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PubMed:10417619 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-130 Sentence denotes Immune complexes from vasculitis patients bind to endothelial Fc receptors independent of the allelic polymorphism of FcgammaRIIa.
TextSentencer_T2 131-142 Sentence denotes UNLABELLED:
TextSentencer_T3 143-395 Sentence denotes Cutaneous leukocytoclastic vasculitis is characterized by the deposition of circulating immune complexes, neutrophil extravasation, and vessel destruction, but mechanisms of circulating immune complexes capture within postcapillary venules are unknown.
TextSentencer_T4 396-553 Sentence denotes We demonstrate that circulating immune complexes from sera of vasculitis patients bind to cultured endothelium in an Fc gamma receptor IIa-dependent fashion.
TextSentencer_T5 554-747 Sentence denotes In lesional skin, endothelial cells bind immunoglobulin G2 > immunoglobulin G3 and immunoglobulin G4, but not immunoglobulin G1, even before obvious neutrophil transmigration and vessel damage.
TextSentencer_T6 748-1098 Sentence denotes As the human Fc gamma receptor IIa proteins exist in two allotypes (one with a histidine at position 131, which binds immunoglobulin G1, 2, 3 and the other with an arginine at position 131, which binds immunoglobulin G1, and 3, but is unable to bind immunoglobulin G2), we expected an altered prevalence of histidine 131 forms in vasculitis patients.
TextSentencer_T7 1099-1196 Sentence denotes Sequence analysis, however, revealed an equal distribution of allotypes in patients and controls.
TextSentencer_T8 1197-1344 Sentence denotes In conclusion, circulating immune complex binding to endothelial Fc gamma receptor IIa is among the initial steps in the development of vasculitis.
TextSentencer_T9 1345-1687 Sentence denotes Although immunoglobulin G2 is the predominant subtype precipitated at endothelial surfaces, it is not required for fixing circulating immune complexes to endothelium, because patients homozygote for Fc gamma receptor IIa-arginine 131 equally develop leukocytoclastic vasculitis as those bearing the Fc gamma receptor IIa-histidine 131 allele.
TextSentencer_T10 1688-2048 Sentence denotes As immunoglobulin G1 is virtually absent in leukocytoclastic vasculitis lesions and immunoglobulin G4 does not bind to both Fc gamma receptor IIa alleles, these complexes, in addition to immunoglobulin G2, should contain immunoglobulin G3 in order to fix to vascular Fc gamma receptor IIa, at least in persons homozygous for Fc gamma receptor IIa-arginine 131.
TextSentencer_T11 2049-2131 Sentence denotes KEYWORDS: CD32/immunoglobulin G subtypes/leukocytoclastic vasculitis/microvessels.
T1 0-130 Sentence denotes Immune complexes from vasculitis patients bind to endothelial Fc receptors independent of the allelic polymorphism of FcgammaRIIa.
T2 131-142 Sentence denotes UNLABELLED:
T3 143-395 Sentence denotes Cutaneous leukocytoclastic vasculitis is characterized by the deposition of circulating immune complexes, neutrophil extravasation, and vessel destruction, but mechanisms of circulating immune complexes capture within postcapillary venules are unknown.
T4 396-553 Sentence denotes We demonstrate that circulating immune complexes from sera of vasculitis patients bind to cultured endothelium in an Fc gamma receptor IIa-dependent fashion.
T5 554-747 Sentence denotes In lesional skin, endothelial cells bind immunoglobulin G2 > immunoglobulin G3 and immunoglobulin G4, but not immunoglobulin G1, even before obvious neutrophil transmigration and vessel damage.
T6 748-1098 Sentence denotes As the human Fc gamma receptor IIa proteins exist in two allotypes (one with a histidine at position 131, which binds immunoglobulin G1, 2, 3 and the other with an arginine at position 131, which binds immunoglobulin G1, and 3, but is unable to bind immunoglobulin G2), we expected an altered prevalence of histidine 131 forms in vasculitis patients.
T7 1099-1196 Sentence denotes Sequence analysis, however, revealed an equal distribution of allotypes in patients and controls.
T8 1197-1344 Sentence denotes In conclusion, circulating immune complex binding to endothelial Fc gamma receptor IIa is among the initial steps in the development of vasculitis.
T9 1345-1687 Sentence denotes Although immunoglobulin G2 is the predominant subtype precipitated at endothelial surfaces, it is not required for fixing circulating immune complexes to endothelium, because patients homozygote for Fc gamma receptor IIa-arginine 131 equally develop leukocytoclastic vasculitis as those bearing the Fc gamma receptor IIa-histidine 131 allele.
T10 1688-2048 Sentence denotes As immunoglobulin G1 is virtually absent in leukocytoclastic vasculitis lesions and immunoglobulin G4 does not bind to both Fc gamma receptor IIa alleles, these complexes, in addition to immunoglobulin G2, should contain immunoglobulin G3 in order to fix to vascular Fc gamma receptor IIa, at least in persons homozygous for Fc gamma receptor IIa-arginine 131.
T11 2049-2131 Sentence denotes KEYWORDS: CD32/immunoglobulin G subtypes/leukocytoclastic vasculitis/microvessels.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
10417619-6#65#86#gene2212 1262-1283 gene2212 denotes Fc gamma receptor IIa
10417619-6#136#146#diseaseC0042384 1333-1343 diseaseC0042384 denotes vasculitis
10417619-9#0#4#gene2212 2059-2063 gene2212 denotes CD32
10417619-9#0#4#gene2213 2059-2063 gene2213 denotes CD32
10417619-9#0#4#gene9103 2059-2063 gene9103 denotes CD32
10417619-9#31#58#diseaseC0151436 2090-2117 diseaseC0151436 denotes leukocytoclastic vasculitis
10417619-9#31#58#diseaseC2973529 2090-2117 diseaseC2973529 denotes leukocytoclastic vasculitis
10417619-9#31#58#diseaseC0151436 2090-2117 diseaseC0151436 denotes leukocytoclastic vasculitis
10417619-9#31#58#diseaseC2973529 2090-2117 diseaseC2973529 denotes leukocytoclastic vasculitis
10417619-9#31#58#diseaseC0151436 2090-2117 diseaseC0151436 denotes leukocytoclastic vasculitis
10417619-9#31#58#diseaseC2973529 2090-2117 diseaseC2973529 denotes leukocytoclastic vasculitis
65#86#gene2212136#146#diseaseC0042384 10417619-6#65#86#gene2212 10417619-6#136#146#diseaseC0042384 associated_with Fc gamma receptor IIa,vasculitis
0#4#gene221231#58#diseaseC0151436 10417619-9#0#4#gene2212 10417619-9#31#58#diseaseC0151436 associated_with CD32,leukocytoclastic vasculitis
0#4#gene221231#58#diseaseC2973529 10417619-9#0#4#gene2212 10417619-9#31#58#diseaseC2973529 associated_with CD32,leukocytoclastic vasculitis
0#4#gene221231#58#diseaseC0151436 10417619-9#0#4#gene2212 10417619-9#31#58#diseaseC0151436 associated_with CD32,leukocytoclastic vasculitis
0#4#gene221231#58#diseaseC2973529 10417619-9#0#4#gene2212 10417619-9#31#58#diseaseC2973529 associated_with CD32,leukocytoclastic vasculitis
0#4#gene221231#58#diseaseC0151436 10417619-9#0#4#gene2212 10417619-9#31#58#diseaseC0151436 associated_with CD32,leukocytoclastic vasculitis
0#4#gene221231#58#diseaseC2973529 10417619-9#0#4#gene2212 10417619-9#31#58#diseaseC2973529 associated_with CD32,leukocytoclastic vasculitis
0#4#gene221331#58#diseaseC0151436 10417619-9#0#4#gene2213 10417619-9#31#58#diseaseC0151436 associated_with CD32,leukocytoclastic vasculitis
0#4#gene221331#58#diseaseC2973529 10417619-9#0#4#gene2213 10417619-9#31#58#diseaseC2973529 associated_with CD32,leukocytoclastic vasculitis
0#4#gene221331#58#diseaseC0151436 10417619-9#0#4#gene2213 10417619-9#31#58#diseaseC0151436 associated_with CD32,leukocytoclastic vasculitis
0#4#gene221331#58#diseaseC2973529 10417619-9#0#4#gene2213 10417619-9#31#58#diseaseC2973529 associated_with CD32,leukocytoclastic vasculitis
0#4#gene221331#58#diseaseC0151436 10417619-9#0#4#gene2213 10417619-9#31#58#diseaseC0151436 associated_with CD32,leukocytoclastic vasculitis
0#4#gene221331#58#diseaseC2973529 10417619-9#0#4#gene2213 10417619-9#31#58#diseaseC2973529 associated_with CD32,leukocytoclastic vasculitis
0#4#gene910331#58#diseaseC0151436 10417619-9#0#4#gene9103 10417619-9#31#58#diseaseC0151436 associated_with CD32,leukocytoclastic vasculitis
0#4#gene910331#58#diseaseC2973529 10417619-9#0#4#gene9103 10417619-9#31#58#diseaseC2973529 associated_with CD32,leukocytoclastic vasculitis
0#4#gene910331#58#diseaseC0151436 10417619-9#0#4#gene9103 10417619-9#31#58#diseaseC0151436 associated_with CD32,leukocytoclastic vasculitis
0#4#gene910331#58#diseaseC2973529 10417619-9#0#4#gene9103 10417619-9#31#58#diseaseC2973529 associated_with CD32,leukocytoclastic vasculitis
0#4#gene910331#58#diseaseC0151436 10417619-9#0#4#gene9103 10417619-9#31#58#diseaseC0151436 associated_with CD32,leukocytoclastic vasculitis
0#4#gene910331#58#diseaseC2973529 10417619-9#0#4#gene9103 10417619-9#31#58#diseaseC2973529 associated_with CD32,leukocytoclastic vasculitis

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1210 2059-2063 gene:2212 denotes CD32
T1211 2090-2117 disease:C0151436 denotes leukocytoclastic vasculitis
R1 T1210 T1211 associated_with CD32,leukocytoclastic vasculitis
R2 T1210 T1211 associated_with CD32,leukocytoclastic vasculitis
R3 T1210 T1211 associated_with CD32,leukocytoclastic vasculitis
R4 T1210 T1211 associated_with CD32,leukocytoclastic vasculitis
R5 T1210 T1211 associated_with CD32,leukocytoclastic vasculitis
R6 T1210 T1211 associated_with CD32,leukocytoclastic vasculitis

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 279-285 http://purl.obolibrary.org/obo/UBERON_0000055 denotes vessel
PD-UBERON-AE-B_T2 733-739 http://purl.obolibrary.org/obo/UBERON_0000055 denotes vessel
PD-UBERON-AE-B_T3 361-382 http://purl.obolibrary.org/obo/UBERON_0035428 denotes postcapillary venules
PD-UBERON-AE-B_T4 375-382 http://purl.obolibrary.org/obo/UBERON_0001979 denotes venules
PD-UBERON-AE-B_T5 495-506 http://purl.obolibrary.org/obo/UBERON_0001986 denotes endothelium
PD-UBERON-AE-B_T6 1499-1510 http://purl.obolibrary.org/obo/UBERON_0001986 denotes endothelium

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 279-285 http://purl.obolibrary.org/obo/UBERON_0000055 denotes vessel
PD-UBERON-AE-B_T2 733-739 http://purl.obolibrary.org/obo/UBERON_0000055 denotes vessel
PD-UBERON-AE-B_T3 495-506 http://purl.obolibrary.org/obo/UBERON_0001986 denotes endothelium
PD-UBERON-AE-B_T4 1499-1510 http://purl.obolibrary.org/obo/UBERON_0001986 denotes endothelium
PD-UBERON-AE-B_T5 361-382 http://purl.obolibrary.org/obo/UBERON_0035428 denotes postcapillary venules
PD-UBERON-AE-B_T6 375-382 http://purl.obolibrary.org/obo/UBERON_0001979 denotes venules

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1544-1561 gene:2209 denotes Fc gamma receptor
T1 1595-1622 disease:C0151436 denotes leukocytoclastic vasculitis
T2 1544-1561 gene:2209 denotes Fc gamma receptor
T3 1595-1622 disease:C2973529 denotes leukocytoclastic vasculitis
T4 1644-1661 gene:2209 denotes Fc gamma receptor
T5 1595-1622 disease:C0151436 denotes leukocytoclastic vasculitis
T6 1644-1661 gene:2209 denotes Fc gamma receptor
T7 1595-1622 disease:C2973529 denotes leukocytoclastic vasculitis
R1 T0 T1 associated_with Fc gamma receptor,leukocytoclastic vasculitis
R2 T2 T3 associated_with Fc gamma receptor,leukocytoclastic vasculitis
R3 T4 T5 associated_with Fc gamma receptor,leukocytoclastic vasculitis
R4 T6 T7 associated_with Fc gamma receptor,leukocytoclastic vasculitis