{"begin":857,"end":861},"obj":"protein"},{"id":"T23","span":{"begin":917,"end":938},"obj":"protein"},{"id":"T24","span":{"begin":975,"end":994},"obj":"DNA"},{"id":"T25","span":{"begin":1004,"end":1029},"obj":"protein"},{"id":"T26","span":{"begin":1034,"end":1039},"obj":"protein"},{"id":"T27","span":{"begin":1082,"end":1101},"obj":"DNA"},{"id":"T28","span":{"begin":1143,"end":1148},"obj":"protein"},{"id":"T29","span":{"begin":1153,"end":1162},"obj":"protein"},{"id":"T30","span":{"begin":1216,"end":1221},"obj":"protein"},{"id":"T31","span":{"begin":1225,"end":1234},"obj":"protein"}],"text":"Selective DNA-binding activity of interleukin-10-stimulated STAT molecules in human monocytes.\nIt has been demonstrated that interferon-gamma (IFN-gamma) and interleukin-10 (IL-10) have various reverse effects on macrophages; however, the molecular mechanism of this difference has not been fully understood. In this study, we analyzed the binding activity of IL-10- and IFN-gamma-activated STAT molecules to two kinds of GAS-motif sequences. IL-10-activated STAT1 could bind to the GAS-motif sequence in the promoter region of the Fcgamma receptor, but not to that in the promoter region of the COX-2 gene, whereas IFN-gamma-activated STAT1 and STAT5 could bind to both sequences. IL-10 inhibited IFN-gamma-induced STAT activation without newly synthesized protein. We further demonstrated that aspirin, but not dexamethasone, suppressed IFN-gamma-induced STAT activation. Taken together, these results suggest that IL-10-activated STAT1 has a specificity in binding to the GAS-motif sequences, whereas IFN-gamma-activated STAT1 and STAT5 have a broader spectrum in binding to the GAS-motif sequences. This may explain the difference between IL-10 and IFN-gamma in biological activity, and the inhibitory effect of IL-10 on IFN-gamma activities."}

    genia-medco-coref

    {"project":"genia-medco-coref","denotations":[{"id":"C1","span":{"begin":34,"end":49},"obj":"NP"},{"id":"C4","span":{"begin":125,"end":153},"obj":"NP"},{"id":"C2","span":{"begin":158,"end":180},"obj":"NP"},{"id":"C3","span":{"begin":360,"end":366},"obj":"NP"},{"id":"C5","span":{"begin":371,"end":381},"obj":"NP"},{"id":"C26","span":{"begin":422,"end":426},"obj":"NP"},{"id":"C25","span":{"begin":409,"end":441},"obj":"NP"},{"id":"C6","span":{"begin":443,"end":458},"obj":"NP"},{"id":"C15","span":{"begin":443,"end":464},"obj":"NP"},{"id":"C27","span":{"begin":483,"end":487},"obj":"NP"},{"id":"C7","span":{"begin":479,"end":501},"obj":"NP"},{"id":"C8","span":{"begin":561,"end":565},"obj":"NP"},{"id":"C9","span":{"begin":616,"end":626},"obj":"NP"},{"id":"C19","span":{"begin":616,"end":651},"obj":"NP"},{"id":"C10","span":{"begin":666,"end":680},"obj":"NP"},{"id":"C11","span":{"begin":682,"end":687},"obj":"NP"},{"id":"C28","span":{"begin":698,"end":708},"obj":"NP"},{"id":"C12","span":{"begin":698,"end":731},"obj":"NP"},{"id":"C29","span":{"begin":839,"end":849},"obj":"NP"},{"id":"C13","span":{"begin":839,"end":872},"obj":"NP"},{"id":"C16","span":{"begin":917,"end":923},"obj":"NP"},{"id":"C14","span":{"begin":917,"end":938},"obj":"NP"},{"id":"C30","span":{"begin":975,"end":979},"obj":"NP"},{"id":"C17","span":{"begin":971,"end":994},"obj":"NP"},{"id":"C20","span":{"begin":1004,"end":1014},"obj":"NP"},{"id":"C18","span":{"begin":1004,"end":1039},"obj":"NP"},{"id":"C31","span":{"begin":1082,"end":1086},"obj":"NP"},{"id":"C21","span":{"begin":1078,"end":1101},"obj":"NP"},{"id":"C22","span":{"begin":1143,"end":1148},"obj":"NP"},{"id":"C23","span":{"begin":1153,"end":1162},"obj":"NP"},{"id":"C24","span":{"begin":1216,"end":1221},"obj":"NP"}],"relations":[{"id":"R1","pred":"coref-ident","subj":"C2","obj":"C1"},{"id":"R2","pred":"coref-ident","subj":"C3","obj":"C2"},{"id":"R3","pred":"coref-ident","subj":"C5","obj":"C4"},{"id":"R4","pred":"coref-ident","subj":"C6","obj":"C3"},{"id":"R5","pred":"coref-ident","subj":"C27","obj":"C26"},{"id":"R6","pred":"coref-part-whole","subj":"C7","obj":"C25"},{"id":"R7","pred":"coref-ident","subj":"C8","obj":"C7"},{"id":"R8","pred":"coref-ident","subj":"C9","obj":"C5"},{"id":"R9","pred":"coref-ident","subj":"C10","obj":"C25"},{"id":"R10","pred":"coref-ident","subj":"C11","obj":"C6"},{"id":"R11","pred":"coref-ident","subj":"C12","obj":"C9"},{"id":"R12","pred":"coref-ident","subj":"C29","obj":"C28"},{"id":"R13","pred":"coref-ident","subj":"C13","obj":"C12"},{"id":"R14","pred":"coref-ident","subj":"C16","obj":"C15"},{"id":"R15","pred":"coref-ident","subj":"C14","obj":"C11"},{"id":"R16","pred":"coref-ident","subj":"C30","obj":"C27"},{"id":"R17","pred":"coref-ident","subj":"C17","obj":"C10"},{"id":"R18","pred":"coref-ident","subj":"C20","obj":"C19"},{"id":"R19","pred":"coref-ident","subj":"C18","obj":"C13"},{"id":"R20","pred":"coref-ident","subj":"C31","obj":"C30"},{"id":"R21","pred":"coref-ident","subj":"C21","obj":"C17"},{"id":"R22","pred":"coref-ident","subj":"C22","obj":"C14"},{"id":"R23","pred":"coref-ident","subj":"C23","obj":"C18"},{"id":"R24","pred":"coref-ident","subj":"C24","obj":"C22"}],"text":"Selective DNA-binding activity of interleukin-10-stimulated STAT molecules in human monocytes.\nIt has been demonstrated that interferon-gamma (IFN-gamma) and interleukin-10 (IL-10) have various reverse effects on macrophages; however, the molecular mechanism of this difference has not been fully understood. In this study, we analyzed the binding activity of IL-10- and IFN-gamma-activated STAT molecules to two kinds of GAS-motif sequences. IL-10-activated STAT1 could bind to the GAS-motif sequence in the promoter region of the Fcgamma receptor, but not to that in the promoter region of the COX-2 gene, whereas IFN-gamma-activated STAT1 and STAT5 could bind to both sequences. IL-10 inhibited IFN-gamma-induced STAT activation without newly synthesized protein. We further demonstrated that aspirin, but not dexamethasone, suppressed IFN-gamma-induced STAT activation. Taken together, these results suggest that IL-10-activated STAT1 has a specificity in binding to the GAS-motif sequences, whereas IFN-gamma-activated STAT1 and STAT5 have a broader spectrum in binding to the GAS-motif sequences. This may explain the difference between IL-10 and IFN-gamma in biological activity, and the inhibitory effect of IL-10 on IFN-gamma activities."}

    pubmed-sentences-benchmark

    {"project":"pubmed-sentences-benchmark","denotations":[{"id":"S1","span":{"begin":0,"end":94},"obj":"Sentence"},{"id":"S2","span":{"begin":95,"end":308},"obj":"Sentence"},{"id":"S3","span":{"begin":309,"end":442},"obj":"Sentence"},{"id":"S4","span":{"begin":443,"end":681},"obj":"Sentence"},{"id":"S5","span":{"begin":682,"end":766},"obj":"Sentence"},{"id":"S6","span":{"begin":767,"end":873},"obj":"Sentence"},{"id":"S7","span":{"begin":874,"end":1102},"obj":"Sentence"},{"id":"S8","span":{"begin":1103,"end":1246},"obj":"Sentence"}],"text":"Selective DNA-binding activity of interleukin-10-stimulated STAT molecules in human monocytes.\nIt has been demonstrated that interferon-gamma (IFN-gamma) and interleukin-10 (IL-10) have various reverse effects on macrophages; however, the molecular mechanism of this difference has not been fully understood. In this study, we analyzed the binding activity of IL-10- and IFN-gamma-activated STAT molecules to two kinds of GAS-motif sequences. IL-10-activated STAT1 could bind to the GAS-motif sequence in the promoter region of the Fcgamma receptor, but not to that in the promoter region of the COX-2 gene, whereas IFN-gamma-activated STAT1 and STAT5 could bind to both sequences. IL-10 inhibited IFN-gamma-induced STAT activation without newly synthesized protein. We further demonstrated that aspirin, but not dexamethasone, suppressed IFN-gamma-induced STAT activation. Taken together, these results suggest that IL-10-activated STAT1 has a specificity in binding to the GAS-motif sequences, whereas IFN-gamma-activated STAT1 and STAT5 have a broader spectrum in binding to the GAS-motif sequences. This may explain the difference between IL-10 and IFN-gamma in biological activity, and the inhibitory effect of IL-10 on IFN-gamma activities."}

    GENIAcorpus

    {"project":"GENIAcorpus","denotations":[{"id":"T1","span":{"begin":10,"end":30},"obj":"other_name"},{"id":"T2","span":{"begin":34,"end":48},"obj":"protein_molecule"},{"id":"T3","span":{"begin":78,"end":93},"obj":"cell_type"},{"id":"T4","span":{"begin":125,"end":141},"obj":"protein_molecule"},{"id":"T5","span":{"begin":143,"end":152},"obj":"protein_molecule"},{"id":"T6","span":{"begin":158,"end":172},"obj":"protein_molecule"},{"id":"T7","span":{"begin":174,"end":179},"obj":"protein_molecule"},{"id":"T8","span":{"begin":213,"end":224},"obj":"cell_type"},{"id":"T9","span":{"begin":422,"end":425},"obj":"DNA_domain_or_region"},{"id":"T10","span":{"begin":443,"end":448},"obj":"protein_molecule"},{"id":"T11","span":{"begin":459,"end":464},"obj":"protein_molecule"},{"id":"T12","span":{"begin":483,"end":501},"obj":"DNA_domain_or_region"},{"id":"T13","span":{"begin":509,"end":524},"obj":"other_name"},{"id":"T14","span":{"begin":532,"end":548},"obj":"protein_family_or_group"},{"id":"T15","span":{"begin":573,"end":588},"obj":"DNA_domain_or_region"},{"id":"T16","span":{"begin":596,"end":606},"obj":"DNA_domain_or_region"},{"id":"T17","span":{"begin":616,"end":625},"obj":"protein_molecule"},{"id":"T18","span":{"begin":636,"end":641},"obj":"protein_molecule"},{"id":"T19","span":{"begin":646,"end":651},"obj":"protein_molecule"},{"id":"T20","span":{"begin":682,"end":687},"obj":"protein_molecule"},{"id":"T21","span":{"begin":698,"end":707},"obj":"protein_molecule"},{"id":"T22","span":{"begin":716,"end":720},"obj":"protein_family_or_group"},{"id":"T23","span":{"begin":740,"end":765},"obj":"protein_family_or_group"},{"id":"T24","span":{"begin":796,"end":803},"obj":"other_organic_compound"},{"id":"T25","span":{"begin":813,"end":826},"obj":"lipid"},{"id":"T26","span":{"begin":839,"end":848},"obj":"protein_molecule"},{"id":"T27","span":{"begin":857,"end":861},"obj":"protein_family_or_group"},{"id":"T28","span":{"begin":917,"end":932},"obj":"protein_molecule"},{"id":"T29","span":{"begin":933,"end":938},"obj":"protein_molecule"},{"id":"T30","span":{"begin":975,"end":994},"obj":"DNA_domain_or_region"},{"id":"T31","span":{"begin":1004,"end":1013},"obj":"protein_molecule"},{"id":"T32","span":{"begin":1024,"end":1029},"obj":"protein_molecule"},{"id":"T33","span":{"begin":1034,"end":1039},"obj":"protein_molecule"},{"id":"T34","span":{"begin":1082,"end":1101},"obj":"DNA_domain_or_region"},{"id":"T35","span":{"begin":1143,"end":1148},"obj":"protein_molecule"},{"id":"T36","span":{"begin":1153,"end":1162},"obj":"protein_molecule"},{"id":"T37","span":{"begin":1166,"end":1185},"obj":"other_name"},{"id":"T38","span":{"begin":1216,"end":1221},"obj":"protein_molecule"},{"id":"T39","span":{"begin":1225,"end":1234},"obj":"protein_molecule"}],"text":"Selective DNA-binding activity of interleukin-10-stimulated STAT molecules in human monocytes.\nIt has been demonstrated that interferon-gamma (IFN-gamma) and interleukin-10 (IL-10) have various reverse effects on macrophages; however, the molecular mechanism of this difference has not been fully understood. In this study, we analyzed the binding activity of IL-10- and IFN-gamma-activated STAT molecules to two kinds of GAS-motif sequences. IL-10-activated STAT1 could bind to the GAS-motif sequence in the promoter region of the Fcgamma receptor, but not to that in the promoter region of the COX-2 gene, whereas IFN-gamma-activated STAT1 and STAT5 could bind to both sequences. IL-10 inhibited IFN-gamma-induced STAT activation without newly synthesized protein. We further demonstrated that aspirin, but not dexamethasone, suppressed IFN-gamma-induced STAT activation. Taken together, these results suggest that IL-10-activated STAT1 has a specificity in binding to the GAS-motif sequences, whereas IFN-gamma-activated STAT1 and STAT5 have a broader spectrum in binding to the GAS-motif sequences. This may explain the difference between IL-10 and IFN-gamma in biological activity, and the inhibitory effect of IL-10 on IFN-gamma activities."}