PubMed:10430944
Annnotations
PMID_GLOBAL
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 1015-1033 | DiseaseOrPhenotypicFeature | denotes | Burkitt's lymphoma | 0007243 |
| T2 | 1058-1082 | DiseaseOrPhenotypicFeature | denotes | nasopharyngeal carcinoma | 0011775|0015459 |
| T4 | 1084-1087 | DiseaseOrPhenotypicFeature | denotes | NPC | 0011775|0015459|0018982 |
| T7 | 1190-1193 | DiseaseOrPhenotypicFeature | denotes | NPC | 0011775|0015459|0018982 |
| T10 | 1261-1264 | DiseaseOrPhenotypicFeature | denotes | NPC | 0011775|0015459|0018982 |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 210-216 | HP_0002664 | denotes | tumors |
| T2 | 1015-1033 | HP_0030080 | denotes | Burkitt's lymphoma |
| T3 | 1025-1033 | HP_0002665 | denotes | lymphoma |
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 4-47 | DNA | denotes | Epstein-Barr virus latency BamHI-Q promoter |
| T2 | 75-80 | protein | denotes | STATs |
| T3 | 85-88 | protein | denotes | Zta |
| T4 | 107-110 | protein | denotes | JAK |
| T5 | 110-115 | protein | denotes | /STAT |
| T6 | 144-160 | DNA | denotes | BamHI-Q promoter |
| T7 | 293-329 | protein | denotes | EBV-encoded nuclear antigen (EBNA)-1 |
| T8 | 386-391 | protein | denotes | EBNAs |
| T9 | 417-421 | protein | denotes | EBNA |
| T10 | 462-478 | DNA | denotes | BamHI-Q promoter |
| T11 | 480-482 | DNA | denotes | Qp |
| T12 | 513-516 | protein | denotes | JAK |
| T13 | 516-521 | protein | denotes | /STAT |
| T14 | 551-553 | DNA | denotes | Qp |
| T15 | 600-615 | DNA | denotes | Qp-CAT reporter |
| T16 | 647-652 | protein | denotes | JAK-1 |
| T17 | 688-696 | protein | denotes | cytokine |
| T18 | 697-701 | protein | denotes | IL-6 |
| T19 | 718-720 | DNA | denotes | Qp |
| T20 | 729-793 | protein | denotes | signal transducer and activator of transcription (STAT) proteins |
| T21 | 887-905 | DNA | denotes | STAT-binding sites |
| T22 | 914-916 | DNA | denotes | Qp |
| T23 | 935-955 | protein | denotes | Janus kinase (JAK)-1 |
| T24 | 984-989 | protein | denotes | STATs |
| T25 | 993-995 | DNA | denotes | Qp |
| T26 | 1006-1008 | DNA | denotes | Qp |
| T27 | 1015-1044 | cell_line | denotes | Burkitt's lymphoma Rael cells |
| T28 | 1049-1094 | cell_type | denotes | cultured nasopharyngeal carcinoma (NPC) cells |
| T29 | 1113-1125 | protein | denotes | STAT protein |
| T30 | 1177-1204 | cell_line | denotes | EBV-positive NPC cell lines |
| T31 | 1231-1233 | DNA | denotes | Qp |
| T32 | 1261-1280 | cell_line | denotes | NPC cell line HK666 |
| T33 | 1316-1321 | DNA | denotes | BZLF1 |
| T34 | 1337-1340 | protein | denotes | Zta |
| T35 | 1353-1355 | DNA | denotes | Qp |
| T36 | 1401-1404 | protein | denotes | Zta |
| T37 | 1442-1444 | DNA | denotes | Qp |
| T38 | 1464-1467 | protein | denotes | Zta |
| T39 | 1476-1478 | DNA | denotes | Qp |
| T40 | 1542-1545 | protein | denotes | Zta |
| T41 | 1593-1596 | protein | denotes | Zta |
| T42 | 1614-1617 | protein | denotes | p53 |
| T43 | 1627-1630 | protein | denotes | p53 |
| T44 | 1658-1661 | protein | denotes | JAK |
| T45 | 1661-1666 | protein | denotes | /STAT |
| T46 | 1681-1683 | DNA | denotes | Qp |
| T47 | 1705-1708 | protein | denotes | JAK |
| T48 | 1708-1713 | protein | denotes | /STAT |
FSU-PRGE
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 75-80 | protein | denotes | STATs |
| T2 | 85-88 | protein | denotes | Zta |
| T3 | 107-110 | protein | denotes | JAK |
| T4 | 111-115 | protein | denotes | STAT |
| T5 | 293-329 | protein | denotes | EBV-encoded nuclear antigen (EBNA)-1 |
| T6 | 386-391 | protein | denotes | EBNAs |
| T7 | 417-421 | protein | denotes | EBNA |
| T8 | 513-516 | protein | denotes | JAK |
| T9 | 517-521 | protein | denotes | STAT |
| T10 | 603-606 | protein | denotes | CAT |
| T11 | 647-652 | protein | denotes | JAK-1 |
| T12 | 688-696 | protein | denotes | cytokine |
| T13 | 697-701 | protein | denotes | IL-6 |
| T14 | 729-777 | protein | denotes | signal transducer and activator of transcription |
| T15 | 779-783 | protein | denotes | STAT |
| T16 | 887-891 | protein | denotes | STAT |
| T17 | 935-955 | protein | denotes | Janus kinase (JAK)-1 |
| T18 | 984-989 | protein | denotes | STATs |
| T19 | 1113-1117 | protein | denotes | STAT |
| T20 | 1316-1321 | protein | denotes | BZLF1 |
| T21 | 1337-1340 | protein | denotes | Zta |
| T22 | 1401-1404 | protein | denotes | Zta |
| T23 | 1464-1467 | protein | denotes | Zta |
| T24 | 1542-1545 | protein | denotes | Zta |
| T25 | 1593-1596 | protein | denotes | Zta |
| T26 | 1614-1617 | protein | denotes | p53 |
| T27 | 1627-1630 | protein | denotes | p53 |
| T28 | 1658-1661 | protein | denotes | JAK |
| T29 | 1662-1666 | protein | denotes | STAT |
| T30 | 1705-1708 | protein | denotes | JAK |
| T31 | 1709-1713 | protein | denotes | STAT |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 10430944-7#156#160#gene6646 | 1113-1117 | gene6646 | denotes | STAT |
| 10430944-7#58#76#diseaseC0006413 | 1015-1033 | diseaseC0006413 | denotes | Burkitt's lymphoma |
| 10430944-7#101#125#diseaseC2931822 | 1058-1082 | diseaseC2931822 | denotes | nasopharyngeal carcinoma |
| 10430944-7#127#130#diseaseC2931822 | 1084-1087 | diseaseC2931822 | denotes | NPC |
| 156#160#gene664658#76#diseaseC0006413 | 10430944-7#156#160#gene6646 | 10430944-7#58#76#diseaseC0006413 | associated_with | STAT,Burkitt's lymphoma |
| 156#160#gene6646101#125#diseaseC2931822 | 10430944-7#156#160#gene6646 | 10430944-7#101#125#diseaseC2931822 | associated_with | STAT,nasopharyngeal carcinoma |
| 156#160#gene6646127#130#diseaseC2931822 | 10430944-7#156#160#gene6646 | 10430944-7#127#130#diseaseC2931822 | associated_with | STAT,NPC |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C5 | 144-169 | NP | denotes | BamHI-Q promoter activity |
| C1 | 174-199 | NP | denotes | Epstein-Barr virus (EBV)- |
| C2 | 293-297 | NP | denotes | EBV- |
| C3 | 458-483 | NP | denotes | the BamHI-Q promoter (Qp) |
| C4 | 551-562 | NP | denotes | Qp activity |
| C6 | 718-720 | NP | denotes | Qp |
| C12 | 993-1004 | NP | denotes | Qp function |
| C7 | 1006-1008 | NP | denotes | Qp |
| C8 | 1177-1181 | NP | denotes | EBV- |
| C9 | 1231-1242 | NP | denotes | Qp activity |
| C10 | 1316-1321 | NP | denotes | BZLF1 |
| C11 | 1323-1328 | NP | denotes | which |
| C16 | 1337-1340 | NP | denotes | Zta |
| C13 | 1353-1364 | NP | denotes | Qp function |
| C14 | 1442-1444 | NP | denotes | Qp |
| C17 | 1464-1467 | NP | denotes | Zta |
| C15 | 1476-1487 | NP | denotes | Qp activity |
| C18 | 1579-1587 | NP | denotes | evidence |
| C19 | 1588-1592 | NP | denotes | that |
| C20 | 1681-1683 | NP | denotes | Qp |
| C23 | 1738-1742 | NP | denotes | EBV- |
| R1 | C2 | C1 | coref-ident | EBV-,Epstein-Barr virus (EBV)- |
| R2 | C4 | C5 | coref-ident | Qp activity,BamHI-Q promoter activity |
| R3 | C6 | C3 | coref-ident | Qp,the BamHI-Q promoter (Qp) |
| R4 | C7 | C6 | coref-ident | Qp,Qp |
| R5 | C8 | C2 | coref-ident | EBV-,EBV- |
| R6 | C9 | C4 | coref-ident | Qp activity,Qp activity |
| R7 | C11 | C10 | coref-relat | which,BZLF1 |
| R8 | C13 | C12 | coref-ident | Qp function,Qp function |
| R9 | C14 | C7 | coref-ident | Qp,Qp |
| R10 | C17 | C16 | coref-ident | Zta,Zta |
| R11 | C15 | C9 | coref-ident | Qp activity,Qp activity |
| R12 | C19 | C18 | coref-relat | that,evidence |
| R13 | C20 | C14 | coref-ident | Qp,Qp |
| R14 | C23 | C8 | coref-ident | EBV-,EBV- |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-170 | Sentence | denotes | The Epstein-Barr virus latency BamHI-Q promoter is positively regulated by STATs and Zta interference with JAK/STAT activation leads to loss of BamHI-Q promoter activity. |
| S2 | 171-292 | Sentence | denotes | In Epstein-Barr virus (EBV)-associated tumors in nonimmunocompromised patients, EBV gene expression is highly restricted. |
| S3 | 293-400 | Sentence | denotes | EBV-encoded nuclear antigen (EBNA)-1 is expressed, whereas the immunogenic and proliferative EBNAs are not. |
| S4 | 401-484 | Sentence | denotes | This pattern of EBNA expression is generated by usage of the BamHI-Q promoter (Qp). |
| S5 | 485-563 | Sentence | denotes | We have determined that the JAK/STAT pathway positively regulates Qp activity. |
| S6 | 564-702 | Sentence | denotes | In transient-transfection assays, a Qp-CAT reporter was activated by cotransfected JAK-1 and by treatment of cells with the cytokine IL-6. |
| S7 | 703-956 | Sentence | denotes | The ability of Qp to bind signal transducer and activator of transcription (STAT) proteins was directly demonstrated by electrophoretic mobility-shift assay, and mutation of potential STAT-binding sites reduced Qp responsiveness to Janus kinase (JAK)-1. |
| S8 | 957-1126 | Sentence | denotes | Consistent with a role for STATs in Qp function, Qp using Burkitt's lymphoma Rael cells and cultured nasopharyngeal carcinoma (NPC) cells contained nuclear STAT protein. |
| S9 | 1127-1243 | Sentence | denotes | We investigated whether the inability to maintain EBV-positive NPC cell lines in culture was related to Qp activity. |
| S10 | 1244-1365 | Sentence | denotes | Passaging of the NPC cell line HK666 led to activation of expression of BZLF1, which encodes Zta and loss of Qp function. |
| S11 | 1366-1445 | Sentence | denotes | Transient expression assays linked Zta expression to the down-regulation of Qp. |
| S12 | 1446-1507 | Sentence | denotes | Cotransfection of Zta reduced Qp activity in reporter assays. |
| S13 | 1508-1567 | Sentence | denotes | This negative regulation required Zta DNA-binding activity. |
| S14 | 1568-1684 | Sentence | denotes | We provide evidence that Zta up-regulation of p53 leads to p53-mediated interference with JAK/STAT activation of Qp. |
| S15 | 1685-1766 | Sentence | denotes | The data imply that JAK/STAT signaling has a role in EBV-associated malignancies. |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 4-22 | virus | denotes | Epstein-Barr virus |
| T2 | 75-80 | protein_family_or_group | denotes | STATs |
| T3 | 85-88 | protein_molecule | denotes | Zta |
| T4 | 107-110 | protein_family_or_group | denotes | JAK |
| T5 | 110-115 | protein_family_or_group | denotes | /STAT |
| T6 | 144-160 | DNA_domain_or_region | denotes | BamHI-Q promoter |
| T7 | 174-192 | virus | denotes | Epstein-Barr virus |
| T8 | 220-249 | multi_cell | denotes | nonimmunocompromised patients |
| T9 | 251-270 | other_name | denotes | EBV gene expression |
| T10 | 293-322 | protein_molecule | denotes | EBV-encoded nuclear antigen ( |
| T11 | 322-326 | protein_family_or_group | denotes | EBNA |
| T12 | 386-391 | protein_family_or_group | denotes | EBNAs |
| T13 | 417-421 | protein_family_or_group | denotes | EBNA |
| T14 | 462-478 | DNA_domain_or_region | denotes | BamHI-Q promoter |
| T15 | 480-482 | DNA_domain_or_region | denotes | Qp |
| T16 | 513-516 | protein_family_or_group | denotes | JAK |
| T17 | 516-521 | protein_family_or_group | denotes | /STAT |
| T18 | 551-553 | DNA_domain_or_region | denotes | Qp |
| T19 | 567-596 | other_name | denotes | transient-transfection assays |
| T20 | 600-602 | DNA_domain_or_region | denotes | Qp |
| T21 | 647-652 | protein_molecule | denotes | JAK-1 |
| T22 | 688-696 | protein_family_or_group | denotes | cytokine |
| T23 | 697-701 | protein_molecule | denotes | IL-6 |
| T24 | 718-720 | DNA_domain_or_region | denotes | Qp |
| T25 | 729-793 | protein_family_or_group | denotes | signal transducer and activator of transcription (STAT) proteins |
| T26 | 823-859 | other_name | denotes | electrophoretic mobility-shift assay |
| T27 | 887-905 | DNA_domain_or_region | denotes | STAT-binding sites |
| T28 | 914-916 | DNA_domain_or_region | denotes | Qp |
| T29 | 935-955 | protein_molecule | denotes | Janus kinase (JAK)-1 |
| T30 | 984-989 | protein_family_or_group | denotes | STATs |
| T31 | 993-995 | DNA_domain_or_region | denotes | Qp |
| T32 | 1006-1008 | DNA_domain_or_region | denotes | Qp |
| T33 | 1015-1044 | cell_line | denotes | Burkitt's lymphoma Rael cells |
| T34 | 1049-1094 | cell_type | denotes | cultured nasopharyngeal carcinoma (NPC) cells |
| T35 | 1113-1125 | protein_family_or_group | denotes | STAT protein |
| T36 | 1177-1204 | cell_line | denotes | EBV-positive NPC cell lines |
| T37 | 1231-1233 | DNA_domain_or_region | denotes | Qp |
| T38 | 1261-1280 | cell_line | denotes | NPC cell line HK666 |
| T39 | 1316-1321 | DNA_domain_or_region | denotes | BZLF1 |
| T40 | 1337-1340 | protein_molecule | denotes | Zta |
| T41 | 1353-1355 | DNA_domain_or_region | denotes | Qp |
| T42 | 1366-1393 | other_name | denotes | Transient expression assays |
| T43 | 1401-1404 | protein_molecule | denotes | Zta |
| T44 | 1442-1444 | DNA_domain_or_region | denotes | Qp |
| T45 | 1464-1467 | protein_molecule | denotes | Zta |
| T46 | 1476-1478 | DNA_domain_or_region | denotes | Qp |
| T47 | 1491-1506 | other_name | denotes | reporter assays |
| T48 | 1542-1545 | protein_molecule | denotes | Zta |
| T49 | 1593-1596 | protein_molecule | denotes | Zta |
| T50 | 1614-1617 | protein_molecule | denotes | p53 |
| T51 | 1627-1630 | protein_molecule | denotes | p53 |
| T52 | 1658-1661 | protein_family_or_group | denotes | JAK |
| T53 | 1661-1666 | protein_family_or_group | denotes | /STAT |
| T54 | 1681-1683 | DNA_domain_or_region | denotes | Qp |
| T55 | 1705-1708 | protein_family_or_group | denotes | JAK |
| T56 | 1708-1713 | protein_family_or_group | denotes | /STAT |
| T57 | 1738-1765 | other_name | denotes | EBV-associated malignancies |
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 1113-1117 | gene:6646 | denotes | STAT |
| T1 | 1025-1033 | disease:C0024299 | denotes | lymphoma |
| T2 | 1113-1117 | gene:6646 | denotes | STAT |
| T3 | 1058-1082 | disease:C2931822 | denotes | nasopharyngeal carcinoma |
| T4 | 1113-1117 | gene:6646 | denotes | STAT |
| T5 | 1084-1087 | disease:C2931822 | denotes | NPC |
| R1 | T0 | T1 | associated_with | STAT,lymphoma |
| R2 | T2 | T3 | associated_with | STAT,nasopharyngeal carcinoma |
| R3 | T4 | T5 | associated_with | STAT,NPC |