PubMed:10425198 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/10425198","sourcedb":"PubMed","sourceid":"10425198","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/10425198","text":"Association of the HGF/SF receptor, c-met, with the cell-surface adhesion molecule, E-cadherin, and catenins in human tumor cells.\nTumour cell metastatic potential is significantly enhanced following treatment with HGF/SF, the ligand for the c-met receptor tyrosine kinase. Following c-met activation in tumour cells, phosphorylation of beta-catenin occurs, together with loss of intercellular adhesion and a gain in the motile and invasive nature of the cell. In this study we show that c-met is co-localised with beta-catenin and E-cadherin at regions of cell-cell contact in human colon cancer (HRT18 and HT115) and two breast cancer (MCF7 and MDA MB 231) cell lines. Immunoprecipitation studies demonstrated an association between c-met and members of the cadherin adhesion complex in these epithelial tumour cells, along with the membrane tyrosine protein phophatase, PTPmu. We conclude that the HGF/SF receptor, c-met, together with members of the cadherin/catenin cell-cell adhesion system and PTPmu, may form part of a protein complex in E-cadherin positive tumour cells that acts to regulate intercellular adhesion following HGF/SF stimulation.","tracks":[{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":131,"end":137},"obj":"HP_0002664"},{"id":"T2","span":{"begin":304,"end":310},"obj":"HP_0002664"},{"id":"T3","span":{"begin":584,"end":596},"obj":"HP_0003003"},{"id":"T4","span":{"begin":584,"end":596},"obj":"HP_0100273"},{"id":"T5","span":{"begin":590,"end":596},"obj":"HP_0002664"},{"id":"T6","span":{"begin":623,"end":636},"obj":"HP_0003002"},{"id":"T7","span":{"begin":623,"end":636},"obj":"HP_0100013"},{"id":"T8","span":{"begin":630,"end":636},"obj":"HP_0002664"},{"id":"T9","span":{"begin":806,"end":812},"obj":"HP_0002664"},{"id":"T10","span":{"begin":1066,"end":1072},"obj":"HP_0002664"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"},{"subj":"T4","pred":"source","obj":"PubmedHPO"},{"subj":"T5","pred":"source","obj":"PubmedHPO"},{"subj":"T6","pred":"source","obj":"PubmedHPO"},{"subj":"T7","pred":"source","obj":"PubmedHPO"},{"subj":"T8","pred":"source","obj":"PubmedHPO"},{"subj":"T9","pred":"source","obj":"PubmedHPO"},{"subj":"T10","pred":"source","obj":"PubmedHPO"}]},{"project":"2015-BEL-Sample","denotations":[{"id":"T1","span":{"begin":274,"end":459},"obj":"kin(p(HGNC:MET)) increases p(HGNC:CTNNB1,pmod(P,Y))"}],"attributes":[{"subj":"T1","pred":"source","obj":"2015-BEL-Sample"}]},{"project":"2015-BEL-Sample-2","denotations":[{"id":"BEL:20000082","span":{"begin":274,"end":459},"obj":"kin(p(HGNC:MET)) increases p(HGNC:CTNNB1,pmod(P,Y))"},{"id":"BEL:20000084","span":{"begin":274,"end":459},"obj":"kin(p(HGNC:MET)) increases bp(GOBP:\"cell migration\")"},{"id":"BEL:20000086","span":{"begin":274,"end":459},"obj":"kin(p(HGNC:MET)) decreases bp(GOBP:\"cell adhesion\")"}],"attributes":[{"subj":"BEL:20000082","pred":"source","obj":"2015-BEL-Sample-2"},{"subj":"BEL:20000084","pred":"source","obj":"2015-BEL-Sample-2"},{"subj":"BEL:20000086","pred":"source","obj":"2015-BEL-Sample-2"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"PubmedHPO","color":"#93a0ec","default":true},{"id":"2015-BEL-Sample","color":"#baec93"},{"id":"2015-BEL-Sample-2","color":"#ec93d4"}]}]}}