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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-87 Sentence denotes Preclinical memory decline in cognitively normal apolipoprotein E-epsilon4 homozygotes.
TextSentencer_T2 88-98 Sentence denotes OBJECTIVE:
TextSentencer_T3 99-253 Sentence denotes To determine, in a cross-sectional evaluation of nondemented individuals, if age-related memory decline is influenced by apolipoprotein E (apoE) genotype.
TextSentencer_T4 254-265 Sentence denotes BACKGROUND:
TextSentencer_T5 266-319 Sentence denotes The apoE-4 allele is an important risk factor for AD.
TextSentencer_T6 320-523 Sentence denotes PET in cognitively normal apoE-4 carriers (mean age, 56 years) shows reduced cerebral metabolism suggestive of very early AD that precedes clinically evident memory loss or MRI-based hippocampal atrophy.
TextSentencer_T7 524-532 Sentence denotes METHODS:
TextSentencer_T8 533-886 Sentence denotes Tests of immediate and delayed recall (primary outcome measures) and other neuropsychological measures (secondary outcome measures) were given to three genetically defined groups of cognitively normal individuals (age, 49 to 69 years) including apoE-4 homozygotes (n = 25), apoE-4 heterozygotes (n = 25, all epsilon3/4), and apoE-4 noncarriers (n = 50).
TextSentencer_T9 887-951 Sentence denotes Groups were matched for age, gender, and educational background.
TextSentencer_T10 952-1108 Sentence denotes Cross-sectional comparisons between the genetic subgroups of the relationship between age and test score were performed for each neuropsychological measure.
TextSentencer_T11 1109-1117 Sentence denotes RESULTS:
TextSentencer_T12 1118-1372 Sentence denotes There were no intergroup differences in mean scores on any neuropsychological measure, but tests sensitive to immediate and delayed recall showed a significant negative correlation with age in the apoE-4 homozygote group relative to the noncarrier group.
TextSentencer_T13 1373-1384 Sentence denotes CONCLUSION:
TextSentencer_T14 1385-1659 Sentence denotes Consistent with previous neuropsychological studies of early AD, this cross-sectional study suggests that age-related memory decline occurs earlier in cognitively healthy apoE-4 homozygotes than in apoE-4 heterozygotes and noncarriers, and precedes clinically detectable AD.
T1 0-87 Sentence denotes Preclinical memory decline in cognitively normal apolipoprotein E-epsilon4 homozygotes.
T2 88-98 Sentence denotes OBJECTIVE:
T3 99-253 Sentence denotes To determine, in a cross-sectional evaluation of nondemented individuals, if age-related memory decline is influenced by apolipoprotein E (apoE) genotype.
T4 254-265 Sentence denotes BACKGROUND:
T5 266-319 Sentence denotes The apoE-4 allele is an important risk factor for AD.
T6 320-523 Sentence denotes PET in cognitively normal apoE-4 carriers (mean age, 56 years) shows reduced cerebral metabolism suggestive of very early AD that precedes clinically evident memory loss or MRI-based hippocampal atrophy.
T7 524-532 Sentence denotes METHODS:
T8 533-886 Sentence denotes Tests of immediate and delayed recall (primary outcome measures) and other neuropsychological measures (secondary outcome measures) were given to three genetically defined groups of cognitively normal individuals (age, 49 to 69 years) including apoE-4 homozygotes (n = 25), apoE-4 heterozygotes (n = 25, all epsilon3/4), and apoE-4 noncarriers (n = 50).
T9 887-951 Sentence denotes Groups were matched for age, gender, and educational background.
T10 952-1108 Sentence denotes Cross-sectional comparisons between the genetic subgroups of the relationship between age and test score were performed for each neuropsychological measure.
T11 1109-1117 Sentence denotes RESULTS:
T12 1118-1372 Sentence denotes There were no intergroup differences in mean scores on any neuropsychological measure, but tests sensitive to immediate and delayed recall showed a significant negative correlation with age in the apoE-4 homozygote group relative to the noncarrier group.
T13 1373-1384 Sentence denotes CONCLUSION:
T14 1385-1659 Sentence denotes Consistent with previous neuropsychological studies of early AD, this cross-sectional study suggests that age-related memory decline occurs earlier in cognitively healthy apoE-4 homozygotes than in apoE-4 heterozygotes and noncarriers, and precedes clinically detectable AD.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
10408560-3#26#32#gene348 346-352 gene348 denotes apoE-4
10408560-3#158#169#diseaseC0002622 478-489 diseaseC0002622 denotes memory loss
10408560-3#158#169#diseaseC0751295 478-489 diseaseC0751295 denotes memory loss
26#32#gene348158#169#diseaseC0002622 10408560-3#26#32#gene348 10408560-3#158#169#diseaseC0002622 associated_with apoE-4,memory loss
26#32#gene348158#169#diseaseC0751295 10408560-3#26#32#gene348 10408560-3#158#169#diseaseC0751295 associated_with apoE-4,memory loss

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1337 346-352 gene:348 denotes apoE-4
T1338 478-489 disease:C0002622 denotes memory loss
R1 T1337 T1338 associated_with apoE-4,memory loss
R2 T1337 T1338 associated_with apoE-4,memory loss