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PubMed:10430025 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 26-30 protein denotes Pax5
T2 73-92 DNA denotes mammalian Pax genes
T3 128-143 DNA denotes mammalian genes
T4 170-177 DNA denotes alleles
T5 279-285 DNA denotes allele
T6 326-342 DNA denotes wild-type allele
T7 446-458 DNA denotes mouse genome
T8 753-772 DNA denotes mammalian Pax genes
T9 892-901 DNA denotes Pax5 gene
T10 916-922 DNA denotes allele
T11 970-974 protein denotes Pax5
T12 1029-1036 DNA denotes alleles
T13 1040-1068 cell_type denotes early B-lymphoid progenitors
T14 1073-1087 cell_type denotes mature B cells
T15 1159-1185 cell_type denotes pre-B and immature B cells
T16 1266-1272 DNA denotes allele
T17 1303-1307 protein denotes Pax5
T18 1341-1354 cell_type denotes B lymphocytes
T19 1375-1388 DNA denotes mutant allele
T20 1394-1400 DNA denotes allele
T21 1424-1428 protein denotes Pax5
T22 1557-1566 DNA denotes Pax genes
T23 1653-1672 DNA denotes mammalian Pax genes
T24 1717-1723 DNA denotes allele
T25 1747-1751 protein denotes Pax5
T26 1900-1919 DNA denotes hematopoietic genes

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 26-30 NP denotes Pax5
C26 73-92 NP denotes mammalian Pax genes
C28 47-92 NP denotes the haploinsufficiency of mammalian Pax genes
C4 165-177 NP denotes both alleles
C2 225-238 NP denotes the advantage
C3 239-243 NP denotes that
C5 275-285 NP denotes one allele
C6 312-359 NP denotes the remaining wild-type allele of the same gene
C7 537-556 NP denotes a minority of genes
C8 621-632 NP denotes these genes
C10 668-682 NP denotes This condition
C11 693-711 NP denotes haploinsufficiency
C12 744-772 NP denotes the nine mammalian Pax genes
C13 774-779 NP denotes which
C14 888-901 NP denotes the Pax5 gene
C20 916-942 NP denotes allele-specific regulation
C15 970-974 NP denotes Pax5
C17 1021-1024 NP denotes its
C18 1303-1307 NP denotes Pax5
C19 1424-1428 NP denotes Pax5
C21 1390-1428 NP denotes The allele-specific regulation of Pax5
C22 1436-1462 NP denotes the intriguing possibility
C23 1463-1467 NP denotes that
C24 1525-1547 NP denotes the haploinsufficiency
C27 1653-1672 NP denotes mammalian Pax genes
C29 1627-1672 NP denotes the haploinsufficiency of mammalian Pax genes
C30 1747-1751 NP denotes Pax5
C31 1713-1751 NP denotes the allele-specific regulation of Pax5
R1 C3 C2 coref-relat that,the advantage
R2 C5 C4 coref-part-whole one allele,both alleles
R3 C6 C4 coref-part-whole the remaining wild-type allele of the same gene,both alleles
R4 C8 C7 coref-ident these genes,a minority of genes
R5 C11 C10 coref-ident haploinsufficiency,This condition
R6 C13 C12 coref-relat which,the nine mammalian Pax genes
R7 C14 C1 coref-ident the Pax5 gene,Pax5
R8 C15 C14 coref-ident Pax5,the Pax5 gene
R9 C17 C15 coref-pron its,Pax5
R10 C18 C15 coref-ident Pax5,Pax5
R11 C19 C18 coref-ident Pax5,Pax5
R12 C21 C20 coref-other The allele-specific regulation of Pax5,allele-specific regulation
R13 C23 C22 coref-relat that,the intriguing possibility
R14 C24 C11 coref-ident the haploinsufficiency,haploinsufficiency
R15 C27 C26 coref-ident mammalian Pax genes,mammalian Pax genes
R16 C29 C28 coref-ident the haploinsufficiency of mammalian Pax genes,the haploinsufficiency of mammalian Pax genes
R17 C30 C19 coref-ident Pax5,Pax5
R18 C31 C21 coref-ident the allele-specific regulation of Pax5,The allele-specific regulation of Pax5

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-93 Sentence denotes Monoallelic expression of Pax5: a paradigm for the haploinsufficiency of mammalian Pax genes?
S2 94-178 Sentence denotes It is generally assumed that most mammalian genes are transcribed from both alleles.
S3 179-360 Sentence denotes Hence, the diploid state of the genome offers the advantage that a loss-of-function mutation in one allele can be compensated for by the remaining wild-type allele of the same gene.
S4 361-527 Sentence denotes Indeed, the vast majority of human disease syndromes and engineered mutations in the mouse genome are recessive, indicating that recessiveness is the 'default' state.
S5 528-667 Sentence denotes However, a minority of genes are semi-dominant, as heterozygous loss-of-function mutation in these genes leads to phenotypic abnormalities.
S6 668-856 Sentence denotes This condition, known as haploinsufficiency, has been described for five of the nine mammalian Pax genes, which are associated with mouse developmental mutants and human disease syndromes.
S7 857-969 Sentence denotes Recently we have reported that the Pax5 gene is subject to allele-specific regulation during B cell development.
S8 970-1186 Sentence denotes Pax5 is predominantly transcribed from only one of its two alleles in early B-lymphoid progenitors and mature B cells, while it transiently switches to a biallelic mode of transcription in pre-B and immature B cells.
S9 1187-1389 Sentence denotes As a consequence, B-lymphoid tissues are mosaic with regard to the transcribed allele, and heterozygous mutation of Pax5 therefore results in deletion of B lymphocytes expressing only the mutant allele.
S10 1390-1567 Sentence denotes The allele-specific regulation of Pax5 raises the intriguing possibility that monoallelic expression may also be the mechanism causing the haploinsufficiency of other Pax genes.
S11 1568-1920 Sentence denotes In this review, we discuss different models accounting for the haploinsufficiency of mammalian Pax genes, provide further evidence in support of the allele-specific regulation of Pax5 and discuss the implication of these findings in the context of the recent literature describing the stochastic and monoallelic activation of other hematopoietic genes.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 26-30 protein_molecule denotes Pax5
T2 51-69 other_name denotes haploinsufficiency
T3 73-92 DNA_family_or_group denotes mammalian Pax genes
T4 128-143 DNA_family_or_group denotes mammalian genes
T5 170-177 DNA_domain_or_region denotes alleles
T6 190-203 other_name denotes diploid state
T7 246-271 other_name denotes loss-of-function mutation
T8 279-285 DNA_domain_or_region denotes allele
T9 326-335 DNA_domain_or_region denotes wild-type
T10 336-342 DNA_domain_or_region denotes allele
T11 390-413 other_name denotes human disease syndromes
T12 446-458 DNA_family_or_group denotes mouse genome
T13 490-503 other_name denotes recessiveness
T14 561-574 other_name denotes semi-dominant
T15 592-617 other_name denotes loss-of-function mutation
T16 642-666 other_name denotes phenotypic abnormalities
T17 753-772 DNA_family_or_group denotes mammalian Pax genes
T18 800-827 other_name denotes mouse developmental mutants
T19 832-855 other_name denotes human disease syndromes
T20 892-896 protein_molecule denotes Pax5
T21 916-922 DNA_domain_or_region denotes allele
T22 950-968 other_name denotes B cell development
T23 970-974 protein_molecule denotes Pax5
T24 1029-1036 DNA_domain_or_region denotes alleles
T25 1040-1068 cell_type denotes early B-lymphoid progenitors
T26 1073-1087 cell_type denotes mature B cells
T27 1205-1223 tissue denotes B-lymphoid tissues
T28 1266-1272 DNA_domain_or_region denotes allele
T29 1278-1299 other_name denotes heterozygous mutation
T30 1303-1307 protein_molecule denotes Pax5
T31 1341-1354 cell_type denotes B lymphocytes
T32 1375-1381 DNA_domain_or_region denotes mutant
T33 1382-1388 DNA_domain_or_region denotes allele
T34 1394-1400 DNA_domain_or_region denotes allele
T35 1424-1428 protein_molecule denotes Pax5
T36 1468-1490 other_name denotes monoallelic expression
T37 1529-1547 other_name denotes haploinsufficiency
T38 1557-1566 DNA_family_or_group denotes Pax genes
T39 1631-1649 other_name denotes haploinsufficiency
T40 1653-1662 DNA_family_or_group denotes mammalian
T41 1663-1672 DNA_family_or_group denotes Pax genes
T42 1717-1723 DNA_domain_or_region denotes allele
T43 1747-1751 protein_molecule denotes Pax5
T44 1853-1863 other_name denotes stochastic
T45 1868-1890 other_name denotes monoallelic activation
T46 1900-1919 DNA_family_or_group denotes hematopoietic genes