PubMed:10409763
Annnotations
PMID_GLOBAL
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 73-78 | DiseaseOrPhenotypicFeature | denotes | tumor | 0005070 |
| T2 | 345-350 | DiseaseOrPhenotypicFeature | denotes | tumor | 0005070 |
| T3 | 1039-1042 | DiseaseOrPhenotypicFeature | denotes | can | 0012833 |
| T4 | 1343-1359 | DiseaseOrPhenotypicFeature | denotes | Burkitt lymphoma | 0007243 |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 345-350 | HP_0002664 | denotes | tumor |
| T2 | 1343-1359 | HP_0030080 | denotes | Burkitt lymphoma |
| T3 | 1351-1359 | HP_0002665 | denotes | lymphoma |
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 4-60 | protein | denotes | Epstein-Barr virus oncoprotein latent membrane protein 1 |
| T2 | 73-123 | protein | denotes | tumor necrosis factor receptor-associated proteins |
| T3 | 124-129 | protein | denotes | TRADD |
| T4 | 134-162 | protein | denotes | receptor-interacting protein |
| T5 | 164-167 | protein | denotes | RIP |
| T6 | 210-213 | protein | denotes | RIP |
| T7 | 218-227 | protein | denotes | NF-kappaB |
| T8 | 254-299 | protein | denotes | Epstein-Barr virus (EBV) transforming protein |
| T9 | 300-304 | protein | denotes | LMP1 |
| T10 | 345-417 | protein | denotes | tumor necrosis factor receptor 1 (TNFR1)-associated death domain protein |
| T11 | 418-423 | protein | denotes | TRADD |
| T12 | 435-444 | protein | denotes | NF-kappaB |
| T13 | 449-472 | protein | denotes | c-Jun N-terminal kinase |
| T14 | 562-566 | protein | denotes | LMP1 |
| T15 | 585-590 | protein | denotes | TRADD |
| T16 | 604-609 | protein | denotes | TNFR1 |
| T17 | 628-633 | protein | denotes | TRADD |
| T18 | 635-639 | protein | denotes | LMP1 |
| T19 | 678-687 | protein | denotes | NF-kappaB |
| T20 | 706-711 | protein | denotes | TRADD |
| T21 | 715-724 | protein | denotes | NF-kappaB |
| T22 | 743-748 | protein | denotes | TNFR1 |
| T23 | 794-798 | protein | denotes | LMP1 |
| T24 | 816-821 | protein | denotes | TRADD |
| T25 | 846-855 | protein | denotes | NF-kappaB |
| T26 | 874-879 | protein | denotes | TNFR1 |
| T27 | 889-894 | protein | denotes | TRADD |
| T28 | 916-920 | protein | denotes | LMP1 |
| T29 | 946-955 | protein | denotes | NF-kappaB |
| T30 | 972-977 | protein | denotes | TRADD |
| T31 | 999-1018 | protein | denotes | residues 122 to 293 |
| T32 | 1027-1032 | protein | denotes | TNFR1 |
| T33 | 1034-1038 | protein | denotes | LMP1 |
| T34 | 1066-1094 | protein | denotes | receptor-interacting protein |
| T35 | 1096-1099 | protein | denotes | RIP |
| T36 | 1128-1131 | protein | denotes | RIP |
| T37 | 1135-1176 | cell_line | denotes | EBV-transformed lymphoblastoid cell lines |
| T38 | 1192-1196 | protein | denotes | LMP1 |
| T39 | 1214-1217 | protein | denotes | RIP |
| T40 | 1222-1231 | protein | denotes | NF-kappaB |
| T41 | 1282-1287 | protein | denotes | TRADD |
| T42 | 1291-1294 | protein | denotes | RIP |
| T43 | 1296-1300 | protein | denotes | LMP1 |
| T44 | 1330-1395 | cell_line | denotes | EBV-negative Burkitt lymphoma or human embryonic kidney 293 cells |
| T45 | 1483-1487 | protein | denotes | LMP1 |
| T46 | 1489-1494 | protein | denotes | TRADD |
| T47 | 1500-1503 | protein | denotes | RIP |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C1 | 0-60 | NP | denotes | The Epstein-Barr virus oncoprotein latent membrane protein 1 |
| C2 | 69-129 | NP | denotes | the tumor necrosis factor receptor-associated proteins TRADD |
| C3 | 134-168 | NP | denotes | receptor-interacting protein (RIP) |
| C4 | 210-213 | NP | denotes | RIP |
| C5 | 218-238 | NP | denotes | NF-kappaB activation |
| C7 | 250-304 | NP | denotes | the Epstein-Barr virus (EBV) transforming protein LMP1 |
| C6 | 240-304 | NP | denotes | A site in the Epstein-Barr virus (EBV) transforming protein LMP1 |
| C8 | 305-309 | NP | denotes | that |
| C9 | 341-423 | NP | denotes | the tumor necrosis factor receptor 1 (TNFR1)-associated death domain protein TRADD |
| C10 | 585-590 | NP | denotes | TRADD |
| C11 | 628-633 | NP | denotes | TRADD |
| C12 | 635-639 | NP | denotes | LMP1 |
| C13 | 715-735 | NP | denotes | NF-kappaB activation |
| C14 | 743-748 | NP | denotes | TNFR1 |
| C15 | 794-798 | NP | denotes | LMP1 |
| C16 | 846-866 | NP | denotes | NF-kappaB activation |
| C17 | 874-879 | NP | denotes | TNFR1 |
| C18 | 916-920 | NP | denotes | LMP1 |
| C19 | 946-966 | NP | denotes | NF-kappaB activation |
| C20 | 1027-1032 | NP | denotes | TNFR1 |
| C21 | 1034-1038 | NP | denotes | LMP1 |
| C22 | 1066-1100 | NP | denotes | receptor-interacting protein (RIP) |
| C23 | 1192-1196 | NP | denotes | LMP1 |
| C24 | 1214-1217 | NP | denotes | RIP |
| C25 | 1222-1242 | NP | denotes | NF-kappaB activation |
| C26 | 1282-1287 | NP | denotes | TRADD |
| C27 | 1291-1294 | NP | denotes | RIP |
| C28 | 1296-1300 | NP | denotes | LMP1 |
| C29 | 1442-1468 | NP | denotes | the molecular interactions |
| C30 | 1477-1482 | NP | denotes | which |
| C31 | 1483-1487 | NP | denotes | LMP1 |
| C32 | 1489-1494 | NP | denotes | TRADD |
| C33 | 1500-1503 | NP | denotes | RIP |
| R1 | C4 | C3 | coref-ident | RIP,receptor-interacting protein (RIP) |
| R2 | C7 | C1 | coref-ident | the Epstein-Barr virus (EBV) transforming protein LMP1,The Epstein-Barr virus oncoprotein latent membrane protein 1 |
| R3 | C8 | C6 | coref-relat | that,A site in the Epstein-Barr virus (EBV) transforming protein LMP1 |
| R4 | C9 | C2 | coref-ident | the tumor necrosis factor receptor 1 (TNFR1)-associated death domain protein TRADD,the tumor necrosis factor receptor-associated proteins TRADD |
| R5 | C10 | C9 | coref-ident | TRADD,the tumor necrosis factor receptor 1 (TNFR1)-associated death domain protein TRADD |
| R6 | C11 | C10 | coref-ident | TRADD,TRADD |
| R7 | C12 | C7 | coref-ident | LMP1,the Epstein-Barr virus (EBV) transforming protein LMP1 |
| R8 | C13 | C5 | coref-ident | NF-kappaB activation,NF-kappaB activation |
| R9 | C15 | C12 | coref-ident | LMP1,LMP1 |
| R10 | C16 | C13 | coref-ident | NF-kappaB activation,NF-kappaB activation |
| R11 | C17 | C14 | coref-ident | TNFR1,TNFR1 |
| R12 | C18 | C15 | coref-ident | LMP1,LMP1 |
| R13 | C19 | C16 | coref-ident | NF-kappaB activation,NF-kappaB activation |
| R14 | C20 | C17 | coref-ident | TNFR1,TNFR1 |
| R15 | C21 | C18 | coref-ident | LMP1,LMP1 |
| R16 | C22 | C4 | coref-ident | receptor-interacting protein (RIP),RIP |
| R17 | C23 | C21 | coref-ident | LMP1,LMP1 |
| R18 | C24 | C22 | coref-ident | RIP,receptor-interacting protein (RIP) |
| R19 | C25 | C19 | coref-ident | NF-kappaB activation,NF-kappaB activation |
| R20 | C26 | C11 | coref-ident | TRADD,TRADD |
| R21 | C27 | C24 | coref-ident | RIP,RIP |
| R22 | C28 | C23 | coref-ident | LMP1,LMP1 |
| R23 | C30 | C29 | coref-relat | which,the molecular interactions |
| R24 | C31 | C28 | coref-ident | LMP1,LMP1 |
| R25 | C32 | C26 | coref-ident | TRADD,TRADD |
| R26 | C33 | C27 | coref-ident | RIP,RIP |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-239 | Sentence | denotes | The Epstein-Barr virus oncoprotein latent membrane protein 1 engages the tumor necrosis factor receptor-associated proteins TRADD and receptor-interacting protein (RIP) but does not induce apoptosis or require RIP for NF-kappaB activation. |
| S2 | 240-544 | Sentence | denotes | A site in the Epstein-Barr virus (EBV) transforming protein LMP1 that constitutively associates with the tumor necrosis factor receptor 1 (TNFR1)-associated death domain protein TRADD to mediate NF-kappaB and c-Jun N-terminal kinase activation is critical for long-term lymphoblastoid cell proliferation. |
| S3 | 545-634 | Sentence | denotes | We now find that LMP1 signaling through TRADD differs from TNFR1 signaling through TRADD. |
| S4 | 635-784 | Sentence | denotes | LMP1 needs only 11 amino acids to activate NF-kappaB or synergize with TRADD in NF-kappaB activation, while TNFR1 requires approximately 70 residues. |
| S5 | 785-915 | Sentence | denotes | Further, LMP1 does not require TRADD residues 294 to 312 for NF-kappaB activation, while TNFR1 requires TRADD residues 296 to 302. |
| S6 | 916-1019 | Sentence | denotes | LMP1 is partially blocked for NF-kappaB activation by a TRADD mutant consisting of residues 122 to 293. |
| S7 | 1020-1177 | Sentence | denotes | Unlike TNFR1, LMP1 can interact directly with receptor-interacting protein (RIP) and stably associates with RIP in EBV-transformed lymphoblastoid cell lines. |
| S8 | 1178-1243 | Sentence | denotes | Surprisingly, LMP1 does not require RIP for NF-kappaB activation. |
| S9 | 1244-1396 | Sentence | denotes | Despite constitutive association with TRADD or RIP, LMP1 does not induce apoptosis in EBV-negative Burkitt lymphoma or human embryonic kidney 293 cells. |
| S10 | 1397-1554 | Sentence | denotes | These results add a different perspective to the molecular interactions through which LMP1, TRADD, and RIP participate in B-lymphocyte activation and growth. |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T43 | 1135-1138 | virus | denotes | EBV |
| T1 | 4-22 | virus | denotes | Epstein-Barr virus |
| T2 | 73-123 | protein_family_or_group | denotes | tumor necrosis factor receptor-associated proteins |
| T3 | 124-129 | protein_family_or_group | denotes | TRADD |
| T4 | 134-162 | protein_molecule | denotes | receptor-interacting protein |
| T5 | 164-167 | protein_molecule | denotes | RIP |
| T6 | 189-198 | other_name | denotes | apoptosis |
| T7 | 210-213 | protein_molecule | denotes | RIP |
| T8 | 218-227 | protein_complex | denotes | NF-kappaB |
| T9 | 254-272 | virus | denotes | Epstein-Barr virus |
| T10 | 274-277 | virus | denotes | EBV |
| T11 | 300-304 | protein_molecule | denotes | LMP1 |
| T12 | 345-377 | protein_molecule | denotes | tumor necrosis factor receptor 1 |
| T13 | 379-384 | protein_molecule | denotes | TNFR1 |
| T14 | 418-423 | protein_family_or_group | denotes | TRADD |
| T15 | 435-444 | protein_complex | denotes | NF-kappaB |
| T16 | 449-472 | protein_molecule | denotes | c-Jun N-terminal kinase |
| T17 | 500-543 | other_name | denotes | long-term lymphoblastoid cell proliferation |
| T18 | 562-566 | protein_molecule | denotes | LMP1 |
| T19 | 585-590 | protein_family_or_group | denotes | TRADD |
| T20 | 604-609 | protein_molecule | denotes | TNFR1 |
| T21 | 628-633 | protein_family_or_group | denotes | TRADD |
| T22 | 635-639 | protein_molecule | denotes | LMP1 |
| T23 | 654-665 | amino_acid_monomer | denotes | amino acids |
| T24 | 678-687 | protein_complex | denotes | NF-kappaB |
| T25 | 706-711 | protein_family_or_group | denotes | TRADD |
| T26 | 715-724 | protein_molecule | denotes | NF-kappaB |
| T27 | 743-748 | protein_molecule | denotes | TNFR1 |
| T28 | 775-783 | amino_acid_monomer | denotes | residues |
| T29 | 794-798 | protein_molecule | denotes | LMP1 |
| T30 | 816-821 | protein_family_or_group | denotes | TRADD |
| T31 | 846-855 | protein_complex | denotes | NF-kappaB |
| T32 | 874-879 | protein_molecule | denotes | TNFR1 |
| T33 | 889-894 | protein_family_or_group | denotes | TRADD |
| T34 | 916-920 | protein_molecule | denotes | LMP1 |
| T35 | 946-955 | protein_complex | denotes | NF-kappaB |
| T36 | 972-977 | protein_family_or_group | denotes | TRADD |
| T37 | 999-1007 | amino_acid_monomer | denotes | residues |
| T38 | 1027-1032 | protein_molecule | denotes | TNFR1 |
| T39 | 1034-1038 | protein_molecule | denotes | LMP1 |
| T40 | 1066-1094 | protein_molecule | denotes | receptor-interacting protein |
| T41 | 1096-1099 | protein_molecule | denotes | RIP |
| T42 | 1128-1131 | protein_molecule | denotes | RIP |
| T44 | 1192-1196 | protein_molecule | denotes | LMP1 |
| T45 | 1214-1217 | protein_molecule | denotes | RIP |
| T46 | 1222-1231 | protein_complex | denotes | NF-kappaB |
| T47 | 1252-1276 | other_name | denotes | constitutive association |
| T48 | 1282-1287 | protein_family_or_group | denotes | TRADD |
| T49 | 1291-1294 | protein_molecule | denotes | RIP |
| T50 | 1296-1300 | protein_molecule | denotes | LMP1 |
| T51 | 1317-1326 | other_name | denotes | apoptosis |
| T52 | 1446-1468 | other_name | denotes | molecular interactions |
| T53 | 1483-1487 | protein_molecule | denotes | LMP1 |
| T54 | 1489-1494 | protein_family_or_group | denotes | TRADD |
| T55 | 1500-1503 | protein_molecule | denotes | RIP |