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sentences

Id	Subject	Object	Predicate	Lexical cue
T1	0-140	Sentence	denotes	Rank-order of potencies for inhibition of the secretion of abeta40 and abeta42 suggests that both are generated by a single gamma-secretase.
T2	141-338	Sentence	denotes	The Alzheimer's disease amyloid peptide Abeta has a heterogeneous COOH terminus, as variants 40 and 42 residues long are found in neuritic plaques and are secreted constitutively by cultured cells.
T3	339-469	Sentence	denotes	The proteolytic activity that liberates the Abeta COOH terminus from the beta-amyloid precursor protein is called gamma-secretase.
T4	470-541	Sentence	denotes	It could be one protease with dual specificity or two distinct enzymes.
T5	542-782	Sentence	denotes	By using enzyme-linked immunosorbent assays selective for Abeta40 or Abeta42, we have measured Abeta secretion by a HeLa cell line, and we have examined the dose responses for a panel of five structurally diverse gamma-secretase inhibitors.
T6	783-1136	Sentence	denotes	The inhibitors lowered Abeta and p3 secretion and increased levels of the COOH-terminal 99-residue beta-amyloid precursor protein derivative that is the precursor for Abeta but did not alter secretion of beta-amyloid precursor protein derivatives generated by other secretases, indicating that the inhibitors blocked the gamma-secretase processing step.
T7	1137-1304	Sentence	denotes	The dose-dependent inhibition of Abeta42 was unusual, as the compounds elevated Abeta42 secretion at sub-inhibitory doses and then inhibited secretion at higher doses.
T8	1305-1515	Sentence	denotes	A compound was identified that elevated Abeta42 secretion at a low concentration without inhibiting Abeta42 or Abeta40 at high concentrations, demonstrating that these phenomena are separable pharmacologically.
T9	1516-1680	Sentence	denotes	Using either of two methods, IC50 values for inhibition of Abeta42 and Abeta40 were found to have the same rank-order and fall on a trend line with near-unit slope.
T10	1681-1805	Sentence	denotes	These results favor the hypothesis that Abeta variants ending at residue 40 or 42 are generated by a single gamma-secretase.

PubmedHPO

Id	Subject	Object	Predicate	Lexical cue
T1	145-164	HP_0002511	denotes	Alzheimer's disease
T2	165-172	HP_0011034	denotes	amyloid
T3	271-287	HP_0100256	denotes	neuritic plaques
T4	417-424	HP_0011034	denotes	amyloid
T5	887-894	HP_0011034	denotes	amyloid
T6	992-999	HP_0011034	denotes	amyloid

UseCases_ArguminSci_Discourse

Id	Subject	Object	Predicate	Lexical cue
T1	0-140	DRI_Background	denotes	Rank-order of potencies for inhibition of the secretion of abeta40 and abeta42 suggests that both are generated by a single gamma-secretase.
T2	141-338	DRI_Background	denotes	The Alzheimer's disease amyloid peptide Abeta has a heterogeneous COOH terminus, as variants 40 and 42 residues long are found in neuritic plaques and are secreted constitutively by cultured cells.
T3	339-469	DRI_Outcome	denotes	The proteolytic activity that liberates the Abeta COOH terminus from the beta-amyloid precursor protein is called gamma-secretase.
T4	470-541	DRI_Outcome	denotes	It could be one protease with dual specificity or two distinct enzymes.
T5	542-782	DRI_Approach	denotes	By using enzyme-linked immunosorbent assays selective for Abeta40 or Abeta42, we have measured Abeta secretion by a HeLa cell line, and we have examined the dose responses for a panel of five structurally diverse gamma-secretase inhibitors.
T6	783-856	DRI_Background	denotes	The inhibitors lowered Abeta and p3 secretion and increased levels of the
T7	857-894	Token_Label.OUTSIDE	denotes	COOH-terminal 99-residue beta-amyloid
T8	895-1136	DRI_Background	denotes	precursor protein derivative that is the precursor for Abeta but did not alter secretion of beta-amyloid precursor protein derivatives generated by other secretases, indicating that the inhibitors blocked the gamma-secretase processing step.
T9	1137-1304	DRI_Background	denotes	The dose-dependent inhibition of Abeta42 was unusual, as the compounds elevated Abeta42 secretion at sub-inhibitory doses and then inhibited secretion at higher doses.
T10	1305-1515	DRI_Background	denotes	A compound was identified that elevated Abeta42 secretion at a low concentration without inhibiting Abeta42 or Abeta40 at high concentrations, demonstrating that these phenomena are separable pharmacologically.
T11	1516-1680	DRI_Background	denotes	Using either of two methods, IC50 values for inhibition of Abeta42 and Abeta40 were found to have the same rank-order and fall on a trend line with near-unit slope.
T12	1681-1805	DRI_Background	denotes	These results favor the hypothesis that Abeta variants ending at residue 40 or 42 are generated by a single gamma-secretase.

mondo_disease

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T1	145-164	Disease	denotes	Alzheimer's disease	http://purl.obolibrary.org/obo/MONDO_0004975
T2	165-172	Disease	denotes	amyloid	http://purl.obolibrary.org/obo/MONDO_0019065
T3	417-424	Disease	denotes	amyloid	http://purl.obolibrary.org/obo/MONDO_0019065
T4	887-894	Disease	denotes	amyloid	http://purl.obolibrary.org/obo/MONDO_0019065
T5	992-999	Disease	denotes	amyloid	http://purl.obolibrary.org/obo/MONDO_0019065

HP-phenotype

Id	Subject	Object	Predicate	Lexical cue	hp_id
T1	145-164	Phenotype	denotes	Alzheimer's disease	HP:0002511
T2	271-287	Phenotype	denotes	neuritic plaques	HP:0100256

CL-cell

Id	Subject	Object	Predicate	Lexical cue	cl_id
T1	323-337	Cell	denotes	cultured cells	http://purl.obolibrary.org/obo/CL:0000010