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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 0-43 protein denotes Monoclonal anti-endothelial cell antibodies
T2 151-194 protein denotes monoclonal anti-endothelial cell antibodies
T3 196-201 protein denotes mAECA
T4 280-318 cell_line denotes human umbilical vein endothelial cells
T5 320-325 cell_line denotes HUVEC
T6 400-405 protein denotes mAECA
T7 425-453 cell_type denotes peripheral blood lymphocytes
T8 550-566 cell_line denotes macrovascular EC
T9 568-573 cell_line denotes HUVEC
T10 579-595 cell_line denotes microvascular EC
T11 597-638 cell_line denotes human bone marrow EC immortalized by SV40
T12 743-764 protein denotes monoclonal antibodies
T13 766-771 protein denotes mAECA
T14 832-846 protein denotes total IgG-AECA
T15 903-908 protein denotes mAECA
T16 912-927 cell_type denotes human aortic EC
T17 989-1002 protein denotes interleukin-6
T18 1004-1008 protein denotes IL-6
T19 1102-1114 cell_line denotes activated EC
T20 1152-1171 cell_line denotes monocytic cell line
T21 1173-1177 cell_line denotes U937
T22 1209-1242 protein denotes vascular cell adhesion molecule 1
T23 1283-1293 protein denotes E-selectin
T24 1332-1348 cell_line denotes mAECA-treated EC
T25 1401-1422 protein denotes nuclear factor kappaB
T26 1424-1433 protein denotes NF-kappaB
T27 1453-1462 protein denotes NF-kappaB
T28 1531-1536 protein denotes mAECA
T29 1625-1628 protein denotes IgG
T30 1675-1680 cell_line denotes HUVEC
T31 1686-1691 protein denotes mAECA
T32 1724-1740 cell_line denotes macrovascular EC
T33 1802-1807 protein denotes mAECA
T34 1817-1833 protein denotes normal human IgG
T35 1884-1889 protein denotes mAECA
T36 1890-1902 cell_line denotes activated EC
T37 1928-1932 protein denotes IL-6
T38 1958-1963 protein denotes mAECA
T39 1989-2007 protein denotes adhesion molecules
T40 2034-2054 cell_type denotes U937 monocytic cells
T41 2058-2060 cell_type denotes EC
T42 2081-2086 protein denotes mAECA
T43 2131-2161 protein denotes NF-kappaB transcription factor
T44 2201-2205 protein denotes AECA
T45 2229-2231 cell_type denotes EC
T46 2275-2292 protein denotes adhesion molecule
T47 2320-2329 protein denotes NF-kappaB
T48 2357-2366 cell_type denotes monocytes

genia-medco-coref

Id Subject Object Predicate Lexical cue
C3 64-82 NP denotes Takayasu arteritis
C2 49-82 NP denotes a patient with Takayasu arteritis
C1 0-82 NP denotes Monoclonal anti-endothelial cell antibodies from a patient with Takayasu arteritis
C6 223-241 NP denotes Takayasu arteritis
C5 208-241 NP denotes a patient with Takayasu arteritis
C4 151-241 NP denotes monoclonal anti-endothelial cell antibodies (mAECA) from a patient with Takayasu arteritis
C7 254-259 NP denotes their
C8 280-326 NP denotes human umbilical vein endothelial cells (HUVEC)
C9 365-378 NP denotes EC activation
C10 400-405 NP denotes mAECA
C12 472-490 NP denotes Takayasu arteritis
C11 457-490 NP denotes a patient with Takayasu arteritis
C13 739-772 NP denotes the monoclonal antibodies (mAECA)
C14 773-778 NP denotes which
C15 852-882 NP denotes the Takayasu arteritis patient
C16 899-908 NP denotes the mAECA
C17 1083-1096 NP denotes EC activation
C18 1150-1178 NP denotes a monocytic cell line (U937)
C19 1384-1434 NP denotes translocation of nuclear factor kappaB (NF-kappaB)
C20 1527-1536 NP denotes Six mAECA
C21 1567-1572 NP denotes which
C22 1675-1680 NP denotes HUVEC
C23 1682-1691 NP denotes All mAECA
C24 1798-1807 NP denotes The mAECA
C26 1878-1889 NP denotes the 6 mAECA
C25 1870-1889 NP denotes Four of the 6 mAECA
C27 1900-1902 NP denotes EC
C28 1952-1963 NP denotes The 4 mAECA
C29 2034-2054 NP denotes U937 monocytic cells
C30 2058-2060 NP denotes EC
C31 2075-2086 NP denotes these mAECA
C32 2098-2161 NP denotes the nuclear translocation of the NF-kappaB transcription factor
C33 2235-2253 NP denotes Takayasu arteritis
C34 2451-2469 NP denotes Takayasu arteritis
R1 C6 C3 coref-ident Takayasu arteritis,Takayasu arteritis
R2 C5 C2 coref-ident a patient with Takayasu arteritis,a patient with Takayasu arteritis
R3 C4 C1 coref-ident monoclonal anti-endothelial cell antibodies (mAECA) from a patient with Takayasu arteritis,Monoclonal anti-endothelial cell antibodies from a patient with Takayasu arteritis
R4 C7 C4 coref-pron their,monoclonal anti-endothelial cell antibodies (mAECA) from a patient with Takayasu arteritis
R5 C12 C6 coref-ident Takayasu arteritis,Takayasu arteritis
R6 C11 C5 coref-ident a patient with Takayasu arteritis,a patient with Takayasu arteritis
R7 C14 C13 coref-relat which,the monoclonal antibodies (mAECA)
R8 C15 C11 coref-ident the Takayasu arteritis patient,a patient with Takayasu arteritis
R9 C16 C10 coref-ident the mAECA,mAECA
R10 C17 C9 coref-ident EC activation,EC activation
R11 C21 C20 coref-pron which,Six mAECA
R12 C22 C8 coref-ident HUVEC,human umbilical vein endothelial cells (HUVEC)
R13 C23 C20 coref-ident All mAECA,Six mAECA
R14 C24 C23 coref-ident The mAECA,All mAECA
R15 C26 C24 coref-ident the 6 mAECA,The mAECA
R16 C28 C25 coref-ident The 4 mAECA,Four of the 6 mAECA
R17 C29 C18 coref-ident U937 monocytic cells,a monocytic cell line (U937)
R18 C30 C27 coref-ident EC,EC
R19 C31 C28 coref-ident these mAECA,The 4 mAECA
R20 C32 C19 coref-ident the nuclear translocation of the NF-kappaB transcription factor,translocation of nuclear factor kappaB (NF-kappaB)
R21 C33 C12 coref-ident Takayasu arteritis,Takayasu arteritis
R22 C34 C33 coref-ident Takayasu arteritis,Takayasu arteritis

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-129 Sentence denotes Monoclonal anti-endothelial cell antibodies from a patient with Takayasu arteritis activate endothelial cells from large vessels.
S2 130-379 Sentence denotes OBJECTIVE: To create monoclonal anti-endothelial cell antibodies (mAECA) from a patient with Takayasu arteritis to evaluate their ability to activate human umbilical vein endothelial cells (HUVEC), and to characterize the mechanism of EC activation.
S3 380-532 Sentence denotes METHODS: A panel of mAECA was generated from peripheral blood lymphocytes of a patient with Takayasu arteritis, using Epstein-Barr virus transformation.
S4 533-699 Sentence denotes Activity against macrovascular EC (HUVEC) and microvascular EC (human bone marrow EC immortalized by SV40) antigens was detected by enzyme-linked immunosorbent assay.
S5 700-883 Sentence denotes Inhibition studies were used to select the monoclonal antibodies (mAECA) which share the same EC epitope binding specificity as the total IgG-AECA from the Takayasu arteritis patient.
S6 884-964 Sentence denotes The binding of the mAECA to human aortic EC was studied by immunohistochemistry.
S7 965-1097 Sentence denotes The secretion levels of interleukin-6 (IL-6) and von Willebrand factor (vWF) were determined, to serve as markers for EC activation.
S8 1098-1294 Sentence denotes The activated EC were examined for the adherence of a monocytic cell line (U937), as well as for expression of vascular cell adhesion molecule 1, intercellular adhesion molecule 1, and E-selectin.
S9 1295-1517 Sentence denotes In addition, nuclear extracts of the mAECA-treated EC were analyzed for the induction of translocation of nuclear factor kappaB (NF-kappaB), using a specific NF-kappaB oligoprobe in an electrophoretic mobility shift assay.
S10 1518-1681 Sentence denotes RESULTS: Six mAECA were selected, the mixture of which produced 100% inhibition of binding of the original IgG (from the patient with Takayasu arteritis) to HUVEC.
S11 1682-1797 Sentence denotes All mAECA possessed high activity against macrovascular EC, but none had significant antimicrovascular EC activity.
S12 1798-1869 Sentence denotes The mAECA, but not normal human IgG, had anti-human aortic EC activity.
S13 1870-1951 Sentence denotes Four of the 6 mAECA activated EC, manifested by increased IL-6 and vWF secretion.
S14 1952-2061 Sentence denotes The 4 mAECA induced EC expression of adhesion molecules and increased adhesion of U937 monocytic cells to EC.
S15 2062-2162 Sentence denotes In addition, these mAECA stimulated the nuclear translocation of the NF-kappaB transcription factor.
S16 2163-2470 Sentence denotes CONCLUSION: Our findings suggest that AECA may directly stimulate EC in Takayasu arteritis through elevation of adhesion molecule expression associated with NF-kappaB activation and adhesion of monocytes, and may therefore play a pathogenic role in the development of the vasculopathy in Takayasu arteritis.

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 0-43 protein_family_or_group denotes Monoclonal anti-endothelial cell antibodies
T2 64-82 other_name denotes Takayasu arteritis
T3 115-128 tissue denotes large vessels
T4 151-194 protein_family_or_group denotes monoclonal anti-endothelial cell antibodies
T5 196-201 protein_family_or_group denotes mAECA
T6 223-241 other_name denotes Takayasu arteritis
T7 280-318 cell_line denotes human umbilical vein endothelial cells
T8 320-325 cell_line denotes HUVEC
T9 365-378 other_name denotes EC activation
T10 400-405 protein_family_or_group denotes mAECA
T11 425-453 cell_type denotes peripheral blood lymphocytes
T12 472-490 other_name denotes Takayasu arteritis
T13 498-531 other_name denotes Epstein-Barr virus transformation
T14 550-566 cell_line denotes macrovascular EC
T15 568-573 cell_line denotes HUVEC
T16 579-595 cell_line denotes microvascular EC
T17 597-633 cell_line denotes human bone marrow EC immortalized by
T18 634-638 virus denotes SV40
T19 665-698 other_name denotes enzyme-linked immunosorbent assay
T20 743-764 protein_family_or_group denotes monoclonal antibodies
T21 766-771 protein_family_or_group denotes mAECA
T22 794-824 other_name denotes EC epitope binding specificity
T23 832-846 protein_molecule denotes total IgG-AECA
T24 856-874 other_name denotes Takayasu arteritis
T25 903-908 protein_family_or_group denotes mAECA
T26 912-927 cell_type denotes human aortic EC
T27 943-963 other_name denotes immunohistochemistry
T28 989-1002 protein_molecule denotes interleukin-6
T29 1004-1008 protein_molecule denotes IL-6
T30 1014-1035 other_name denotes von Willebrand factor
T31 1037-1040 other_name denotes vWF
T32 1083-1096 other_name denotes EC activation
T33 1102-1114 cell_line denotes activated EC
T34 1152-1171 cell_line denotes monocytic cell line
T35 1173-1177 cell_line denotes U937
T36 1209-1242 protein_molecule denotes vascular cell adhesion molecule 1
T37 1283-1293 protein_molecule denotes E-selectin
T38 1308-1324 cell_component denotes nuclear extracts
T39 1332-1337 protein_family_or_group denotes mAECA
T40 1401-1422 protein_complex denotes nuclear factor kappaB
T41 1424-1433 protein_complex denotes NF-kappaB
T42 1453-1462 protein_complex denotes NF-kappaB
T43 1480-1516 other_name denotes electrophoretic mobility shift assay
T44 1531-1536 protein_family_or_group denotes mAECA
T45 1625-1628 protein_family_or_group denotes IgG
T46 1652-1670 other_name denotes Takayasu arteritis
T47 1675-1680 cell_line denotes HUVEC
T48 1686-1691 protein_family_or_group denotes mAECA
T49 1724-1740 cell_line denotes macrovascular EC
T50 1767-1796 other_name denotes antimicrovascular EC activity
T51 1802-1807 protein_family_or_group denotes mAECA
T52 1817-1829 protein_family_or_group denotes normal human
T53 1830-1833 protein_family_or_group denotes IgG
T54 1839-1868 other_name denotes anti-human aortic EC activity
T55 1884-1889 protein_family_or_group denotes mAECA
T56 1890-1902 cell_line denotes activated EC
T57 1928-1932 protein_molecule denotes IL-6
T58 1937-1940 other_name denotes vWF
T59 1958-1963 protein_family_or_group denotes mAECA
T60 1972-1985 other_name denotes EC expression
T61 1989-2007 protein_family_or_group denotes adhesion molecules
T62 2034-2038 cell_line denotes U937
T63 2058-2060 cell_type denotes EC
T64 2081-2086 protein_family_or_group denotes mAECA
T65 2102-2123 other_name denotes nuclear translocation
T66 2131-2140 protein_complex denotes NF-kappaB
T67 2201-2205 protein_molecule denotes AECA
T68 2229-2231 cell_type denotes EC
T69 2235-2253 other_name denotes Takayasu arteritis
T70 2275-2292 protein_family_or_group denotes adhesion molecule
T71 2320-2329 protein_complex denotes NF-kappaB
T72 2357-2366 cell_type denotes monocytes
T73 2435-2447 other_name denotes vasculopathy
T74 2451-2469 other_name denotes Takayasu arteritis