PubMed:10421629 JSONTXT

{"project":"PMID_GLOBAL","denotations":[{"id":"T1","span":{"begin":190,"end":195},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0005070"}],"text":"Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex.\nThe stabilization of beta-catenin is a key regulatory step during cell fate changes and transformations to tumor cells. Several interacting proteins, including Axin, APC, and the protein kinase GSK-3beta are implicated in regulating beta-catenin phosphorylation and its subsequent degradation. Wnt signaling stabilizes beta-catenin, but it was not clear whether and how Wnt signaling regulates the beta-catenin complex. Here we show that Axin is dephosphorylated in response to Wnt signaling. The dephosphorylated Axin binds beta-catenin less efficiently than the phosphorylated form. Thus, Wnt signaling lowers Axin's affinity for beta-catenin, thereby disengaging beta-catenin from the degradation machinery."}

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":190,"end":195},"obj":"HP_0002664"}],"text":"Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex.\nThe stabilization of beta-catenin is a key regulatory step during cell fate changes and transformations to tumor cells. Several interacting proteins, including Axin, APC, and the protein kinase GSK-3beta are implicated in regulating beta-catenin phosphorylation and its subsequent degradation. Wnt signaling stabilizes beta-catenin, but it was not clear whether and how Wnt signaling regulates the beta-catenin complex. Here we show that Axin is dephosphorylated in response to Wnt signaling. The dephosphorylated Axin binds beta-catenin less efficiently than the phosphorylated form. Thus, Wnt signaling lowers Axin's affinity for beta-catenin, thereby disengaging beta-catenin from the degradation machinery."}

{"project":"bionlp-st-pc-2013-training","denotations":[{"id":"T1","span":{"begin":0,"end":3},"obj":"Gene_or_gene_product"},{"id":"T2","span":{"begin":33,"end":37},"obj":"Gene_or_gene_product"},{"id":"T3","span":{"begin":47,"end":59},"obj":"Gene_or_gene_product"},{"id":"T4","span":{"begin":69,"end":81},"obj":"Complex"},{"id":"T5","span":{"begin":104,"end":116},"obj":"Gene_or_gene_product"},{"id":"T6","span":{"begin":243,"end":247},"obj":"Gene_or_gene_product"},{"id":"T7","span":{"begin":249,"end":252},"obj":"Gene_or_gene_product"},{"id":"T8","span":{"begin":277,"end":286},"obj":"Gene_or_gene_product"},{"id":"T9","span":{"begin":316,"end":328},"obj":"Gene_or_gene_product"},{"id":"T10","span":{"begin":377,"end":380},"obj":"Gene_or_gene_product"},{"id":"T11","span":{"begin":402,"end":414},"obj":"Gene_or_gene_product"},{"id":"T12","span":{"begin":453,"end":456},"obj":"Gene_or_gene_product"},{"id":"T13","span":{"begin":481,"end":501},"obj":"Complex"},{"id":"T14","span":{"begin":521,"end":525},"obj":"Gene_or_gene_product"},{"id":"T15","span":{"begin":561,"end":564},"obj":"Gene_or_gene_product"},{"id":"T16","span":{"begin":597,"end":601},"obj":"Gene_or_gene_product"},{"id":"T17","span":{"begin":608,"end":620},"obj":"Gene_or_gene_product"},{"id":"T18","span":{"begin":674,"end":677},"obj":"Gene_or_gene_product"},{"id":"T19","span":{"begin":695,"end":699},"obj":"Gene_or_gene_product"},{"id":"T20","span":{"begin":715,"end":727},"obj":"Gene_or_gene_product"},{"id":"T21","span":{"begin":749,"end":761},"obj":"Gene_or_gene_product"}],"text":"Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex.\nThe stabilization of beta-catenin is a key regulatory step during cell fate changes and transformations to tumor cells. Several interacting proteins, including Axin, APC, and the protein kinase GSK-3beta are implicated in regulating beta-catenin phosphorylation and its subsequent degradation. Wnt signaling stabilizes beta-catenin, but it was not clear whether and how Wnt signaling regulates the beta-catenin complex. Here we show that Axin is dephosphorylated in response to Wnt signaling. The dephosphorylated Axin binds beta-catenin less efficiently than the phosphorylated form. Thus, Wnt signaling lowers Axin's affinity for beta-catenin, thereby disengaging beta-catenin from the degradation machinery."}