PubMed:10400755 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	mondo_id
T1	403-405	DiseaseOrPhenotypicFeature	denotes	MG	0009688
T2	406-417	DiseaseOrPhenotypicFeature	denotes	astrocytoma	0019781
T3	433-439	DiseaseOrPhenotypicFeature	denotes	defect	0008568
T4	684-690	DiseaseOrPhenotypicFeature	denotes	defect	0008568
T5	812-814	DiseaseOrPhenotypicFeature	denotes	MG	0009688
T6	948-951	DiseaseOrPhenotypicFeature	denotes	can	0012833
T7	974-976	DiseaseOrPhenotypicFeature	denotes	MG	0009688
T8	1019-1028	DiseaseOrPhenotypicFeature	denotes	infection	0005550
T9	1079-1085	DiseaseOrPhenotypicFeature	denotes	defect	0008568

Id	Subject	Object	Predicate	Lexical cue
T1	406-417	HP_0009592	denotes	astrocytoma

Id	Subject	Object	Predicate	Lexical cue
T1	37-43	protein	denotes	HLA-DR
T2	107-123	protein	denotes	gamma interferon
T3	132-155	protein	denotes	class II transactivator
T4	358-367	protein	denotes	IFN-gamma
T5	377-383	protein	denotes	HLA-DR
T6	398-423	cell_line	denotes	U373 MG astrocytoma cells
T7	454-459	protein	denotes	STAT1
T8	542-547	DNA	denotes	CIITA
T9	603-612	protein	denotes	IFN-gamma
T10	661-667	protein	denotes	HLA-DR
T11	735-764	protein	denotes	major immediate-early protein
T12	765-768	protein	denotes	IE1
T13	781-801	cell_line	denotes	CD4(+) T-cell clones
T14	807-820	cell_line	denotes	U373 MG cells
T15	830-854	cell_type	denotes	antigen-presenting cells
T16	873-882	protein	denotes	IFN-gamma
T17	944-947	protein	denotes	IE1
T18	969-982	cell_line	denotes	U373 MG cells
T19	1004-1009	DNA	denotes	CIITA
T20	1135-1164	DNA	denotes	IFN-gamma-responsive promoter
T21	1168-1173	DNA	denotes	CIITA
T22	1232-1237	DNA	denotes	CIITA

Id	Subject	Object	Predicate	Lexical cue
C1	10-31	NP	denotes	human cytomegalovirus
C2	168-196	NP	denotes	Human cytomegalovirus (HCMV)
C3	198-215	NP	denotes	a betaherpesvirus
C4	220-230	NP	denotes	a pathogen
C5	231-236	NP	denotes	which
C6	320-324	NP	denotes	HCMV
C7	398-423	NP	denotes	U373 MG astrocytoma cells
C8	807-820	NP	denotes	U373 MG cells
C9	888-892	NP	denotes	HCMV
C10	969-982	NP	denotes	U373 MG cells
C11	1004-1009	NP	denotes	CIITA
C12	1034-1038	NP	denotes	HCMV
C13	1097-1101	NP	denotes	HCMV
C14	1168-1173	NP	denotes	CIITA
R1	C2	C1	coref-ident	Human cytomegalovirus (HCMV),human cytomegalovirus
R2	C3	C2	coref-appos	a betaherpesvirus,Human cytomegalovirus (HCMV)
R3	C5	C4	coref-relat	which,a pathogen
R4	C6	C2	coref-ident	HCMV,Human cytomegalovirus (HCMV)
R5	C8	C7	coref-ident	U373 MG cells,U373 MG astrocytoma cells
R6	C9	C6	coref-ident	HCMV,HCMV
R7	C10	C8	coref-ident	U373 MG cells,U373 MG cells
R8	C12	C9	coref-ident	HCMV,HCMV
R9	C13	C12	coref-ident	HCMV,HCMV
R10	C14	C11	coref-ident	CIITA,CIITA

Id	Subject	Object	Predicate	Lexical cue
S1	0-167	Sentence	denotes	Escape of human cytomegalovirus from HLA-DR-restricted CD4(+) T-cell response is mediated by repression of gamma interferon-induced class II transactivator expression.
S2	168-291	Sentence	denotes	Human cytomegalovirus (HCMV), a betaherpesvirus, is a pathogen which escapes immune recognition through various mechanisms.
S3	292-502	Sentence	denotes	In this paper, we show that HCMV down regulates gamma interferon (IFN-gamma)-induced HLA-DR expression in U373 MG astrocytoma cells due to a defect downstream of STAT1 phosphorylation and nuclear translocation.
S4	503-678	Sentence	denotes	Repression of class II transactivator (CIITA) mRNA expression is detected within the first hours of IFN-gamma-HCMV coincubation and results in the absence of HLA-DR synthesis.
S5	679-893	Sentence	denotes	This defect leads to the absence of presentation of the major immediate-early protein IE1 to specific CD4(+) T-cell clones when U373 MG cells, used as antigen-presenting cells, are treated with IFN-gamma plus HCMV.
S6	894-1039	Sentence	denotes	However, presentation of endogenously synthesized IE1 can be restored when U373 MG cells are transfected with CIITA prior to infection with HCMV.
S7	1040-1174	Sentence	denotes	Altogether, the data indicate that the defect induced by HCMV resides in the activation of the IFN-gamma-responsive promoter of CIITA.
S8	1175-1249	Sentence	denotes	This is the first demonstration of a viral inhibition of CIITA expression.

Id	Subject	Object	Predicate	Lexical cue
T1	10-31	virus	denotes	human cytomegalovirus
T2	37-43	protein_molecule	denotes	HLA-DR
T3	107-123	protein_family_or_group	denotes	gamma interferon
T4	132-155	protein_molecule	denotes	class II transactivator
T5	168-189	virus	denotes	Human cytomegalovirus
T6	191-195	virus	denotes	HCMV
T7	200-215	virus	denotes	betaherpesvirus
T8	245-263	other_name	denotes	immune recognition
T9	320-324	virus	denotes	HCMV
T10	340-358	other_name	denotes	gamma interferon (
T11	358-367	protein_molecule	denotes	IFN-gamma
T12	377-383	protein_molecule	denotes	HLA-DR
T13	398-423	cell_line	denotes	U373 MG astrocytoma cells
T14	454-459	protein_molecule	denotes	STAT1
T15	517-542	other_name	denotes	class II transactivator (
T16	542-547	DNA_domain_or_region	denotes	CIITA
T17	603-612	protein_molecule	denotes	IFN-gamma
T18	612-617	virus	denotes	-HCMV
T19	661-667	protein_molecule	denotes	HLA-DR
T20	735-764	protein_family_or_group	denotes	major immediate-early protein
T21	765-768	protein_molecule	denotes	IE1
T22	781-801	cell_line	denotes	CD4(+) T-cell clones
T23	807-820	cell_line	denotes	U373 MG cells
T24	830-854	cell_type	denotes	antigen-presenting cells
T25	873-882	protein_molecule	denotes	IFN-gamma
T26	888-892	virus	denotes	HCMV
T27	944-947	protein_molecule	denotes	IE1
T28	969-982	cell_line	denotes	U373 MG cells
T29	1004-1009	DNA_domain_or_region	denotes	CIITA
T30	1034-1038	virus	denotes	HCMV
T31	1097-1101	virus	denotes	HCMV
T32	1135-1144	protein_molecule	denotes	IFN-gamma
T33	1168-1173	DNA_domain_or_region	denotes	CIITA
T34	1232-1237	DNA_domain_or_region	denotes	CIITA