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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 14-19 protein denotes STAT5
T2 23-27 protein denotes IL-4
T3 38-50 protein denotes Janus kinase
T4 225-230 protein denotes STAT5
T5 254-273 protein denotes human IL-4 receptor
T6 275-280 protein denotes IL-4R
T7 310-326 protein denotes receptor mutants
T8 334-356 cell_line denotes murine pro-B cell line
T9 357-362 cell_line denotes Ba/F3
T10 427-444 protein denotes IL-4R alpha chain
T11 465-469 protein denotes IL-4
T12 478-483 protein denotes STAT5
T13 519-564 protein denotes membrane-proximal proline-rich sequence motif
T14 567-571 protein denotes box1
T15 599-614 protein denotes bipartite IL-4R
T16 677-690 protein denotes Janus kinases
T17 691-695 protein denotes JAK1
T18 700-704 protein denotes JAK3
T19 715-719 protein denotes IL-4
T20 744-749 protein denotes STAT5
T21 788-813 protein denotes dominant-negative version
T22 817-823 protein denotes STAT5b
T23 836-842 protein denotes STAT5a
T24 860-864 protein denotes IL-4
T25 890-901 cell_line denotes Ba/F3 cells
T26 932-938 protein denotes STAT5b
T27 984-989 protein denotes IL-4R
T28 1069-1074 protein denotes STAT5
T29 1142-1146 protein denotes IL-4
T30 1162-1168 protein denotes STAT5a
T31 1173-1179 protein denotes STAT5b
T32 1198-1202 protein denotes IL-4

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 14-19 protein_molecule denotes STAT5
T2 23-27 protein_molecule denotes IL-4
T3 38-50 protein_family_or_group denotes Janus kinase
T4 71-79 other_name denotes receptor
T5 80-88 amino_acid_monomer denotes tyrosine
T6 133-151 other_name denotes cell proliferation
T7 156-171 other_name denotes gene regulation
T8 225-230 protein_molecule denotes STAT5
T9 254-259 protein_molecule denotes human
T10 260-264 protein_molecule denotes IL-4
T11 275-280 protein_molecule denotes IL-4R
T12 310-326 protein_family_or_group denotes receptor mutants
T13 334-356 cell_line denotes murine pro-B cell line
T14 357-362 cell_line denotes Ba/F3
T15 383-397 amino_acid_monomer denotes phosphorylated
T16 398-406 amino_acid_monomer denotes tyrosine
T17 427-444 protein_subunit denotes IL-4R alpha chain
T18 465-469 protein_molecule denotes IL-4
T19 478-483 protein_molecule denotes STAT5
T20 599-614 protein_molecule denotes bipartite IL-4R
T21 634-648 other_name denotes ligand-induced
T22 649-657 amino_acid_monomer denotes tyrosine
T23 677-690 protein_family_or_group denotes Janus kinases
T24 691-695 protein_molecule denotes JAK1
T25 700-704 protein_molecule denotes JAK3
T26 715-719 protein_molecule denotes IL-4
T27 744-749 protein_molecule denotes STAT5
T28 754-765 other_name denotes concomitant
T29 766-784 other_name denotes cell proliferation
T30 788-813 protein_family_or_group denotes dominant-negative version
T31 817-823 protein_molecule denotes STAT5b
T32 836-842 protein_molecule denotes STAT5a
T33 860-864 protein_molecule denotes IL-4
T34 890-901 cell_line denotes Ba/F3 cells
T35 932-938 protein_molecule denotes STAT5b
T36 957-975 other_name denotes cell proliferation
T37 984-989 protein_molecule denotes IL-4R
T38 1069-1074 protein_molecule denotes STAT5
T39 1142-1146 protein_molecule denotes IL-4
T40 1162-1168 protein_molecule denotes STAT5a
T41 1173-1179 protein_molecule denotes STAT5b
T42 1198-1202 protein_molecule denotes IL-4

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 14-19 NP denotes STAT5
C3 0-19 NP denotes Activation of STAT5
C2 23-27 NP denotes IL-4
C4 225-241 NP denotes STAT5 activation
C12 250-281 NP denotes the human IL-4 receptor (IL-4R)
C5 465-470 NP denotes IL-4-
C6 715-720 NP denotes IL-4-
C7 744-749 NP denotes STAT5
C9 817-823 NP denotes STAT5b
C15 836-842 NP denotes STAT5a
C8 860-865 NP denotes IL-4-
C10 932-938 NP denotes STAT5b
C11 984-989 NP denotes IL-4R
C13 1142-1146 NP denotes IL-4
C14 1162-1168 NP denotes STAT5a
C16 1173-1179 NP denotes STAT5b
R1 C4 C3 coref-ident STAT5 activation,Activation of STAT5
R2 C5 C2 coref-ident IL-4-,IL-4
R3 C6 C5 coref-ident IL-4-,IL-4-
R4 C7 C1 coref-ident STAT5,STAT5
R5 C8 C6 coref-ident IL-4-,IL-4-
R6 C10 C9 coref-ident STAT5b,STAT5b
R7 C11 C12 coref-ident IL-4R,the human IL-4 receptor (IL-4R)
R8 C13 C8 coref-ident IL-4,IL-4-
R9 C14 C15 coref-ident STAT5a,STAT5a
R10 C16 C10 coref-ident STAT5b,STAT5b

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-172 Sentence denotes Activation of STAT5 by IL-4 relies on Janus kinase function but not on receptor tyrosine phosphorylation, and can contribute to both cell proliferation and gene regulation.
S2 173-282 Sentence denotes We have investigated mechanisms and consequences of STAT5 activation through the human IL-4 receptor (IL-4R).
S3 283-493 Sentence denotes By functionally expressing receptor mutants in the murine pro-B cell line Ba/F3, we could show that phosphorylated tyrosine residues within the IL-4R alpha chain are dispensable for IL-4-induced STAT5 activity.
S4 494-785 Sentence denotes However, disruption of a membrane-proximal proline-rich sequence motif ('box1') in either subunit of the bipartite IL-4R abolished not only ligand-induced tyrosine phosphorylation of Janus kinases JAK1 and JAK3, but also IL-4-triggered activation of STAT5 and concomitant cell proliferation.
S5 786-990 Sentence denotes A dominant-negative version of STAT5b, but not of STAT5a, interfered with IL-4-induced DNA synthesis in Ba/F3 cells, suggesting an involvement of STAT5b in the control of cell proliferation through IL-4R.
S6 991-1237 Sentence denotes Reporter gene experiments finally showed that transcription from promoters of STAT5 target genes can be specifically induced by challenging cells with IL-4, and that both STAT5a and STAT5b can contribute to IL-4-triggered transcriptional control.