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PubMed:10423406 JSONTXT

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PubmedHPO

Id Subject Object Predicate Lexical cue
T1 1597-1603 HP_0002099 denotes asthma

jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 15-25 cell_type denotes neutrophil
T2 26-39 protein denotes interleukin-8
T3 54-92 protein denotes eosinophil granule major basic protein
T4 122-160 protein denotes eosinophil granule major basic protein
T5 162-165 protein denotes MBP
T6 180-198 protein denotes interleukin (IL)-8
T7 213-224 cell_type denotes neutrophils
T8 226-229 protein denotes MBP
T9 333-337 protein denotes IL-8
T10 364-367 protein denotes MBP
T11 411-415 protein denotes IL-8
T12 499-526 protein denotes eosinophil cationic protein
T13 563-584 protein denotes eosinophil peroxidase
T14 625-629 protein denotes IL-8
T15 642-645 protein denotes MBP
T16 677-695 RNA denotes IL-8 messenger RNA
T17 697-701 RNA denotes mRNA
T18 815-818 protein denotes MBP
T19 874-900 protein denotes nuclear factor (NF)-kappaB
T20 904-923 protein denotes activator protein-1
T21 928-935 protein denotes NF-IL-6
T22 1026-1029 protein denotes MBP
T23 1057-1066 RNA denotes IL-8 mRNA
T24 1068-1071 protein denotes MBP
T25 1108-1112 RNA denotes mRNA
T26 1117-1161 protein denotes macrophage inflammatory protein (MIP)-1alpha
T27 1166-1175 protein denotes MIP-1beta
T28 1221-1230 protein denotes chemokine
T29 1261-1264 protein denotes MBP
T30 1288-1315 protein denotes eosinophil granule proteins
T31 1334-1344 cell_type denotes neutrophil
T32 1345-1349 protein denotes IL-8
T33 1392-1402 cell_type denotes neutrophil
T34 1403-1407 protein denotes IL-8
T35 1419-1422 protein denotes MBP
T36 1507-1510 protein denotes MBP
T37 1530-1534 protein denotes IL-8
T38 1538-1549 cell_type denotes neutrophils

genia-medco-coref

Id Subject Object Predicate Lexical cue
C24 15-50 NP denotes neutrophil interleukin-8 production
C1 54-92 NP denotes eosinophil granule major basic protein
C2 122-166 NP denotes eosinophil granule major basic protein (MBP)
C23 213-224 NP denotes neutrophils
C21 180-224 NP denotes interleukin (IL)-8 production by neutrophils
C3 226-229 NP denotes MBP
C15 411-423 NP denotes IL-8 release
C22 625-640 NP denotes IL-8 production
C6 642-645 NP denotes MBP
C11 677-702 NP denotes IL-8 messenger RNA (mRNA)
C7 709-732 NP denotes 1 and 3 h of incubation
C8 734-739 NP denotes which
C9 815-818 NP denotes MBP
C10 1026-1029 NP denotes MBP
C12 1057-1066 NP denotes IL-8 mRNA
C13 1068-1071 NP denotes MBP
C14 1261-1264 NP denotes MBP
C16 1334-1357 NP denotes neutrophil IL-8 release
C17 1392-1415 NP denotes neutrophil IL-8 release
C18 1419-1422 NP denotes MBP
C19 1507-1511 NP denotes MBP-
C25 1538-1549 NP denotes neutrophils
R1 C2 C1 coref-ident eosinophil granule major basic protein (MBP),eosinophil granule major basic protein
R2 C21 C24 coref-ident interleukin (IL)-8 production by neutrophils,neutrophil interleukin-8 production
R3 C3 C2 coref-ident MBP,eosinophil granule major basic protein (MBP)
R4 C22 C21 coref-ident IL-8 production,interleukin (IL)-8 production by neutrophils
R5 C6 C3 coref-ident MBP,MBP
R6 C8 C7 coref-relat which,1 and 3 h of incubation
R7 C9 C6 coref-ident MBP,MBP
R8 C10 C9 coref-ident MBP,MBP
R9 C12 C11 coref-ident IL-8 mRNA,IL-8 messenger RNA (mRNA)
R10 C13 C10 coref-ident MBP,MBP
R11 C14 C13 coref-ident MBP,MBP
R12 C16 C15 coref-ident neutrophil IL-8 release,IL-8 release
R13 C17 C16 coref-ident neutrophil IL-8 release,neutrophil IL-8 release
R14 C18 C14 coref-ident MBP,MBP
R15 C19 C18 coref-ident MBP-,MBP
R16 C25 C23 coref-ident neutrophils,neutrophils

semrep-sample

Id Subject Object Predicate Lexical cue
E1-ti-1 0-11 cui:C1292856 denotes Stimulation
E2-ti-1 26-39 cui:C0079633 denotes interleukin-8
E3-ti-1 15-50 cui:C0312833 denotes neutrophil interleukin-8 production
E4-ti-1 65-72 cui:C0010837 denotes granule
E5-ti-1 54-92 cui:C0059406 denotes eosinophil granule major basic protein
T1 0-11 AUGMENTS denotes Stimulation
T2 65-92 PART_OF denotes granule major basic protein
E1-ab-1 111-118 cui:C0085732 denotes ability
E2-ab-1 133-140 cui:C0010837 denotes granule
E3-ab-1 122-160 cui:C0059406 denotes eosinophil granule major basic protein
E4-ab-1 180-198 cui:C0079633 denotes interleukin (IL)-8
E5-ab-1 199-209 cui:C0033268 denotes production
E6-ab-1 213-224 cui:C0027950 denotes neutrophils
T3 133-160 PART_OF denotes granule major basic protein
T4 199-209 PRODUCES denotes production
E1-ab-2 226-229 cui:C0205164 denotes MBP
E2-ab-2 226-229 cui:C1527178 denotes MBP
E3-ab-2 226-229 cui:C0033684 denotes MBP
E4-ab-2 230-234 cui:C0205136 denotes over
E5-ab-2 253-258 cui:C1514721 denotes range
E6-ab-2 272-278 cui:C0439201 denotes microM
E7-ab-2 311-324 cui:C0332232 denotes approximately
E8-ab-2 333-335 cui:C0021764 denotes IL
E1-ab-3 357-363 cui:C0439201 denotes microM
E2-ab-3 364-367 cui:C0205164 denotes MBP
E3-ab-3 364-367 cui:C1527178 denotes MBP
E4-ab-3 364-367 cui:C0033684 denotes MBP
E5-ab-3 393-396 cui:C0024219 denotes lag
E6-ab-3 411-415 cui:C0079633 denotes IL-8
E7-ab-3 439-443 cui:C0040223 denotes time
E8-ab-3 448-461 cui:C0332232 denotes approximately
E1-ab-4 477-483 cui:C0439201 denotes microM
E2-ab-4 499-526 cui:C0950373 denotes eosinophil cationic protein
E3-ab-4 528-557 cui:C0059409 denotes eosinophil-derived neurotoxin
E4-ab-4 563-584 cui:C0059407 denotes eosinophil peroxidase
E5-ab-4 589-592 cui:C1518422 denotes not
E6-ab-4 603-621 cui:C0814896 denotes significant levels
E7-ab-4 625-629 cui:C0079633 denotes IL-8
E8-ab-4 630-640 cui:C0033268 denotes production
T5 630-640 PRODUCES denotes production
T6 630-640 PRODUCES denotes production
T7 630-640 PRODUCES denotes production
E1-ab-5 642-645 cui:C0205164 denotes MBP
E2-ab-5 642-645 cui:C1527178 denotes MBP
E3-ab-5 642-645 cui:C0033684 denotes MBP
E4-ab-5 659-663 cui:C0332462 denotes fold
E5-ab-5 677-681 cui:C0079633 denotes IL-8
E6-ab-5 682-695 cui:C0035696 denotes messenger RNA
E7-ab-5 756-768 cui:C1550147 denotes pretreatment
E8-ab-5 774-787 cui:C0010934 denotes actinomycin D
E1-ab-6 798-809 cui:C1292856 denotes stimulation
E2-ab-6 815-818 cui:C0205164 denotes MBP
E3-ab-6 815-818 cui:C1527178 denotes MBP
E4-ab-6 815-818 cui:C0033684 denotes MBP
E5-ab-6 823-826 cui:C1518422 denotes not
E6-ab-6 838-846 cui:C0442805 denotes increase
E7-ab-6 862-870 cui:C0439167 denotes activity
E8-ab-6 874-881 cui:C0521447 denotes nuclear
E9-ab-6 882-888 cui:C1521761 denotes factor
E10-ab-6 904-923 cui:C0085828 denotes activator protein-1
E1-ab-7 928-930 cui:C0521447 denotes NF
E2-ab-7 928-930 cui:C1521761 denotes NF
E3-ab-7 931-943 cui:C1149241 denotes IL-6 binding
E4-ab-7 944-952 cui:C0439167 denotes activity
E5-ab-7 973-977 cui:C0445247 denotes same
E6-ab-7 978-994 cui:C1518434 denotes nuclear extracts
E1-ab-8 999-1007 cui:C0442796 denotes addition
E2-ab-8 1009-1020 cui:C1292856 denotes stimulation
E3-ab-8 1026-1029 cui:C0205164 denotes MBP
E4-ab-8 1026-1029 cui:C1527178 denotes MBP
E5-ab-8 1026-1029 cui:C0033684 denotes MBP
E6-ab-8 1044-1053 cui:C1317741 denotes stability
E7-ab-8 1057-1061 cui:C0079633 denotes IL-8
E8-ab-8 1062-1066 cui:C0035696 denotes mRNA
E1-ab-9 1068-1071 cui:C0205164 denotes MBP
E2-ab-9 1068-1071 cui:C1527178 denotes MBP
E3-ab-9 1068-1071 cui:C0033684 denotes MBP
E4-ab-9 1085-1094 cui:C0205374 denotes transient
E5-ab-9 1095-1104 cui:C0442805 denotes increases
E6-ab-9 1108-1112 cui:C0035696 denotes mRNA
E7-ab-9 1117-1148 cui:C0376579 denotes macrophage inflammatory protein
E8-ab-9 1166-1169 cui:C0376579 denotes MIP
E9-ab-9 1185-1188 cui:C1518422 denotes not
E10-ab-9 1221-1230 cui:C0282554 denotes chemokine
E1-ab-10 1238-1246 cui:C0243095 denotes findings
E2-ab-10 1261-1264 cui:C0205164 denotes MBP
E3-ab-10 1261-1264 cui:C1527178 denotes MBP
E4-ab-10 1261-1264 cui:C0033684 denotes MBP
E5-ab-10 1288-1315 cui:C0116275 denotes eosinophil granule proteins
E6-ab-10 1321-1329 cui:C0234402 denotes stimulus
E7-ab-10 1334-1344 cui:C0027950 denotes neutrophil
E8-ab-10 1345-1349 cui:C0079633 denotes IL-8
E9-ab-10 1363-1370 cui:C1517331 denotes further
E10-ab-10 1377-1388 cui:C1292856 denotes stimulation
E11-ab-10 1392-1402 cui:C0027950 denotes neutrophil
E12-ab-10 1403-1407 cui:C0079633 denotes IL-8
E13-ab-10 1419-1422 cui:C0205164 denotes MBP
E14-ab-10 1419-1422 cui:C1527178 denotes MBP
E15-ab-10 1419-1422 cui:C0033684 denotes MBP
E16-ab-10 1437-1452 cui:C0040649 denotes transcriptional
E17-ab-10 1477-1487 cui:C0851285 denotes regulation
T8 1423-1431 AFFECTS denotes involves
E1-ab-11 1507-1510 cui:C0205164 denotes MBP
E2-ab-11 1507-1510 cui:C1527178 denotes MBP
E3-ab-11 1507-1510 cui:C0033684 denotes MBP
E4-ab-11 1511-1518 cui:C0205263 denotes induced
E5-ab-11 1530-1534 cui:C0079633 denotes IL-8
E6-ab-11 1538-1549 cui:C0027950 denotes neutrophils
E7-ab-11 1572-1587 cui:C0277785 denotes pathophysiology
E8-ab-11 1591-1603 cui:C0582415 denotes acute asthma
E9-ab-11 1614-1626 cui:C0333348 denotes inflammatory
E10-ab-11 1627-1640 cui:C0024115 denotes lung diseases
T9 1591-1640 ISA denotes acute asthma and other inflammatory lung diseases
T10 1591-1640 ISA denotes acute asthma and other inflammatory lung diseases
T11 1554-1564 PREDISPOSES denotes contribute
R1 E5-ti-1 T1 subjectOf eosinophil granule major basic protein,Stimulation
R2 E3-ti-1 T1 objectOf neutrophil interleukin-8 production,Stimulation
R3 E5-ti-1 T2 subjectOf eosinophil granule major basic protein,granule major basic protein
R4 E4-ti-1 T2 objectOf granule,granule major basic protein
R5 E3-ab-1 T3 subjectOf eosinophil granule major basic protein,granule major basic protein
R6 E2-ab-1 T3 objectOf granule,granule major basic protein
R7 E6-ab-1 T4 subjectOf neutrophils,production
R8 E4-ab-1 T4 objectOf interleukin (IL)-8,production
R9 E4-ab-4 T5 subjectOf eosinophil peroxidase,production
R10 E7-ab-4 T5 objectOf IL-8,production
R11 E3-ab-4 T6 subjectOf eosinophil-derived neurotoxin,production
R12 E7-ab-4 T6 objectOf IL-8,production
R13 E2-ab-4 T7 subjectOf eosinophil cationic protein,production
R14 E7-ab-4 T7 objectOf IL-8,production
R15 E10-ab-10 T8 subjectOf stimulation,involves
R16 E16-ab-10 T8 objectOf transcriptional,involves
R17 E8-ab-11 T9 subjectOf acute asthma,acute asthma and other inflammatory lung diseases
R18 E10-ab-11 T9 objectOf lung diseases,acute asthma and other inflammatory lung diseases
R19 E10-ab-11 T10 subjectOf lung diseases,acute asthma and other inflammatory lung diseases
R20 E8-ab-11 T10 objectOf acute asthma,acute asthma and other inflammatory lung diseases
R21 E5-ab-11 T11 subjectOf IL-8,contribute
R22 E7-ab-11 T11 objectOf pathophysiology,contribute

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-93 Sentence denotes Stimulation of neutrophil interleukin-8 production by eosinophil granule major basic protein.
S2 94-225 Sentence denotes We evaluated the ability of eosinophil granule major basic protein (MBP) to stimulate interleukin (IL)-8 production by neutrophils.
S3 226-338 Sentence denotes MBP over the concentration range of 0.1 to 10 microM stimulated the release of up to approximately 8 ng/ml IL-8.
S4 339-467 Sentence denotes Incubation with 2 microM MBP showed that, after a 1 h lag, the level of IL-8 release increased with time for approximately 10 h.
S5 468-641 Sentence denotes At the 2 microM concentration, eosinophil cationic protein, eosinophil-derived neurotoxin, and eosinophil peroxidase did not stimulate significant levels of IL-8 production.
S6 642-788 Sentence denotes MBP stimulated 2-fold increases in IL-8 messenger RNA (mRNA) after 1 and 3 h of incubation, which were blocked by pretreatment with actinomycin D.
S7 789-924 Sentence denotes However, stimulation with MBP did not produce an increase in the binding activity of nuclear factor (NF)-kappaB or activator protein-1.
S8 925-995 Sentence denotes No NF-IL-6 binding activity was detected in the same nuclear extracts.
S9 996-1067 Sentence denotes In addition, stimulation with MBP prolonged the stability of IL-8 mRNA.
S10 1068-1231 Sentence denotes MBP also induced transient increases in mRNA for macrophage inflammatory protein (MIP)-1alpha and MIP-1beta, but did not stimulate the release of either chemokine.
S11 1232-1488 Sentence denotes These findings indicate that MBP is selective among the eosinophil granule proteins as a stimulus for neutrophil IL-8 release and, further, that stimulation of neutrophil IL-8 release by MBP involves both transcriptional and posttranscriptional regulation.
S12 1489-1641 Sentence denotes We postulate that MBP-induced release of IL-8 by neutrophils may contribute to the pathophysiology of acute asthma and other inflammatory lung diseases.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 15-25 cell_type denotes neutrophil
T2 26-39 protein_molecule denotes interleukin-8
T3 54-92 protein_molecule denotes eosinophil granule major basic protein
T4 122-160 protein_molecule denotes eosinophil granule major basic protein
T5 162-165 protein_molecule denotes MBP
T6 180-198 protein_molecule denotes interleukin (IL)-8
T7 213-224 cell_type denotes neutrophils
T8 226-229 protein_molecule denotes MBP
T9 333-337 protein_molecule denotes IL-8
T10 364-367 protein_molecule denotes MBP
T11 411-415 protein_molecule denotes IL-8
T12 499-526 protein_molecule denotes eosinophil cationic protein
T13 528-557 other_organic_compound denotes eosinophil-derived neurotoxin
T14 563-584 protein_molecule denotes eosinophil peroxidase
T15 625-629 protein_molecule denotes IL-8
T16 642-645 protein_molecule denotes MBP
T17 677-681 protein_molecule denotes IL-8
T18 697-701 RNA_family_or_group denotes mRNA
T19 774-787 other_organic_compound denotes actinomycin D
T20 815-818 protein_molecule denotes MBP
T21 874-900 protein_complex denotes nuclear factor (NF)-kappaB
T22 904-923 protein_molecule denotes activator protein-1
T23 928-935 protein_molecule denotes NF-IL-6
T24 978-994 cell_component denotes nuclear extracts
T25 1026-1029 protein_molecule denotes MBP
T26 1057-1061 protein_molecule denotes IL-8
T27 1068-1071 protein_molecule denotes MBP
T28 1108-1112 RNA_family_or_group denotes mRNA
T29 1117-1161 protein_molecule denotes macrophage inflammatory protein (MIP)-1alpha
T30 1166-1175 protein_molecule denotes MIP-1beta
T31 1221-1230 protein_family_or_group denotes chemokine
T32 1261-1264 protein_molecule denotes MBP
T33 1288-1315 protein_family_or_group denotes eosinophil granule proteins
T34 1334-1344 cell_type denotes neutrophil
T35 1345-1349 protein_molecule denotes IL-8
T36 1392-1402 cell_type denotes neutrophil
T37 1403-1407 protein_molecule denotes IL-8
T38 1419-1422 protein_molecule denotes MBP
T39 1507-1510 protein_molecule denotes MBP
T40 1530-1534 protein_molecule denotes IL-8
T41 1538-1549 cell_type denotes neutrophils
T42 1572-1587 other_name denotes pathophysiology
T43 1591-1603 other_name denotes acute asthma
T44 1614-1640 other_name denotes inflammatory lung diseases

metamap-sample

Id Subject Object Predicate Lexical cue
T1 1539-1550 C0027950 denotes eutrophils
T2 214-225 C0027950 denotes eutrophils.
T3 16-26 C0027950 denotes eutrophil
T4 1531-1535 C0079633 denotes L-8
T5 1058-1062 C0079633 denotes L-8
T6 678-682 C0079633 denotes L-8
T7 412-416 C0079633 denotes L-8
T8 334-338 C0079633 denotes L-8.
T9 123-161 C1418889 denotes osinophil granule major basic protein
T10 1508-1511 C0033684 denotes BP-
T11 1069-1072 C0033684 denotes BP
T12 1027-1030 C0033684 denotes BP
T13 816-819 C0033684 denotes BP
T14 643-646 C0033684 denotes BP
T15 365-368 C0033684 denotes BP
T16 1109-1113 C0035696 denotes RNA
T17 1063-1067 C0035696 denotes RNA.
T18 683-696 C0035696 denotes essenger RNA
T19 1508-1511 C1527178 denotes BP-
T20 1069-1072 C1527178 denotes BP
T21 1027-1030 C1527178 denotes BP
T22 816-819 C1527178 denotes BP
T23 643-646 C1527178 denotes BP
T24 365-368 C1527178 denotes BP
T25 227-230 C1527178 denotes BP
T26 1508-1511 C0205164 denotes BP-
T27 1069-1072 C0205164 denotes BP
T28 1027-1030 C0205164 denotes BP
T29 816-819 C0205164 denotes BP
T30 643-646 C0205164 denotes BP
T31 365-368 C0205164 denotes BP
T32 227-230 C0205164 denotes BP
T33 1520-1527 C1283071 denotes elease
T34 1204-1211 C1283071 denotes elease
T35 417-424 C1283071 denotes elease
T36 295-302 C1283071 denotes elease
T37 564-585 C0059407 denotes osinophil peroxidase
T38 1167-1170 C0376579 denotes IP-
T39 1289-1299 C0014467 denotes osinophil
T40 905-924 C0085828 denotes ctivator protein-1.
T41 1222-1231 C0282554 denotes hemokine.
T42 1186-1189 C1518422 denotes ot
T43 824-827 C1518422 denotes ot
T44 590-593 C1518422 denotes ot
T45 775-788 C0010934 denotes ctinomycin D.
T46 98-107 C0220825 denotes valuated
T47 1438-1453 C0040649 denotes ranscriptional
T48 716-719 C0041119 denotes h
T49 112-119 C0085732 denotes bility
T50 1378-1389 C1292856 denotes timulation
T51 1010-1021 C1292856 denotes timulation
T52 799-810 C1292856 denotes timulation
T53 1096-1105 C0442805 denotes ncreases
T54 839-847 C0442805 denotes ncrease
T55 665-674 C0442805 denotes ncreases
T56 647-657 C1948023 denotes timulated
T57 280-290 C1948023 denotes timulated
T58 1573-1588 C0031847 denotes athophysiology
T59 1512-1519 C0205263 denotes nduced
T60 1078-1084 C0205263 denotes nduced
T61 626-641 C1819461 denotes L-8 production.
T62 616-622 C0441889 denotes evels
T63 403-408 C0441889 denotes evel
T64 658-659 C2981700 denotes -
T65 476-477 C2981700 denotes
T66 449-462 C0332232 denotes pproximately
T67 312-325 C0332232 denotes pproximately
T68 440-444 C0040223 denotes ime
T69 710-711 C2827734 denotes
T70 1000-1008 C1883712 denotes ddition,
T71 1364-1371 C1517331 denotes urther,
T72 1239-1247 C2926606 denotes indings
T73 1031-1040 C0439590 denotes rolonged
T74 500-527 C1419409 denotes osinophil cationic protein,
T75 1322-1330 C0234402 denotes timulus
T76 369-375 C1547282 denotes howed
T77 660-664 C0332462 denotes old
T78 485-498 C1446561 denotes oncentration,
T79 394-397 C1416797 denotes ag,
T80 746-753 C0332206 denotes locked
T81 425-434 C0205217 denotes ncreased
T82 757-769 C1550147 denotes retreatment
T83 757-769 C2709094 denotes retreatment
T84 1592-1604 C0582415 denotes cute asthma
T85 979-995 C1518434 denotes uclear extracts.
T86 958-966 C0442726 denotes etected
T87 974-978 C0445247 denotes ame
T88 1555-1565 C1880177 denotes ontribute
T89 1045-1054 C2347098 denotes tability
T90 604-622 C0814896 denotes ignificant levels
T91 1615-1627 C0333348 denotes nflammatory
T92 328-333 C0439275 denotes g/ml
T93 929-931 C1521761 denotes F-
T94 929-931 C0521447 denotes F-
T95 855-871 C2266866 denotes inding activity
T96 1086-1095 C0205374 denotes ransient
T97 1300-1307 C0993609 denotes ranule
T98 604-615 C0750502 denotes ignificant
T99 1063-1067 C0169911 denotes RNA.
T100 254-259 C1514721 denotes ange